IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 9.224
EU - Europa 8.475
AS - Asia 1.348
OC - Oceania 17
SA - Sud America 15
AF - Africa 12
Continente sconosciuto - Info sul continente non disponibili 12
Totale 19.103
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Nazione #
US - Stati Uniti d'America 9.178
GB - Regno Unito 2.643
IE - Irlanda 1.466
IT - Italia 1.442
CN - Cina 1.017
SE - Svezia 758
UA - Ucraina 642
DE - Germania 569
FR - Francia 376
FI - Finlandia 232
TR - Turchia 137
RU - Federazione Russa 81
SG - Singapore 65
ES - Italia 61
CA - Canada 45
CZ - Repubblica Ceca 45
AT - Austria 33
BE - Belgio 33
IN - India 33
IR - Iran 24
GR - Grecia 23
VN - Vietnam 20
NL - Olanda 16
AU - Australia 15
EU - Europa 11
JP - Giappone 11
RO - Romania 10
PL - Polonia 9
PT - Portogallo 9
BR - Brasile 6
EG - Egitto 6
BG - Bulgaria 5
ID - Indonesia 5
KR - Corea 5
SA - Arabia Saudita 5
HU - Ungheria 4
PK - Pakistan 4
CH - Svizzera 3
CL - Cile 3
DK - Danimarca 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
MA - Marocco 3
RS - Serbia 3
HK - Hong Kong 2
HR - Croazia 2
IL - Israele 2
KH - Cambogia 2
MY - Malesia 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PE - Perù 2
TW - Taiwan 2
ZA - Sudafrica 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BO - Bolivia 1
CO - Colombia 1
EC - Ecuador 1
EE - Estonia 1
IM - Isola di Man 1
JO - Giordania 1
KE - Kenya 1
KZ - Kazakistan 1
LV - Lettonia 1
MC - Monaco 1
PA - Panama 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
VE - Venezuela 1
Totale 19.103
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Città #
Southend 2.462
Fairfield 1.553
Dublin 1.454
Ashburn 885
Chandler 737
Woodbridge 701
Wilmington 579
Seattle 570
Siena 563
Houston 547
Cambridge 541
Jacksonville 534
Ann Arbor 397
Princeton 251
Beijing 250
Nanjing 197
Dearborn 145
Izmir 122
Fremont 119
New York 110
Helsinki 106
Florence 104
Boardman 99
Shanghai 93
San Mateo 74
San Diego 73
Washington 62
Moscow 60
Nanchang 59
Málaga 55
Lancaster 47
Hebei 42
Brno 40
Milan 40
Rome 39
Shenyang 39
Singapore 38
Jiaxing 36
Aachen 34
Lappeenranta 34
Redwood City 33
Venezia 33
Kunming 32
Brussels 31
Norwalk 30
Jinan 29
London 29
Menlo Park 26
Vienna 26
Düsseldorf 25
Tianjin 25
Ottawa 24
Guangzhou 23
Ningbo 23
Changsha 19
Dong Ket 19
Turin 16
Hefei 15
Parma 15
San Francisco 15
Avellino 14
Hangzhou 14
Prato 14
Toronto 14
Munich 13
Los Angeles 12
Marietta 12
Pisa 12
Borgo San Lorenzo 11
Hanover 11
San Giovanni Valdarno 11
Salerno 10
Zhengzhou 10
Maletto 9
Naples 9
Arezzo 8
Catanzaro 8
Palermo 8
Taizhou 8
Ventimiglia 8
Bari 7
Changchun 7
Fisciano 7
Palo Alto 7
Tokyo 7
Catania 6
Lanzhou 6
Philadelphia 6
Tegoleto 6
Zanjan 6
Albosaggia 5
Amsterdam 5
Andover 5
Bologna 5
Certaldo 5
Edinburgh 5
Frankfurt am Main 5
Innsbruck 5
Leawood 5
Licata 5
Totale 14.710
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Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 286
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 263
Development of novel cyclic peptides as pro-apoptotic agents 254
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 252
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 244
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 238
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 221
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 219
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 207
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 206
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 206
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 205
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 205
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 203
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 202
null 195
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 193
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 192
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 190
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 188
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 186
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 181
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 181
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 180
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 176
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 175
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 174
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 169
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 168
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 167
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 167
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 164
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 163
Telomerase-based cancer therapeutics: a review on their clinical trials 162
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 161
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 161
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 159
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 159
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 159
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 158
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 158
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 157
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 157
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 156
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 156
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 154
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 154
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 153
A stereoselective approach to peptidomimetic BACE1 inhibitors 153
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 151
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 150
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 149
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies. 147
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. 146
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 146
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 145
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 143
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. 142
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 142
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 141
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 139
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 139
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 138
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 137
Malaria chemotherapy: recent advances in drug development 136
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 136
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 135
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 132
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 131
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 131
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 131
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 129
Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate 129
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships. 129
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 128
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 126
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 126
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 126
Computational tool for fast in silico evaluation of hERG K+ channel affinity 125
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 124
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 122
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 120
Rational design of the first difluorostatone-based PfSUB1 inhibitors 120
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 120
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 119
Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach 118
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands 117
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis 117
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 115
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 114
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 114
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. 114
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation and protein-ligand X-ray studies 113
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 113
NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 111
In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors 110
CONDENSED PYRIMIDINONES ACTIVE ON GLUTAMATERGIC RECEPTORS 110
null 109
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas 108
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 107
Totale 15.657
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Categoria #
all - tutte 59.407
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.407
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20204.046 461 156 244 613 293 390 376 452 326 374 113 248
2020/20213.638 146 285 128 317 263 586 299 439 300 416 287 172
2021/20222.323 197 269 210 144 101 55 124 100 112 265 273 473
2022/20232.908 167 275 402 366 315 563 83 228 274 101 83 51
2023/20242.800 100 53 253 126 175 742 854 41 28 87 113 228
2024/202596 96 0 0 0 0 0 0 0 0 0 0 0
Totale 19.530