A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.
S., R., Innitzer, A., Falciani, C., Tintori, C., F., C., M., W., et al. (2009). Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19, 3615-3618 [10.1016/j.bmcl.2009.04.132].
Exploration of novel thiobarbituric acid- rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors
INNITZER, ANNA;TINTORI, CRISTINA;MASSA, SILVIO;BOTTA, MAURIZIO;
2009-01-01
Abstract
A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar activity both in enzymatic and cellular assays.
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https://hdl.handle.net/11365/9490
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