IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 17.143
EU - Europa 14.946
AS - Asia 7.176
SA - Sud America 1.045
AF - Africa 434
OC - Oceania 44
Continente sconosciuto - Info sul continente non disponibili 16
AN - Antartide 1
Totale 40.805
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Nazione #
US - Stati Uniti d'America 16.852
IT - Italia 3.189
GB - Regno Unito 3.176
RU - Federazione Russa 2.874
CN - Cina 2.431
SG - Singapore 2.132
IE - Irlanda 1.567
DE - Germania 874
SE - Svezia 838
BR - Brasile 818
UA - Ucraina 743
VN - Vietnam 671
FR - Francia 655
HK - Hong Kong 560
FI - Finlandia 363
KR - Corea 298
IN - India 274
ZA - Sudafrica 234
TR - Turchia 173
BD - Bangladesh 163
CA - Canada 161
ES - Italia 117
NL - Olanda 113
AR - Argentina 83
MX - Messico 80
PL - Polonia 72
JP - Giappone 64
AT - Austria 62
CZ - Repubblica Ceca 53
IQ - Iraq 48
BE - Belgio 45
CI - Costa d'Avorio 43
NG - Nigeria 41
PK - Pakistan 41
IR - Iran 33
RO - Romania 33
ID - Indonesia 31
AU - Australia 30
UZ - Uzbekistan 30
EC - Ecuador 29
MA - Marocco 28
VE - Venezuela 28
SA - Arabia Saudita 27
CO - Colombia 25
GR - Grecia 25
EG - Egitto 23
LT - Lituania 23
CL - Cile 22
IL - Israele 20
AZ - Azerbaigian 19
JO - Giordania 19
CH - Svizzera 16
KE - Kenya 16
PT - Portogallo 16
AE - Emirati Arabi Uniti 15
JM - Giamaica 15
TN - Tunisia 15
ET - Etiopia 14
DK - Danimarca 13
KZ - Kazakistan 13
BO - Bolivia 12
PH - Filippine 12
MY - Malesia 11
NZ - Nuova Zelanda 11
PE - Perù 11
EU - Europa 10
NP - Nepal 10
EE - Estonia 9
LV - Lettonia 9
RS - Serbia 9
DZ - Algeria 8
GE - Georgia 8
KG - Kirghizistan 8
PA - Panama 8
PY - Paraguay 8
BY - Bielorussia 7
CR - Costa Rica 7
HU - Ungheria 7
TH - Thailandia 7
TW - Taiwan 7
UY - Uruguay 7
BG - Bulgaria 6
OM - Oman 6
SY - Repubblica araba siriana 6
HN - Honduras 5
LA - Repubblica Popolare Democratica del Laos 5
LB - Libano 5
MC - Monaco 5
PS - Palestinian Territory 5
SN - Senegal 5
AL - Albania 4
KW - Kuwait 4
MD - Moldavia 4
NO - Norvegia 4
XK - ???statistics.table.value.countryCode.XK??? 4
AM - Armenia 3
AO - Angola 3
BA - Bosnia-Erzegovina 3
DO - Repubblica Dominicana 3
HR - Croazia 3
Totale 40.755
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Città #
Southend 2.794
Dallas 2.155
Fairfield 1.754
Ashburn 1.574
Dublin 1.551
Singapore 1.153
San Jose 794
Woodbridge 789
Chandler 787
Siena 732
Moscow 721
Santa Clara 687
Seattle 661
Wilmington 643
Beijing 629
Houston 622
Milan 606
Jacksonville 605
Cambridge 604
Hong Kong 535
Ann Arbor 443
Hefei 387
Seoul 291
Los Angeles 275
Council Bluffs 273
Princeton 264
New York 246
Rome 246
Johannesburg 214
Nanjing 211
The Dalles 210
Ho Chi Minh City 204
Florence 175
Lauterbourg 171
Helsinki 163
Hanoi 159
Dearborn 146
Munich 127
Fremont 116
Izmir 116
Shanghai 114
Boardman 110
San Diego 94
Bengaluru 91
Orem 90
Buffalo 87
San Mateo 84
Washington 81
São Paulo 80
Nanchang 74
London 67
Lappeenranta 61
Düsseldorf 60
Frankfurt am Main 57
Tokyo 57
Málaga 56
Warsaw 56
Turin 52
Lancaster 49
Chennai 47
Denver 47
Guangzhou 47
Hebei 46
Abidjan 43
Brno 42
Naples 42
San Francisco 40
Shenyang 40
Vienna 40
Abuja 39
Jiaxing 39
Brussels 37
Columbus 37
Da Nang 37
Montreal 37
Redondo Beach 37
Toronto 37
Atlanta 36
Nuremberg 36
Tianjin 36
Brooklyn 35
Redwood City 35
Aachen 34
Jinan 34
Mexico City 34
Changsha 33
Figino 33
Haiphong 33
Kunming 33
Phoenix 33
Bologna 31
Norwalk 31
Amsterdam 30
Turku 30
Venezia 30
Chicago 28
Portsmouth 28
Stockholm 27
Tashkent 27
Menlo Park 26
Totale 27.720
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 444
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 406
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 398
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 396
Development of novel cyclic peptides as pro-apoptotic agents 390
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 389
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 385
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 370
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 365
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 345
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 343
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin 337
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 335
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 335
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 334
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 332
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 325
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 322
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 320
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 315
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 314
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 313
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 313
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 310
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 310
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 305
A stereoselective approach to peptidomimetic BACE1 inhibitors 297
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 296
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 292
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 284
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 284
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 283
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 283
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 282
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 279
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 279
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 279
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 277
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 276
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 274
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 273
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 271
Telomerase-based cancer therapeutics: a review on their clinical trials 269
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 268
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 267
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 267
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 265
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 264
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 264
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 263
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 263
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 261
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 256
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 255
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 255
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 255
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 254
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 252
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 252
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 250
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 249
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 248
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 248
Malaria chemotherapy: recent advances in drug development 246
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 246
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 244
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 243
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 243
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 242
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 242
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 241
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 240
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 240
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 240
Novel aryl piperazine derivatives with medical utility 239
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 239
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 239
Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor 237
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 237
Computational tool for fast in silico evaluation of hERG K+ channel affinity 236
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 232
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 232
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 232
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 232
Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products 232
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 231
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 230
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 230
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 229
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 226
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 225
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 225
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 221
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 221
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 220
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 220
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 220
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles 220
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 219
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 217
Totale 27.593
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Categoria #
all - tutte 119.530
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 119.530
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.602 229 307 226 156 123 73 133 111 123 330 294 497
2022/20233.081 178 302 415 392 337 602 89 242 277 100 93 54
2023/20242.984 107 55 276 137 183 797 895 42 30 99 124 239
2024/20255.393 165 223 658 303 620 297 173 282 616 250 490 1.316
2025/202614.277 972 1.721 1.875 1.698 2.599 590 1.548 480 456 848 365 1.125
2026/2027242 242 0 0 0 0 0 0 0 0 0 0 0
Totale 41.388