IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 9.790
EU - Europa 7.684
AS - Asia 1.256
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 11
SA - Sud America 9
AF - Africa 6
Totale 18.771
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Nazione #
US - Stati Uniti d'America 9.743
GB - Regno Unito 2.967
IT - Italia 1.364
CN - Cina 1.020
SE - Svezia 837
UA - Ucraina 726
DE - Germania 569
FR - Francia 433
IE - Irlanda 315
FI - Finlandia 181
TR - Turchia 126
BE - Belgio 94
ES - Italia 65
CA - Canada 46
IN - India 36
AT - Austria 27
GR - Grecia 22
RU - Federazione Russa 21
RO - Romania 20
VN - Vietnam 19
IR - Iran 17
NL - Olanda 14
AU - Australia 13
EU - Europa 10
JP - Giappone 7
KR - Corea 7
PL - Polonia 7
ID - Indonesia 6
BR - Brasile 5
SA - Arabia Saudita 4
ZA - Sudafrica 4
BG - Bulgaria 3
CL - Cile 3
DK - Danimarca 3
IL - Israele 3
NO - Norvegia 3
RS - Serbia 3
EG - Egitto 2
LA - Repubblica Popolare Democratica del Laos 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BD - Bangladesh 1
CH - Svizzera 1
CZ - Repubblica Ceca 1
HR - Croazia 1
HU - Ungheria 1
IM - Isola di Man 1
KZ - Kazakistan 1
LK - Sri Lanka 1
LT - Lituania 1
MC - Monaco 1
MY - Malesia 1
PA - Panama 1
PE - Perù 1
PK - Pakistan 1
TW - Taiwan 1
Totale 18.771
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Città #
Southend 2.781
Fairfield 1.762
Chandler 836
Woodbridge 786
Ashburn 711
Seattle 653
Wilmington 639
Siena 626
Jacksonville 602
Houston 599
Cambridge 596
Ann Arbor 430
Dublin 315
Princeton 264
Beijing 259
Nanjing 212
Dearborn 146
Fremont 116
Izmir 115
Brussels 94
San Diego 87
Boardman 86
San Mateo 84
Washington 77
Helsinki 75
Nanchang 73
Málaga 58
Lancaster 50
Hebei 46
Shenyang 39
Jiaxing 38
Redwood City 35
Aachen 34
Kunming 33
Milan 33
Jinan 32
Norwalk 31
Tianjin 31
Venezia 30
Florence 29
London 29
Rome 29
Changsha 27
Düsseldorf 27
Menlo Park 26
Ningbo 25
Guangzhou 24
Ottawa 24
Shanghai 24
Vienna 20
Dong Ket 19
Philadelphia 18
Hefei 16
San Francisco 16
Hangzhou 15
Avellino 14
Timisoara 14
Parma 13
Toronto 12
Pisa 11
San Giovanni Valdarno 11
Zhengzhou 11
Hanover 10
Prato 10
Changchun 9
Maletto 9
Palermo 9
Salerno 9
Borgo San Lorenzo 8
Catanzaro 8
Mestre 8
Palo Alto 8
Taizhou 8
Ventimiglia 8
Lanuvio 7
Turin 7
Catania 6
Chiswick 6
Islington 6
Lanzhou 6
Leawood 6
Mumbai 6
Naples 6
Serra 6
Tegoleto 6
Amsterdam 5
Andover 5
Bologna 5
Certaldo 5
Falls Church 5
Innsbruck 5
Suri 5
Tokyo 5
Winnipeg 5
Zanjan 5
Auburn Hills 4
Bacoli 4
Berlin 4
Ceppaloni 4
Frankfurt am Main 4
Totale 14.210
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Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 263
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 241
Development of novel cyclic peptides as pro-apoptotic agents 230
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 224
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 222
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 215
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 213
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 199
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 197
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 196
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 195
null 195
A NEW MICROTUBULE TARGETING COMPOUND PBOX-15 INHIBITS T- CELL MIGRATION VIA POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN; 194
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 189
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 188
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 183
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 182
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 180
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 177
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 172
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 170
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 170
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 170
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 167
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 166
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 165
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 160
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 159
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 156
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 154
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 153
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 153
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 153
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 151
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 150
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 148
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 147
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 146
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 146
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 145
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 144
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium. 144
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 144
Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors 144
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 142
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 141
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats 140
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 140
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 139
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. 138
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 138
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 138
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 137
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 137
A stereoselective approach to peptidomimetic BACE1 inhibitors 137
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 135
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 135
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 134
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials 132
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 130
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 128
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. 128
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies. 127
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. 126
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 126
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 126
null 123
“A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring” 122
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 122
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. 122
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 121
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 120
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 120
null 120
COMPOUNDS WITH ATYPICAL ANTIPSYCHOTIC ACTIVITY 119
Novel aryl piperazine derivatives with medical utility 117
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 117
Malaria chemotherapy: recent advances in drug development 115
null 115
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 113
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 113
CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 113
null 113
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships. 113
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase 111
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 111
null 111
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 111
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 111
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 110
null 109
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. 109
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases. 108
Rational design of the first difluorostatone-based PfSUB1 inhibitors 108
Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines 108
The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells 107
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 106
null 105
null 104
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 104
Totale 14.565
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Categoria #
all - tutte 43.325
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.325
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20192.603 0 0 188 28 59 182 184 154 118 350 725 615
2019/20204.465 507 176 270 698 309 425 402 512 377 399 122 268
2020/20214.014 162 338 203 358 260 608 329 463 323 465 317 188
2021/20222.603 228 310 226 155 123 72 133 111 123 329 296 497
2022/20233.335 192 316 447 434 352 638 101 263 307 103 114 68
2023/2024471 124 78 269 0 0 0 0 0 0 0 0 0
Totale 19.190