Perspectives on the role of “-Omics” in predicting response to immunotherapy

The annual Immuno-Oncology “Think Tank” held in October 2023 in Siena reviewed the rapidly evolving systems-biological approaches which are now providing a deeper understanding of tumor and tumor microenvironment heterogeneity. Based on this understanding opportunities for novel therapies may be identified to overcome resistance to immunotherapy. There is increasing evidence that malignant disease processes are not limited to purely intracellular or genetic events but constitute a dynamic int...

The impact of environmental pollution on metabolic health and the risk of non-communicable chronic metabolic diseases in humans

Aims: This review aims to provide a comprehensive overview to understand the role of pollution in the development of noncommunicable diseases (NCDs), with a focus on metabolic diseases. Data synthesis: In the context of NCDs, the incidence of metabolic diseases such as obesity and diabetes are increasing at an alarming rate. In addition to the well-known role of the so-called “obesogenic” environment, characterized by unhealthy diet and physical inactivity, great attention has been paid in re...

Analog and digital complete denture bases accuracy and dimensional stability: an in-vitro evaluation at 24 hours and 6 months

Objectives: The study aimed to evaluate the accuracy of 3D printed complete denture bases compared to analog and milling manufacturing. Methods: Denture bases (n = 60) were created using three methods: milling (n = 10), analog (flasking) (n = 10), and 3D printing (n = 40). The 3D printing group was further divided into subgroups and each of the material groups. All samples were scanned, and their surfaces were analyzed using 3D software (Geomagic Control X software, 3D Systems) to compare the...

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