As a continuation of our efforts to develop innovative ligands for D 3, 5-HT1A, and 5-HT2A receptors with low propensity to block hERG channels, we propose a series bishetero(homo) arylpiperazines 5a-m as novel and potent multifunctional ligands characterized by low occupancy at D2 and 5-HT2C receptors. © 2010 American Chemical Society.
Butini, S., Campiani, G., Franceschini, S., Trotta, F., Kumar, V., Guarino, E., et al. (2010). Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors. JOURNAL OF MEDICINAL CHEMISTRY, 53(12), 4803-4807 [10.1021/jm100294b].
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors
BUTINI S.;CAMPIANI G.;FRANCESCHINI S.;TROTTA F.;GUARINO E.;FIORINI I.;GEMMA S.
2010-01-01
Abstract
As a continuation of our efforts to develop innovative ligands for D 3, 5-HT1A, and 5-HT2A receptors with low propensity to block hERG channels, we propose a series bishetero(homo) arylpiperazines 5a-m as novel and potent multifunctional ligands characterized by low occupancy at D2 and 5-HT2C receptors. © 2010 American Chemical Society.
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https://hdl.handle.net/11365/3434
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