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Gastric Cancer (GC) with Peritoneal Metastases (PMs): An Overview of Italian PSM Oncoteam Evidence and Study Purposes

Gastric cancer (GC) continues to be one of the leading types of malignancies worldwide, despite an ongoing decrease in incidence. It is the fifth most frequent type of cancer in the world and the fourth leading cause of cancer death. Peritoneal metastases (PMs) occur in 20–30% of cases during the natural history of the disease. Systemic chemotherapy (SC) is undoubtedly the standard of care for patients with GC and PMs. However, with the development of highly effective regimens (SC combined wi...

Diagnostic and Therapeutic Pathway in Diffuse Malignant Peritoneal Mesothelioma

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare form of mesothelioma that carries a very poor prognosis. The 5-year overall survival is about 20% (±5.9). Survival is optimal for patients suitable for cytoreductive surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), with a median OS ranging from 34 to 92 months. However, selecting patients for surgery remains a complex task and requires a careful preoperative workup, rational analysis of prognostic profiles, and ri...

Role of p53 in the regulation of cellular senescence

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle arrest that has a crucial role in aging, and it also represents a robust physiological antitumor response, which counteracts oncogenic insults. In addition, senescent cells can also negatively impac...

Diagnostic and Therapeutic Pathway of Advanced Ovarian Cancer with Peritoneal Metastases

Over two thirds of ovarian cancer patients present with advanced stage disease at the time of diagnosis. In this scenario, standard treatment includes a combination of cytoreductive surgery and carboplatinum–paclitaxel-based chemotherapy. Despite the survival advantage of patients treated with upfront cytoreductive surgery compared to women undergoing neo-adjuvant chemotherapy (NACT) and interval debulking surgery (IDS) due to high tumor load or poor performance status has been demonstrated b...

Vanillin prevents doxorubicin-induced apoptosis and oxidative stress in rat H9c2 cardiomyocytes

Doxorubicin (doxo) is an effective anticancer compound in several tumor types. However, as a consequence of oxidative stress induction and ROS overproduction, its high cardiotoxicity demands urgent attention. Vanillin possesses antioxidant, antiproliferative, antidepressant and anti-glycating properties. Therefore, we investigated the potential vanillin protective effects against doxo-induced cardiotoxicity in H9c2 cells. Using multiparametric approach, we demonstrated that vanillin restored ...

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Tipologia
  • 1 Contributo su Rivista54088
  • 2 Contributo in Volume3
Autore
  • GIORDANO, ANTONIO787
  • NANTE, NICOLA624
  • PAOLETTI, RICCARDO569
  • FEDERICO, ANTONIO530
  • RUBEGNI, PIETRO520
  • CANTARINI, LUCA489
  • ROVIELLO, FRANCO477
  • PETRAGLIA, FELICE436
  • FREDIANI, BRUNO429
  • GALEAZZI, MAURO429
Data di pubblicazione
  • In corso di stampa30
  • 2020 - 202510986
  • 2010 - 201919466
  • 2000 - 200913848
  • 1990 - 19996761
  • 1980 - 19892503
  • 1970 - 1979476
  • 1966 - 196919
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  • STUDI SENESI296
  • IL FORO ITALIANO247
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  • PLOS ONE220
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  • JOURNAL OF CELLULAR PHYSIOLOGY192
  • NEUROLOGICAL SCIENCES164
  • PHYSICS LETTERS. SECTION B164
  • INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES163
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  • I WORKING PAPERS - CENTRO STUDI DI DIRITTO DEL LAVORO EUROPEO "MASSIMO D'ANTONA"1
  • INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY1
  • KORPUS IM TEXT1
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  • Italy702
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  • bul9
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  • embargoed12
  • mixed9
Appartenenza
  • Dipartimento di Biotecnologie Mediche6861
  • Dipartimento di Biotecnologie, Chimica e Farmacia5061
  • Dipartimento di Economia Politica e Statistica1656
  • Dipartimento di Filologia e Critica delle Letterature Antiche e Moderne2712
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