IRIS
GEMMA, SANDRA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 9.283
EU - Europa 8.363
AS - Asia 1.287
OC - Oceania 17
SA - Sud America 13
Continente sconosciuto - Info sul continente non disponibili 12
AF - Africa 11
Totale 18.986
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 9.237
GB - Regno Unito 2.642
IE - Irlanda 1.553
IT - Italia 1.346
CN - Cina 1.023
SE - Svezia 781
UA - Ucraina 642
DE - Germania 555
FR - Francia 396
FI - Finlandia 205
TR - Turchia 135
ES - Italia 62
CA - Canada 45
BE - Belgio 35
IN - India 34
AT - Austria 32
GR - Grecia 23
IR - Iran 21
RU - Federazione Russa 21
VN - Vietnam 19
AU - Australia 15
NL - Olanda 15
EU - Europa 11
JP - Giappone 11
RO - Romania 10
PL - Polonia 9
PT - Portogallo 9
ID - Indonesia 7
BR - Brasile 6
EG - Egitto 6
BG - Bulgaria 5
KR - Corea 5
SA - Arabia Saudita 5
SG - Singapore 5
CH - Svizzera 3
CL - Cile 3
DK - Danimarca 3
HU - Ungheria 3
KW - Kuwait 3
LA - Repubblica Popolare Democratica del Laos 3
PK - Pakistan 3
RS - Serbia 3
CZ - Repubblica Ceca 2
HK - Hong Kong 2
HR - Croazia 2
IL - Israele 2
MA - Marocco 2
MY - Malesia 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PE - Perù 2
TW - Taiwan 2
ZA - Sudafrica 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BO - Bolivia 1
IM - Isola di Man 1
KE - Kenya 1
KH - Cambogia 1
KZ - Kazakistan 1
LV - Lettonia 1
MC - Monaco 1
PA - Panama 1
TH - Thailandia 1
VE - Venezuela 1
Totale 18.986
Salva come PNG Salva come JPEG
Città #
Southend 2.462
Fairfield 1.553
Dublin 1.541
Ashburn 893
Chandler 777
Woodbridge 701
Wilmington 579
Seattle 570
Houston 547
Cambridge 541
Siena 535
Jacksonville 534
Ann Arbor 397
Princeton 251
Beijing 250
Nanjing 197
Dearborn 145
Izmir 122
Fremont 119
New York 118
Helsinki 107
Shanghai 100
Florence 93
Boardman 84
San Mateo 74
San Diego 73
Washington 63
Nanchang 59
Málaga 56
Lancaster 47
Hebei 42
Shenyang 39
Milan 37
Jiaxing 36
Aachen 34
Brussels 33
Redwood City 33
Venezia 33
Kunming 32
Rome 31
Norwalk 30
Jinan 29
London 28
Menlo Park 26
Düsseldorf 25
Tianjin 25
Vienna 25
Ottawa 24
Guangzhou 23
Ningbo 23
Changsha 19
Dong Ket 19
Hefei 15
Avellino 14
Hangzhou 14
Toronto 14
Parma 13
Hanover 12
Marietta 12
Borgo San Lorenzo 11
San Francisco 11
San Giovanni Valdarno 11
Naples 10
Zhengzhou 10
Maletto 9
Palermo 9
Pisa 9
Prato 9
Arezzo 8
Catanzaro 8
Salerno 8
Taizhou 8
Ventimiglia 8
Bari 7
Changchun 7
Palo Alto 7
Tokyo 7
Turin 7
Bologna 6
Catania 6
Lanzhou 6
Lappeenranta 6
Mumbai 6
Philadelphia 6
Tegoleto 6
Zanjan 6
Andover 5
Certaldo 5
Edinburgh 5
Innsbruck 5
Leawood 5
Licata 5
Mestre 5
Modena 5
Redmond 5
Serra 5
Sofia 5
Suri 5
Amsterdam 4
Bacoli 4
Totale 14.608
Salva come PNG Salva come JPEG
Nome #
Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages 280
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 256
Development of novel cyclic peptides as pro-apoptotic agents 250
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 245
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation 240
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 235
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies 218
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds 210
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases 206
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents 205
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors 204
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) 203
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 201
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain 199
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme 197
null 195
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases 192
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 191
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking 187
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation 184
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents 184
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 180
Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX 180
Selective Kainate Receptor (GluK1) Ligands Structurally Based upon 1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: Synthesis, Molecular Modeling, and Pharmacological and Biostructural Characterization 179
Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase 175
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 174
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues 171
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials 168
1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators 167
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 166
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 164
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 163
Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases 163
Non-Nucleoside Inhibitors of Human Adenosine Kinase: Synthesis, Molecular Modeling, and Biological Studies 159
The Interactions of the 5-HT3 Receptor with Quipazine-Like Arylpiperazine Ligands. The Journey Track at the End of the First Decade of the Third Millennium 158
Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues 157
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues 157
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 157
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision 157
Synthesis and structure–activity relationship studies in serotonin 5-HT1A receptor agonists based on fused pyrrolidone scaffolds 157
Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives 156
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 155
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides 155
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 154
Synthetic studies toward bicyclic endoperoxides presenting polar side chains 154
Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D-3 and Serotonin 5-HT1A and 5-HT2A Receptors 154
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials 154
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 153
A stereoselective approach to peptidomimetic BACE1 inhibitors 152
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 149
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation 148
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. 147
Development of Antitubercular Compounds Based on a 4-Quinolylhydrazone Scaffold. Further Structure-activity Relationship Studies. 146
Dopamine D3 receptor antagonists as potential therapeutics for the treatment of neurological diseases 146
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. 145
ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE 143
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. 141
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies 140
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors 140
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils 138
Multifunctional Cholinesterase and Amyloid Beta Fibrillization Modulators. Synthesis and Biological Investigation 138
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. 138
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 134
Malaria chemotherapy: recent advances in drug development 134
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 131
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties 131
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 131
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 130
A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs 130
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 128
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 127
Disease modifying anti-Alzheimer’s drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation 127
Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate 127
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 127
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships. 127
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 125
null 123
The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional 122
Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations 122
Rational design of the first difluorostatone-based PfSUB1 inhibitors 120
null 120
An efficient approach to chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as peptidomimetic scaffolds 118
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands 117
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis 117
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 115
null 115
Retinitis Pigmentosa and Retinal Degenerations: Deciphering Pathways and Targets for Drug Discovery and Development 115
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents 114
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation and protein-ligand X-ray studies 113
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants 113
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ‘‘primer grip’’ region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants. 113
null 113
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 112
null 111
null 109
CONDENSED PYRIMIDINONES ACTIVE ON GLUTAMATERGIC RECEPTORS 109
NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS 108
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 105
null 105
null 104
Totale 15.422
Salva come PNG Salva come JPEG
Categoria #
all - tutte 56.705
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.705
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.507 0 0 0 0 0 0 0 0 0 301 658 548
2019/20204.046 461 156 244 613 293 390 376 452 326 374 113 248
2020/20213.638 146 285 128 317 263 586 299 439 300 416 287 172
2021/20222.323 197 269 210 144 101 55 124 100 112 265 273 473
2022/20233.067 177 287 428 399 325 594 85 237 293 103 86 53
2023/20242.571 111 58 267 139 181 782 906 46 29 52 0 0
Totale 19.364