IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 15.029
EU - Europa 13.479
AS - Asia 5.719
SA - Sud America 883
AF - Africa 142
OC - Oceania 34
Continente sconosciuto - Info sul continente non disponibili 14
AN - Antartide 1
Totale 35.301
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Nazione #
US - Stati Uniti d'America 14.829
GB - Regno Unito 3.116
RU - Federazione Russa 2.873
CN - Cina 2.253
IT - Italia 2.178
SG - Singapore 1.792
IE - Irlanda 1.561
SE - Svezia 835
DE - Germania 828
UA - Ucraina 739
BR - Brasile 737
FR - Francia 473
HK - Hong Kong 449
FI - Finlandia 322
KR - Corea 298
VN - Vietnam 216
IN - India 197
TR - Turchia 158
CA - Canada 119
ES - Italia 109
NL - Olanda 69
AT - Austria 61
AR - Argentina 55
PL - Polonia 53
CZ - Repubblica Ceca 52
MX - Messico 50
BD - Bangladesh 48
JP - Giappone 47
BE - Belgio 43
CI - Costa d'Avorio 42
ZA - Sudafrica 40
RO - Romania 30
IR - Iran 29
IQ - Iraq 26
GR - Grecia 24
AU - Australia 22
EC - Ecuador 22
ID - Indonesia 21
PK - Pakistan 21
LT - Lituania 19
MA - Marocco 19
SA - Arabia Saudita 19
UZ - Uzbekistan 19
EG - Egitto 17
IL - Israele 16
CO - Colombia 14
PT - Portogallo 14
VE - Venezuela 14
AZ - Azerbaigian 13
CH - Svizzera 13
AE - Emirati Arabi Uniti 11
CL - Cile 11
PE - Perù 11
EU - Europa 10
JO - Giordania 10
EE - Estonia 9
KZ - Kazakistan 9
NZ - Nuova Zelanda 9
DK - Danimarca 8
JM - Giamaica 8
KG - Kirghizistan 8
LV - Lettonia 8
BO - Bolivia 7
TN - Tunisia 7
BG - Bulgaria 6
HU - Ungheria 6
NP - Nepal 6
PA - Panama 6
PY - Paraguay 6
RS - Serbia 6
GE - Georgia 5
KE - Kenya 5
LA - Repubblica Popolare Democratica del Laos 5
MY - Malesia 5
CR - Costa Rica 4
HN - Honduras 4
LB - Libano 4
NO - Norvegia 4
SY - Repubblica araba siriana 4
TH - Thailandia 4
TW - Taiwan 4
UY - Uruguay 4
AM - Armenia 3
AO - Angola 3
BA - Bosnia-Erzegovina 3
BY - Bielorussia 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
KW - Kuwait 3
LK - Sri Lanka 3
MD - Moldavia 3
OM - Oman 3
PH - Filippine 3
XK - ???statistics.table.value.countryCode.XK??? 3
AL - Albania 2
BB - Barbados 2
BN - Brunei Darussalam 2
DZ - Algeria 2
GY - Guiana 2
HR - Croazia 2
Totale 35.276
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Città #
Southend 2.794
Dallas 2.138
Fairfield 1.754
Dublin 1.546
Ashburn 1.382
Singapore 977
Woodbridge 789
Chandler 787
Siena 730
Moscow 721
Seattle 659
Wilmington 643
Santa Clara 640
Beijing 622
Houston 613
Cambridge 603
Jacksonville 603
Hong Kong 448
Ann Arbor 443
Hefei 328
Seoul 291
Princeton 264
Los Angeles 224
Nanjing 210
New York 206
Milan 155
Dearborn 146
Florence 144
Helsinki 128
Munich 126
Fremont 115
Izmir 115
Boardman 109
Shanghai 104
Rome 95
Bengaluru 91
San Diego 88
The Dalles 87
San Mateo 84
Washington 79
Buffalo 75
Nanchang 74
São Paulo 71
Ho Chi Minh City 62
Düsseldorf 60
Lappeenranta 58
Málaga 56
London 53
Lancaster 49
Hebei 46
Council Bluffs 44
Abidjan 42
Brno 42
Guangzhou 42
Tokyo 42
Shenyang 40
Hanoi 39
Jiaxing 39
Vienna 39
Warsaw 39
Columbus 37
Denver 37
Redondo Beach 37
Brussels 36
Redwood City 35
Aachen 34
Jinan 34
Changsha 33
Kunming 33
San Francisco 33
Tianjin 33
Brooklyn 32
Frankfurt am Main 32
Norwalk 31
Nuremberg 31
Venezia 30
Toronto 29
Atlanta 28
Portsmouth 28
Turku 28
Johannesburg 27
Montreal 27
Menlo Park 26
Ottawa 26
Ningbo 25
Phoenix 25
Poplar 25
Belo Horizonte 24
Chennai 24
Stockholm 24
Dong Ket 23
Lauterbourg 23
Boston 22
Orem 21
Rio de Janeiro 21
Mexico City 20
Naples 20
Pisa 19
Tashkent 19
Berlin 18
Totale 24.203
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 403
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 378
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 371
Development of novel cyclic peptides as pro-apoptotic agents 367
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 358
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 349
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 340
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 330
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin 305
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 303
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 301
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 300
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 297
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 294
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 293
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 292
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 291
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 290
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 283
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 283
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 281
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 278
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 277
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 276
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 275
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 274
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 268
A stereoselective approach to peptidomimetic BACE1 inhibitors 268
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 266
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 259
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 258
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 256
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 253
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 253
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 250
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 250
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 249
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 247
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 246
Telomerase-based cancer therapeutics: a review on their clinical trials 246
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 246
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 245
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 244
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 243
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 243
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 239
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 237
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 233
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 233
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 231
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 230
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 229
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 229
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 228
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 227
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 226
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 223
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 222
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 222
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 220
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 220
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 219
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 218
Malaria chemotherapy: recent advances in drug development 218
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 218
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 218
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 217
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 216
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 216
Novel aryl piperazine derivatives with medical utility 215
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 215
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 214
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 213
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 212
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 212
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 211
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 211
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 210
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 209
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 209
Computational tool for fast in silico evaluation of hERG K+ channel affinity 208
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 208
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 207
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 206
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 204
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 203
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 198
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 198
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 197
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 196
null 195
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 194
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 193
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 191
Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors 191
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 190
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 189
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 187
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases 187
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats 187
Totale 24.528
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Categoria #
all - tutte 105.406
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.406
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20212.709 0 0 0 0 0 609 331 463 322 475 317 192
2021/20222.602 229 307 226 156 123 73 133 111 123 330 294 497
2022/20233.081 178 302 415 392 337 602 89 242 277 100 93 54
2023/20242.984 107 55 276 137 183 797 895 42 30 99 124 239
2024/20255.393 165 223 658 303 620 297 173 282 616 250 490 1.316
2025/20268.993 972 1.721 1.875 1.698 2.599 128 0 0 0 0 0 0
Totale 35.862