IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 15.082
EU - Europa 12.918
AS - Asia 6.645
SA - Sud America 1.005
AF - Africa 390
OC - Oceania 38
Continente sconosciuto - Info sul continente non disponibili 16
AN - Antartide 1
Totale 36.095
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Nazione #
US - Stati Uniti d'America 14.825
GB - Regno Unito 2.815
RU - Federazione Russa 2.710
CN - Cina 2.272
IT - Italia 2.120
SG - Singapore 1.991
IE - Irlanda 1.475
DE - Germania 796
BR - Brasile 792
SE - Svezia 776
UA - Ucraina 660
VN - Vietnam 630
FR - Francia 615
HK - Hong Kong 516
FI - Finlandia 331
KR - Corea 284
IN - India 266
ZA - Sudafrica 205
TR - Turchia 175
CA - Canada 144
ES - Italia 116
NL - Olanda 86
BD - Bangladesh 84
AR - Argentina 74
MX - Messico 74
PL - Polonia 72
AT - Austria 64
JP - Giappone 57
CZ - Repubblica Ceca 53
IQ - Iraq 46
BE - Belgio 39
CI - Costa d'Avorio 38
NG - Nigeria 38
IR - Iran 34
PK - Pakistan 32
EC - Ecuador 29
AU - Australia 27
MA - Marocco 27
CO - Colombia 26
GR - Grecia 26
ID - Indonesia 25
UZ - Uzbekistan 25
VE - Venezuela 25
SA - Arabia Saudita 23
RO - Romania 22
LT - Lituania 21
EG - Egitto 20
CL - Cile 19
AZ - Azerbaigian 18
IL - Israele 18
JO - Giordania 17
KE - Kenya 17
PT - Portogallo 16
AE - Emirati Arabi Uniti 15
ET - Etiopia 14
KZ - Kazakistan 14
TN - Tunisia 14
CH - Svizzera 13
PH - Filippine 13
BO - Bolivia 12
PE - Perù 12
DK - Danimarca 11
EU - Europa 11
EE - Estonia 10
JM - Giamaica 10
MY - Malesia 10
RS - Serbia 10
NP - Nepal 9
LV - Lettonia 8
NZ - Nuova Zelanda 8
PA - Panama 8
TW - Taiwan 8
BG - Bulgaria 7
CR - Costa Rica 7
DZ - Algeria 7
GE - Georgia 7
HU - Ungheria 7
KG - Kirghizistan 7
PY - Paraguay 7
UY - Uruguay 7
BY - Bielorussia 6
LB - Libano 6
MD - Moldavia 6
OM - Oman 6
TH - Thailandia 6
AL - Albania 5
MC - Monaco 5
PS - Palestinian Territory 5
SN - Senegal 4
SY - Repubblica araba siriana 4
XK - ???statistics.table.value.countryCode.XK??? 4
AO - Angola 3
DO - Repubblica Dominicana 3
HN - Honduras 3
HR - Croazia 3
KH - Cambogia 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LK - Sri Lanka 3
NO - Norvegia 3
Totale 36.056
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Città #
Southend 2.462
Dallas 2.038
Fairfield 1.553
Dublin 1.462
Ashburn 1.285
Singapore 1.093
Chandler 732
Woodbridge 702
Moscow 682
Santa Clara 617
San Jose 609
Siena 607
Beijing 589
Wilmington 580
Seattle 577
Houston 562
Cambridge 543
Jacksonville 537
Hong Kong 488
Ann Arbor 397
Hefei 376
Seoul 279
Los Angeles 254
Princeton 251
New York 225
Nanjing 200
Ho Chi Minh City 190
Johannesburg 188
Milan 181
The Dalles 173
Council Bluffs 167
Lauterbourg 160
Florence 158
Helsinki 154
Dearborn 145
Hanoi 145
Izmir 124
Munich 120
Fremont 118
Shanghai 110
Boardman 103
Bengaluru 96
Rome 94
Orem 79
San Diego 75
San Mateo 74
São Paulo 74
Buffalo 71
London 65
Washington 65
Nanchang 59
Warsaw 57
Düsseldorf 56
Málaga 55
Lappeenranta 54
Tokyo 52
Frankfurt am Main 49
Chennai 47
Lancaster 47
Guangzhou 43
Redondo Beach 43
Hebei 42
Vienna 41
Brno 40
Shenyang 40
Denver 39
Montreal 39
Abidjan 38
Jiaxing 37
Abuja 36
Da Nang 36
Aachen 34
Brussels 34
Brooklyn 33
Redwood City 33
Venezia 33
Kunming 32
Nuremberg 32
Tianjin 32
Toronto 32
Atlanta 31
Jinan 30
Norwalk 30
San Francisco 30
Haiphong 29
Naples 29
Columbus 28
Amsterdam 27
Changsha 27
Mexico City 27
Phoenix 27
Stockholm 27
Turku 27
Menlo Park 26
Ottawa 26
Portsmouth 26
Boston 25
Poplar 25
Rio de Janeiro 24
Ningbo 23
Totale 24.418
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Nome #
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 436
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 402
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 392
Development of novel cyclic peptides as pro-apoptotic agents 385
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 374
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 364
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 356
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 335
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients 332
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 326
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 325
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 320
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy 317
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 317
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 316
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 311
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 311
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 310
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 310
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 307
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 304
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 304
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 299
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 298
A stereoselective approach to peptidomimetic BACE1 inhibitors 290
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 287
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 277
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 276
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 276
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 274
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 273
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 273
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 273
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 272
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 272
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 270
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 270
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 267
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 267
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 263
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 263
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 261
Telomerase-based cancer therapeutics: a review on their clinical trials 261
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 260
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 257
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 256
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 255
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 255
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 250
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 248
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 246
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 244
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 244
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 243
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 243
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 242
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 242
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 241
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 241
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 240
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 238
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 237
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 237
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 236
Malaria chemotherapy: recent advances in drug development 235
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 235
(+)-(R)- and (−)-(S)-Perhexiline maleate: enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages 235
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 234
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 234
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 231
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 230
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 230
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 230
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 229
Computational tool for fast in silico evaluation of hERG K+ channel affinity 227
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 226
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 225
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 224
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 222
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 220
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 219
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 218
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity 217
Biostimulants for Sustainable Food Production: Effects of Wood Distillate to Fortify Chickpea Flour for Development of Functional Bakery Products 217
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 213
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 213
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 213
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 212
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 210
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 210
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 210
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 207
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 206
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles 206
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 205
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 205
Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor 204
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors 204
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 202
NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 202
Totale 26.231
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Categoria #
all - tutte 105.635
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.635
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021875 0 0 0 0 0 0 0 0 0 416 287 172
2021/20222.322 197 269 210 144 101 55 124 100 112 265 273 472
2022/20232.888 167 271 398 364 314 558 82 228 272 100 83 51
2023/20242.789 100 52 253 126 171 740 852 41 28 87 113 226
2024/20255.107 139 212 610 269 609 280 169 266 595 248 467 1.243
2025/202612.100 921 1.608 1.793 1.620 2.484 551 1.484 435 443 761 0 0
Totale 36.609