IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 13.827
EU - Europa 12.369
AS - Asia 5.504
SA - Sud America 889
AF - Africa 150
OC - Oceania 30
Continente sconosciuto - Info sul continente non disponibili 16
AN - Antartide 1
Totale 32.786
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Nazione #
US - Stati Uniti d'America 13.624
GB - Regno Unito 2.767
RU - Federazione Russa 2.708
CN - Cina 2.116
IT - Italia 1.977
SG - Singapore 1.696
IE - Irlanda 1.470
SE - Svezia 775
DE - Germania 757
BR - Brasile 731
UA - Ucraina 657
FR - Francia 442
HK - Hong Kong 423
FI - Finlandia 292
KR - Corea 284
VN - Vietnam 260
IN - India 204
TR - Turchia 167
CA - Canada 120
ES - Italia 110
AT - Austria 63
AR - Argentina 60
NL - Olanda 56
PL - Polonia 56
BD - Bangladesh 54
MX - Messico 53
CZ - Repubblica Ceca 51
JP - Giappone 45
ZA - Sudafrica 44
BE - Belgio 37
CI - Costa d'Avorio 37
IR - Iran 34
IQ - Iraq 28
EC - Ecuador 24
GR - Grecia 24
MA - Marocco 23
AU - Australia 19
PK - Pakistan 19
RO - Romania 18
LT - Lituania 17
SA - Arabia Saudita 17
UZ - Uzbekistan 17
CO - Colombia 16
ID - Indonesia 16
VE - Venezuela 16
EG - Egitto 15
IL - Israele 15
PT - Portogallo 14
AZ - Azerbaigian 13
AE - Emirati Arabi Uniti 12
PE - Perù 12
CH - Svizzera 11
EU - Europa 11
CL - Cile 10
EE - Estonia 10
JO - Giordania 10
KZ - Kazakistan 10
BO - Bolivia 8
NZ - Nuova Zelanda 8
TN - Tunisia 8
BG - Bulgaria 7
ET - Etiopia 7
JM - Giamaica 7
KE - Kenya 7
KG - Kirghizistan 7
LV - Lettonia 7
DK - Danimarca 6
HU - Ungheria 6
PA - Panama 6
PY - Paraguay 6
RS - Serbia 6
LB - Libano 5
MY - Malesia 5
TW - Taiwan 5
CR - Costa Rica 4
GE - Georgia 4
MC - Monaco 4
NP - Nepal 4
OM - Oman 4
PH - Filippine 4
UY - Uruguay 4
XK - ???statistics.table.value.countryCode.XK??? 4
AL - Albania 3
AO - Angola 3
DO - Repubblica Dominicana 3
HN - Honduras 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LK - Sri Lanka 3
MD - Moldavia 3
NO - Norvegia 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
DZ - Algeria 2
GY - Guiana 2
Totale 32.757
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Città #
Southend 2.462
Dallas 2.033
Fairfield 1.553
Dublin 1.458
Ashburn 1.202
Singapore 930
Chandler 732
Woodbridge 702
Moscow 682
Santa Clara 611
Siena 605
Beijing 583
Wilmington 580
Seattle 577
Houston 559
Cambridge 542
Jacksonville 535
Hong Kong 421
Ann Arbor 397
Hefei 315
Seoul 279
Princeton 251
Los Angeles 222
New York 208
Nanjing 199
Milan 160
Florence 147
Dearborn 145
Izmir 123
Helsinki 121
Munich 119
Fremont 118
Boardman 102
Shanghai 102
Bengaluru 96
Rome 88
The Dalles 76
San Mateo 74
San Diego 73
Ho Chi Minh City 72
São Paulo 67
Buffalo 66
Washington 64
Nanchang 59
Düsseldorf 56
London 56
Málaga 55
Lappeenranta 51
Hanoi 48
Lancaster 47
Redondo Beach 43
Hebei 42
Warsaw 42
Tokyo 41
Brno 40
Shenyang 40
Vienna 40
Guangzhou 39
Abidjan 37
Jiaxing 37
Denver 36
Aachen 34
Council Bluffs 34
Brussels 33
Redwood City 33
Venezia 33
Johannesburg 32
Kunming 32
Brooklyn 31
Montreal 31
Jinan 30
Norwalk 30
Atlanta 29
San Francisco 29
Tianjin 29
Toronto 29
Columbus 28
Changsha 27
Frankfurt am Main 27
Nuremberg 27
Orem 27
Phoenix 27
Menlo Park 26
Ottawa 26
Portsmouth 26
Stockholm 26
Chennai 25
Poplar 25
Turku 25
Boston 24
Ningbo 23
Rio de Janeiro 23
Lauterbourg 22
Belo Horizonte 20
Naples 20
Dong Ket 19
Mexico City 19
Parma 18
Brescia 17
Dhaka 17
Totale 22.293
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 404
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 380
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 371
Development of novel cyclic peptides as pro-apoptotic agents 369
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 354
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 341
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 331
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 304
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 303
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 303
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 298
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 296
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 295
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 295
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 293
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 292
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 284
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 284
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 283
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 281
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 278
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 277
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 277
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 270
A stereoselective approach to peptidomimetic BACE1 inhibitors 270
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 268
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 261
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 260
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 259
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 258
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 254
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 253
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 252
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 252
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 251
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 250
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 248
Telomerase-based cancer therapeutics: a review on their clinical trials 248
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 248
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 247
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 247
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 244
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 243
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 241
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 236
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 235
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 232
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 231
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 230
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 229
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 229
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 228
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 227
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 225
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 223
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 223
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 222
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 222
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 221
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 221
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 220
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 219
Malaria chemotherapy: recent advances in drug development 218
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 218
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 217
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 217
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 216
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 215
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 215
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 214
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 212
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 212
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 212
Computational tool for fast in silico evaluation of hERG K+ channel affinity 210
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 210
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 209
(+)-(R)- and (−)-(S)-Perhexiline maleate: enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages 208
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 208
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 206
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 203
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 200
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 199
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 198
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 198
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 195
null 195
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 194
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 193
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 191
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 190
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 189
Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach 187
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 186
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 186
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 186
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 185
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 185
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 183
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 183
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 182
Totale 24.215
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Categoria #
all - tutte 99.514
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 99.514
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20212.499 0 0 0 0 0 586 299 439 300 416 287 172
2021/20222.322 197 269 210 144 101 55 124 100 112 265 273 472
2022/20232.888 167 271 398 364 314 558 82 228 272 100 83 51
2023/20242.789 100 52 253 126 171 740 852 41 28 87 113 226
2024/20255.107 139 212 610 269 609 280 169 266 595 248 467 1.243
2025/20268.782 921 1.608 1.793 1.620 2.484 356 0 0 0 0 0 0
Totale 33.291