IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 15.742
EU - Europa 13.769
AS - Asia 6.778
SA - Sud America 1.014
AF - Africa 391
OC - Oceania 40
Continente sconosciuto - Info sul continente non disponibili 17
AN - Antartide 1
Totale 37.752
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Nazione #
US - Stati Uniti d'America 15.462
IT - Italia 2.956
GB - Regno Unito 2.819
RU - Federazione Russa 2.710
CN - Cina 2.288
SG - Singapore 2.017
IE - Irlanda 1.475
BR - Brasile 797
DE - Germania 797
SE - Svezia 776
UA - Ucraina 661
VN - Vietnam 630
FR - Francia 615
HK - Hong Kong 523
FI - Finlandia 331
KR - Corea 284
IN - India 270
ZA - Sudafrica 206
TR - Turchia 176
CA - Canada 159
BD - Bangladesh 155
ES - Italia 117
NL - Olanda 92
MX - Messico 77
AR - Argentina 74
PL - Polonia 73
AT - Austria 64
JP - Giappone 58
CZ - Repubblica Ceca 53
IQ - Iraq 46
BE - Belgio 39
CI - Costa d'Avorio 38
NG - Nigeria 38
IR - Iran 34
PK - Pakistan 34
EC - Ecuador 30
CO - Colombia 28
AU - Australia 27
GR - Grecia 27
MA - Marocco 27
ID - Indonesia 26
UZ - Uzbekistan 26
VE - Venezuela 25
SA - Arabia Saudita 23
RO - Romania 22
LT - Lituania 21
CL - Cile 20
EG - Egitto 20
AZ - Azerbaigian 18
IL - Israele 18
JO - Giordania 17
KE - Kenya 17
PT - Portogallo 16
AE - Emirati Arabi Uniti 15
ET - Etiopia 14
KZ - Kazakistan 14
TN - Tunisia 14
CH - Svizzera 13
JM - Giamaica 13
MY - Malesia 13
PH - Filippine 13
BO - Bolivia 12
PE - Perù 12
DK - Danimarca 11
EU - Europa 11
EE - Estonia 10
NZ - Nuova Zelanda 10
RS - Serbia 10
NP - Nepal 9
LV - Lettonia 8
PA - Panama 8
TW - Taiwan 8
BG - Bulgaria 7
CR - Costa Rica 7
DZ - Algeria 7
GE - Georgia 7
HU - Ungheria 7
KG - Kirghizistan 7
PY - Paraguay 7
UY - Uruguay 7
BY - Bielorussia 6
LB - Libano 6
MD - Moldavia 6
OM - Oman 6
TH - Thailandia 6
AL - Albania 5
MC - Monaco 5
PS - Palestinian Territory 5
SN - Senegal 4
SY - Repubblica araba siriana 4
XK - ???statistics.table.value.countryCode.XK??? 4
AO - Angola 3
DO - Repubblica Dominicana 3
HN - Honduras 3
HR - Croazia 3
KH - Cambogia 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LK - Sri Lanka 3
NO - Norvegia 3
Totale 37.710
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Città #
Southend 2.462
Dallas 2.051
Fairfield 1.553
Dublin 1.462
Ashburn 1.364
Singapore 1.098
San Jose 750
Chandler 732
Woodbridge 702
Moscow 682
Santa Clara 645
Siena 607
Beijing 590
Milan 586
Wilmington 580
Seattle 578
Houston 566
Cambridge 543
Jacksonville 537
Hong Kong 494
Ann Arbor 397
Hefei 376
Seoul 279
Los Angeles 269
Council Bluffs 260
Princeton 251
New York 246
Rome 239
Nanjing 200
Ho Chi Minh City 190
Johannesburg 189
The Dalles 188
Florence 180
Lauterbourg 160
Helsinki 154
Dearborn 145
Hanoi 145
Izmir 124
Munich 120
Fremont 119
Shanghai 112
Boardman 103
Bengaluru 96
Orem 82
San Diego 79
Buffalo 77
San Mateo 74
São Paulo 74
London 67
Washington 65
Nanchang 59
Warsaw 57
Düsseldorf 56
Málaga 55
Lappeenranta 54
Tokyo 52
Frankfurt am Main 50
Chennai 47
Lancaster 47
Denver 44
Guangzhou 44
Turin 44
Redondo Beach 43
Hebei 42
Figino 41
Vienna 41
Brno 40
Montreal 40
Shenyang 40
Naples 39
Abidjan 38
Jiaxing 37
Toronto 37
Abuja 36
Da Nang 36
San Francisco 36
Aachen 34
Atlanta 34
Brussels 34
Brooklyn 33
Phoenix 33
Redwood City 33
Venezia 33
Kunming 32
Nuremberg 32
Tianjin 32
Bologna 31
Jinan 30
Mexico City 30
Norwalk 30
Haiphong 29
Columbus 28
Amsterdam 27
Changsha 27
Stockholm 27
Turku 27
Menlo Park 26
Ottawa 26
Portsmouth 26
Boston 25
Totale 25.516
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 444
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 406
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 398
Development of novel cyclic peptides as pro-apoptotic agents 390
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 389
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 385
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 370
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 365
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 345
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 343
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 335
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 335
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 334
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 332
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 325
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 322
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 320
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 315
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 314
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 313
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 313
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 310
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 310
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 305
A stereoselective approach to peptidomimetic BACE1 inhibitors 297
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 295
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 287
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 284
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 284
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 283
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 283
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 282
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 279
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 279
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 279
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 277
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 276
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 274
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 273
Telomerase-based cancer therapeutics: a review on their clinical trials 269
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 268
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 267
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 267
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 265
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 264
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 264
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 263
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 262
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 261
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 256
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 255
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 254
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 254
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 254
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 252
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 250
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 250
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 249
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 249
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 248
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 248
(+)-(R)- and (−)-(S)-Perhexiline maleate: enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages 247
Malaria chemotherapy: recent advances in drug development 246
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 246
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 244
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 243
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 242
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 242
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 240
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 240
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 240
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 239
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 239
Computational tool for fast in silico evaluation of hERG K+ channel affinity 236
Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor 235
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 232
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 232
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 232
Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products 232
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 231
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 231
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 229
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 229
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 226
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 225
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 225
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 221
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 221
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 220
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 220
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 220
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles 220
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 219
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 217
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 215
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 214
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 214
NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 211
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 209
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 208
Totale 27.151
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Categoria #
all - tutte 111.804
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 111.804
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.322 197 269 210 144 101 55 124 100 112 265 273 472
2022/20232.888 167 271 398 364 314 558 82 228 272 100 83 51
2023/20242.789 100 52 253 126 171 740 852 41 28 87 113 226
2024/20255.107 139 212 610 269 609 280 169 266 595 248 467 1.243
2025/202613.554 921 1.608 1.793 1.620 2.484 551 1.484 435 443 797 320 1.098
2026/2027216 216 0 0 0 0 0 0 0 0 0 0 0
Totale 38.279