A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs. (c) 2006 Elsevier Ltd. All rights reserved.
Gemma, S., Kukreja, G., Fattorusso, C., Persico, M., Romano, M.P., Altarelli, M., et al. (2006). Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, 16(20), 5384-5388 [10.1016/j.bmcl.2006.07.060].
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains
Gemma, Sandra;Campiani, Giuseppe;Butini, Stefania
2006-01-01
Abstract
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs. (c) 2006 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/3104
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