IRIS
BOTTA, MAURIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 50.524
EU - Europa 30.277
AS - Asia 17.120
SA - Sud America 3.119
AF - Africa 746
OC - Oceania 60
Continente sconosciuto - Info sul continente non disponibili 29
Totale 101.875
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Nazione #
US - Stati Uniti d'America 50.004
GB - Regno Unito 7.588
CN - Cina 6.385
RU - Federazione Russa 5.778
SG - Singapore 5.050
IE - Irlanda 4.222
UA - Ucraina 2.732
BR - Brasile 2.599
SE - Svezia 2.139
FR - Francia 2.120
IT - Italia 1.901
DE - Germania 1.822
VN - Vietnam 1.467
HK - Hong Kong 1.354
KR - Corea 915
FI - Finlandia 871
IN - India 472
ZA - Sudafrica 301
CA - Canada 271
BD - Bangladesh 249
TR - Turchia 241
ES - Italia 185
AR - Argentina 163
JP - Giappone 151
BE - Belgio 147
MX - Messico 147
NL - Olanda 142
IQ - Iraq 129
CZ - Repubblica Ceca 125
NG - Nigeria 119
PL - Polonia 104
ID - Indonesia 93
PK - Pakistan 86
RO - Romania 82
CI - Costa d'Avorio 77
EC - Ecuador 77
VE - Venezuela 71
CO - Colombia 64
SA - Arabia Saudita 59
CL - Cile 52
JO - Giordania 51
MA - Marocco 50
AU - Australia 49
KE - Kenya 47
EG - Egitto 45
AT - Austria 43
UZ - Uzbekistan 43
AE - Emirati Arabi Uniti 41
PY - Paraguay 39
IR - Iran 35
TN - Tunisia 31
GR - Grecia 30
NP - Nepal 30
DZ - Algeria 28
LT - Lituania 28
HU - Ungheria 26
EU - Europa 25
MY - Malesia 25
PH - Filippine 25
AZ - Azerbaigian 24
IL - Israele 23
BG - Bulgaria 21
EE - Estonia 21
KZ - Kazakistan 20
PE - Perù 19
PT - Portogallo 19
OM - Oman 18
TH - Thailandia 18
HR - Croazia 16
UY - Uruguay 16
DK - Danimarca 15
JM - Giamaica 15
AL - Albania 14
BO - Bolivia 14
CH - Svizzera 14
PA - Panama 14
LB - Libano 13
DO - Repubblica Dominicana 12
LV - Lettonia 12
CR - Costa Rica 11
NO - Norvegia 11
SN - Senegal 11
TT - Trinidad e Tobago 11
ET - Etiopia 10
GE - Georgia 10
NZ - Nuova Zelanda 10
NI - Nicaragua 9
LK - Sri Lanka 8
RS - Serbia 8
SK - Slovacchia (Repubblica Slovacca) 8
SY - Repubblica araba siriana 8
TW - Taiwan 8
BH - Bahrain 7
KG - Kirghizistan 7
AM - Armenia 6
AO - Angola 6
BY - Bielorussia 6
CG - Congo 6
HN - Honduras 6
KH - Cambogia 6
Totale 101.756
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Città #
Dallas 11.642
Southend 6.750
Fairfield 4.492
Dublin 4.186
Menlo Park 3.585
Ashburn 2.850
Singapore 2.707
Chandler 2.505
Jacksonville 2.253
Woodbridge 2.094
Wilmington 1.751
Seattle 1.634
Houston 1.626
Cambridge 1.560
Moscow 1.556
Beijing 1.504
Santa Clara 1.321
Ann Arbor 1.312
Hong Kong 1.289
San Jose 1.042
Hefei 941
Seoul 904
Nanjing 817
Princeton 802
Siena 708
The Dalles 676
New York 537
Los Angeles 527
Ho Chi Minh City 470
Lauterbourg 445
Boardman 385
Helsinki 352
Hanoi 332
Nanchang 306
Council Bluffs 280
San Diego 274
Buffalo 257
Johannesburg 243
São Paulo 233
Munich 201
San Mateo 199
Shenyang 180
Düsseldorf 171
Orem 158
Shanghai 158
Columbus 155
London 149
Bengaluru 142
Tianjin 141
Dong Ket 138
Brussels 137
Milan 134
Hebei 128
Changsha 123
Izmir 123
Tokyo 123
Venezia 121
Fremont 120
Abuja 113
Kunming 109
Dearborn 108
San Francisco 90
Toronto 89
Jiaxing 87
Málaga 86
Rome 81
Frankfurt am Main 80
Montreal 78
Abidjan 77
Amsterdam 77
Chennai 77
Jinan 76
Warsaw 76
Norwalk 75
Turku 75
Lancaster 73
Rio de Janeiro 73
Brno 71
Phoenix 70
Redwood City 70
Chicago 67
Hangzhou 67
Zhengzhou 65
Atlanta 63
Redondo Beach 63
Guangzhou 62
Brooklyn 59
Belo Horizonte 56
Ningbo 54
Baghdad 52
Dhaka 52
Haiphong 50
Da Nang 48
Denver 48
Mexico City 48
Stockholm 48
Amman 47
Florence 47
Poplar 47
Mumbai 46
Totale 72.849
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.500
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 531
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 488
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 420
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors 399
1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies 398
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 390
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 388
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 372
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 362
Linear guanidine derivatives, methods of preparation and uses thereof 360
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 359
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling 354
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 344
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 331
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02 329
2-Aminothiazolones as anti-hiv agents that act as gp120-cd4 inhibitors 328
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 328
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 326
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents 317
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 306
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 301
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma 299
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains 299
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl 298
DDX3X inhibitors, an effective way to overcome HIV-1 resistance 298
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 297
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 295
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 293
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 291
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 291
The potential beneficial effects of Tenebrio molitor (Coleoptera Tenebrionidae) and Galleria mellonella (Lepidoptera Pyralidae) on human health 290
Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions 290
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update 289
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 288
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 286
Lc/Esi/Ms/Ms determination of postharvest fungicide residues in citrus juices 286
(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV-1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity 285
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors 284
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors 284
DDX3X Helicase Inhibitors as a New Strategy to Fight the West Nile Virus Infection 284
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors 279
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 278
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 277
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 272
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors 272
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 271
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 270
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 270
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity 270
From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity 269
‘LC/ESI/MS method for the quantitative detection of guazatine residues in cereales’ 269
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels 269
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 269
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus 267
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors 266
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 265
Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4- d]pyrimidines for Targeting Hepatocellular Carcinoma 265
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 265
Presence of Destruxin A and Beauvericin in cereals 265
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 264
Discovery of in vitro antitubercular agents through in silico ligand-based approaches 262
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 262
Potent and selective carboxylic acid inhibitors of tumor-associated carbonic anhydrases IX and XII 261
A Novel Route to Calix[4]arenes. 2. Solution- and Solid-State Structural Analyses and Molecular Modeling Studies 261
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 261
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein 261
Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) 260
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 259
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 257
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X 257
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 256
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 254
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 254
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 253
Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 252
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 251
'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells 250
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 249
HIV-1 RT inhibitors with a novel mechanism of action: NNRTIs that compete with the nucleotide substrate 248
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 248
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation 248
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 247
A new linker for anchoring/masking primary amines on solid support 247
In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains 247
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors 245
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 245
4­-Amino­substituted pyrazolo[3,4­d]pyrimidines: synthesis and biological properties 244
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 243
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 243
Bioaccumulation of deltamethrin, tebuconazole and chlormequat chloride in T. molitor larvae and risks associated with their human consumption 243
New insights into small-molecule inhibitors of Bcr-Abl 242
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 242
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 242
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 242
Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and Synthesis of Innovative Macrocyclic Amidinoureas 241
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data 240
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines 240
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 240
5-HT and Benzodiazepine Receptor Ligands. III. Synthesis and Receptor Affinities of 1,2,4,-Triazolo[4',3':1,6]pyridazino[4,5-b]quinoline and 2,3-Dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinoline-1-one Derivatives 237
Totale 35.884
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Categoria #
all - tutte 291.198
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 291.198
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021619 0 0 0 0 0 0 0 0 0 0 0 619
2021/20225.936 453 957 298 298 239 191 329 201 334 662 641 1.333
2022/20238.896 574 726 1.190 1.315 899 1.749 186 762 892 157 297 149
2023/20246.061 257 125 406 283 186 1.734 2.159 210 22 127 81 471
2024/202511.356 269 670 1.133 585 1.167 499 279 672 1.021 469 1.228 3.364
2025/202633.383 2.264 6.344 8.500 3.227 5.119 1.109 2.704 767 1.004 1.434 616 295
Totale 102.394