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Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-re...

Complete Data Inventory of a Geothermal Power Plant for Robust Cradle-to-Grave Life Cycle Assessment Results

Technologies to produce electric energy from renewable geothermal source are gaining increasing attention, due to their ability to provide a stable output suitable for baseload production. Performing life cycle assessment (LCA) of geothermal systems has become essential to evaluate their environmental performance. However, so far, no documented nor reliable information has been made available for developing robust LCA studies. This work provides a comprehensive inventory of the Italian Bagnor...

Definition of LCA Guidelines in the geothermal sector to enhance result comparability

Geothermal energy could play a crucial role in the European energy market and future scenarios focused on sustainable development. Thanks to its constant supply of concentrated energy, it can support the transition towards a low-carbon economy. In the energy sector, the decision-making process should always be supported by a holistic science-based approach to allow a comprehensive environmental assessment of the technological system, such as the life cycle assessment (LCA) methodology. In the...

SARS-CoV-2 receptor Angiotensin I-Converting Enzyme type 2 (ACE2) is expressed in human pancreatic β-cells and in the human pancreas microvasculature

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the recent data highlighting an association between COVID-19 and diabetes, a detailed analysis aimed at evaluating ACE2 expression pattern distribution in human pancreas is still lacking. Here, we took advantage of INNODIA network EUnPOD biobank collection to thoroughly analyze ACE2, both at mRNA and protein level, in mu...

Combined experimental and multivariate model approaches for glycoalkaloid quantification in tomatoes

The intake of tomato glycoalkaloids can exert beneficial effects on human health. For this reason, methods for a rapid quantification of these compounds are required. Most of the methods for α-tomatine and dehydrotomatine quantification are based on chromatographic techniques. However, these techniques require complex and time-consuming sample pre-treatments. In this work, HPLC-ESI-QqQ-MS/MS was used as reference method. Subsequently, multiple linear regression (MLR) and partial least squares...

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