IRIS
GEMMA, SANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 10.525
EU - Europa 9.949
AS - Asia 3.338
SA - Sud America 627
AF - Africa 91
OC - Oceania 22
Continente sconosciuto - Info sul continente non disponibili 12
Totale 24.564
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Nazione #
US - Stati Uniti d'America 10.414
GB - Regno Unito 2.710
IT - Italia 1.835
IE - Irlanda 1.469
CN - Cina 1.326
SG - Singapore 908
SE - Svezia 754
DE - Germania 737
RU - Federazione Russa 691
UA - Ucraina 649
BR - Brasile 551
FR - Francia 417
HK - Hong Kong 377
FI - Finlandia 278
IN - India 166
TR - Turchia 152
KR - Corea 133
ES - Italia 80
CA - Canada 76
AT - Austria 63
CZ - Repubblica Ceca 51
VN - Vietnam 43
CI - Costa d'Avorio 37
NL - Olanda 35
BD - Bangladesh 33
BE - Belgio 33
IR - Iran 29
GR - Grecia 24
AR - Argentina 23
PL - Polonia 22
AU - Australia 18
MX - Messico 17
SA - Arabia Saudita 16
UZ - Uzbekistan 16
IQ - Iraq 15
JP - Giappone 15
MA - Marocco 14
PT - Portogallo 14
RO - Romania 14
EG - Egitto 13
ZA - Sudafrica 13
EU - Europa 11
PK - Pakistan 11
AZ - Azerbaigian 10
CO - Colombia 10
EE - Estonia 10
IL - Israele 10
PE - Perù 10
VE - Venezuela 10
AE - Emirati Arabi Uniti 9
CH - Svizzera 9
CL - Cile 7
EC - Ecuador 7
KZ - Kazakistan 7
LT - Lituania 7
LV - Lettonia 7
BG - Bulgaria 6
BO - Bolivia 6
DK - Danimarca 6
ID - Indonesia 6
JM - Giamaica 6
JO - Giordania 6
KG - Kirghizistan 6
PA - Panama 6
HU - Ungheria 5
RS - Serbia 5
GE - Georgia 4
KE - Kenya 4
LB - Libano 4
MY - Malesia 4
NZ - Nuova Zelanda 4
TN - Tunisia 4
TW - Taiwan 4
AL - Albania 3
CR - Costa Rica 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
LK - Sri Lanka 3
OM - Oman 3
AM - Armenia 2
BY - Bielorussia 2
HR - Croazia 2
KH - Cambogia 2
MD - Moldavia 2
NG - Nigeria 2
NO - Norvegia 2
NP - Nepal 2
PH - Filippine 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
UY - Uruguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BN - Brunei Darussalam 1
DZ - Algeria 1
ET - Etiopia 1
GY - Guiana 1
Totale 24.554
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Città #
Southend 2.462
Fairfield 1.553
Dublin 1.457
Ashburn 915
Chandler 732
Woodbridge 702
Siena 604
Santa Clara 591
Wilmington 580
Seattle 573
Houston 548
Cambridge 542
Jacksonville 534
Singapore 476
Ann Arbor 397
Beijing 388
Hong Kong 376
Princeton 251
Nanjing 198
Dearborn 145
Florence 137
Milan 130
New York 128
Seoul 128
Izmir 123
Helsinki 120
Fremont 118
Hefei 114
Munich 111
Boardman 99
Shanghai 98
Bengaluru 96
San Mateo 74
Rome 73
San Diego 73
Los Angeles 68
Washington 63
Moscow 59
Nanchang 59
Düsseldorf 56
Málaga 55
Lancaster 47
Hebei 42
London 41
Brno 40
Vienna 40
Lappeenranta 39
Shenyang 39
São Paulo 39
Abidjan 37
Jiaxing 36
Aachen 34
Redwood City 33
Venezia 33
Kunming 32
Brussels 31
Norwalk 30
Jinan 29
Columbus 28
Guangzhou 27
Menlo Park 26
Ottawa 26
Portsmouth 26
Tianjin 26
Nuremberg 25
San Francisco 24
Toronto 24
Turku 24
Ningbo 23
The Dalles 23
Lauterbourg 22
Frankfurt am Main 20
Changsha 19
Dallas 19
Dong Ket 19
Parma 18
Brescia 17
Trieste 17
Council Bluffs 16
Tashkent 16
Turin 16
Belo Horizonte 15
Brooklyn 15
Dhaka 15
Naples 15
Rio de Janeiro 15
Avellino 14
Hangzhou 14
Messina 14
Prato 14
Boston 13
Pisa 13
Marietta 12
Zhengzhou 12
Borgo San Lorenzo 11
Hanover 11
San Giovanni Valdarno 11
Tokyo 11
Chicago 10
Phoenix 10
Totale 17.374
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Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 321
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 296
Development of novel cyclic peptides as pro-apoptotic agents 294
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 293
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 291
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 278
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 254
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 250
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 245
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 244
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 238
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 237
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 237
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 228
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 227
Old but gold: tracking the new guise of Histone Deacetylase 6 (HDAC6) enzyme as a biomarker and therapeutic target in rare diseases 227
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 226
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 225
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 223
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 218
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 215
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 209
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 208
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 206
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 205
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 203
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 203
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 200
Telomerase-based cancer therapeutics: a review on their clinical trials 200
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 199
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation 198
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 196
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 195
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Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 195
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 194
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 194
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 193
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 190
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 190
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 190
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 189
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 189
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 189
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 188
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 187
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 187
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 186
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 185
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 185
A stereoselective approach to peptidomimetic BACE1 inhibitors 185
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 184
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 183
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 182
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 182
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 180
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies 178
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 178
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains 177
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling 177
Malaria chemotherapy: recent advances in drug development 176
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 174
Retinitis pigmentosa and retinal degenerations: deciphering pathways and targets for drug discovery and development 172
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 171
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 170
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 170
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 167
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 167
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 167
Computational tool for fast in silico evaluation of hERG K+ channel affinity 166
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 163
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 161
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 160
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 159
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 158
Site-directed mutagenesis of key residues unveiled a novel allosteric site on human adenosine kinase for Pyrrolobenzoxa(thia)zepinone non-nucleoside inhibitors 155
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 155
Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents 154
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation 154
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 152
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 151
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells 151
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 151
Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate 151
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 147
Rational design of the first difluorostatone-based PfSUB1 inhibitors 146
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants 145
Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach 145
Extra virgin olive oil extracts of indigenous Southern Tuscany cultivar act as anti-inflammatory and vasorelaxant nutraceuticals 145
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 144
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 144
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 144
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 142
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies 141
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 140
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition 140
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis 140
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 140
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation and protein-ligand X-ray studies 139
HCV-targeted Antivirals: Current Status and Future Challenges 138
Totale 18.876
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Categoria #
all - tutte 83.524
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 83.524
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20213.638 146 285 128 317 263 586 299 439 300 416 287 172
2021/20222.322 197 269 210 144 101 55 124 100 112 265 273 472
2022/20232.888 167 271 398 364 314 558 82 228 272 100 83 51
2023/20242.789 100 52 253 126 171 740 852 41 28 87 113 226
2024/20255.107 139 212 610 269 609 280 169 266 595 248 467 1.243
2025/2026552 552 0 0 0 0 0 0 0 0 0 0 0
Totale 25.061