The use of Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition permitted the synthesis of a new compound that is able to inhibit the HGF-induced scattering of MDCK (epithelial cells) and in vitro tumorigenesis of H1437 (non-small-cell lung cancer) and GTL-16 (human gastric carcinoma). In agreement with biochemical and biological results, docking studies within the ATP binding site of Met suggested for the new synthesized compound a binding mode similar to that of the active compound Triflorcas previously reported. © 2012 Elsevier Ltd. All rights reserved.
Colombo, F., Tintori, C., Furlan, A., Borrelli, S., Christodoulou, M.s., Dono, R., et al. (2012). 'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(14), 4693-4696 [10.1016/j.bmcl.2012.05.078].
'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells
TINTORI, CRISTINA;BOTTA, MAURIZIO;
2012-01-01
Abstract
The use of Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition permitted the synthesis of a new compound that is able to inhibit the HGF-induced scattering of MDCK (epithelial cells) and in vitro tumorigenesis of H1437 (non-small-cell lung cancer) and GTL-16 (human gastric carcinoma). In agreement with biochemical and biological results, docking studies within the ATP binding site of Met suggested for the new synthesized compound a binding mode similar to that of the active compound Triflorcas previously reported. © 2012 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/49131
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