A versatile approach for the synthesis of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines has been developed. Starting from commercially available allopurinol, TBAF mediated N1-functionalization and subsequent C4 nucleophilic substitution, under microwave assisted- or standard heating conditions, granted access to highly functionalized pyrazolo[3,4-d]pyrimidines of potential biological interest. © 2013 Elsevier Ltd. All rights reserved.
Botta, M., Bernardo, V., Vignaroli, G., Brai, A., Biava, M., Schenone, S., et al. (2013). An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines. TETRAHEDRON LETTERS, 54(38), 5204-5206 [10.1016/j.tetlet.2013.07.069].
An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines
Botta, Maurizio;Bernardo, Vincenzo;Vignaroli, Giulia;Brai, Annalaura;
2013-01-01
Abstract
A versatile approach for the synthesis of 1,4-disubstituted pyrazolo[3,4-d]pyrimidines has been developed. Starting from commercially available allopurinol, TBAF mediated N1-functionalization and subsequent C4 nucleophilic substitution, under microwave assisted- or standard heating conditions, granted access to highly functionalized pyrazolo[3,4-d]pyrimidines of potential biological interest. © 2013 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/49145
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