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Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. (C) 2008 Elsevier Ltd. All rights reserved.

Gemma, S., Kukreja, G., Tripaldi, P., Altarelli, M., Bernetti, M., Franceschini, S., et al. (2008). Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives. TETRAHEDRON LETTERS, 49(13), 2074-2077 [10.1016/j.tetlet.2008.01.128].

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

Gemma, Sandra;Kukreja, G.;Tripaldi, Pierangela;Altarelli, Maria;Bernetti, Matteo;Savini, Luisa;Campiani, Giuseppe;Butini, Stefania
2008-01-01

Abstract

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. (C) 2008 Elsevier Ltd. All rights reserved.
2008
TETRAHEDRON LETTERS
Gemma, S., Kukreja, G., Tripaldi, P., Altarelli, M., Bernetti, M., Franceschini, S., et al. (2008). Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives. TETRAHEDRON LETTERS, 49(13), 2074-2077 [10.1016/j.tetlet.2008.01.128].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/27232
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