A rapid protocol for the multicomponent microwave-assisted organocatalytic domino Knoevenagel/hetero Diels–Alder reaction (DKHDA) has been developed for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles. The reported procedure could be used for the fast generation of novel substituted 2,3-dihydropyran[2,3-c]pyrazoles with potential anti-tuberculosis activity.
Radi, M., Bernardo, V., Bechi, B., Castagnolo, D., Pagano, M., Botta, M. (2009). Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles. TETRAHEDRON LETTERS, 50(47), 6572-6575 [10.1016/j.tetlet.2009.09.047].
Microwave-assisted organocatalytic multicomponent Knoevenagel/Hetero Diels Alder reaction for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles
Radi, Marco;Bernardo, Vincenzo;Bechi, Beatrice;Castagnolo, Daniele;Pagano, Mafalda;Botta, Maurizio
2009-01-01
Abstract
A rapid protocol for the multicomponent microwave-assisted organocatalytic domino Knoevenagel/hetero Diels–Alder reaction (DKHDA) has been developed for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles. The reported procedure could be used for the fast generation of novel substituted 2,3-dihydropyran[2,3-c]pyrazoles with potential anti-tuberculosis activity.
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https://hdl.handle.net/11365/9219
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