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Five-Year Analysis of Adjuvant Pembrolizumab or Placebo in Stage III Melanoma

BackgroundIn the previously reported primary analyses of this phase 3 trial, 12 months of adjuvant pembrolizumab resulted in significantly longer recurrence- and distant metastasis-free survival than placebo in patients with resected high-risk stage III melanoma. To confirm the stability of these benefits, longer-term data were needed.MethodsWe randomly assigned 1019 patients to receive 200 mg of pembrolizumab or placebo intravenously every 3 weeks for a total of 18 doses (approximately 1 yea...

Nivolumab for Resected Stage III or IV Melanoma at 9 Years

Background In the CheckMate 238 trial, patients with resected stage IIIB-C or stage IV melanoma who were treated with nivolumab had longer recurrence-free survival than those who received ipilimumab. Data were needed on longer-term survival.Methods We randomly assigned patients in a 1:1 ratio to receive an intravenous infusion of nivolumab (at a dose of 3 mg per kilogram of body weight every 2 weeks) or ipilimumab (at a dose of 10 mg per kilogram every 3 weeks for four doses, then every 12 we...

Predictors of responses to immune checkpoint blockade in advanced melanoma

Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-based approach to an assessment of 779 paired blood and tumor markers in 37 stage III MMel patients, we analyzed association between blood immune parameters and the functional im...

The Italian Network for Tumor Biotherapy (NIBIT)-M1 study: 2-years survival update for metastatic melanoma patients treated with ipilimumab in combination with fotemustine

Inter nos / intra nos: el espacio como marca identitaria de los exilios femeninos a Hispanoamérica (1933-1989). Introducción

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Tipologia
  • 1 Contributo su Rivista56088
  • 2 Contributo in Volume4
Autore
  • GIORDANO, ANTONIO788
  • NANTE, NICOLA632
  • CERRI, ALESSANDRO628
  • PAOLETTI, RICCARDO572
  • RUBEGNI, PIETRO541
  • FEDERICO, ANTONIO530
  • CANTARINI, LUCA510
  • ROVIELLO, FRANCO485
  • FREDIANI, BRUNO456
  • DE STEFANO, NICOLA452
Data di pubblicazione
  • In corso di stampa22
  • 2020 - 202612890
  • 2010 - 201919570
  • 2000 - 200913851
  • 1990 - 19996762
  • 1980 - 19892501
  • 1970 - 1979475
  • 1966 - 196919
Editore
  • Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598145
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Rivista
  • PHYSICAL REVIEW LETTERS454
  • STUDI SENESI304
  • IL FORO ITALIANO248
  • EUROPEAN JOURNAL OF PUBLIC HEALTH235
  • PLOS ONE224
  • INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES204
  • JOURNAL OF MEDICINAL CHEMISTRY201
  • JOURNAL OF CELLULAR PHYSIOLOGY193
  • JOURNAL OF CLINICAL MEDICINE172
  • PHYSICS LETTERS. SECTION B172
Serie
  • I WORKING PAPERS - CENTRO STUDI DI DIRITTO DEL LAVORO EUROPEO "MASSIMO D'ANTONA"1
  • INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY1
  • KORPUS IM TEXT1
Keyword
  • Humans2855
  • Female1397
  • Male1353
  • Middle Aged879
  • Adult791
  • Italy733
  • Aged703
  • Animals521
  • Medicine (all)386
  • Treatment Outcome384
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  • fre331
  • spa207
  • ger88
  • por28
  • lat27
  • rus18
  • enm14
  • bul9
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  • no fulltext22408
  • open9822
  • partially open968
  • restricted98
  • internalNetwork96
  • embargoed10
  • mixed6
Appartenenza
  • Dipartimento di Biotecnologie Mediche7248
  • Dipartimento di Biotecnologie, Chimica e Farmacia5257
  • Dipartimento di Economia Politica e Statistica1733
  • Dipartimento di Filologia e Critica delle Letterature Antiche e Moderne2901
  • Dipartimento di Giurisprudenza2683
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  • Dipartimento di Medicina Molecolare e dello Sviluppo5464
  • Dipartimento di Scienze della Formazione, Scienze Umane e della Comunicazione Interculturale470
  • Dipartimento di Scienze della Vita4041
  • Dipartimento di Scienze Fisiche, della Terra e dell'Ambiente5946