IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 10.257
EU - Europa 9.533
AS - Asia 1.442
OC - Oceania 20
AF - Africa 16
SA - Sud America 15
Continente sconosciuto - Info sul continente non disponibili 11
Totale 21.294
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Nazione #
US - Stati Uniti d'America 10.207
GB - Regno Unito 2.990
IT - Italia 1.659
IE - Irlanda 1.551
CN - Cina 1.087
SE - Svezia 815
UA - Ucraina 726
DE - Germania 611
FR - Francia 410
FI - Finlandia 258
RU - Federazione Russa 234
TR - Turchia 127
SG - Singapore 92
ES - Italia 63
CA - Canada 48
CZ - Repubblica Ceca 46
IN - India 37
BE - Belgio 36
AT - Austria 29
VN - Vietnam 24
GR - Grecia 23
RO - Romania 22
IR - Iran 19
AU - Australia 18
NL - Olanda 14
JP - Giappone 11
EU - Europa 10
PT - Portogallo 9
BR - Brasile 7
EG - Egitto 7
KR - Corea 7
PL - Polonia 7
ID - Indonesia 6
SA - Arabia Saudita 5
ZA - Sudafrica 5
BG - Bulgaria 4
HU - Ungheria 4
IL - Israele 4
MA - Marocco 4
CH - Svizzera 3
CL - Cile 3
DK - Danimarca 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LV - Lettonia 3
NO - Norvegia 3
PK - Pakistan 3
RS - Serbia 3
HK - Hong Kong 2
HR - Croazia 2
MY - Malesia 2
NZ - Nuova Zelanda 2
PA - Panama 2
PE - Perù 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BO - Bolivia 1
CO - Colombia 1
EC - Ecuador 1
EE - Estonia 1
GE - Georgia 1
IM - Isola di Man 1
JO - Giordania 1
KH - Cambogia 1
KZ - Kazakistan 1
LT - Lituania 1
MC - Monaco 1
SY - Repubblica araba siriana 1
TW - Taiwan 1
Totale 21.294
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Città #
Southend 2.794
Fairfield 1.754
Dublin 1.536
Ashburn 1.065
Woodbridge 788
Chandler 787
Siena 690
Seattle 653
Wilmington 642
Cambridge 602
Jacksonville 602
Houston 601
Ann Arbor 443
Princeton 264
Beijing 255
Nanjing 208
Dearborn 146
Fremont 115
Izmir 114
Helsinki 112
New York 112
Boardman 106
Florence 100
Shanghai 95
San Diego 87
San Mateo 84
Washington 78
Nanchang 74
Moscow 65
Singapore 58
Málaga 56
Lancaster 49
Rome 48
Hebei 46
Brno 42
Lappeenranta 41
Milan 40
Shenyang 40
Jiaxing 38
Redwood City 35
Aachen 34
Brussels 34
Jinan 33
Kunming 33
Norwalk 31
Tianjin 31
Venezia 30
London 29
Changsha 27
Düsseldorf 27
Menlo Park 26
Ningbo 25
Guangzhou 24
Ottawa 24
Dong Ket 23
Vienna 22
San Francisco 20
Turin 17
Hangzhou 16
Hefei 16
Parma 15
Prato 15
Avellino 14
Pisa 14
Timisoara 14
Toronto 14
Munich 13
Los Angeles 12
Marietta 12
Frankfurt am Main 11
Salerno 11
San Giovanni Valdarno 11
Zhengzhou 11
Palermo 10
Changchun 9
Fisciano 9
Hanover 9
Lastra a Signa 9
Maletto 9
Naples 9
Philadelphia 9
Arezzo 8
Borgo San Lorenzo 8
Catanzaro 8
Mestre 8
Palo Alto 8
Taizhou 8
Ventimiglia 8
Bari 7
Lanuvio 7
Tokyo 7
Catania 6
Dallas 6
Lanzhou 6
Leawood 6
Serra 6
Tegoleto 6
Albosaggia 5
Amsterdam 5
Andover 5
Totale 16.355
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Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 287
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 264
Development of novel cyclic peptides as pro-apoptotic agents 256
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 252
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 246
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 241
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 239
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 224
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 220
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 215
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin 213
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 209
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 208
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 207
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 206
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 206
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 205
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 202
null 195
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 194
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 193
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 190
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 189
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 189
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 182
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 182
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 182
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 178
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 175
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 170
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 170
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 169
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 168
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 168
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 166
Telomerase-based cancer therapeutics: a review on their clinical trials 163
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 163
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 162
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 161
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 160
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 159
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 159
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 159
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 158
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 158
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 158
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 157
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 157
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 156
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 155
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 155
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 154
A stereoselective approach to peptidomimetic BACE1 inhibitors 154
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats 153
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 153
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 152
Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors 151
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 150
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 149
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 149
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 148
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 148
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 148
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 144
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 144
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 143
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 142
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 140
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 140
Novel aryl piperazine derivatives with medical utility 139
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 139
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 139
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 138
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 138
Malaria chemotherapy: recent advances in drug development 137
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 137
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 133
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 133
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 132
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 131
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 131
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 130
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 130
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 129
COMPOUNDS WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY 128
Computational tool for fast in silico evaluation of hERG K+ channel affinity 128
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 127
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 126
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 124
CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 124
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases 123
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 121
Rational design of the first difluorostatone-based PfSUB1 inhibitors 121
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 120
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 119
Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach 119
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 116
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 116
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 115
The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells 115
Totale 16.320
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Categoria #
all - tutte 65.181
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.181
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.959 0 176 270 698 309 426 402 513 379 399 119 268
2020/20214.033 161 338 204 358 263 609 331 463 322 475 317 192
2021/20222.602 229 307 226 156 123 73 133 111 123 330 294 497
2022/20233.081 178 302 415 392 337 602 89 242 277 100 93 54
2023/20242.984 107 55 276 137 183 797 895 42 30 99 124 239
2024/2025312 165 147 0 0 0 0 0 0 0 0 0 0
Totale 21.788