| Nome |
# |
|
The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery, file 6781001f-ab33-403c-9079-ab079958a5aa
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133
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The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity, file e0feeaa6-9119-44d2-e053-6605fe0a8db0
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130
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null, file e0feeaa8-2a90-44d2-e053-6605fe0a8db0
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107
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Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors, file e0feeaa7-e076-44d2-e053-6605fe0a8db0
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95
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Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking, file e0feeaa9-a954-44d2-e053-6605fe0a8db0
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92
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|
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors, file a37488a1-d109-4d41-b740-279c2ca77c38
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85
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Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases, file e0feeaa9-a724-44d2-e053-6605fe0a8db0
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84
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|
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation, file e0feeaab-8ed3-44d2-e053-6605fe0a8db0
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67
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Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems, file e0feeaaa-d53a-44d2-e053-6605fe0a8db0
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62
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null, file e0feeaaa-1d6e-44d2-e053-6605fe0a8db0
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61
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Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity, file e0feeaab-2d59-44d2-e053-6605fe0a8db0
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52
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iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome, file e0feeaab-ab72-44d2-e053-6605fe0a8db0
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51
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Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease, file e0feeaab-e2e3-44d2-e053-6605fe0a8db0
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51
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First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents, file e0feeaab-afe0-44d2-e053-6605fe0a8db0
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46
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Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages, file e0feeaab-5e05-44d2-e053-6605fe0a8db0
|
43
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Development of novel cyclic peptides as pro-apoptotic agents, file e0feeaab-defe-44d2-e053-6605fe0a8db0
|
37
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|
null, file e0feeaab-1f41-44d2-e053-6605fe0a8db0
|
35
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Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies, file e0feeaab-6326-44d2-e053-6605fe0a8db0
|
33
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|
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation, file e0feeaab-be5a-44d2-e053-6605fe0a8db0
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28
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Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues, file e0feeaab-8d37-44d2-e053-6605fe0a8db0
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27
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Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats, file e0feeaab-7f5a-44d2-e053-6605fe0a8db0
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23
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Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases, file e0feeaab-a2f7-44d2-e053-6605fe0a8db0
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22
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Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents, file e0feeaaa-d08a-44d2-e053-6605fe0a8db0
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21
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Polypharmacological approaches for CNS diseases: focus on endocannabinoid degradation inhibition, file e0feeaab-552b-44d2-e053-6605fe0a8db0
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20
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Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach, file e0feeaa8-a748-44d2-e053-6605fe0a8db0
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17
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Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX, file e0feeaab-aaea-44d2-e053-6605fe0a8db0
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17
|
|
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, file e0feeaaa-4452-44d2-e053-6605fe0a8db0
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15
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|
In Silico Analysis of Peptide-Based Derivatives Containing Bifunctional Warheads Engaging Prime and Non-Prime Subsites to Covalent Binding SARS-CoV-2 Main Protease (Mpro), file e0feeaab-b9ab-44d2-e053-6605fe0a8db0
|
14
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A non-toxic, reversibly released imaging probe for oral cancer that is derived from natural compounds, file e0feeaaa-4507-44d2-e053-6605fe0a8db0
|
12
|
|
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain, file e0feeaab-8ed4-44d2-e053-6605fe0a8db0
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12
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Synthetic spirocyclic endoperoxides: new antimalarial scaffolds, file e0feeaab-add3-44d2-e053-6605fe0a8db0
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12
|
|
Covalent reversible inhibitors of cysteine proteases containing the nitrile warhead: recent advancement in the field of viral and parasitic diseases, file e0feeaab-cb16-44d2-e053-6605fe0a8db0
|
11
|
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Design and Synthesis of Oligopeptidic Parvulin Inhibitors, file f1a566fa-68f7-4bf2-a542-b94619cf83a9
|
8
|
|
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues, file e0feeaa7-7f44-44d2-e053-6605fe0a8db0
|
7
|
|
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain, file e0feeaa7-68c7-44d2-e053-6605fe0a8db0
|
6
|
|
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease, file e0feeaaa-109f-44d2-e053-6605fe0a8db0
|
5
|
|
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats, file e0feeaaa-48ab-44d2-e053-6605fe0a8db0
|
5
|
|
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies, file e0feeaa7-9deb-44d2-e053-6605fe0a8db0
|
4
|
|
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, file e0feeaa7-bb57-44d2-e053-6605fe0a8db0
|
4
|
|
Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals, file e0feeaab-a614-44d2-e053-6605fe0a8db0
|
4
|
|
Synthesis of Unsymmetrical Squaramides as Allosteric GSK-3β Inhibitors Promoting β-Catenin-Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells, file 63435645-5e52-41ac-a389-115df67c162a
|
3
|
|
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders, file e0feeaa7-e754-44d2-e053-6605fe0a8db0
|
3
|
|
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems, file e0feeaa8-38dc-44d2-e053-6605fe0a8db0
|
3
|
|
Bronchoalveolar-Lavage-Derived Fibroblast Cell Line (B-LSDM7) as a New Protocol for Investigating the Mechanisms of Idiopathic Pulmonary Fibrosis, file 91ec9de9-8671-4cb1-a792-84a2631f79fc
|
2
|
|
null, file c5da9a26-56df-4df2-b01d-174bf8a6f71e
|
2
|
|
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies, file e0feeaa4-e9ad-44d2-e053-6605fe0a8db0
|
2
|
|
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors, file e0feeaa8-2a8b-44d2-e053-6605fe0a8db0
|
2
|
|
Development of novel cyclic peptides as pro-apoptotic agents, file e0feeaa9-e7ed-44d2-e053-6605fe0a8db0
|
2
|
|
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX, file e0feeaaa-1461-44d2-e053-6605fe0a8db0
|
2
|
|
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors, file e0feeaaa-274a-44d2-e053-6605fe0a8db0
|
2
|
|
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents, file e0feeaaa-3456-44d2-e053-6605fe0a8db0
|
2
|
|
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds, file e0feeaaa-41e0-44d2-e053-6605fe0a8db0
|
2
|
|
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation, file e0feeaaa-638f-44d2-e053-6605fe0a8db0
|
2
|
|
Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment, file f1251dc2-80b2-49fa-93b2-fc33881534c6
|
2
|
|
A NEW MICROTUBULE TARGETING COMPOUND PBOX-15 INHIBITS T- CELL MIGRATION VIA POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN;, file e0feeaa4-cc50-44d2-e053-6605fe0a8db0
|
1
|
|
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents., file e0feeaa4-dcf8-44d2-e053-6605fe0a8db0
|
1
|
|
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds, file e0feeaa4-e5b9-44d2-e053-6605fe0a8db0
|
1
|
|
null, file e0feeaa5-39ae-44d2-e053-6605fe0a8db0
|
1
|
|
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome, file e0feeaa7-7f45-44d2-e053-6605fe0a8db0
|
1
|
|
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents, file e0feeaa7-c244-44d2-e053-6605fe0a8db0
|
1
|
|
Synthetic studies toward bicyclic endoperoxides presenting polar side chains, file e0feeaa7-d88a-44d2-e053-6605fe0a8db0
|
1
|
|
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II), file e0feeaa8-2a91-44d2-e053-6605fe0a8db0
|
1
|
|
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases, file e0feeaa9-3be8-44d2-e053-6605fe0a8db0
|
1
|
|
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors, file e0feeaa9-e37f-44d2-e053-6605fe0a8db0
|
1
|
|
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages, file e0feeaaa-0912-44d2-e053-6605fe0a8db0
|
1
|
| Totale |
1.600 |