IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 13.763
EU - Europa 12.350
AS - Asia 5.399
SA - Sud America 863
AF - Africa 135
OC - Oceania 30
Continente sconosciuto - Info sul continente non disponibili 15
AN - Antartide 1
Totale 32.556
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Nazione #
US - Stati Uniti d'America 13.565
GB - Regno Unito 2.763
RU - Federazione Russa 2.708
CN - Cina 2.112
IT - Italia 1.971
SG - Singapore 1.691
IE - Irlanda 1.470
SE - Svezia 774
DE - Germania 757
BR - Brasile 719
UA - Ucraina 657
FR - Francia 441
HK - Hong Kong 421
FI - Finlandia 292
KR - Corea 284
VN - Vietnam 202
IN - India 201
TR - Turchia 163
CA - Canada 118
ES - Italia 109
AT - Austria 63
PL - Polonia 55
NL - Olanda 54
AR - Argentina 51
CZ - Repubblica Ceca 51
MX - Messico 50
BD - Bangladesh 45
JP - Giappone 42
ZA - Sudafrica 40
BE - Belgio 37
CI - Costa d'Avorio 37
IR - Iran 33
GR - Grecia 24
IQ - Iraq 24
EC - Ecuador 23
AU - Australia 19
MA - Marocco 19
RO - Romania 18
LT - Lituania 17
PK - Pakistan 17
SA - Arabia Saudita 17
CO - Colombia 16
ID - Indonesia 16
UZ - Uzbekistan 16
EG - Egitto 15
IL - Israele 14
PT - Portogallo 14
VE - Venezuela 14
AZ - Azerbaigian 12
PE - Perù 12
AE - Emirati Arabi Uniti 11
CH - Svizzera 11
EU - Europa 11
CL - Cile 10
EE - Estonia 10
KZ - Kazakistan 10
JO - Giordania 8
NZ - Nuova Zelanda 8
BG - Bulgaria 7
BO - Bolivia 7
JM - Giamaica 7
KG - Kirghizistan 7
LV - Lettonia 7
TN - Tunisia 7
DK - Danimarca 6
HU - Ungheria 6
KE - Kenya 6
PA - Panama 6
RS - Serbia 6
LB - Libano 5
MY - Malesia 5
PY - Paraguay 5
TW - Taiwan 5
CR - Costa Rica 4
GE - Georgia 4
NP - Nepal 4
UY - Uruguay 4
AL - Albania 3
AO - Angola 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
HN - Honduras 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LK - Sri Lanka 3
MD - Moldavia 3
NO - Norvegia 3
OM - Oman 3
PH - Filippine 3
TH - Thailandia 3
XK - ???statistics.table.value.countryCode.XK??? 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
DZ - Algeria 2
GY - Guiana 2
HR - Croazia 2
KH - Cambogia 2
Totale 32.530
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Città #
Southend 2.462
Dallas 2.033
Fairfield 1.553
Dublin 1.458
Ashburn 1.188
Singapore 926
Chandler 732
Woodbridge 702
Moscow 682
Santa Clara 610
Siena 605
Beijing 583
Wilmington 580
Seattle 576
Houston 559
Cambridge 542
Jacksonville 535
Hong Kong 419
Ann Arbor 397
Hefei 315
Seoul 279
Princeton 251
Los Angeles 219
New York 204
Nanjing 199
Milan 154
Florence 147
Dearborn 145
Izmir 123
Helsinki 121
Munich 119
Fremont 118
Boardman 102
Shanghai 102
Bengaluru 96
Rome 88
The Dalles 76
San Mateo 74
San Diego 73
Buffalo 66
São Paulo 66
Washington 64
Nanchang 59
Düsseldorf 56
Ho Chi Minh City 55
Málaga 55
London 53
Lappeenranta 51
Lancaster 47
Redondo Beach 43
Hebei 42
Warsaw 41
Brno 40
Shenyang 40
Vienna 40
Guangzhou 39
Tokyo 38
Abidjan 37
Jiaxing 37
Hanoi 36
Aachen 34
Council Bluffs 34
Denver 34
Brussels 33
Redwood City 33
Venezia 33
Kunming 32
Brooklyn 30
Jinan 30
Norwalk 30
Johannesburg 29
Montreal 29
San Francisco 29
Tianjin 29
Toronto 29
Atlanta 28
Columbus 28
Changsha 27
Frankfurt am Main 27
Nuremberg 27
Menlo Park 26
Ottawa 26
Phoenix 26
Portsmouth 26
Chennai 25
Stockholm 25
Turku 25
Boston 24
Poplar 24
Ningbo 23
Lauterbourg 22
Rio de Janeiro 21
Belo Horizonte 20
Naples 20
Dong Ket 19
Mexico City 19
Orem 19
Parma 18
Brescia 17
Messina 17
Totale 22.199
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 403
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 378
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 371
Development of novel cyclic peptides as pro-apoptotic agents 367
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 349
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 340
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 330
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 303
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 301
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 300
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 297
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 294
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 293
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 292
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 291
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 290
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 283
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 283
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 281
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 278
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 277
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 276
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 275
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 268
A stereoselective approach to peptidomimetic BACE1 inhibitors 268
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 266
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 259
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 259
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 258
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 256
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 253
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 253
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 250
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 250
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 249
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 247
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 246
Telomerase-based cancer therapeutics: a review on their clinical trials 246
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 246
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 246
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 244
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 243
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 243
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 239
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 233
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 233
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 231
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 230
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 229
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 229
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 228
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 227
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 226
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 223
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 222
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 222
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 221
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 220
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 220
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 219
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 218
Malaria chemotherapy: recent advances in drug development 218
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 218
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 218
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 217
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 216
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 216
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 215
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 214
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 212
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 211
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 211
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 210
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 209
Computational tool for fast in silico evaluation of hERG K+ channel affinity 208
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 208
(+)-(R)- and (−)-(S)-Perhexiline maleate: enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages 207
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 206
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 204
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 203
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 198
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 198
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 197
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 196
null 195
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 194
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 193
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 191
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 190
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 189
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 187
Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach 186
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 185
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 184
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 183
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 182
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 182
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 180
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 179
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants 179
Totale 24.061
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Categoria #
all - tutte 98.793
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 98.793
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20212.499 0 0 0 0 0 586 299 439 300 416 287 172
2021/20222.322 197 269 210 144 101 55 124 100 112 265 273 472
2022/20232.888 167 271 398 364 314 558 82 228 272 100 83 51
2023/20242.789 100 52 253 126 171 740 852 41 28 87 113 226
2024/20255.107 139 212 610 269 609 280 169 266 595 248 467 1.243
2025/20268.552 921 1.608 1.793 1.620 2.484 126 0 0 0 0 0 0
Totale 33.061