FIORINI, ISABELLA
FIORINI, ISABELLA
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators
2008-01-01 Butini, Stefania; Pickering, Darryl S.; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K.; Gemma, Sandra
A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor
1994-01-01 Greco, Giovanni; Novellino, Ettore; Fiorini, Isabella; Nacci, Vito; Campiani, Giuseppe; Ciani, Silvia M.; Garofalo, Antonio; Bernasconi, Paola; Mennini, Tiziana
A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors
1995-01-01 Dalpiaz, Alessandro; Bertolasi, Valerio; Boreal, Pier Andrea; Nacci, Vito; Fiorini, Isabella; Campiani, Giuseppe; Mennini, Tiziana; Manzoni, Cristina; Novellino, Ettore; Greco, Giovanni
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring
2003-01-01 Gemma, Sandra; Butini, Stefania; Fattorusso, Caterina; Fiorini, Isabella; Nacci, Vito; Bellebaum, Katherine; Mckissic, Down; Saxena, Ashima; Campiani, Giuseppe
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds
2008-01-01 Butini, Stefania; Gabellieri, Emanuele; PAUL BRADY, Huleatt; Campiani, Giuseppe; Franceschini, Silvia; Brindisi, Margherita; Sindu, Ros; SANNA COCCONE, Salvatore; Fiorini, Isabella; Ettore, Novellino; Giorgi, Gianluca; Gemma, Sandra
Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation
1993-01-01 Garofalo, A.; Campiani, G.; Fiorini, I.; Nacci, V.
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR): From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers
1996-01-01 Campiani, Giuseppe; Fiorini, Isabella; De Filippis, Maria P.; Ciani, Silvia M.; Garofalo, Antonio; Nacci, Vito; Giorgi, Gianluca; Sega, Alessandro; Botta, Maurizio; Chiarini, Alberto; Budriesi, Roberta; Bruni, Giancarlo
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies
2008-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, G.; Sanna Coccone, Salvatore; Joshi, B.; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Fattorusso, E; Taglialatela Scafati, O.; Savini, Luisa; Taramelli, D.; Basilico, N.; Parapini, S.; Morace, G.; Yardley, V.; Croft, S.; Coletta, M.; Marini, S.; Fattorusso, Caterina
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials
2009-01-01 Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B. P.; Kukreja, G.; Sanna Coccone, Salvatore; Bernetti, Matteo; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Taramelli, D.; Basilico, N.; Parapini, S.; Yardley, V.; Croft, S.; Kellere Maerki, S.; Rottmann, M.; Brun, R.; Coletta, M.; Marini, S.; Guiso, G.; Caccia, S.; Fattorusso, C.
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior
2009-01-01 Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Borriello, Marianna; Ceres, Nicoletta; Sindu, Ros; Coccone, Salvatore Sanna; Bernetti, Matteo; De Angelis, Meri; Brindisi, Margherita; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Cagnotto, Alfredo; Mennini, Tiziana; Sandager-Nielsen, Karin; Andreasen, Jesper Tobias; Scheel-Kruger, Jorgen; Mikkelsen, Jens D.; Fattorusso, Caterina
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors
2010-01-01 Butini, S.; Campiani, G.; Franceschini, S.; Trotta, F.; Kumar, V.; Guarino, E.; Borrelli, G.; Fiorini, I.; Novellino, E.; Fattorusso, C.; Persico, M.; Orteca, N.; SANDAGER-NIELSEN, K.; Jacobsen, T. A.; Madsen, K.; SCHEEL-KRUGER, J.; Gemma, S.
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants
2011-01-01 Butini, S.; Gemma, S.; Brindisi, M.; Borrelli, G.; Fiorini, I.; Samuele, A.; Karytinos, A.; Facchini, M.; Lossani, A.; Zanoli, S.; Campiani, G.; Novellino, E.; Focher, F.; Maga, G.
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors
2008-01-01 Butini, Stefania; Campiani, Giuseppe; Borriello, M.; Gemma, Sandra; Panico, Alessandro; Persico, M.; Catalanotti, B.; Ros, S.; Brindisi, Margherita; Agnusdei, M.; Fiorini, Isabella; Nacci, Vito; Novellino, E.; Belinskaya, T.; Saxena, A.; Fattorusso, C.
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents
2012-01-01 Gemma, Sandra; Camodeca, Caterina; Brindisi, Margherita; Brogi, Simone; Gagan, Kukreja; Kunjir, SANIL ASHOK; Emanuele, Gabellieri; Leonardo, Lucantoni; Annette, Habluetzel; Donatella, Taramelli; Nicoletta, Basilico; Roberta, Gualdani; Francesco Tadini, Buoninsegni; Gianluca, Bartolommei; Maria Rosa, Moncelli; Rowena E., Martin; Robert L., Summers; Lamponi, Stefania; Savini, Luisa; Fiorini, Isabella; Valoti, Massimo; Ettore, Novellino; Campiani, Giuseppe; Butini, Stefania
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases
2003-01-01 Campiani, G.; Fattorusso, C.; DE ANGELIS, M.; Catalanotti, B.; Butini, S.; Fattorusso, R.; Fiorini, I.; Nacci, V.; Novellino, E.
New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure
1998-01-01 Campiani, Giuseppe; Nacci, Vito; Bechelli, Susanna; Ciani, Silvia M.; Garofalo, Antonio; Fiorini, Isabella; Wikström, Håkan; De Boer, Peter; Liao, Yi; Tepper, Pieter G.; Cagnotto, Alfredo; Mennini, Tiziana
New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site
1997-01-01 Campiani, G.; Nacci, V.; Fiorini, I.; De Filippis, M. P.; Garofalo, A.; Ciani, S. M.; Greco, G.; Novellino, E.; Manzoni, C.; Mennini, T.
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies
2011-01-01 Butini, Stefania; Gemma, Sandra; Brindisi, Margherita; Borrelli, Giuseppe; Lossani, Andrea; Ponte, Anna Maria; Torti, Andrea; Maga, Giovanni; Marinelli, Luciana; La Pietra, Valeria; Fiorini, Isabella; Lamponi, Stefania; Campiani, Giuseppe; Zisterer, Daniela M.; Nathwani, Seema-Maria; Sartini, Stefania; La Motta, Concettina; Da Settimo, Federico; Novellino, Ettore; Focher, Federico
Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia
2003-01-01 Butini, Stefania; Campiani, Giuseppe; De Angelis, Meri; Fattorusso, Caterina; Nacci, Vito; Fiorini, Isabella
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies
2005-01-01 Campiani, Giuseppe; Butini, Stefania; Fattorusso, Caterina; Frotta, Francesco; Gemma, Sandra; Catalanotti, Bruno; Nacci, Vito; Fiorini, Isabella; Cagnotto, Alfredo; Mereghetti, Ilario; Mennini, Tiziana; Minetti, Patrizia; Di Cesare, M. Assunta; Stasi, M. Antonietta; Di Serio, Stefano; Ghirardi, Orlando; Tinti, Ornella; Carminati, Paolo
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| 1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators | 1-gen-2008 | Butini, Stefania; Pickering, Darryl S.; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K.; Gemma, Sandra | - | |
| A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor | 1-gen-1994 | Greco, Giovanni; Novellino, Ettore; Fiorini, Isabella; Nacci, Vito; Campiani, Giuseppe; Ciani, Silvia M.; Garofalo, Antonio; Bernasconi, Paola; Mennini, Tiziana | - | |
| A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors | 1-gen-1995 | Dalpiaz, Alessandro; Bertolasi, Valerio; Boreal, Pier Andrea; Nacci, Vito; Fiorini, Isabella; Campiani, Giuseppe; Mennini, Tiziana; Manzoni, Cristina; Novellino, Ettore; Greco, Giovanni | - | |
| A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring | 1-gen-2003 | Gemma, Sandra; Butini, Stefania; Fattorusso, Caterina; Fiorini, Isabella; Nacci, Vito; Bellebaum, Katherine; Mckissic, Down; Saxena, Ashima; Campiani, Giuseppe | - | |
| An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds | 1-gen-2008 | Butini, Stefania; Gabellieri, Emanuele; PAUL BRADY, Huleatt; Campiani, Giuseppe; Franceschini, Silvia; Brindisi, Margherita; Sindu, Ros; SANNA COCCONE, Salvatore; Fiorini, Isabella; Ettore, Novellino; Giorgi, Gianluca; Gemma, Sandra | - | |
| Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation | 1-gen-1993 | Garofalo, A.; Campiani, G.; Fiorini, I.; Nacci, V. | - | |
| Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR): From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers | 1-gen-1996 | Campiani, Giuseppe; Fiorini, Isabella; De Filippis, Maria P.; Ciani, Silvia M.; Garofalo, Antonio; Nacci, Vito; Giorgi, Gianluca; Sega, Alessandro; Botta, Maurizio; Chiarini, Alberto; Budriesi, Roberta; Bruni, Giancarlo | - | |
| Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies | 1-gen-2008 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Kukreja, G.; Sanna Coccone, Salvatore; Joshi, B.; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Fattorusso, E; Taglialatela Scafati, O.; Savini, Luisa; Taramelli, D.; Basilico, N.; Parapini, S.; Morace, G.; Yardley, V.; Croft, S.; Coletta, M.; Marini, S.; Fattorusso, Caterina | - | |
| Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials | 1-gen-2009 | Gemma, Sandra; Campiani, Giuseppe; Butini, Stefania; Joshi, B. P.; Kukreja, G.; Sanna Coccone, Salvatore; Bernetti, Matteo; Persico, M.; Nacci, Vito; Fiorini, Isabella; Novellino, E.; Taramelli, D.; Basilico, N.; Parapini, S.; Yardley, V.; Croft, S.; Kellere Maerki, S.; Rottmann, M.; Brun, R.; Coletta, M.; Marini, S.; Guiso, G.; Caccia, S.; Fattorusso, C. | - | |
| Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior | 1-gen-2009 | Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Franceschini, Silvia; Trotta, Francesco; Borriello, Marianna; Ceres, Nicoletta; Sindu, Ros; Coccone, Salvatore Sanna; Bernetti, Matteo; De Angelis, Meri; Brindisi, Margherita; Nacci, Vito; Fiorini, Isabella; Novellino, Ettore; Cagnotto, Alfredo; Mennini, Tiziana; Sandager-Nielsen, Karin; Andreasen, Jesper Tobias; Scheel-Kruger, Jorgen; Mikkelsen, Jens D.; Fattorusso, Caterina | - | |
| Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors | 1-gen-2010 | Butini, S.; Campiani, G.; Franceschini, S.; Trotta, F.; Kumar, V.; Guarino, E.; Borrelli, G.; Fiorini, I.; Novellino, E.; Fattorusso, C.; Persico, M.; Orteca, N.; SANDAGER-NIELSEN, K.; Jacobsen, T. A.; Madsen, K.; SCHEEL-KRUGER, J.; Gemma, S. | - | |
| Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants | 1-gen-2011 | Butini, S.; Gemma, S.; Brindisi, M.; Borrelli, G.; Fiorini, I.; Samuele, A.; Karytinos, A.; Facchini, M.; Lossani, A.; Zanoli, S.; Campiani, G.; Novellino, E.; Focher, F.; Maga, G. | - | |
| Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors | 1-gen-2008 | Butini, Stefania; Campiani, Giuseppe; Borriello, M.; Gemma, Sandra; Panico, Alessandro; Persico, M.; Catalanotti, B.; Ros, S.; Brindisi, Margherita; Agnusdei, M.; Fiorini, Isabella; Nacci, Vito; Novellino, E.; Belinskaya, T.; Saxena, A.; Fattorusso, C. | - | |
| Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents | 1-gen-2012 | Gemma, Sandra; Camodeca, Caterina; Brindisi, Margherita; Brogi, Simone; Gagan, Kukreja; Kunjir, SANIL ASHOK; Emanuele, Gabellieri; Leonardo, Lucantoni; Annette, Habluetzel; Donatella, Taramelli; Nicoletta, Basilico; Roberta, Gualdani; Francesco Tadini, Buoninsegni; Gianluca, Bartolommei; Maria Rosa, Moncelli; Rowena E., Martin; Robert L., Summers; Lamponi, Stefania; Savini, Luisa; Fiorini, Isabella; Valoti, Massimo; Ettore, Novellino; Campiani, Giuseppe; Butini, Stefania | - | |
| Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases | 1-gen-2003 | Campiani, G.; Fattorusso, C.; DE ANGELIS, M.; Catalanotti, B.; Butini, S.; Fattorusso, R.; Fiorini, I.; Nacci, V.; Novellino, E. | - | |
| New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure | 1-gen-1998 | Campiani, Giuseppe; Nacci, Vito; Bechelli, Susanna; Ciani, Silvia M.; Garofalo, Antonio; Fiorini, Isabella; Wikström, Håkan; De Boer, Peter; Liao, Yi; Tepper, Pieter G.; Cagnotto, Alfredo; Mennini, Tiziana | - | |
| New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site | 1-gen-1997 | Campiani, G.; Nacci, V.; Fiorini, I.; De Filippis, M. P.; Garofalo, A.; Ciani, S. M.; Greco, G.; Novellino, E.; Manzoni, C.; Mennini, T. | - | |
| Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies | 1-gen-2011 | Butini, Stefania; Gemma, Sandra; Brindisi, Margherita; Borrelli, Giuseppe; Lossani, Andrea; Ponte, Anna Maria; Torti, Andrea; Maga, Giovanni; Marinelli, Luciana; La Pietra, Valeria; Fiorini, Isabella; Lamponi, Stefania; Campiani, Giuseppe; Zisterer, Daniela M.; Nathwani, Seema-Maria; Sartini, Stefania; La Motta, Concettina; Da Settimo, Federico; Novellino, Ettore; Focher, Federico | - | |
| Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia | 1-gen-2003 | Butini, Stefania; Campiani, Giuseppe; De Angelis, Meri; Fattorusso, Caterina; Nacci, Vito; Fiorini, Isabella | - | |
| Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies | 1-gen-2005 | Campiani, Giuseppe; Butini, Stefania; Fattorusso, Caterina; Frotta, Francesco; Gemma, Sandra; Catalanotti, Bruno; Nacci, Vito; Fiorini, Isabella; Cagnotto, Alfredo; Mereghetti, Ilario; Mennini, Tiziana; Minetti, Patrizia; Di Cesare, M. Assunta; Stasi, M. Antonietta; Di Serio, Stefano; Ghirardi, Orlando; Tinti, Ornella; Carminati, Paolo | - |