IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 9518
EU - Europa 7416
AS - Asia 1187
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 11
SA - Sud America 8
AF - Africa 6
Totale 18158
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Nazione #
US - Stati Uniti d'America 9471
GB - Regno Unito 2948
IT - Italia 1300
CN - Cina 957
SE - Svezia 843
UA - Ucraina 732
DE - Germania 536
FR - Francia 437
IE - Irlanda 317
TR - Turchia 127
FI - Finlandia 116
BE - Belgio 55
CA - Canada 46
IN - India 31
AT - Austria 26
VN - Vietnam 23
GR - Grecia 22
RO - Romania 21
RU - Federazione Russa 20
IR - Iran 17
NL - Olanda 13
AU - Australia 10
EU - Europa 10
KR - Corea 7
ES - Italia 6
PL - Polonia 6
ID - Indonesia 5
JP - Giappone 5
BR - Brasile 4
IL - Israele 4
ZA - Sudafrica 4
BG - Bulgaria 3
CL - Cile 3
DK - Danimarca 3
RS - Serbia 3
SA - Arabia Saudita 3
EG - Egitto 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
CH - Svizzera 1
CZ - Repubblica Ceca 1
HR - Croazia 1
IM - Isola di Man 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
MY - Malesia 1
PA - Panama 1
PE - Perù 1
PK - Pakistan 1
TW - Taiwan 1
Totale 18158
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Città #
Southend 2801
Fairfield 1771
Chandler 851
Woodbridge 794
Ashburn 712
Seattle 657
Wilmington 647
Siena 613
Jacksonville 607
Cambridge 606
Houston 602
Ann Arbor 444
Dublin 317
Princeton 266
Beijing 259
Nanjing 213
Dearborn 146
Fremont 116
Izmir 116
San Diego 87
Boardman 85
San Mateo 84
Nanchang 74
Brussels 53
Lancaster 50
Hebei 46
Shenyang 40
Jiaxing 38
Redwood City 35
Aachen 34
Jinan 33
Kunming 33
Milan 32
Norwalk 31
Tianjin 31
Venezia 30
Changsha 27
Düsseldorf 27
Rome 27
Menlo Park 26
Ningbo 25
Guangzhou 24
Ottawa 24
Dong Ket 23
Florence 21
London 20
Vienna 19
Hefei 16
Hangzhou 15
Avellino 14
San Francisco 14
Timisoara 14
Parma 13
Toronto 12
Philadelphia 11
Pisa 11
San Giovanni Valdarno 11
Zhengzhou 11
Hanover 10
Helsinki 10
Prato 10
Changchun 9
Maletto 9
Borgo San Lorenzo 8
Catanzaro 8
Mestre 8
Palo Alto 8
Taizhou 8
Ventimiglia 8
Lanuvio 7
Naples 7
Salerno 7
Catania 6
Lanzhou 6
Leawood 6
Serra 6
Shanghai 6
Tegoleto 6
Andover 5
Certaldo 5
Falls Church 5
Innsbruck 5
Suri 5
Turin 5
Winnipeg 5
Zanjan 5
Amsterdam 4
Auburn Hills 4
Bacoli 4
Berlin 4
Bologna 4
Ceppaloni 4
Frankfurt am Main 4
Haikou 4
Monteriggioni 4
Napoli 4
Nottingham 4
Pratovecchio 4
Redmond 4
Albinea 3
Totale 14007
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Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 253
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 238
Development of novel cyclic peptides as pro-apoptotic agents 225
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 218
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 213
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 211
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 207
null 195
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 192
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 192
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 191
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 191
A NEW MICROTUBULE TARGETING COMPOUND PBOX-15 INHIBITS T- CELL MIGRATION VIA POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN; 186
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 184
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 180
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 179
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 174
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 172
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 168
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 168
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 167
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 166
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 164
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 158
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 158
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 158
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 156
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 154
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 151
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 149
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 149
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 148
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 146
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 146
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 145
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 143
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 142
Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors 142
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 141
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 141
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium. 140
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 139
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 139
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 139
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 138
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 136
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats 136
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. 134
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 134
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 134
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 133
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 132
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 132
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 132
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 131
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 130
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 130
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials 130
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 128
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 127
A stereoselective approach to peptidomimetic BACE1 inhibitors 126
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 124
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. 123
null 123
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. 121
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies. 120
null 120
“A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring” 119
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 119
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 119
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 118
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 118
COMPOUNDS WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY 115
null 115
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 115
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. 115
Novel aryl piperazine derivatives with medical utility 114
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 114
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 113
null 113
Malaria chemotherapy: recent advances in drug development 111
null 111
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 110
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 109
null 109
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships. 109
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 108
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 107
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase 106
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 106
CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 106
Rational design of the first difluorostatone-based PfSUB1 inhibitors 105
Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines 105
null 105
The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells 104
null 104
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 104
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. 103
null 101
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases. 100
Totale 14122
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Categoria #
all - tutte 31722
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31722
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018251 0000 00 00 642210857
2018/20192663 26918928 59182 185155 120355733622
2019/20204503 514177273703 311429 404516 382401122271
2020/20214050 162340204359 265612 331466 324476318193
2021/20222615 229310226158 12373 134111 124331296500
2022/20233075 193318453440 358649 102270 292000
Totale 18575