IRIS
BOTTA, MAURIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 49.783
EU - Europa 30.191
AS - Asia 16.939
SA - Sud America 3.112
AF - Africa 745
OC - Oceania 60
Continente sconosciuto - Info sul continente non disponibili 29
Totale 100.859
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Nazione #
US - Stati Uniti d'America 49.312
GB - Regno Unito 7.586
CN - Cina 6.331
RU - Federazione Russa 5.778
SG - Singapore 5.013
IE - Irlanda 4.222
UA - Ucraina 2.730
BR - Brasile 2.594
SE - Svezia 2.139
FR - Francia 2.120
IT - Italia 1.826
DE - Germania 1.819
VN - Vietnam 1.458
HK - Hong Kong 1.337
KR - Corea 914
FI - Finlandia 871
IN - India 468
ZA - Sudafrica 301
CA - Canada 251
TR - Turchia 238
BD - Bangladesh 200
ES - Italia 182
AR - Argentina 163
JP - Giappone 151
BE - Belgio 147
NL - Olanda 141
MX - Messico 133
IQ - Iraq 129
CZ - Repubblica Ceca 125
NG - Nigeria 119
PL - Polonia 104
ID - Indonesia 92
PK - Pakistan 85
RO - Romania 82
CI - Costa d'Avorio 77
EC - Ecuador 77
VE - Venezuela 71
CO - Colombia 63
SA - Arabia Saudita 59
CL - Cile 51
JO - Giordania 51
MA - Marocco 50
AU - Australia 49
KE - Kenya 47
EG - Egitto 45
AT - Austria 43
UZ - Uzbekistan 43
AE - Emirati Arabi Uniti 40
PY - Paraguay 39
IR - Iran 35
TN - Tunisia 31
GR - Grecia 30
NP - Nepal 29
DZ - Algeria 28
LT - Lituania 28
HU - Ungheria 26
EU - Europa 25
PH - Filippine 25
AZ - Azerbaigian 24
IL - Israele 23
MY - Malesia 22
BG - Bulgaria 21
EE - Estonia 21
KZ - Kazakistan 20
PE - Perù 19
PT - Portogallo 19
OM - Oman 18
TH - Thailandia 18
HR - Croazia 16
UY - Uruguay 16
DK - Danimarca 15
AL - Albania 14
BO - Bolivia 14
CH - Svizzera 14
PA - Panama 14
LB - Libano 13
DO - Repubblica Dominicana 12
LV - Lettonia 12
JM - Giamaica 11
NO - Norvegia 11
SN - Senegal 11
ET - Etiopia 10
GE - Georgia 10
NZ - Nuova Zelanda 10
LK - Sri Lanka 8
NI - Nicaragua 8
RS - Serbia 8
SK - Slovacchia (Repubblica Slovacca) 8
SY - Repubblica araba siriana 8
TT - Trinidad e Tobago 8
TW - Taiwan 8
BH - Bahrain 7
KG - Kirghizistan 7
AM - Armenia 6
AO - Angola 6
BY - Bielorussia 6
CG - Congo 6
CR - Costa Rica 6
HN - Honduras 6
KH - Cambogia 6
Totale 100.743
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Città #
Dallas 11.630
Southend 6.750
Fairfield 4.492
Dublin 4.186
Menlo Park 3.585
Ashburn 2.794
Singapore 2.691
Chandler 2.504
Jacksonville 2.253
Woodbridge 2.094
Wilmington 1.751
Seattle 1.633
Houston 1.621
Cambridge 1.559
Moscow 1.556
Beijing 1.494
Ann Arbor 1.312
Hong Kong 1.274
Santa Clara 1.256
Hefei 941
San Jose 909
Seoul 904
Nanjing 817
Princeton 802
Siena 708
The Dalles 675
New York 519
Los Angeles 511
Ho Chi Minh City 467
Lauterbourg 445
Boardman 384
Helsinki 352
Hanoi 330
Nanchang 306
Council Bluffs 279
San Diego 272
Buffalo 250
Johannesburg 243
São Paulo 233
Munich 201
San Mateo 199
Shenyang 180
Düsseldorf 171
Shanghai 154
Columbus 152
Orem 150
London 148
Bengaluru 142
Tianjin 141
Dong Ket 138
Brussels 137
Milan 130
Hebei 128
Izmir 123
Tokyo 123
Venezia 121
Fremont 120
Changsha 119
Abuja 113
Kunming 109
Dearborn 108
San Francisco 89
Toronto 88
Jiaxing 87
Málaga 86
Frankfurt am Main 80
Abidjan 77
Amsterdam 77
Jinan 76
Warsaw 76
Norwalk 75
Turku 75
Chennai 73
Lancaster 73
Rio de Janeiro 73
Montreal 72
Brno 71
Redwood City 70
Rome 70
Phoenix 67
Hangzhou 66
Zhengzhou 65
Redondo Beach 63
Guangzhou 62
Chicago 61
Atlanta 57
Belo Horizonte 55
Ningbo 54
Baghdad 52
Brooklyn 52
Dhaka 51
Haiphong 50
Stockholm 48
Amman 47
Da Nang 47
Poplar 47
Florence 46
Mumbai 46
Denver 44
Curitiba 43
Totale 72.400
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.496
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 529
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 487
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 418
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors 399
1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies 397
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 386
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 382
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 368
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 358
Linear guanidine derivatives, methods of preparation and uses thereof 358
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 355
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling 347
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 341
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 331
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 327
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 326
2-Aminothiazolones as anti-hiv agents that act as gp120-cd4 inhibitors 324
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02 324
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents 314
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 303
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 299
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma 298
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl 296
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains 295
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 294
DDX3X inhibitors, an effective way to overcome HIV-1 resistance 291
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 289
Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions 289
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 288
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 287
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 287
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update 284
(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity 284
Lc/Esi/Ms/Ms determination of postharvest fungicide residues in citrus juices 283
DDX3X Helicase Inhibitors as a New Strategy to Fight the West Nile Virus Infection 282
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors 280
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors 279
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 278
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 278
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 276
The potential beneficial effects of Tenebrio molitor (Coleoptera Tenebrionidae) and Galleria mellonella (Lepidoptera Pyralidae) on human health 276
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors 275
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 274
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 272
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors 269
From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity 268
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 268
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 268
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 268
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity 268
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 267
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 265
‘LC/ESI/MS method for the quantitative detection of guazatine residues in cereales’ 265
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors 264
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 264
Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4- d]pyrimidines for Targeting Hepatocellular Carcinoma 263
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus 262
Discovery of in vitro antitubercular agents through in silico ligand-based approaches 262
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 262
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 261
Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) 259
Potent and selective carboxylic acid inhibitors of tumor-associated carbonic anhydrases IX and XII 259
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 259
A Novel Route to Calix[4]arenes. 2. Solution- and Solid-State Structural Analyses and Molecular Modeling Studies 258
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein 258
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels 257
Presence of Destruxin A and Beauvericin in cereals 257
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 255
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 254
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 253
Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 251
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 251
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X 251
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 250
'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells 250
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 250
HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that compete with the nucleotide substrate 248
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 248
A new linker for anchoring/masking primary amines on solid support 247
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains 247
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 246
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 246
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation 246
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 245
New insights into small-molecule inhibitors of Bcr-Abl 241
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 241
4­-Amino­substituted pyrazolo[3,4­d]pyrimidines: synthesis and biological properties 241
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors 240
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data 239
Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and Synthesis of Innovative Macrocyclic Amidinoureas 239
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 239
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 239
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 239
Bioaccumulation of deltamethrin, tebuconazole and chlormequat chloride in T. molitor larvae and risks associated with their human consumption 239
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 238
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 238
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 237
Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle 236
Anti-Inflammatory Activity of a New Class of Nitric Oxide Synthase Inhibitors That Release Nitric Oxide 235
Totale 35.574
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Categoria #
all - tutte 281.132
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 281.132
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.895 0 0 0 0 0 0 0 0 0 631 645 619
2021/20225.936 453 957 298 298 239 191 329 201 334 662 641 1.333
2022/20238.896 574 726 1.190 1.315 899 1.749 186 762 892 157 297 149
2023/20246.061 257 125 406 283 186 1.734 2.159 210 22 127 81 471
2024/202511.356 269 670 1.133 585 1.167 499 279 672 1.021 469 1.228 3.364
2025/202632.367 2.264 6.344 8.500 3.227 5.119 1.109 2.704 767 1.004 1.329 0 0
Totale 101.378