IRIS
BUTINI, STEFANIA
 Distribuzione geografica
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Continente #
NA - Nord America 18.244
EU - Europa 15.030
AS - Asia 7.242
SA - Sud America 1.094
Continente sconosciuto - Info sul continente non disponibili 599
AF - Africa 436
OC - Oceania 44
AN - Antartide 1
Totale 42.690
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Nazione #
US - Stati Uniti d'America 17.907
IT - Italia 3.247
GB - Regno Unito 3.184
RU - Federazione Russa 2.874
CN - Cina 2.440
SG - Singapore 2.153
IE - Irlanda 1.569
DE - Germania 875
SE - Svezia 839
BR - Brasile 838
UA - Ucraina 744
VN - Vietnam 674
FR - Francia 656
HK - Hong Kong 567
FI - Finlandia 363
KR - Corea 298
IN - India 274
ZA - Sudafrica 234
CA - Canada 183
TR - Turchia 174
BD - Bangladesh 169
ES - Italia 122
NL - Olanda 114
AR - Argentina 86
MX - Messico 81
PL - Polonia 72
JP - Giappone 64
AT - Austria 62
CZ - Repubblica Ceca 53
IQ - Iraq 48
BE - Belgio 47
CI - Costa d'Avorio 43
NG - Nigeria 41
PK - Pakistan 41
CO - Colombia 37
ID - Indonesia 37
EC - Ecuador 36
RO - Romania 34
VE - Venezuela 34
IR - Iran 33
AU - Australia 30
UZ - Uzbekistan 30
MA - Marocco 28
SA - Arabia Saudita 28
GR - Grecia 25
CL - Cile 23
EG - Egitto 23
LT - Lituania 23
IL - Israele 20
AZ - Azerbaigian 19
JO - Giordania 19
CH - Svizzera 18
AE - Emirati Arabi Uniti 17
JM - Giamaica 17
KE - Kenya 16
PH - Filippine 16
PT - Portogallo 16
MY - Malesia 15
TN - Tunisia 15
ET - Etiopia 14
DK - Danimarca 13
KZ - Kazakistan 13
BO - Bolivia 12
CR - Costa Rica 12
NZ - Nuova Zelanda 11
PE - Perù 11
EU - Europa 10
NP - Nepal 10
EE - Estonia 9
HN - Honduras 9
KG - Kirghizistan 9
LV - Lettonia 9
RS - Serbia 9
DZ - Algeria 8
GE - Georgia 8
PA - Panama 8
PY - Paraguay 8
TH - Thailandia 8
BG - Bulgaria 7
BY - Bielorussia 7
HU - Ungheria 7
TW - Taiwan 7
UY - Uruguay 7
OM - Oman 6
SY - Repubblica araba siriana 6
LA - Repubblica Popolare Democratica del Laos 5
LB - Libano 5
MC - Monaco 5
PS - Palestinian Territory 5
SN - Senegal 5
AL - Albania 4
BB - Barbados 4
KW - Kuwait 4
MD - Moldavia 4
NI - Nicaragua 4
NO - Norvegia 4
PR - Porto Rico 4
XK - ???statistics.table.value.countryCode.XK??? 4
AM - Armenia 3
AO - Angola 3
Totale 42.046
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Città #
Southend 2.794
Dallas 2.165
Fairfield 1.754
Ashburn 1.698
Dublin 1.552
Singapore 1.166
San Jose 974
Woodbridge 789
Chandler 787
Siena 733
Santa Clara 725
Moscow 721
Seattle 662
Wilmington 643
Beijing 633
Houston 624
Milan 622
Jacksonville 607
Cambridge 604
Hong Kong 540
Ann Arbor 443
Hefei 387
Council Bluffs 379
Los Angeles 300
Seoul 291
Princeton 264
New York 258
Rome 250
Johannesburg 214
Nanjing 211
The Dalles 210
Ho Chi Minh City 206
Florence 175
Lauterbourg 171
Helsinki 163
Hanoi 160
Dearborn 146
Munich 128
Boardman 120
Fremont 116
Izmir 116
Shanghai 115
San Diego 96
Orem 92
Bengaluru 91
Buffalo 90
Washington 88
San Mateo 84
São Paulo 82
Columbus 74
Nanchang 74
London 69
Lappeenranta 61
Düsseldorf 60
Frankfurt am Main 57
Tokyo 57
Málaga 56
Warsaw 56
Turin 52
Denver 50
Lancaster 50
Chennai 47
Guangzhou 47
Hebei 46
Naples 46
Abidjan 43
San Francisco 43
Brno 42
Brooklyn 42
Atlanta 41
Montreal 40
Shenyang 40
Vienna 40
Abuja 39
Jiaxing 39
Toronto 39
Brussels 37
Da Nang 37
Phoenix 37
Redondo Beach 37
Nuremberg 36
Tianjin 36
Chicago 35
Figino 35
Redwood City 35
Aachen 34
Jinan 34
Mexico City 34
Changsha 33
Haiphong 33
Kunming 33
Norwalk 33
Bologna 31
Amsterdam 30
Turku 30
Venezia 30
Portsmouth 28
Stockholm 27
Tashkent 27
Menlo Park 26
Totale 28.377
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 456
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 425
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 418
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 403
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 400
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome 397
Development of novel cyclic peptides as pro-apoptotic agents 395
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 394
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 377
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 373
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin 363
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 350
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 348
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 345
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 338
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 338
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 337
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 336
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 326
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 325
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 324
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 323
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 322
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 317
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 315
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 313
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 312
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 306
A stereoselective approach to peptidomimetic BACE1 inhibitors 304
The 1-(2,3-dichlorophenyl)-piperazine-to-aripiprazole ratio at steady state in rats and schizophrenic patients 297
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 291
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 290
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 289
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 288
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 287
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 286
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 285
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 284
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 284
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 280
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 277
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 276
Unravelling the response of chronic lymphocytic leukemia to a novel class of anticancer agents, the pyrrolonaphthoxazepines (PNOXs) 276
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 274
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 273
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 272
Telomerase-based cancer therapeutics: a review on their clinical trials 272
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 272
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 271
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 269
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 269
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 269
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 267
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 264
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 263
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 261
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 260
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 258
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 257
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 256
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 253
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 253
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 252
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 252
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 249
Malaria chemotherapy: recent advances in drug development 249
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation 249
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 248
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 248
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 247
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 246
Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor 245
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 244
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 244
Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products 244
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 243
The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity 243
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 243
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders 243
Novel aryl piperazine derivatives with medical utility 242
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 242
Computational tool for fast in silico evaluation of hERG K+ channel affinity 242
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 240
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 239
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 237
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 237
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 236
ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS. 234
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 234
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 233
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 231
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles 228
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 228
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 227
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 226
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 226
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 225
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 225
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 223
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 222
Totale 28.369
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Categoria #
all - tutte 125.411
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 125.411
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.066 0 0 226 156 123 73 133 111 123 330 294 497
2022/20233.081 178 302 415 392 337 602 89 242 277 100 93 54
2023/20242.984 107 55 276 137 183 797 895 42 30 99 124 239
2024/20255.393 165 223 658 303 620 297 173 282 616 250 490 1.316
2025/202614.277 972 1.721 1.875 1.698 2.599 590 1.548 480 456 848 365 1.125
2026/20271.544 526 537 481 0 0 0 0 0 0 0 0 0
Totale 42.690