The synthesis of two new Huperzine A analogues is reported. Both products present an amino substituted benzo-fused system in place of the pyridone ring of the natural alkaloid. The synthetic strategy to the two analogues is based on three different key palladium-catalyzed steps, namely a carbonylation reaction, an epoxide isomerization and a bicycloannulation reaction. © 2002 Elsevier Science Ltd. All rights reserved.
Gemma, S., Butini, S., Fattorusso, C., Fiorini, I., Nacci, V., Bellebaum, K., et al. (2003). A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring. TETRAHEDRON, 59(1), 87-93 [10.1016/S0040-4020(02)01449-7].
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring
Gemma, Sandra;Butini, Stefania;Fiorini, Isabella;Nacci, Vito;Campiani, Giuseppe
2003-01-01
Abstract
The synthesis of two new Huperzine A analogues is reported. Both products present an amino substituted benzo-fused system in place of the pyridone ring of the natural alkaloid. The synthetic strategy to the two analogues is based on three different key palladium-catalyzed steps, namely a carbonylation reaction, an epoxide isomerization and a bicycloannulation reaction. © 2002 Elsevier Science Ltd. All rights reserved.
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https://hdl.handle.net/11365/11273
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