The identification of a novel hit compound inhibitor of the protein-protein interaction between the influenza RNA-polymerase PA and PB1 subunits has been accomplished by means of high-throughput screening. A small family of structurally related molecules has been synthesized and biologically evaluated with most of the compounds showing micromolar potency of inhibition against viral replication. (C) 2013 Elsevier Ltd. All rights reserved.
Kessler, U., Castagnolo, D., Pagano, M., Deodato, D., Bernardini, M., Pilger, B., et al. (2013). Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23(20), 5575-5577 [10.1016/j.bmcl.2013.08.048].
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus
Castagnolo, Daniele;Pagano, Mafalda;Deodato, Davide;Botta, Maurizio
2013-01-01
Abstract
The identification of a novel hit compound inhibitor of the protein-protein interaction between the influenza RNA-polymerase PA and PB1 subunits has been accomplished by means of high-throughput screening. A small family of structurally related molecules has been synthesized and biologically evaluated with most of the compounds showing micromolar potency of inhibition against viral replication. (C) 2013 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/49147
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