IRIS
BOTTA, MAURIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 31.267
EU - Europa 23.946
AS - Asia 4.548
AF - Africa 107
SA - Sud America 69
OC - Oceania 48
Continente sconosciuto - Info sul continente non disponibili 27
Totale 60.012
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Nazione #
US - Stati Uniti d'America 31.165
GB - Regno Unito 7.294
IE - Irlanda 4.218
CN - Cina 3.248
UA - Ucraina 2.696
SE - Svezia 2.087
IT - Italia 1.654
RU - Federazione Russa 1.639
FR - Francia 1.531
DE - Germania 1.505
SG - Singapore 737
FI - Finlandia 680
TR - Turchia 154
VN - Vietnam 140
BE - Belgio 133
ES - Italia 118
CZ - Repubblica Ceca 103
CA - Canada 85
CI - Costa d'Avorio 68
RO - Romania 68
IN - India 63
NL - Olanda 53
AU - Australia 42
JP - Giappone 36
BR - Brasile 29
HK - Hong Kong 29
EU - Europa 25
IR - Iran 25
GR - Grecia 24
PL - Polonia 21
CL - Cile 19
EG - Egitto 17
BG - Bulgaria 15
KR - Corea 12
AE - Emirati Arabi Uniti 11
CH - Svizzera 11
DK - Danimarca 10
EE - Estonia 10
ZA - Sudafrica 10
AT - Austria 8
HU - Ungheria 8
IL - Israele 8
LV - Lettonia 8
PA - Panama 8
PT - Portogallo 8
TH - Thailandia 8
AL - Albania 6
ID - Indonesia 6
LK - Sri Lanka 6
LT - Lituania 6
MA - Marocco 6
NO - Norvegia 6
NZ - Nuova Zelanda 6
PK - Pakistan 6
AZ - Azerbaigian 5
BD - Bangladesh 5
BO - Bolivia 5
HR - Croazia 5
KZ - Kazakistan 5
SK - Slovacchia (Repubblica Slovacca) 5
CO - Colombia 4
IM - Isola di Man 4
JO - Giordania 4
LA - Repubblica Popolare Democratica del Laos 4
PE - Perù 4
PH - Filippine 4
SA - Arabia Saudita 4
AR - Argentina 3
EC - Ecuador 3
KG - Kirghizistan 3
MK - Macedonia 3
MY - Malesia 3
RS - Serbia 3
TJ - Tagikistan 3
TN - Tunisia 3
UZ - Uzbekistan 3
AM - Armenia 2
DO - Repubblica Dominicana 2
IQ - Iraq 2
KH - Cambogia 2
LU - Lussemburgo 2
MD - Moldavia 2
MX - Messico 2
PR - Porto Rico 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
BT - Bhutan 1
CR - Costa Rica 1
CY - Cipro 1
DZ - Algeria 1
FK - Isole Falkland (Malvinas) 1
GE - Georgia 1
GH - Ghana 1
KW - Kuwait 1
MS - Montserrat 1
OM - Oman 1
QA - Qatar 1
SC - Seychelles 1
Totale 60.006
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Città #
Southend 6.755
Fairfield 4.509
Dublin 4.183
Menlo Park 3.599
Chandler 2.504
Jacksonville 2.253
Ashburn 2.188
Woodbridge 2.100
Wilmington 1.756
Seattle 1.626
Houston 1.602
Cambridge 1.564
Ann Arbor 1.313
Nanjing 819
Princeton 804
Beijing 729
Siena 705
Singapore 458
Boardman 383
New York 355
Nanchang 305
San Diego 266
Helsinki 245
San Mateo 200
Moscow 175
Shenyang 175
Düsseldorf 153
Dong Ket 138
Shanghai 136
Hebei 129
Brussels 125
Izmir 121
Tianjin 121
Venezia 121
Fremont 120
Changsha 109
Dearborn 108
Kunming 103
London 93
Milan 89
Jiaxing 87
Málaga 86
Norwalk 75
Lancaster 72
Redwood City 70
Abidjan 68
Jinan 68
San Francisco 61
Brno 55
Hangzhou 54
Toronto 53
Ningbo 50
Zhengzhou 49
Los Angeles 47
Mestre 43
Timisoara 43
Rome 42
Florence 41
Guangzhou 39
Munich 39
Philadelphia 33
Olomouc 30
Taizhou 29
Changchun 28
Washington 27
Amsterdam 26
Phoenix 25
Kilburn 24
Lanzhou 24
Frankfurt am Main 23
Santa Clara 22
Paris 19
Hefei 18
Leawood 17
Chicago 16
Dallas 16
Edinburgh 16
Melbourne 16
Cairo 15
Hong Kong 15
Sofia 15
Hounslow 14
Salamanca 14
Tappahannock 14
Tokyo 14
Saint Petersburg 13
Canberra 12
Grünheide 12
Prague 12
Sydney 12
São Paulo 12
Fuzhou 11
Lappeenranta 11
Pune 11
Shenzhen 11
Zanjan 11
Bonndorf 10
Tallinn 10
Besançon 9
Gdynia 9
Totale 45.055
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Nome #
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 373
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 348
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 290
1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies 284
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 267
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 255
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 235
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 234
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 224
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 219
Linear guanidine derivatives, methods of preparation and uses thereof 217
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 215
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents 215
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update 212
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 211
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02 210
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 208
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains 200
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors 199
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 199
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 196
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity 196
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling 195
Potent and selective carboxylic acid inhibitors of tumor-associated carbonic anhydrases IX and XII 194
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma 194
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 193
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 190
Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions 189
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 189
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 187
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 187
SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment 187
‘LC/ESI/MS method for the quantitative detection of guazatine residues in cereales’ 185
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 185
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 182
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 182
DDX3X Helicase Inhibitors as a New Strategy to Fight the West Nile Virus Infection 180
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 178
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors 177
Lc/Esi/Ms/Ms determination of postharvest fungicide residues in citrus juices 177
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels 177
2-Aminothiazolones as anti-hiv agents that act as gp120-cd4 inhibitors 174
Discovery of in vitro antitubercular agents through in silico ligand-based approaches 174
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 173
Synthesis of an original oxygenated taxuspine X analogue: a versatile non-natural natural product with remarkable P-gp modulating activity 171
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 171
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 171
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl 171
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 171
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 170
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 169
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 169
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication 168
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 168
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 168
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 168
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents 167
Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4- d]pyrimidines for Targeting Hepatocellular Carcinoma 167
DDX3X inhibitors, an effective way to overcome HIV-1 resistance 167
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors 166
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 165
Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) 165
From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity 164
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 164
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 164
THE POTENTIAL BENEFICIAL EFFECTS OF TENEBRIO MOLITOR (COLEOPTERA TENEBRIONIDAE) AND GALLERIA MELLONELLA (LEPIDOPTERA PYRALIDAE) ON HUMAN HEALTH 164
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors 163
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 163
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 163
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 162
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 162
Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules 161
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data 159
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 159
Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 159
Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma 158
4­-Amino­substituted pyrazolo[3,4­d]pyrimidines: synthesis and biological properties 158
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 158
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 157
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors 157
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X 157
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies 156
Synthesis, Cannabinoid Receptor Affinity, and Molecular Modeling Studies of Substituted 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides 156
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 156
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 155
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 155
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 155
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 154
Pyrrolo[2,1-c][1,4]benzothiazines: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Cardiovascular Activity 153
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors 153
null 153
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus 152
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides 152
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 152
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells 152
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 151
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 151
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 150
Multitarget hedgehog pathway inhibitors and uses thereof 150
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors 149
Totale 18.245
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Categoria #
all - tutte 184.629
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 184.629
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20207.337 0 0 0 0 803 915 996 1.575 1.020 1.003 272 753
2020/20218.610 476 903 173 906 478 1.114 374 1.296 993 631 647 619
2021/20225.948 454 960 299 298 239 191 330 201 335 663 642 1.336
2022/20238.903 575 726 1.191 1.317 899 1.752 186 762 892 157 297 149
2023/20246.066 257 125 407 283 186 1.737 2.160 210 22 127 81 471
2024/20252.750 269 672 1.134 586 89 0 0 0 0 0 0 0
Totale 60.509