GEMMA, SANDRA
GEMMA, SANDRA
Dipartimento di Biotecnologie, Chimica e Farmacia
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one
2002-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; E., Morelli; P., Minetti; O., Tinti; Nacci, Vito
(+)-(R)- and (−)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages
2020-01-01 Guidi, A.; Prasanth Saraswati, A.; Relitti, N.; Gimmelli, R.; Saccoccia, F.; Sirignano, C.; Taglialatela-Scafati, O.; Campiani, G.; Ruberti, G.; Gemma, S.
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation
2018-01-01 Brogi, Simone; Brindisi, Margherita; Butini, Stefania; Kshirsagar, Giridhar U.; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonytė, Raminta; Han, Liwei; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S.
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators
2008-01-01 Butini, Stefania; DARRYL S., Pickering; Elena, Morelli; SANNA COCCONE, Salvatore; Trotta, Francesco; MERI DE, Angelis; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Ettore, Novellino; Arne, Schousboe; JEPPE K., Christensen; Gemma, Sandra
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents
2018-01-01 Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Zisterer, Daniela M.; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision
2019-01-01 Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G.
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis
2021-01-01 Vanni, Francesca; Lopresti, Ludovica; Zurli, Vanessa; Kabanova, Anna; Cattaneo, Francesca; Sicuranza, Anna; Gozzetti, Alessandro; Gemma, Sandra; Zisterer, Daniela M; Bocchia, Monica; Campiani, Giuseppe; Baldari, Cosima T; Butini, Stefania; Ulivieri, Cristina
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles
2019-01-01 Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S.
A stereoselective approach to peptidomimetic BACE1 inhibitors
2013-01-01 Butini, Stefania; Emanuele, Gabellieri; Brindisi, Margherita; Giovani, Simone; Maramai, Samuele; Kshirsagar, Giridhar; Egeria, Guarino; Brogi, Simone; Valeria La, Pietra; Mariateresa, Giustiniano; Luciana, Marinelli; Ettore, Novellino; Campiani, Giuseppe; Cappelli, Andrea; Gemma, Sandra
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues
2013-01-01 Brindisi, Margherita; Gemma, Sandra; Alfano, Gloria; Kshirsagar, Giridhar; Ettore, Novellino; Campiani, Giuseppe; Butini, Stefania
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs
2012-01-01 Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides
2013-01-01 Gemma, Sandra; Kunjir, SANIL ASHOK; Brindisi, Margherita; Ettore, Novellino; Campiani, Giuseppe; Butini, Stefania
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors
2022-01-01 Fontana, A.; Cursaro, I.; Carullo, G.; Gemma, S.; Butini, S.; Campiani, G.
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation
2017-01-01 Brogi, Simone; Maramai, Samuele; Brindisi, Margherita; Chemi, Giulia; Porcari, Valentina; Corallo, Claudio; Gennari, Luigi; Novellino, Ettore; Ramunno, Anna; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds
2008-01-01 Butini, Stefania; Gabellieri, Emanuele; PAUL BRADY, Huleatt; Campiani, Giuseppe; Franceschini, Silvia; Brindisi, Margherita; Sindu, Ros; SANNA COCCONE, Salvatore; Fiorini, Isabella; Ettore, Novellino; Giorgi, Gianluca; Gemma, Sandra
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues
2018-01-01 Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE
2007-01-01 Campiani, Giuseppe; Gemma, Sandra; C., Fattorusso; G., Kukreja; B. P., Joshi; O., TAGLIALATELA SCAFATI; Savini, Luisa; M., DE ANGELIS; E., Fattorusso
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells
2016-01-01 Fiore, Donatella; Proto, Maria Chiara; Pisanti, Simona; Picardi, Paola; Pagano Zottola, Antonio Christian; Butini, Stefania; Gemma, Sandra; Casagni, Alice; Laezza, Chiara; Vitale, Mario; Ligresti, Alessia; Di Marzo, Vincenzo; Zisterer, Daniela M; Nathwani, Seema; Williams, D. Clive; Campiani, Giuseppe; Gazzerro, Patrizia; Bifulco, Maurizio
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas
2020-01-01 Khan, T.; Relitti, N.; Brindisi, M.; Magnano, S.; Zisterer, D.; Gemma, S.; Butini, S.; Campiani, G.
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
2022-01-01 Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| 'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one | 1-gen-2002 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; E., Morelli; P., Minetti; O., Tinti; Nacci, Vito | - | |
| (+)-(R)- and (−)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages | 1-gen-2020 | Guidi, A.; Prasanth Saraswati, A.; Relitti, N.; Gimmelli, R.; Saccoccia, F.; Sirignano, C.; Taglialatela-Scafati, O.; Campiani, G.; Ruberti, G.; Gemma, S. | - | |
| (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation | 1-gen-2018 | Brogi, Simone; Brindisi, Margherita; Butini, Stefania; Kshirsagar, Giridhar U.; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonytė, Raminta; Han, Liwei; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S. | - | |
| 1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators | 1-gen-2008 | Butini, Stefania; DARRYL S., Pickering; Elena, Morelli; SANNA COCCONE, Salvatore; Trotta, Francesco; MERI DE, Angelis; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Ettore, Novellino; Arne, Schousboe; JEPPE K., Christensen; Gemma, Sandra | - | |
| A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents | 1-gen-2018 | Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Zisterer, Daniela M.; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - | |
| A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision | 1-gen-2019 | Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G. | - | |
| A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis | 1-gen-2021 | Vanni, Francesca; Lopresti, Ludovica; Zurli, Vanessa; Kabanova, Anna; Cattaneo, Francesca; Sicuranza, Anna; Gozzetti, Alessandro; Gemma, Sandra; Zisterer, Daniela M; Bocchia, Monica; Campiani, Giuseppe; Baldari, Cosima T; Butini, Stefania; Ulivieri, Cristina | - | |
| A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles | 1-gen-2019 | Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S. | - | |
| A stereoselective approach to peptidomimetic BACE1 inhibitors | 1-gen-2013 | Butini, Stefania; Emanuele, Gabellieri; Brindisi, Margherita; Giovani, Simone; Maramai, Samuele; Kshirsagar, Giridhar; Egeria, Guarino; Brogi, Simone; Valeria La, Pietra; Mariateresa, Giustiniano; Luciana, Marinelli; Ettore, Novellino; Campiani, Giuseppe; Cappelli, Andrea; Gemma, Sandra | - | |
| A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues | 1-gen-2013 | Brindisi, Margherita; Gemma, Sandra; Alfano, Gloria; Kshirsagar, Giridhar; Ettore, Novellino; Campiani, Giuseppe; Butini, Stefania | - | |
| A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs | 1-gen-2012 | Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe | - | |
| A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides | 1-gen-2013 | Gemma, Sandra; Kunjir, SANIL ASHOK; Brindisi, Margherita; Ettore, Novellino; Campiani, Giuseppe; Butini, Stefania | - | |
| A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors | 1-gen-2022 | Fontana, A.; Cursaro, I.; Carullo, G.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation | 1-gen-2017 | Brogi, Simone; Maramai, Samuele; Brindisi, Margherita; Chemi, Giulia; Porcari, Valentina; Corallo, Claudio; Gennari, Luigi; Novellino, Ettore; Ramunno, Anna; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra | - | |
| An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds | 1-gen-2008 | Butini, Stefania; Gabellieri, Emanuele; PAUL BRADY, Huleatt; Campiani, Giuseppe; Franceschini, Silvia; Brindisi, Margherita; Sindu, Ros; SANNA COCCONE, Salvatore; Fiorini, Isabella; Ettore, Novellino; Giorgi, Gianluca; Gemma, Sandra | - | |
| Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues | 1-gen-2018 | Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - | |
| ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE | 1-gen-2007 | Campiani, Giuseppe; Gemma, Sandra; C., Fattorusso; G., Kukreja; B. P., Joshi; O., TAGLIALATELA SCAFATI; Savini, Luisa; M., DE ANGELIS; E., Fattorusso | - | |
| Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells | 1-gen-2016 | Fiore, Donatella; Proto, Maria Chiara; Pisanti, Simona; Picardi, Paola; Pagano Zottola, Antonio Christian; Butini, Stefania; Gemma, Sandra; Casagni, Alice; Laezza, Chiara; Vitale, Mario; Ligresti, Alessia; Di Marzo, Vincenzo; Zisterer, Daniela M; Nathwani, Seema; Williams, D. Clive; Campiani, Giuseppe; Gazzerro, Patrizia; Bifulco, Maurizio | - | |
| Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas | 1-gen-2020 | Khan, T.; Relitti, N.; Brindisi, M.; Magnano, S.; Zisterer, D.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability | 1-gen-2022 | Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G. | - |