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Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic pharmacophore, related to clotrimazole, to develop innovative antimalarial agents. This study allowed us to discover compounds characterized by a high in vitro potency, particularly against Pf CQ-resistant strains selectively targeting free heme, which are easy to synthesize by low-cost synthetic strategies. © 2007 American Chemical Society.

Gemma, S., Campiani, G., Butini, S., Joshi, B., Kukreja, G., Persico, M., et al. (2007). Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. JOURNAL OF MEDICINAL CHEMISTRY, 50(4), 595-598 [10.1021/jm061429p].

Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore

Gemma, Sandra;Campiani, Giuseppe;Butini, Stefania;Nacci, Vito;Savini, Luisa;
2007-01-01

Abstract

Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic pharmacophore, related to clotrimazole, to develop innovative antimalarial agents. This study allowed us to discover compounds characterized by a high in vitro potency, particularly against Pf CQ-resistant strains selectively targeting free heme, which are easy to synthesize by low-cost synthetic strategies. © 2007 American Chemical Society.
2007
JOURNAL OF MEDICINAL CHEMISTRY
Gemma, S., Campiani, G., Butini, S., Joshi, B., Kukreja, G., Persico, M., et al. (2007). Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. JOURNAL OF MEDICINAL CHEMISTRY, 50(4), 595-598 [10.1021/jm061429p].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/20364
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