IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 10.353
EU - Europa 9.276
AS - Asia 1.354
OC - Oceania 21
AF - Africa 14
SA - Sud America 13
Continente sconosciuto - Info sul continente non disponibili 11
Totale 21.042
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Nazione #
US - Stati Uniti d'America 10.303
GB - Regno Unito 2.989
IE - Irlanda 1.668
IT - Italia 1.531
CN - Cina 1.095
SE - Svezia 844
UA - Ucraina 726
DE - Germania 593
FR - Francia 443
FI - Finlandia 225
TR - Turchia 125
ES - Italia 65
CA - Canada 48
BE - Belgio 38
IN - India 37
AT - Austria 27
GR - Grecia 23
RU - Federazione Russa 23
VN - Vietnam 23
RO - Romania 22
AU - Australia 18
IR - Iran 16
NL - Olanda 14
JP - Giappone 11
EU - Europa 10
PT - Portogallo 9
ID - Indonesia 8
PL - Polonia 8
BR - Brasile 7
EG - Egitto 7
KR - Corea 7
SA - Arabia Saudita 5
SG - Singapore 5
ZA - Sudafrica 5
BG - Bulgaria 4
IL - Israele 4
CH - Svizzera 3
CL - Cile 3
DK - Danimarca 3
HU - Ungheria 3
KW - Kuwait 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
RS - Serbia 3
HK - Hong Kong 2
HR - Croazia 2
LA - Repubblica Popolare Democratica del Laos 2
LV - Lettonia 2
MA - Marocco 2
MY - Malesia 2
PA - Panama 2
PE - Perù 2
PK - Pakistan 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BO - Bolivia 1
CZ - Repubblica Ceca 1
IM - Isola di Man 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LT - Lituania 1
MC - Monaco 1
TW - Taiwan 1
Totale 21.042
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Città #
Southend 2.794
Fairfield 1.754
Dublin 1.653
Ashburn 1.073
Chandler 845
Woodbridge 788
Siena 654
Seattle 653
Wilmington 642
Cambridge 602
Jacksonville 602
Houston 601
Ann Arbor 443
Princeton 264
Beijing 255
Nanjing 208
Dearborn 146
New York 122
Fremont 115
Izmir 114
Helsinki 112
Shanghai 103
Boardman 93
Florence 87
San Diego 87
San Mateo 84
Washington 79
Nanchang 74
Málaga 58
Lancaster 49
Hebei 46
Shenyang 40
Jiaxing 38
Milan 37
Brussels 36
Redwood City 35
Aachen 34
Jinan 33
Kunming 33
Rome 33
Norwalk 31
Tianjin 31
Venezia 30
London 28
Changsha 27
Düsseldorf 27
Menlo Park 26
Ningbo 25
Guangzhou 24
Ottawa 24
Dong Ket 23
Vienna 20
Hangzhou 16
Hefei 16
San Francisco 16
Avellino 14
Timisoara 14
Toronto 14
Parma 13
Marietta 12
Palermo 11
Pisa 11
San Giovanni Valdarno 11
Zhengzhou 11
Hanover 10
Naples 10
Prato 10
Changchun 9
Maletto 9
Philadelphia 9
Salerno 9
Arezzo 8
Borgo San Lorenzo 8
Catanzaro 8
Lappeenranta 8
Mestre 8
Palo Alto 8
Taizhou 8
Ventimiglia 8
Bari 7
Lanuvio 7
Tokyo 7
Turin 7
Bologna 6
Catania 6
Lanzhou 6
Leawood 6
Mumbai 6
Serra 6
Tegoleto 6
Amsterdam 5
Andover 5
Certaldo 5
Falls Church 5
Frankfurt am Main 5
Innsbruck 5
Licata 5
Suri 5
Winnipeg 5
Zanjan 5
Totale 16.244
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Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 280
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 256
Development of novel cyclic peptides as pro-apoptotic agents 250
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 245
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 239
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 236
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 235
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 218
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 212
A NEW MICROTUBULE TARGETING COMPOUND PBOX-15 INHIBITS T- CELL MIGRATION VIA POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN; 211
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 210
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 206
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 205
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 204
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 203
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 199
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 199
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 197
null 195
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 192
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 191
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 187
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 184
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 184
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 180
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 180
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 179
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 174
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 171
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 168
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 167
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 167
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 166
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 164
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 163
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 163
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 159
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 158
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 157
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 157
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 157
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 157
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 157
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 156
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 155
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 155
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 154
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 154
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 154
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials 154
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 153
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 153
A stereoselective approach to peptidomimetic BACE1 inhibitors 152
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 151
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats 149
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 149
Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors 149
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 148
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. 147
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies. 146
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 146
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 145
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. 145
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. 141
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 140
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 140
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 138
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 138
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. 138
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 137
Novel aryl piperazine derivatives with medical utility 134
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 134
Malaria chemotherapy: recent advances in drug development 134
“A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring” 131
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 131
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 131
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 130
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 130
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 128
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 127
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 127
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 127
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships. 127
COMPOUNDS WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY 125
null 123
CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 123
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases. 122
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 122
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 122
Rational design of the first difluorostatone-based PfSUB1 inhibitors 120
null 120
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 118
null 115
Retinitis Pigmentosa and Retinal Degenerations: Deciphering Pathways and Targets for Drug Discovery and Development 115
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 114
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents 114
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 113
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. 113
null 113
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 112
Totale 15.964
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Categoria #
all - tutte 60.883
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.883
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.697 0 0 0 0 0 0 0 0 0 353 726 618
2019/20204.469 510 176 270 698 309 426 402 513 379 399 119 268
2020/20214.033 161 338 204 358 263 609 331 463 322 475 317 192
2021/20222.602 229 307 226 156 123 73 133 111 123 330 294 497
2022/20233.309 192 317 450 438 356 646 92 254 302 104 98 60
2023/20242.760 119 61 295 151 191 847 962 49 31 54 0 0
Totale 21.480