IRIS
BOTTA, MAURIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 52.674
EU - Europa 32.254
AS - Asia 17.259
SA - Sud America 3.152
AF - Africa 751
Continente sconosciuto - Info sul continente non disponibili 550
OC - Oceania 61
Totale 106.701
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Nazione #
US - Stati Uniti d'America 52.091
GB - Regno Unito 7.589
CN - Cina 6.427
RU - Federazione Russa 5.778
SG - Singapore 5.100
IE - Irlanda 4.222
IT - Italia 3.798
UA - Ucraina 2.734
BR - Brasile 2.608
SE - Svezia 2.188
FR - Francia 2.124
DE - Germania 1.823
VN - Vietnam 1.470
HK - Hong Kong 1.372
KR - Corea 916
FI - Finlandia 871
IN - India 475
ZA - Sudafrica 301
CA - Canada 292
BD - Bangladesh 261
TR - Turchia 243
ES - Italia 191
AR - Argentina 171
MX - Messico 155
JP - Giappone 151
BE - Belgio 148
NL - Olanda 143
IQ - Iraq 129
CZ - Repubblica Ceca 127
NG - Nigeria 119
PL - Polonia 106
ID - Indonesia 94
PK - Pakistan 87
RO - Romania 83
EC - Ecuador 78
CI - Costa d'Avorio 77
VE - Venezuela 72
CO - Colombia 70
SA - Arabia Saudita 59
CL - Cile 55
JO - Giordania 51
AU - Australia 50
MA - Marocco 50
KE - Kenya 47
EG - Egitto 45
AT - Austria 43
UZ - Uzbekistan 43
AE - Emirati Arabi Uniti 42
PY - Paraguay 41
IR - Iran 35
GR - Grecia 31
TN - Tunisia 31
NP - Nepal 30
DZ - Algeria 28
LT - Lituania 28
HU - Ungheria 26
MY - Malesia 26
PH - Filippine 26
EU - Europa 25
AZ - Azerbaigian 24
IL - Israele 23
BG - Bulgaria 22
JM - Giamaica 22
EE - Estonia 21
PE - Perù 21
TH - Thailandia 21
KZ - Kazakistan 20
PT - Portogallo 20
OM - Oman 18
CR - Costa Rica 16
HR - Croazia 16
UY - Uruguay 16
AL - Albania 15
DK - Danimarca 15
TT - Trinidad e Tobago 15
BO - Bolivia 14
CH - Svizzera 14
PA - Panama 14
DO - Repubblica Dominicana 13
LB - Libano 13
LV - Lettonia 12
RS - Serbia 12
NI - Nicaragua 11
NO - Norvegia 11
SN - Senegal 11
ET - Etiopia 10
GE - Georgia 10
NZ - Nuova Zelanda 10
HN - Honduras 9
GT - Guatemala 8
LK - Sri Lanka 8
SK - Slovacchia (Repubblica Slovacca) 8
SY - Repubblica araba siriana 8
TW - Taiwan 8
BH - Bahrain 7
BY - Bielorussia 7
KG - Kirghizistan 7
AM - Armenia 6
AO - Angola 6
CG - Congo 6
Totale 106.044
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Città #
Dallas 11.659
Southend 6.750
Fairfield 4.492
Dublin 4.186
Menlo Park 3.585
Ashburn 3.205
Singapore 2.742
Chandler 2.505
Jacksonville 2.256
Woodbridge 2.094
Wilmington 1.752
Seattle 1.641
Houston 1.629
Cambridge 1.560
Moscow 1.556
Beijing 1.520
Santa Clara 1.439
Ann Arbor 1.312
Hong Kong 1.306
Milan 1.210
San Jose 1.166
Hefei 941
Council Bluffs 932
Seoul 905
Nanjing 817
Princeton 802
Siena 709
The Dalles 676
New York 551
Los Angeles 534
Ho Chi Minh City 470
Lauterbourg 445
Rome 420
Boardman 385
Helsinki 352
Hanoi 333
Nanchang 306
San Diego 275
Buffalo 258
Johannesburg 243
São Paulo 234
Columbus 214
Munich 201
San Mateo 199
Shenyang 180
Düsseldorf 171
Shanghai 163
Orem 158
London 150
Bengaluru 142
Tianjin 141
Brussels 138
Dong Ket 138
Hebei 128
Changsha 123
Izmir 123
Tokyo 123
Venezia 121
Fremont 120
Abuja 113
Figino 112
Kunming 109
Dearborn 108
Chicago 92
San Francisco 90
Toronto 89
Jiaxing 87
Málaga 86
Montreal 81
Frankfurt am Main 80
Chennai 78
Abidjan 77
Amsterdam 77
Jinan 76
Turin 76
Warsaw 76
Norwalk 75
Turku 75
Lancaster 74
Rio de Janeiro 74
Atlanta 73
Phoenix 73
Brno 71
Redwood City 70
Hangzhou 67
Brooklyn 66
Zhengzhou 65
Redondo Beach 63
Guangzhou 62
Florence 58
Belo Horizonte 57
Boston 56
Mexico City 55
Philadelphia 55
Dhaka 54
Ningbo 54
Baghdad 52
Haiphong 50
Denver 49
Da Nang 48
Totale 75.889
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.510
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 543
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 499
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 430
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors 412
1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies 409
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 403
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 394
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 388
Lc/Esi/Ms/Ms determination of postharvest fungicide residues in citrus juices 383
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 375
Linear guanidine derivatives, methods of preparation and uses thereof 371
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 370
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling 361
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 355
Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers 353
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02 349
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 343
2-Aminothiazolones as anti-hiv agents that act as gp120-cd4 inhibitors 340
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 340
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 335
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents 319
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 312
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl 312
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 311
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 310
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma 309
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update 308
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 308
DDX3X inhibitors, an effective way to overcome HIV-1 resistance 308
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 305
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 304
(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity 303
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 303
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains 301
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 300
The potential beneficial effects of Tenebrio molitor (Coleoptera Tenebrionidae) and Galleria mellonella (Lepidoptera Pyralidae) on human health 299
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors 296
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors 293
Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions 292
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors 291
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 291
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 289
DDX3X Helicase Inhibitors as a New Strategy to Fight the West Nile Virus Infection 289
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity 288
From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity 285
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors 284
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 284
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 282
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 281
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 280
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors 279
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 278
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels 276
‘LC/ESI/MS method for the quantitative detection of guazatine residues in cereales’ 275
Presence of Destruxin A and Beauvericin in cereals 275
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 274
Potent and selective carboxylic acid inhibitors of tumor-associated carbonic anhydrases IX and XII 274
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 274
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus 273
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 272
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 272
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 272
A Novel Route to Calix[4]arenes. 2. Solution- and Solid-State Structural Analyses and Molecular Modeling Studies 271
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 271
Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4- d]pyrimidines for Targeting Hepatocellular Carcinoma 269
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 269
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 268
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 268
Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) 267
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X 267
Discovery of in vitro antitubercular agents through in silico ligand-based approaches 266
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 263
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 263
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein 263
HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that compete with the nucleotide substrate 262
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation 260
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains 260
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 259
4­-Amino­substituted pyrazolo[3,4­d]pyrimidines: synthesis and biological properties 259
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 258
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 257
Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 257
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors 256
A new linker for anchoring/masking primary amines on solid support 256
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 255
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 255
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 254
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 254
'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells 254
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 252
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 252
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 251
Alpha1-Adrenoceptor Antagonists. 4. Pharmacophore-based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives 250
5-HT and Benzodiazepine Receptor Ligands. III. Synthesis and Receptor Affinities of 1,2,4,-Triazolo[4',3':1,6]pyridazino[4,5-b]quinoline and 2,3-Dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one Derivatives 249
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data 249
Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and Synthesis of Innovative Macrocyclic Amidinoureas 248
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 248
Bioaccumulation of deltamethrin, tebuconazole and chlormequat chloride in T. molitor larvae and risks associated with their human consumption 248
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 246
Totale 37.048
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Categoria #
all - tutte 303.785
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 303.785
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20225.483 0 957 298 298 239 191 329 201 334 662 641 1.333
2022/20238.896 574 726 1.190 1.315 899 1.749 186 762 892 157 297 149
2023/20246.061 257 125 406 283 186 1.734 2.159 210 22 127 81 471
2024/202511.356 269 670 1.133 585 1.167 499 279 672 1.021 469 1.228 3.364
2025/202635.421 2.264 6.344 8.500 3.227 5.119 1.109 2.704 767 1.004 1.434 616 2.333
2026/20272.269 1.382 887 0 0 0 0 0 0 0 0 0 0
Totale 106.701