IRIS
SAPONARA, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 8.735
EU - Europa 6.715
AS - Asia 2.991
SA - Sud America 523
AF - Africa 54
OC - Oceania 26
Continente sconosciuto - Info sul continente non disponibili 6
Totale 19.050
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Nazione #
US - Stati Uniti d'America 8.642
GB - Regno Unito 1.361
RU - Federazione Russa 1.361
CN - Cina 1.187
IT - Italia 1.181
SG - Singapore 926
IE - Irlanda 835
BR - Brasile 429
SE - Svezia 421
FR - Francia 387
UA - Ucraina 372
DE - Germania 328
HK - Hong Kong 242
KR - Corea 185
FI - Finlandia 184
VN - Vietnam 145
IN - India 89
CA - Canada 58
TR - Turchia 58
ES - Italia 51
AR - Argentina 37
NL - Olanda 36
AT - Austria 32
BD - Bangladesh 25
BE - Belgio 25
JP - Giappone 23
CZ - Repubblica Ceca 22
MX - Messico 22
PL - Polonia 22
BG - Bulgaria 20
AU - Australia 19
EE - Estonia 17
EC - Ecuador 16
ZA - Sudafrica 16
MA - Marocco 14
ID - Indonesia 13
PK - Pakistan 11
EG - Egitto 10
IQ - Iraq 10
IR - Iran 10
CO - Colombia 9
LT - Lituania 9
PE - Perù 8
UZ - Uzbekistan 8
UY - Uruguay 7
AE - Emirati Arabi Uniti 6
CH - Svizzera 6
NZ - Nuova Zelanda 6
RS - Serbia 6
BO - Bolivia 5
CI - Costa d'Avorio 5
DK - Danimarca 5
EU - Europa 5
PT - Portogallo 5
SA - Arabia Saudita 5
CL - Cile 4
GR - Grecia 4
HU - Ungheria 4
IL - Israele 4
JO - Giordania 4
LB - Libano 4
PY - Paraguay 4
RO - Romania 4
AF - Afghanistan, Repubblica islamica di 3
BY - Bielorussia 3
JM - Giamaica 3
KH - Cambogia 3
KZ - Kazakistan 3
LU - Lussemburgo 3
LV - Lettonia 3
MD - Moldavia 3
MY - Malesia 3
NO - Norvegia 3
NP - Nepal 3
OM - Oman 3
PA - Panama 3
PH - Filippine 3
VE - Venezuela 3
AZ - Azerbaigian 2
BH - Bahrain 2
DO - Repubblica Dominicana 2
GE - Georgia 2
HN - Honduras 2
LK - Sri Lanka 2
NG - Nigeria 2
SN - Senegal 2
TN - Tunisia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
BB - Barbados 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
CY - Cipro 1
DM - Dominica 1
DZ - Algeria 1
ET - Etiopia 1
FK - Isole Falkland (Malvinas) 1
GH - Ghana 1
IM - Isola di Man 1
IS - Islanda 1
KI - Kiribati 1
Totale 19.045
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Città #
Dallas 2.070
Southend 1.217
Fairfield 880
Dublin 823
Ashburn 728
Singapore 498
Chandler 395
Siena 379
Moscow 370
Woodbridge 354
Santa Clara 352
Houston 348
Seattle 348
Beijing 333
Jacksonville 296
Cambridge 292
Wilmington 290
Ann Arbor 259
Hong Kong 240
Seoul 184
Hefei 167
Princeton 132
Los Angeles 128
Nanjing 110
Florence 94
Helsinki 91
Milan 90
Munich 77
New York 74
Boardman 70
Fremont 65
Washington 64
Council Bluffs 60
San Mateo 54
The Dalles 53
Columbus 51
Shanghai 51
San Diego 49
Izmir 45
Bengaluru 42
Ho Chi Minh City 40
Menlo Park 40
Dearborn 39
Buffalo 37
Nanchang 36
Redondo Beach 36
São Paulo 35
Málaga 33
Rome 32
London 30
Dong Ket 29
Tianjin 29
San Francisco 28
Hanoi 27
Hebei 26
Brussels 25
Guangzhou 24
Turku 23
Chicago 22
Shenyang 21
Düsseldorf 20
Vienna 20
Nuremberg 19
Toronto 18
Phoenix 17
Tokyo 17
Frankfurt am Main 16
Redwood City 16
Sofia 16
Brescia 15
Jinan 14
Ottawa 14
Lappeenranta 13
Rio de Janeiro 13
Torino 13
Zhengzhou 13
Hangzhou 12
Lauterbourg 12
Montreal 12
Naples 12
Norwalk 12
Warsaw 12
Belo Horizonte 11
Changsha 11
Jiaxing 11
Newcastle 11
Amsterdam 10
Brno 10
Kunming 10
Ningbo 10
Portsmouth 10
Prato 10
Stockholm 10
Atlanta 9
Brooklyn 9
Curitiba 9
Jakarta 9
Olomouc 9
Taizhou 9
Tappahannock 9
Totale 13.338
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Nome #
New dimension of ciprofloxacin hybrids: Synthesis, characterization and anticancer evaluation of newly C3-modified ciprofloxacin derivatives 752
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity 417
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 380
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 354
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 333
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 321
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 316
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 284
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 268
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 265
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 254
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 252
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 250
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 250
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 249
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart 245
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development 241
In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies 237
In vitro assessement of tariquidar toxicity towards vasculature 234
2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation 233
New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations 232
Repurposing old drugs to fight multidrug resistant cancers 232
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 231
(+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells 229
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility 227
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 225
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts 225
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 224
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile 222
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 222
Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes 217
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 214
Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies 213
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery 211
MC225, a novel probe for P-glycoprotein PET Imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation 210
Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans 209
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 205
Mitochondrial-targeting nitrooxy-doxorubicin: effects on P-glycoprotein and assessment of their vascular effects 203
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 203
Failure Effect Analysis of Patch-Clamp Electronic Instrumentation in Electrophysiology Experiments 202
Flavonoids and hERG channels: Friends or foes? 202
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy 200
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 198
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 197
Interference measurements and failure analysis of patch-clamp laboratory instrumentation for electrophysiology tests 190
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker 189
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 189
Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes 187
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 187
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 187
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 186
The multi-factorial nature of clinical multidrug resistance in cancer 180
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 179
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature 179
L-type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage 176
The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects 171
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 170
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions 169
Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells 168
Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells 163
Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells 163
Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles 162
Mechanism of myricetin stimulation of vascular L-type Ca2+ current 157
Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels 156
Playing with opening and closing of heterocycles: using the Cusmano-Ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors 154
Synthesis and antiperoxidant activity of new phenolic O-glycosides 152
L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles 152
Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current 149
Tyrosine kinase inhibitor Si409 has in vitro and in vivo anti-tumor activity against diffuse large B-cell lymphoma 148
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: synthesis and biological evaluation 146
Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles 146
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 144
The Enigma of Norbormide, a Rattus-Selective Toxicant 144
The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels 143
Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels 140
In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin 140
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 140
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors 140
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels 135
Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical 134
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies 129
Mechanism of osthole inhibition of vascular Cav1.2 current 128
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 128
Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv 125
Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. 123
Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. 123
Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart 119
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 117
Screening for potential hazardous effects of an H2S-donating anthracycline on the cardiovascular system. 115
null 106
A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound 104
Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment 104
null 103
Inhibition of iron-dependent decomposition of H2O2 as a method for assessing the free-radical-scavenging activity of novel antioxidants in a hydrophilic environment. 102
Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols 98
Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients 98
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity 90
Hypoxia as a driver of resistance to immunotherapy 85
Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance 74
null 67
Totale 19.241
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Categoria #
all - tutte 59.568
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.568
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.223 0 0 0 0 0 210 98 217 163 270 144 121
2021/20221.489 104 188 117 101 65 60 107 55 109 163 155 265
2022/20231.747 109 154 248 258 121 313 69 152 174 55 66 28
2023/20241.689 78 30 183 80 114 480 457 31 6 44 42 144
2024/20253.061 81 138 267 189 369 195 187 218 282 152 314 669
2025/20265.464 550 1.685 1.125 725 1.248 131 0 0 0 0 0 0
Totale 19.364