Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in the initiation and progression of cancer. Currently, three hydroxamate-containing HDAC pan-inhibitors have been approved as antitumor agents.
Brindisi, M., Cavella, C., Brogi, S., Nebbioso, A., Senger, J., Maramai, S., et al. (2016). Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies. FUTURE MEDICINAL CHEMISTRY, 8(13), 1573-1587 [10.4155/fmc-2016-0068].
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies
CAVELLA, CATERINA;MARAMAI, SAMUELE;BUTINI, STEFANIA;LAMPONI, STEFANIA;CAMPIANI, GIUSEPPE;GEMMA, SANDRA
2016-01-01
Abstract
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins involved in the initiation and progression of cancer. Currently, three hydroxamate-containing HDAC pan-inhibitors have been approved as antitumor agents.
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https://hdl.handle.net/11365/995522