BOTTA, MAURIZIO
 Distribuzione geografica
Continente #
NA - Nord America 1.649
EU - Europa 996
AS - Asia 338
AF - Africa 26
SA - Sud America 9
OC - Oceania 4
Totale 3.022
Nazione #
US - Stati Uniti d'America 1.611
IT - Italia 411
GB - Regno Unito 142
CN - Cina 138
IE - Irlanda 117
DE - Germania 80
FR - Francia 67
VN - Vietnam 67
IN - India 55
NL - Olanda 39
CA - Canada 33
RU - Federazione Russa 31
SE - Svezia 28
IR - Iran 15
PK - Pakistan 14
UA - Ucraina 14
ZA - Sudafrica 12
CZ - Repubblica Ceca 11
JP - Giappone 11
LT - Lituania 11
HK - Hong Kong 8
FI - Finlandia 7
TR - Turchia 7
KR - Corea 6
CH - Svizzera 5
CL - Cile 5
GR - Grecia 5
MX - Messico 5
BR - Brasile 4
EG - Egitto 4
ET - Etiopia 4
PL - Polonia 4
RO - Romania 4
TW - Taiwan 4
BE - Belgio 3
ES - Italia 3
HU - Ungheria 3
ID - Indonesia 3
LV - Lettonia 3
SG - Singapore 3
AT - Austria 2
AU - Australia 2
DZ - Algeria 2
IL - Israele 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
BF - Burkina Faso 1
DK - Danimarca 1
KW - Kuwait 1
LI - Liechtenstein 1
MA - Marocco 1
MY - Malesia 1
NG - Nigeria 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
UG - Uganda 1
YE - Yemen 1
Totale 3.022
Città #
Fairfield 193
Siena 191
Houston 190
Ashburn 128
Ann Arbor 109
Dublin 106
Seattle 92
Woodbridge 91
Buffalo 88
Santa Cruz 86
Cambridge 72
Dong Ket 64
Wilmington 59
Beijing 38
Bengaluru 30
Witney 29
Rome 27
Stockholm 25
Southend 24
San Diego 20
Ottawa 18
Shanghai 18
Chicago 16
Genoa 15
Clearwater 14
Romford 13
Las Vegas 12
Phoenix 12
University Park 12
Council Bluffs 11
London 11
Florence 10
Milan 10
Boardman 9
Nanjing 9
Amsterdam 8
Lake Forest 8
Los Angeles 8
Muizenberg 8
Asti 7
Cedar Knolls 7
Helsinki 7
Munich 7
Piemonte 7
St Petersburg 7
Wuhan 7
Columbus 6
Getzville 6
Guangzhou 6
Hangzhou 6
Henderson 6
Toronto 6
Vilnius 6
Berlin 5
Dearborn 5
Moscow 5
New York 5
Riva 5
San Francisco 5
Tappahannock 5
Amstelveen 4
Bologna 4
Cassano Magnago 4
Delhi 4
Islamabad 4
Leicester 4
Mountain View 4
Napoli 4
Nashville 4
Passau 4
Saint Petersburg 4
Suzhou 4
Taipei 4
Xian 4
Atherstone 3
Elkins Park 3
Fuzhou 3
Groningen 3
Hong Kong 3
Manchester 3
Milpitas 3
Nijmegen 3
Padova 3
Parsippany 3
Perm 3
Salerno 3
Scranton 3
Shahrood 3
Trieste 3
Venustiano Carranza 3
Athens 2
Atlanta 2
Auburn 2
Auckland 2
Bethesda 2
Bogor 2
Boulder 2
Büdelsdorf 2
Castellar Guidobono 2
Chennai 2
Totale 2.134
Nome #
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling, file e0feeaa7-68ca-44d2-e053-6605fe0a8db0 484
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound, file e0feeaa7-7284-44d2-e053-6605fe0a8db0 306
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor, file e0feeaa8-1371-44d2-e053-6605fe0a8db0 273
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family, file e0feeaa7-691f-44d2-e053-6605fe0a8db0 219
Functionalized Graphene Derivatives: Antibacterial Properties and Cytotoxicity, file e0feeaa7-f264-44d2-e053-6605fe0a8db0 219
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels, file e0feeaa7-6921-44d2-e053-6605fe0a8db0 210
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02, file e0feeaa7-fe22-44d2-e053-6605fe0a8db0 172
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents, file e0feeaa5-c8e0-44d2-e053-6605fe0a8db0 158
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X, file e0feeaa8-5c2a-44d2-e053-6605fe0a8db0 136
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors, file e0feeaa8-b0c8-44d2-e053-6605fe0a8db0 118
null, file e0feeaa7-ef73-44d2-e053-6605fe0a8db0 110
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents, file e0feeaa9-e011-44d2-e053-6605fe0a8db0 98
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model, file e0feeaa6-3f5d-44d2-e053-6605fe0a8db0 72
Novel broad spectrum virucidal molecules against enveloped viruses, file e0feeaa7-f355-44d2-e053-6605fe0a8db0 67
Modulators of 14-3-3 Protein-Protein Interactions, file e0feeaa7-ef71-44d2-e053-6605fe0a8db0 59
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery, file e0feeaa6-039a-44d2-e053-6605fe0a8db0 58
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update, file e0feeaab-b9c5-44d2-e053-6605fe0a8db0 55
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B, file e0feeaab-d5f1-44d2-e053-6605fe0a8db0 46
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line, file e0feeaab-5e02-44d2-e053-6605fe0a8db0 26
Presence of Destruxin A and Beauvericin in cereals, file e0feeaa7-ebd6-44d2-e053-6605fe0a8db0 23
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart, file e0feeaa7-fd94-44d2-e053-6605fe0a8db0 22
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart, file e0feeaa7-fe2c-44d2-e053-6605fe0a8db0 21
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats, file e0feeaa9-324f-44d2-e053-6605fe0a8db0 16
Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides, file e0feeaa9-e80f-44d2-e053-6605fe0a8db0 12
Erratum: Lipase-catalyzed regioselective acylation of resorcin[4]arenes, file e0feeaa4-ee13-44d2-e053-6605fe0a8db0 10
Structure, function, involvement in diseases and targeting of 14-3-3 proteins: An Update, file e0feeaa7-e870-44d2-e053-6605fe0a8db0 8
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof, file e0feeaa4-f029-44d2-e053-6605fe0a8db0 7
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria, file e0feeaa5-afab-44d2-e053-6605fe0a8db0 5
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes, file e0feeaa4-df83-44d2-e053-6605fe0a8db0 4
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof, file e0feeaa6-4719-44d2-e053-6605fe0a8db0 4
Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma, file e0feeaa6-f847-44d2-e053-6605fe0a8db0 4
Lipase-catalyzed regioselective acylation of resorcin[4]arenes, file e0feeaa4-e162-44d2-e053-6605fe0a8db0 3
SRC family kinase inhibition through a new pyrazolo[3,4-d]pyrimidine derivative as a feasible approach for glioblastoma treatment., file e0feeaa5-cfb3-44d2-e053-6605fe0a8db0 3
Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives, file e0feeaa7-4067-44d2-e053-6605fe0a8db0 3
The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma, file 06070e0b-d4ed-4042-8a92-b6cf0efcbeab 2
Docking, 3D-QSAR studies and in silicoADME prediction on c-Src tyrosine kinase inhibitors, file e0feeaa4-c7b5-44d2-e053-6605fe0a8db0 2
Antifungal Agents. 11.N-Substituted Derivatives of 1-[(Aryl)(4-aryl-1H-pyrrol-3yl)methyl]-1H-imidazole: Synthesis, Anti-Candida Activity, and QSAR Studies, file e0feeaa4-c93e-44d2-e053-6605fe0a8db0 2
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds, file e0feeaa4-dbe0-44d2-e053-6605fe0a8db0 2
Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling, file e0feeaa4-dd3f-44d2-e053-6605fe0a8db0 2
Parallel solution phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines, file e0feeaa4-e631-44d2-e053-6605fe0a8db0 2
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases, file e0feeaa4-e80f-44d2-e053-6605fe0a8db0 2
Conformational search of antisense nucleotides. Part. 2, file e0feeaa4-e9b5-44d2-e053-6605fe0a8db0 2
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees, file e0feeaa6-3e2e-44d2-e053-6605fe0a8db0 2
Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition, file e0feeaa7-1861-44d2-e053-6605fe0a8db0 2
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B, file e0feeaa7-f05b-44d2-e053-6605fe0a8db0 2
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model, file e0feeaa7-f325-44d2-e053-6605fe0a8db0 2
Bioaccumulation risk assessment of Aflatoxin B1, Ochratoxin and Fumonisin B1 In T. Molitor Larvae, file e0feeaa9-7b42-44d2-e053-6605fe0a8db0 2
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line, file e0feeaaa-1033-44d2-e053-6605fe0a8db0 2
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria, file e0feeaaa-3a05-44d2-e053-6605fe0a8db0 2
null, file e0feeaab-65c5-44d2-e053-6605fe0a8db0 2
Flattened Cone 2,8,14,20-Tetrakis(l-valinamido)-[4]resorcinarene: An Enantioselective Allosteric Receptor in the Gas Phase, file e0feeaa4-c255-44d2-e053-6605fe0a8db0 1
α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus, file e0feeaa4-c396-44d2-e053-6605fe0a8db0 1
Modelling Amphetamine/Receptor Interactions: A Gas-Phase Study of Complexes Formed between Amphetamine and Some Chiral Amido[4]resorcinarenes, file e0feeaa4-c82c-44d2-e053-6605fe0a8db0 1
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanism, file e0feeaa4-c862-44d2-e053-6605fe0a8db0 1
New insights into small-molecule inhibitors of Bcr-Abl, file e0feeaa4-c865-44d2-e053-6605fe0a8db0 1
Identification of the First Non-Peptidic Small Molecule Inhibitor of the c-Abl/14-3-3 Protein-Protein Interactions Able to Drive Sensitive and Imatinib-Resistant Leukemia Cells to Apoptosis, file e0feeaa4-d877-44d2-e053-6605fe0a8db0 1
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case, file e0feeaa4-d96a-44d2-e053-6605fe0a8db0 1
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents, file e0feeaa4-db1b-44d2-e053-6605fe0a8db0 1
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof, file e0feeaa4-dbcd-44d2-e053-6605fe0a8db0 1
Metadynamics Simulations of Enantioselective Acylation Give Insights into the Catalytic Mechanism of Burkholderia cepacia Lipase, file e0feeaa4-dca3-44d2-e053-6605fe0a8db0 1
Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3., file e0feeaa4-dcb5-44d2-e053-6605fe0a8db0 1
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors, file e0feeaa4-de5b-44d2-e053-6605fe0a8db0 1
Synthesis and Preliminary Biological Evaluation of 4,6-Disubstituted 3-Cyanopyridin-2(1H)-ones, a New Class of Calcium Entry Blockers, file e0feeaa4-df7c-44d2-e053-6605fe0a8db0 1
New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization., file e0feeaa4-e389-44d2-e053-6605fe0a8db0 1
A new linker for anchoring/masking primary amines on solid support, file e0feeaa4-e41a-44d2-e053-6605fe0a8db0 1
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study, file e0feeaa4-e479-44d2-e053-6605fe0a8db0 1
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl, file e0feeaa4-e4e7-44d2-e053-6605fe0a8db0 1
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors, file e0feeaa4-e584-44d2-e053-6605fe0a8db0 1
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies, file e0feeaa4-e6ad-44d2-e053-6605fe0a8db0 1
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides, file e0feeaa4-e7db-44d2-e053-6605fe0a8db0 1
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones, file e0feeaa4-e994-44d2-e053-6605fe0a8db0 1
Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity Toward alpha1- and alpha2- Adrenoceptors, file e0feeaa4-ea6d-44d2-e053-6605fe0a8db0 1
Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells, file e0feeaa4-eb53-44d2-e053-6605fe0a8db0 1
Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase, file e0feeaa4-ee0a-44d2-e053-6605fe0a8db0 1
Conformational search of antisense nucleotides, file e0feeaa4-efda-44d2-e053-6605fe0a8db0 1
Unconventional Plasticity of HIV-1 Reverse Transcriptase: How Inhibitors Could Open a Connection "Gate" between Allosteric and Catalytic Sites., file e0feeaa5-0018-44d2-e053-6605fe0a8db0 1
Conformational search of antisense nucleotides, file e0feeaa5-4f15-44d2-e053-6605fe0a8db0 1
Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents, file e0feeaa5-972e-44d2-e053-6605fe0a8db0 1
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction., file e0feeaa5-9b54-44d2-e053-6605fe0a8db0 1
null, file e0feeaa6-00fa-44d2-e053-6605fe0a8db0 1
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof, file e0feeaa6-4139-44d2-e053-6605fe0a8db0 1
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto, file e0feeaa6-47d3-44d2-e053-6605fe0a8db0 1
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor, file e0feeaa6-ecf1-44d2-e053-6605fe0a8db0 1
Studies towards the synthesis of the bicyclic 3,8-secotaxanediterpenoid system using a ring closing metathesis strategy, file e0feeaa7-27ef-44d2-e053-6605fe0a8db0 1
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart, file e0feeaa7-ef6f-44d2-e053-6605fe0a8db0 1
Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein, file e0feeaa7-ef74-44d2-e053-6605fe0a8db0 1
Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure–Activity Relationships, file e0feeaa7-ef75-44d2-e053-6605fe0a8db0 1
Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1, file e0feeaa7-f05a-44d2-e053-6605fe0a8db0 1
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol, file e0feeaa7-f5ec-44d2-e053-6605fe0a8db0 1
Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein, file e0feeaa8-3458-44d2-e053-6605fe0a8db0 1
Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1, file e0feeaa8-600e-44d2-e053-6605fe0a8db0 1
A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1, file e0feeaa8-600f-44d2-e053-6605fe0a8db0 1
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines, file e0feeaa8-9725-44d2-e053-6605fe0a8db0 1
null, file e0feeaa8-b0cc-44d2-e053-6605fe0a8db0 1
Si113-prodrugs selectively activated by plasmin against hepatocellular and ovarian carcinoma, file e0feeaaa-cf9f-44d2-e053-6605fe0a8db0 1
Totale 3.108
Categoria #
all - tutte 22.198
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 22.198


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201995 0 0 0 0 0 0 0 0 0 0 58 37
2019/2020538 55 35 29 61 51 47 57 51 52 32 41 27
2020/2021634 20 40 29 34 65 72 57 42 42 79 59 95
2021/2022803 51 55 35 158 133 26 42 21 36 37 140 69
2022/2023554 17 36 116 58 56 85 36 31 25 40 30 24
2023/2024323 16 18 32 46 23 46 67 19 4 32 20 0
Totale 3.108