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Nuovi adempimenti formali e perduranti discrasie "strutturali" tra assunzione e documentazione di atti investigativi pubblici e privati

La "riforma Cartabia" ha introdotto nuove disposizioni in tema di documentazione e di deposito degli atti investigativi difensivi. L'Autore, dopo aver esaminato tali regole - affrontandone, in particolare, le questioni interpretative irrisolte - prospetta alcune soluzioni per tentare di uniformare la disciplina rispettivamente concernente l'attività investigativa pubblica e quella privata.

Functional and Molecular Characterization of Melamine-Induced Disruption of Human Spermatozoa via Oxidative Stress and Apoptotic Pathways: An In Vitro Study

: Melamine, a nitrogen-rich industrial chemical, has raised increasing concern as an emerging environmental contaminant with potential reproductive toxicity. While its nephrotoxic effects are well established, the direct impact of melamine on human sperm remains poorly defined. In this study, we investigated the in vitro effects of melamine on human sperm, under both capacitating and non-capacitating conditions. Functional analyses revealed that the exposure to 0.8 mM melamine, the highest no...

Sugar-mediated physical constraints drive the evolution of pollination drops into nectar

Unlabelled: It is now well established that the chemical composition of ovular secretions in gymnosperms and angiosperms plays a key role in pollination biology, and the evolutionary history of this chemical profile has attracted considerable attention. In this work, for the first time, we focus on the physical properties of ovular secretions and their potential central role in the evolutionary success of angiosperms. Through wettability measurements on model systems, artificial secretions de...

Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study

Pleural mesothelioma (PM) has a poor prognosis and standard therapy with immune checkpoint inhibitors (ICIs) CTLA-4 and PD-1 is still clinically unsatisfying. No predictive biomarkers of ICI efficacy in PM are available yet. In the retrospective multicenter NIBIT-EPI-MESO study, multi-omics analysis of pre-ICI therapy tumor lesions from 91 patients with PM treated in earlier clinical trials or in daily practice identified four PM subsets with progressively increasing global DNA methylation pr...

Custom-made donut technique: An innovative approach to treating scalp arteriovenous fistula

Scalp arteriovenous fistulas are rare, high-flow vascular anomalies, often of post-traumatic origin. Their management remains a subject of debate owing to the limited number of reported cases. This study presents a novel approach for the treatment of a post-traumatic right mastoid scalp arteriovenous fistula in a patient with a history of multiple unsuccessful treatments. A customized, in-house three-dimensional-printed device, designed in a donut shape, was used to enhance the precision of d...

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