IRIS
BOTTA, MAURIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 32.520
EU - Europa 24.048
AS - Asia 4.751
SA - Sud America 158
AF - Africa 113
OC - Oceania 48
Continente sconosciuto - Info sul continente non disponibili 27
Totale 61.665
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Nazione #
US - Stati Uniti d'America 32.402
GB - Regno Unito 7.304
IE - Irlanda 4.218
CN - Cina 3.307
UA - Ucraina 2.697
SE - Svezia 2.089
IT - Italia 1.675
RU - Federazione Russa 1.641
FR - Francia 1.532
DE - Germania 1.509
SG - Singapore 849
FI - Finlandia 706
TR - Turchia 156
BE - Belgio 142
VN - Vietnam 140
ES - Italia 118
BR - Brasile 110
CZ - Repubblica Ceca 103
CA - Canada 100
RO - Romania 69
CI - Costa d'Avorio 68
IN - India 63
NL - Olanda 61
AU - Australia 42
JP - Giappone 36
HK - Hong Kong 32
EU - Europa 25
GR - Grecia 25
IR - Iran 25
PL - Polonia 22
CL - Cile 19
EG - Egitto 17
AE - Emirati Arabi Uniti 16
BG - Bulgaria 15
TH - Thailandia 13
KR - Corea 12
LT - Lituania 12
AT - Austria 11
CH - Svizzera 11
DK - Danimarca 11
ZA - Sudafrica 11
EE - Estonia 10
IL - Israele 10
HU - Ungheria 9
LV - Lettonia 9
BD - Bangladesh 8
HR - Croazia 8
MA - Marocco 8
PA - Panama 8
PK - Pakistan 8
PT - Portogallo 8
AL - Albania 6
AZ - Azerbaigian 6
EC - Ecuador 6
ID - Indonesia 6
KZ - Kazakistan 6
LK - Sri Lanka 6
NO - Norvegia 6
NZ - Nuova Zelanda 6
PH - Filippine 6
BO - Bolivia 5
CO - Colombia 5
JO - Giordania 5
SA - Arabia Saudita 5
SK - Slovacchia (Repubblica Slovacca) 5
AR - Argentina 4
IM - Isola di Man 4
IQ - Iraq 4
LA - Repubblica Popolare Democratica del Laos 4
PE - Perù 4
TJ - Tagikistan 4
TN - Tunisia 4
UZ - Uzbekistan 4
DO - Repubblica Dominicana 3
DZ - Algeria 3
KG - Kirghizistan 3
MK - Macedonia 3
MY - Malesia 3
RS - Serbia 3
AM - Armenia 2
KH - Cambogia 2
LU - Lussemburgo 2
MD - Moldavia 2
MX - Messico 2
PR - Porto Rico 2
VE - Venezuela 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
BT - Bhutan 1
CR - Costa Rica 1
CY - Cipro 1
FK - Isole Falkland (Malvinas) 1
GE - Georgia 1
GH - Ghana 1
KW - Kuwait 1
MS - Montserrat 1
OM - Oman 1
PY - Paraguay 1
Totale 61.657
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Città #
Southend 6.755
Fairfield 4.509
Dublin 4.183
Menlo Park 3.599
Chandler 2.504
Jacksonville 2.253
Ashburn 2.188
Woodbridge 2.100
Wilmington 1.756
Seattle 1.626
Houston 1.602
Cambridge 1.564
Ann Arbor 1.313
Santa Clara 1.161
Nanjing 819
Princeton 804
Beijing 732
Siena 708
Singapore 561
Boardman 383
New York 356
Nanchang 305
Helsinki 270
San Diego 266
San Mateo 200
Moscow 176
Shenyang 175
Düsseldorf 153
Dong Ket 138
Shanghai 138
Brussels 134
Hebei 129
Tianjin 123
Izmir 121
Venezia 121
Fremont 120
Changsha 109
Dearborn 108
Kunming 105
London 99
Milan 93
Jiaxing 87
Málaga 86
Norwalk 75
Lancaster 72
Redwood City 70
Abidjan 68
Jinan 68
Toronto 64
San Francisco 62
Brno 55
Hangzhou 55
Los Angeles 53
Zhengzhou 52
Ningbo 51
Mestre 43
Timisoara 43
Rome 42
Florence 41
Guangzhou 41
Munich 39
Philadelphia 33
Olomouc 30
Taizhou 29
Changchun 28
Washington 28
Amsterdam 26
Frankfurt am Main 25
Phoenix 25
Kilburn 24
Lanzhou 24
Hefei 20
Paris 20
Hong Kong 18
São Paulo 18
Leawood 17
Chicago 16
Dallas 16
Edinburgh 16
Melbourne 16
Cairo 15
Sofia 15
Hounslow 14
Salamanca 14
Tappahannock 14
Tokyo 14
Newark 13
Saint Petersburg 13
Canberra 12
Fuzhou 12
Grünheide 12
Prague 12
Shenzhen 12
Sydney 12
Lappeenranta 11
Pune 11
Zanjan 11
Bonndorf 10
Tallinn 10
Besançon 9
Totale 46.401
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Nome #
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 378
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 354
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 295
1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies 289
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 274
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 260
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 240
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 237
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 230
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 226
Linear guanidine derivatives, methods of preparation and uses thereof 222
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 220
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents 220
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains 219
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 217
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update 217
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02 216
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 212
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors 205
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 203
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity 202
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 202
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 201
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling 200
Potent and selective carboxylic acid inhibitors of tumor-associated carbonic anhydrases IX and XII 200
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels 200
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma 198
Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions 195
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 194
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 192
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 191
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 191
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 191
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 190
SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment 189
‘LC/ESI/MS method for the quantitative detection of guazatine residues in cereales’ 188
DDX3X Helicase Inhibitors as a New Strategy to Fight the West Nile Virus Infection 187
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 186
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 185
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 185
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 184
Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules 182
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors 182
Lc/Esi/Ms/Ms determination of postharvest fungicide residues in citrus juices 181
2-Aminothiazolones as anti-hiv agents that act as gp120-cd4 inhibitors 180
Discovery of in vitro antitubercular agents through in silico ligand-based approaches 179
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents 177
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 177
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors 177
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 177
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 176
Synthesis of an original oxygenated taxuspine X analogue: a versatile non-natural natural product with remarkable P-gp modulating activity 176
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 176
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl 176
DDX3X inhibitors, an effective way to overcome HIV-1 resistance 174
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 174
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 173
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 172
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 172
Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4- d]pyrimidines for Targeting Hepatocellular Carcinoma 172
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 172
From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity 171
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors 171
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication 170
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 170
Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) 170
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors 169
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 169
Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 168
THE POTENTIAL BENEFICIAL EFFECTS OF TENEBRIO MOLITOR (COLEOPTERA TENEBRIONIDAE) AND GALLERIA MELLONELLA (LEPIDOPTERA PYRALIDAE) ON HUMAN HEALTH 168
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 167
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 167
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 166
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 166
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 165
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 164
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data 162
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 162
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 162
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X 162
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies 161
Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma 161
Synthesis, Cannabinoid Receptor Affinity, and Molecular Modeling Studies of Substituted 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides 160
4­-Amino­substituted pyrazolo[3,4­d]pyrimidines: synthesis and biological properties 160
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 158
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 158
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 158
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors 158
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 157
Pyrrolo[2,1-c][1,4]benzothiazines: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Cardiovascular Activity 157
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors 157
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus 157
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 156
HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that compete with the nucleotide substrate 156
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors 156
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides 156
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 155
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 155
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 155
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 153
Totale 18.823
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Categoria #
all - tutte 194.324
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 194.324
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20205.619 0 0 0 0 0 0 996 1.575 1.020 1.003 272 753
2020/20218.610 476 903 173 906 478 1.114 374 1.296 993 631 647 619
2021/20225.948 454 960 299 298 239 191 330 201 335 663 642 1.336
2022/20238.903 575 726 1.191 1.317 899 1.752 186 762 892 157 297 149
2023/20246.066 257 125 407 283 186 1.737 2.160 210 22 127 81 471
2024/20254.407 269 672 1.134 586 1.168 499 79 0 0 0 0 0
Totale 62.166