IRIS
SAPONARA, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 10.634
EU - Europa 7.578
AS - Asia 3.804
SA - Sud America 589
Continente sconosciuto - Info sul continente non disponibili 326
AF - Africa 152
OC - Oceania 27
Totale 23.110
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Nazione #
US - Stati Uniti d'America 10.501
IT - Italia 1.758
GB - Regno Unito 1.411
RU - Federazione Russa 1.362
CN - Cina 1.278
SG - Singapore 1.174
IE - Irlanda 841
FR - Francia 515
BR - Brasile 471
SE - Svezia 423
UA - Ucraina 375
VN - Vietnam 365
DE - Germania 343
HK - Hong Kong 287
FI - Finlandia 203
KR - Corea 186
BD - Bangladesh 124
IN - India 117
CA - Canada 79
ZA - Sudafrica 71
TR - Turchia 61
ES - Italia 60
NL - Olanda 56
AR - Argentina 42
AT - Austria 33
MX - Messico 29
JP - Giappone 28
BE - Belgio 27
PL - Polonia 27
BG - Bulgaria 23
CZ - Repubblica Ceca 22
IQ - Iraq 21
AU - Australia 20
EC - Ecuador 20
ID - Indonesia 20
PK - Pakistan 20
NG - Nigeria 19
EE - Estonia 17
MA - Marocco 16
EG - Egitto 13
CO - Colombia 12
LT - Lituania 12
UZ - Uzbekistan 12
IR - Iran 11
DK - Danimarca 10
UY - Uruguay 10
AE - Emirati Arabi Uniti 9
CL - Cile 9
PE - Perù 9
PH - Filippine 9
CH - Svizzera 8
KE - Kenya 8
KZ - Kazakistan 8
RO - Romania 8
SA - Arabia Saudita 8
CI - Costa d'Avorio 7
IL - Israele 6
JO - Giordania 6
MY - Malesia 6
NP - Nepal 6
NZ - Nuova Zelanda 6
PT - Portogallo 6
RS - Serbia 6
BO - Bolivia 5
EU - Europa 5
OM - Oman 5
PY - Paraguay 5
BY - Bielorussia 4
DO - Repubblica Dominicana 4
GR - Grecia 4
HU - Ungheria 4
KH - Cambogia 4
LB - Libano 4
LV - Lettonia 4
MD - Moldavia 4
NO - Norvegia 4
VE - Venezuela 4
AF - Afghanistan, Repubblica islamica di 3
CR - Costa Rica 3
ET - Etiopia 3
GE - Georgia 3
JM - Giamaica 3
LU - Lussemburgo 3
PA - Panama 3
SN - Senegal 3
SV - El Salvador 3
TH - Thailandia 3
TN - Tunisia 3
TW - Taiwan 3
AL - Albania 2
AZ - Azerbaigian 2
BH - Bahrain 2
CG - Congo 2
DZ - Algeria 2
GT - Guatemala 2
HN - Honduras 2
LK - Sri Lanka 2
NI - Nicaragua 2
PS - Palestinian Territory 2
QA - Qatar 2
Totale 22.768
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Città #
Dallas 2.084
Southend 1.217
Ashburn 900
Fairfield 880
Dublin 826
Singapore 609
Santa Clara 407
Chandler 395
Siena 379
Moscow 370
Woodbridge 355
Houston 351
Seattle 350
Milan 346
Beijing 338
San Jose 332
Jacksonville 300
Cambridge 293
Wilmington 291
Hong Kong 272
Council Bluffs 262
Ann Arbor 259
Hefei 201
Seoul 184
Los Angeles 180
Princeton 132
Rome 125
The Dalles 123
Florence 114
Nanjing 110
Helsinki 108
New York 106
Ho Chi Minh City 103
Lauterbourg 98
Hanoi 88
Munich 77
Columbus 74
Boardman 71
Washington 67
Fremont 66
Johannesburg 60
San Mateo 54
Shanghai 54
Buffalo 51
San Diego 49
Izmir 45
Bengaluru 43
Menlo Park 40
São Paulo 40
Dearborn 39
Orem 37
Nanchang 36
Redondo Beach 36
London 35
Chicago 34
Málaga 33
San Francisco 32
Dong Ket 29
Tianjin 29
Frankfurt am Main 28
Naples 28
Brussels 27
Hebei 26
Guangzhou 25
Turku 23
Phoenix 22
Haiphong 21
Shenyang 21
Tokyo 21
Toronto 21
Vienna 21
Düsseldorf 20
Da Nang 19
Nuremberg 19
Sofia 19
Atlanta 18
Bologna 18
Abuja 17
Montreal 17
Amsterdam 16
Redwood City 16
Brescia 15
Brooklyn 15
Lappeenranta 15
Turin 15
Jinan 14
Ottawa 14
Salt Lake City 14
Warsaw 14
Figino 13
Hangzhou 13
Manchester 13
Rio de Janeiro 13
Torino 13
Zhengzhou 13
Belo Horizonte 12
Boston 12
Chennai 12
Norwalk 12
Padua 12
Totale 15.336
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Nome #
New dimension of ciprofloxacin hybrids: Synthesis, characterization and anticancer evaluation of newly C3-modified ciprofloxacin derivatives 821
Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. 628
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity 477
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 411
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 391
Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans 376
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 370
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 366
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 346
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 321
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 301
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 299
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 285
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 282
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 280
Repurposing old drugs to fight multidrug resistant cancers 279
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts 277
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 275
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart 273
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 269
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development 269
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 268
2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation 263
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 263
(+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells 261
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 260
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile 260
In vitro assessement of tariquidar toxicity towards vasculature 258
New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations 256
In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies 255
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility 255
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 247
MC225, a novel probe for P-glycoprotein PET Imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation 244
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 240
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 239
Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes 232
Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies 230
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 230
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery 229
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 229
Flavonoids and hERG channels: Friends or foes? 228
Mitochondrial-targeting nitrooxy-doxorubicin: effects on P-glycoprotein and assessment of their vascular effects 227
Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes 226
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 226
Failure Effect Analysis of Patch-Clamp Electronic Instrumentation in Electrophysiology Experiments 223
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 222
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 218
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 218
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy 211
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: synthesis and biological evaluation 210
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker 209
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 209
Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells 206
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 206
The multi-factorial nature of clinical multidrug resistance in cancer 203
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature 203
The Enigma of Norbormide, a Rattus-Selective Toxicant 202
Interference measurements and failure analysis of patch-clamp laboratory instrumentation for electrophysiology tests 201
L-type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage 199
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions 198
The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects 197
Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical 194
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 191
Mechanism of myricetin stimulation of vascular L-type Ca2+ current 183
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies 182
Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells 182
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 180
Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels 179
Tyrosine kinase inhibitor Si409 has in vitro and in vivo anti-tumor activity against diffuse large B-cell lymphoma 178
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors 178
Targeting class I histone deacetylases triggers antitumor responses in colorectal cancer in vitro and in vivo 177
Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells 177
Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles 176
Synthesis and antiperoxidant activity of new phenolic O-glycosides 174
Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current 174
L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles 172
Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles 169
Playing with opening and closing of heterocycles: using the Cusmano-Ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors 169
In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin 167
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels 164
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 164
The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels 160
Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients 158
Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels 158
Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv 158
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 155
Screening for potential hazardous effects of an H2S-donating anthracycline on the cardiovascular system. 146
Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. 143
A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound 140
Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols 139
Mechanism of osthole inhibition of vascular Cav1.2 current 138
Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment 136
Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart 132
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 130
Inhibition of iron-dependent decomposition of H2O2 as a method for assessing the free-radical-scavenging activity of novel antioxidants in a hydrophilic environment. 112
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity 111
PERTRAS observational study: clinical and economic analysis of trastuzumab plus neoadjuvant pertuzumab in women with HER-2 positive breast cancer. [Studio osservazionale PERTRAS: analisi clinica ed economica di trastuzumab più pertuzumab neoadiuvante in donne con carcinoma mammario HER-2 positivo] 110
null 106
null 103
Hypoxia as a driver of resistance to immunotherapy 95
Totale 22.817
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Categoria #
all - tutte 69.227
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 69.227
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.385 0 188 117 101 65 60 107 55 109 163 155 265
2022/20231.747 109 154 248 258 121 313 69 152 174 55 66 28
2023/20241.689 78 30 183 80 114 480 457 31 6 44 42 144
2024/20253.061 81 138 267 189 369 195 187 218 282 152 314 669
2025/20268.704 550 1.685 1.125 725 1.248 259 749 236 276 385 718 748
2026/2027506 321 185 0 0 0 0 0 0 0 0 0 0
Totale 23.110