IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 16.418
EU - Europa 14.072
AS - Asia 7.017
SA - Sud America 1.036
AF - Africa 433
OC - Oceania 42
Continente sconosciuto - Info sul continente non disponibili 15
AN - Antartide 1
Totale 39.034
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Nazione #
US - Stati Uniti d'America 16.159
GB - Regno Unito 3.171
RU - Federazione Russa 2.874
CN - Cina 2.411
IT - Italia 2.332
SG - Singapore 2.093
IE - Irlanda 1.567
DE - Germania 873
SE - Svezia 838
BR - Brasile 812
UA - Ucraina 742
VN - Vietnam 671
FR - Francia 655
HK - Hong Kong 552
FI - Finlandia 363
KR - Corea 298
IN - India 270
ZA - Sudafrica 233
TR - Turchia 172
CA - Canada 143
ES - Italia 116
NL - Olanda 106
BD - Bangladesh 88
AR - Argentina 82
MX - Messico 74
PL - Polonia 71
JP - Giappone 63
AT - Austria 62
CZ - Repubblica Ceca 53
IQ - Iraq 48
BE - Belgio 45
CI - Costa d'Avorio 43
NG - Nigeria 41
PK - Pakistan 38
RO - Romania 33
AU - Australia 30
IR - Iran 30
UZ - Uzbekistan 30
EC - Ecuador 29
ID - Indonesia 29
MA - Marocco 28
VE - Venezuela 28
SA - Arabia Saudita 27
GR - Grecia 25
CO - Colombia 23
EG - Egitto 23
LT - Lituania 23
CL - Cile 22
IL - Israele 20
AZ - Azerbaigian 19
JO - Giordania 19
CH - Svizzera 16
KE - Kenya 16
PT - Portogallo 16
AE - Emirati Arabi Uniti 15
TN - Tunisia 15
ET - Etiopia 14
DK - Danimarca 13
KZ - Kazakistan 13
BO - Bolivia 12
PH - Filippine 12
JM - Giamaica 11
PE - Perù 11
EU - Europa 10
NP - Nepal 10
EE - Estonia 9
LV - Lettonia 9
NZ - Nuova Zelanda 9
RS - Serbia 9
DZ - Algeria 8
GE - Georgia 8
KG - Kirghizistan 8
MY - Malesia 8
PA - Panama 8
PY - Paraguay 8
BY - Bielorussia 7
CR - Costa Rica 7
HU - Ungheria 7
TH - Thailandia 7
TW - Taiwan 7
UY - Uruguay 7
BG - Bulgaria 6
OM - Oman 6
SY - Repubblica araba siriana 6
LA - Repubblica Popolare Democratica del Laos 5
LB - Libano 5
MC - Monaco 5
PS - Palestinian Territory 5
SN - Senegal 5
AL - Albania 4
HN - Honduras 4
KW - Kuwait 4
MD - Moldavia 4
NO - Norvegia 4
XK - ???statistics.table.value.countryCode.XK??? 4
AM - Armenia 3
AO - Angola 3
BA - Bosnia-Erzegovina 3
DO - Repubblica Dominicana 3
HR - Croazia 3
Totale 38.989
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Città #
Southend 2.794
Dallas 2.143
Fairfield 1.754
Dublin 1.551
Ashburn 1.481
Singapore 1.145
Woodbridge 789
Chandler 787
Siena 732
Moscow 721
Seattle 660
San Jose 648
Santa Clara 648
Wilmington 643
Beijing 627
Houston 617
Jacksonville 605
Cambridge 604
Hong Kong 528
Ann Arbor 443
Hefei 387
Seoul 291
Princeton 264
Los Angeles 259
New York 224
Johannesburg 213
Nanjing 211
Ho Chi Minh City 204
The Dalles 195
Council Bluffs 186
Milan 184
Lauterbourg 171
Helsinki 163
Hanoi 159
Florence 155
Dearborn 146
Munich 127
Izmir 116
Fremont 115
Shanghai 112
Boardman 110
Rome 102
Bengaluru 91
San Diego 90
Orem 87
San Mateo 84
São Paulo 80
Washington 80
Buffalo 79
Nanchang 74
London 64
Lappeenranta 61
Düsseldorf 60
Tokyo 57
Frankfurt am Main 56
Málaga 56
Warsaw 56
Lancaster 49
Chennai 47
Guangzhou 46
Hebei 46
Abidjan 43
Brno 42
Denver 42
Shenyang 40
Vienna 40
Abuja 39
Jiaxing 39
Brussels 37
Columbus 37
Da Nang 37
Redondo Beach 37
Montreal 36
Nuremberg 36
Tianjin 36
Brooklyn 35
Redwood City 35
Aachen 34
Jinan 34
San Francisco 34
Changsha 33
Haiphong 33
Kunming 33
Toronto 32
Atlanta 31
Norwalk 31
Amsterdam 30
Turku 30
Venezia 30
Naples 29
Mexico City 28
Portsmouth 28
Phoenix 27
Stockholm 27
Tashkent 27
Menlo Park 26
Ottawa 26
Poplar 26
Ningbo 25
Belo Horizonte 24
Totale 26.566
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 435
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 402
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 394
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 392
Development of novel cyclic peptides as pro-apoptotic agents 385
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 374
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 364
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 356
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 335
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 331
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin 329
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 326
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 325
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 320
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 317
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 317
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 315
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 311
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 311
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 310
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 310
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 307
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 304
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 304
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 299
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 298
A stereoselective approach to peptidomimetic BACE1 inhibitors 290
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 287
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 286
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 277
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 276
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 274
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 273
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 273
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 273
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 272
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 272
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 270
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 270
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 267
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 267
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 263
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 263
Telomerase-based cancer therapeutics: a review on their clinical trials 261
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 260
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 260
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 259
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 257
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 256
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 255
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 255
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 250
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 248
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 246
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 244
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 244
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 243
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 243
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 242
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 242
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 241
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 240
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 238
Novel aryl piperazine derivatives with medical utility 237
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 237
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 237
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 237
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 237
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 236
Malaria chemotherapy: recent advances in drug development 235
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 235
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 234
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 234
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 231
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 230
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 230
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 230
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 229
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 229
Computational tool for fast in silico evaluation of hERG K+ channel affinity 227
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 226
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 225
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 224
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 223
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 222
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 220
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 219
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 218
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 217
Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products 217
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 213
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 213
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 213
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 212
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 210
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 210
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 210
Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors 209
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 207
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 206
Totale 26.687
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Categoria #
all - tutte 112.606
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 112.606
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021984 0 0 0 0 0 0 0 0 0 475 317 192
2021/20222.602 229 307 226 156 123 73 133 111 123 330 294 497
2022/20233.081 178 302 415 392 337 602 89 242 277 100 93 54
2023/20242.984 107 55 276 137 183 797 895 42 30 99 124 239
2024/20255.393 165 223 658 303 620 297 173 282 616 250 490 1.316
2025/202612.735 972 1.721 1.875 1.698 2.599 590 1.548 480 456 796 0 0
Totale 39.604