IRIS
BOTTA, MAURIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 31.026
EU - Europa 22.410
AS - Asia 3.878
SA - Sud America 58
OC - Oceania 45
AF - Africa 34
Continente sconosciuto - Info sul continente non disponibili 27
Totale 57.478
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Nazione #
US - Stati Uniti d'America 30.934
GB - Regno Unito 7.285
IE - Irlanda 4.232
CN - Cina 3.189
UA - Ucraina 2.695
SE - Svezia 2.092
IT - Italia 1.614
FR - Francia 1.531
DE - Germania 1.473
FI - Finlandia 663
RU - Federazione Russa 222
SG - Singapore 161
TR - Turchia 154
VN - Vietnam 140
BE - Belgio 122
ES - Italia 118
CZ - Repubblica Ceca 101
CA - Canada 78
RO - Romania 68
IN - India 61
NL - Olanda 50
AU - Australia 41
JP - Giappone 33
HK - Hong Kong 29
BR - Brasile 26
EU - Europa 25
IR - Iran 25
GR - Grecia 24
PL - Polonia 20
CL - Cile 16
EG - Egitto 15
BG - Bulgaria 12
CH - Svizzera 10
EE - Estonia 10
KR - Corea 10
AE - Emirati Arabi Uniti 8
HU - Ungheria 8
IL - Israele 8
ZA - Sudafrica 8
AT - Austria 7
TH - Thailandia 7
DK - Danimarca 6
LV - Lettonia 6
PT - Portogallo 6
BD - Bangladesh 5
HR - Croazia 5
LK - Sri Lanka 5
MA - Marocco 5
NO - Norvegia 5
PA - Panama 5
SK - Slovacchia (Repubblica Slovacca) 5
AL - Albania 4
AZ - Azerbaigian 4
BO - Bolivia 4
ID - Indonesia 4
IM - Isola di Man 4
JO - Giordania 4
NZ - Nuova Zelanda 4
PH - Filippine 4
CO - Colombia 3
EC - Ecuador 3
KZ - Kazakistan 3
MK - Macedonia 3
PK - Pakistan 3
RS - Serbia 3
SA - Arabia Saudita 3
TN - Tunisia 3
AM - Armenia 2
AR - Argentina 2
DO - Repubblica Dominicana 2
IQ - Iraq 2
KH - Cambogia 2
LU - Lussemburgo 2
MD - Moldavia 2
MX - Messico 2
MY - Malesia 2
PE - Perù 2
PR - Porto Rico 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AF - Afghanistan, Repubblica islamica di 1
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
BT - Bhutan 1
CR - Costa Rica 1
CY - Cipro 1
DZ - Algeria 1
FK - Isole Falkland (Malvinas) 1
GE - Georgia 1
GH - Ghana 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
MS - Montserrat 1
SC - Seychelles 1
SI - Slovenia 1
SS - ???statistics.table.value.countryCode.SS??? 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TW - Taiwan 1
UZ - Uzbekistan 1
VE - Venezuela 1
Totale 57.478
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Città #
Southend 6.755
Fairfield 4.509
Dublin 4.196
Menlo Park 3.599
Chandler 2.509
Jacksonville 2.253
Ashburn 2.159
Woodbridge 2.100
Wilmington 1.756
Seattle 1.626
Houston 1.602
Cambridge 1.564
Ann Arbor 1.313
Nanjing 819
Princeton 804
Beijing 727
Siena 686
Boardman 381
New York 357
Nanchang 305
San Diego 266
Helsinki 232
San Mateo 201
Moscow 175
Shenyang 174
Düsseldorf 153
Dong Ket 138
Shanghai 131
Hebei 129
Fremont 121
Izmir 121
Venezia 121
Tianjin 120
Brussels 114
Changsha 108
Dearborn 108
Kunming 103
London 89
Milan 89
Jiaxing 87
Málaga 87
Singapore 84
Norwalk 75
Lancaster 72
Redwood City 70
Jinan 68
San Francisco 61
Brno 55
Hangzhou 54
Ningbo 50
Toronto 49
Zhengzhou 49
Mestre 43
Timisoara 43
Florence 40
Rome 39
Guangzhou 36
Philadelphia 33
Olomouc 30
Taizhou 29
Changchun 28
Amsterdam 26
Washington 25
Kilburn 24
Lanzhou 24
Phoenix 24
Los Angeles 21
Paris 18
Frankfurt am Main 17
Hefei 17
Leawood 17
Chicago 16
Edinburgh 16
Melbourne 16
Hong Kong 15
Hounslow 14
Salamanca 14
Tappahannock 14
Cairo 13
Munich 13
Saint Petersburg 13
Canberra 12
Grünheide 12
Sofia 12
Sydney 12
São Paulo 12
Tokyo 12
Fuzhou 11
Lappeenranta 11
Pune 11
Zanjan 11
Bonndorf 10
Prague 10
Tallinn 10
Besançon 9
Gdynia 9
Haikou 9
Indiana 9
Nashville 9
Auburn Hills 8
Totale 44.451
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Nome #
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 353
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 321
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 281
1-[(3-Aryloxy-3-aryl)propyl]-2H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies 273
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 259
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 244
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 224
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 223
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 219
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 210
Linear guanidine derivatives, methods of preparation and uses thereof 208
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update 208
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents 207
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 204
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02 204
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line 203
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 198
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 195
Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains 192
Potent and selective carboxylic acid inhibitors of tumor-associated carbonic anhydrases IX and XII 189
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 189
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity 189
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling 186
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors 186
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. 186
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 185
Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions 184
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. 184
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 183
SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment 181
‘LC/ESI/MS method for the quantitative detection of guazatine residues in cereales’ 178
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 176
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors 176
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 172
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 172
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 172
DDX3X Helicase Inhibitors as a New Strategy to Fight the West Nile Virus Infection 171
Arylation of 2-Furyl 4-Fluorophenyl Ketone: an extension of Heck Chemistry towards Novel Integrase Inhibitors 169
Lc/Esi/Ms/Ms determination of postharvest fungicide residues in citrus juices 168
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 167
Synthesis of an original oxygenated taxuspine X analogue: a versatile non-natural natural product with remarkable P-gp modulating activity 167
Discovery of in vitro antitubercular agents through in silico ligand-based approaches 167
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication. 166
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 166
2-Aminothiazolones as anti-hiv agents that act as gp120-cd4 inhibitors 165
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 165
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl 165
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 165
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 163
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents 162
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels 162
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 161
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 161
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 160
The fight against the influenza A virus H1N1: synthesis, molecular modeling, and biological evaluation of benzofurazan derivatives as viral RNA polymerase inhibitors. 160
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 159
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 159
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 159
Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) 159
Plasmin-Binding Tripeptide-Decorated Liposomes Loading Pyrazolo[3,4- d]pyrimidines for Targeting Hepatocellular Carcinoma 159
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 159
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 157
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 157
DDX3X inhibitors, an effective way to overcome HIV-1 resistance 157
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors 155
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles 155
From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity 155
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 155
Discovery of 14-3-3 Protein-Protein Interaction Inhibitors that Sensitize Multidrug-Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 155
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 155
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data 154
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors 154
Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma 153
THE POTENTIAL BENEFICIAL EFFECTS OF TENEBRIO MOLITOR (COLEOPTERA TENEBRIONIDAE) AND GALLERIA MELLONELLA (LEPIDOPTERA PYRALIDAE) ON HUMAN HEALTH 153
null 153
Synthesis, Cannabinoid Receptor Affinity, and Molecular Modeling Studies of Substituted 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 152
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 152
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies. 151
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 151
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 151
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 150
Pyrrolo[2,1-c][1,4]benzothiazines: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Cardiovascular Activity 150
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 150
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 149
4­-Amino­substituted pyrazolo[3,4­d]pyrimidines: synthesis and biological properties 149
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 148
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 147
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action 147
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 147
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X 147
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. 146
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction 146
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides 145
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors 145
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 145
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors 144
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes 144
Inhibition of HIV-1 Reverse Transcriptase Dimerization by Small Molecules 144
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 144
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 143
Totale 17.453
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Categoria #
all - tutte 170.134
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 170.134
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202012.328 1.602 477 803 2.109 803 915 996 1.575 1.020 1.003 272 753
2020/20218.610 476 903 173 906 478 1.114 374 1.296 993 631 647 619
2021/20225.948 454 960 299 298 239 191 330 201 335 663 642 1.336
2022/20238.929 575 730 1.194 1.321 900 1.758 188 762 892 158 300 151
2023/20246.088 260 125 408 285 187 1.741 2.169 211 22 127 81 472
2024/2025148 148 0 0 0 0 0 0 0 0 0 0 0
Totale 57.955