IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 16.790
EU - Europa 13.849
AS - Asia 6.852
SA - Sud America 1.065
Continente sconosciuto - Info sul continente non disponibili 544
AF - Africa 392
OC - Oceania 40
AN - Antartide 1
Totale 39.533
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Nazione #
US - Stati Uniti d'America 16.472
IT - Italia 3.011
GB - Regno Unito 2.826
RU - Federazione Russa 2.710
CN - Cina 2.299
SG - Singapore 2.038
IE - Irlanda 1.477
BR - Brasile 817
DE - Germania 798
SE - Svezia 777
UA - Ucraina 662
VN - Vietnam 633
FR - Francia 615
HK - Hong Kong 531
FI - Finlandia 331
KR - Corea 285
IN - India 270
ZA - Sudafrica 206
TR - Turchia 177
CA - Canada 174
BD - Bangladesh 161
ES - Italia 122
NL - Olanda 94
MX - Messico 78
AR - Argentina 77
PL - Polonia 73
AT - Austria 64
JP - Giappone 58
CZ - Repubblica Ceca 53
IQ - Iraq 46
CO - Colombia 42
BE - Belgio 41
CI - Costa d'Avorio 38
NG - Nigeria 38
EC - Ecuador 37
IR - Iran 37
PK - Pakistan 35
ID - Indonesia 33
VE - Venezuela 31
AU - Australia 27
GR - Grecia 27
MA - Marocco 27
UZ - Uzbekistan 26
SA - Arabia Saudita 24
RO - Romania 23
CL - Cile 21
LT - Lituania 21
EG - Egitto 20
AZ - Azerbaigian 18
IL - Israele 18
AE - Emirati Arabi Uniti 17
JO - Giordania 17
KE - Kenya 17
PH - Filippine 17
JM - Giamaica 16
PT - Portogallo 16
CH - Svizzera 15
MY - Malesia 15
ET - Etiopia 14
KZ - Kazakistan 14
TN - Tunisia 14
BO - Bolivia 12
PE - Perù 12
DK - Danimarca 11
EU - Europa 11
CR - Costa Rica 10
EE - Estonia 10
NZ - Nuova Zelanda 10
RS - Serbia 10
NP - Nepal 9
BG - Bulgaria 8
KG - Kirghizistan 8
LV - Lettonia 8
PA - Panama 8
TH - Thailandia 8
TW - Taiwan 8
DZ - Algeria 7
GE - Georgia 7
HN - Honduras 7
HU - Ungheria 7
PY - Paraguay 7
UY - Uruguay 7
BY - Bielorussia 6
LB - Libano 6
MD - Moldavia 6
OM - Oman 6
AL - Albania 5
MC - Monaco 5
PS - Palestinian Territory 5
BB - Barbados 4
SN - Senegal 4
SY - Repubblica araba siriana 4
XK - ???statistics.table.value.countryCode.XK??? 4
AO - Angola 3
DO - Repubblica Dominicana 3
HR - Croazia 3
KH - Cambogia 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LK - Sri Lanka 3
Totale 38.952
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Città #
Southend 2.462
Dallas 2.059
Fairfield 1.553
Ashburn 1.478
Dublin 1.463
Singapore 1.111
San Jose 927
Chandler 732
Woodbridge 702
Santa Clara 683
Moscow 682
Siena 608
Milan 602
Beijing 595
Wilmington 580
Seattle 579
Houston 566
Cambridge 543
Jacksonville 538
Hong Kong 500
Ann Arbor 397
Hefei 376
Council Bluffs 355
Los Angeles 292
Seoul 280
New York 257
Princeton 251
Rome 243
Nanjing 200
Ho Chi Minh City 192
Johannesburg 189
The Dalles 188
Florence 180
Lauterbourg 160
Helsinki 154
Dearborn 146
Hanoi 146
Izmir 124
Munich 121
Fremont 119
Shanghai 113
Boardman 112
Bengaluru 96
Orem 84
San Diego 80
Buffalo 79
São Paulo 76
San Mateo 74
Washington 71
Columbus 68
London 68
Nanchang 59
Warsaw 57
Düsseldorf 56
Málaga 55
Lappeenranta 54
Tokyo 52
Frankfurt am Main 50
Lancaster 48
Chennai 47
Denver 46
Guangzhou 44
Naples 44
Turin 44
Montreal 43
Redondo Beach 43
Figino 42
Hebei 42
Vienna 41
Atlanta 40
Brno 40
Brooklyn 40
Shenyang 40
San Francisco 39
Abidjan 38
Toronto 38
Jiaxing 37
Phoenix 37
Abuja 36
Da Nang 36
Aachen 34
Brussels 34
Redwood City 33
Venezia 33
Chicago 32
Kunming 32
Norwalk 32
Nuremberg 32
Tianjin 32
Bologna 31
Jinan 30
Mexico City 30
Haiphong 29
Amsterdam 27
Changsha 27
Stockholm 27
Turku 27
Boston 26
Menlo Park 26
Ottawa 26
Totale 26.142
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 456
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 424
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 418
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 403
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 400
Development of novel cyclic peptides as pro-apoptotic agents 395
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 394
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 377
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 372
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 350
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 348
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 344
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 338
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 338
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 337
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 336
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 326
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 324
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 324
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 323
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 322
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 317
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 315
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 312
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 312
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 306
A stereoselective approach to peptidomimetic BACE1 inhibitors 304
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 293
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 291
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 290
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 289
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 288
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 287
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 285
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 284
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 284
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 284
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 280
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 277
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 276
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 274
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 273
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 272
Telomerase-based cancer therapeutics: a review on their clinical trials 272
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 272
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 271
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 269
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 269
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 269
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 267
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 264
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 263
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 260
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 260
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 258
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 257
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 257
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 256
(+)-(R)- and (−)-(S)-Perhexiline maleate: enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages 254
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 253
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 253
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 252
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 252
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 249
Malaria chemotherapy: recent advances in drug development 249
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 248
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 248
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 247
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 246
Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor 245
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 244
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 244
Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products 244
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 243
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 243
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 242
Computational tool for fast in silico evaluation of hERG K+ channel affinity 242
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 240
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 239
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 237
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 237
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 236
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 234
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 233
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 230
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles 228
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 227
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 227
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 226
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 226
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 225
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 225
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 223
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 222
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 221
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 221
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 219
NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 216
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 215
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 214
Totale 27.925
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Categoria #
all - tutte 117.520
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 117.520
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.856 0 0 210 144 101 55 124 100 112 265 273 472
2022/20232.888 167 271 398 364 314 558 82 228 272 100 83 51
2023/20242.789 100 52 253 126 171 740 852 41 28 87 113 226
2024/20255.107 139 212 610 269 609 280 169 266 595 248 467 1.243
2025/202613.554 921 1.608 1.793 1.620 2.484 551 1.484 435 443 797 320 1.098
2026/20271.470 523 511 436 0 0 0 0 0 0 0 0 0
Totale 39.533