Distribuzione geografica
Continente #
NA - Nord America 4751
EU - Europa 3477
AS - Asia 555
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 6
SA - Sud America 5
AF - Africa 1
Totale 8801
Nazione #
US - Stati Uniti d'America 4731
GB - Regno Unito 1281
IT - Italia 677
CN - Cina 456
SE - Svezia 417
UA - Ucraina 363
FR - Francia 277
IE - Irlanda 160
DE - Germania 158
FI - Finlandia 53
TR - Turchia 48
VN - Vietnam 29
BE - Belgio 27
CA - Canada 20
AT - Austria 15
IR - Iran 7
AU - Australia 6
IN - India 6
NL - Olanda 6
PL - Polonia 6
EU - Europa 5
PT - Portogallo 5
ES - Italia 4
GR - Grecia 4
JP - Giappone 4
RS - Serbia 4
BG - Bulgaria 3
DK - Danimarca 3
RO - Romania 3
RU - Federazione Russa 3
BR - Brasile 2
CL - Cile 2
HU - Ungheria 2
KR - Corea 2
MD - Moldavia 2
NO - Norvegia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
EE - Estonia 1
EG - Egitto 1
FK - Isole Falkland (Malvinas) 1
ID - Indonesia 1
IM - Isola di Man 1
KZ - Kazakistan 1
MY - Malesia 1
Totale 8801
Città #
Southend 1217
Fairfield 880
Chandler 406
Woodbridge 354
Seattle 345
Houston 340
Ashburn 333
Siena 332
Jacksonville 295
Cambridge 291
Wilmington 285
Ann Arbor 258
Dublin 160
Princeton 132
Beijing 129
Nanjing 108
Fremont 65
San Mateo 53
San Diego 48
Izmir 45
Boardman 44
Menlo Park 40
Dearborn 39
Nanchang 35
Milan 30
Dong Ket 29
Brussels 27
Florence 26
Hebei 26
Tianjin 25
London 21
Shenyang 21
Los Angeles 20
Redwood City 16
Vienna 15
Guangzhou 14
San Francisco 14
Jinan 13
Torino 13
Norwalk 12
Hangzhou 11
Jiaxing 11
Kunming 9
Ningbo 9
Ottawa 8
Taizhou 8
Toronto 8
Hefei 7
Zhengzhou 7
Changsha 6
Citta 6
Düsseldorf 6
Lancaster 6
Naples 6
Rome 6
Lisbon 5
Ambrogio 4
Bacoli 4
Belgrade 4
Hanover 4
Lanzhou 4
Latina 4
Phoenix 4
Prato 4
Queens 4
Ventimiglia 4
Zanjan 4
Andover 3
Arezzo 3
Camparada 3
Changchun 3
Frankfurt am Main 3
Groningen 3
Helsinki 3
Inverigo 3
Mestre 3
Modena 3
New York 3
Redmond 3
Tegoleto 3
Tokyo 3
Udine 3
Villa di Briano 3
Winnipeg 3
Avellino 2
Barberino Val d'Elsa 2
Barcelona 2
Berlin 2
Bracigliano 2
Buffalo 2
Canberra 2
Casalnuovo Di Napoli 2
Columbus 2
Copenhagen 2
Crotone 2
Falls Church 2
Figline Valdarno 2
Hendon 2
Oberhausen 2
Oslo 2
Totale 6802
Nome #
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 232
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 218
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 211
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 193
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 184
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 181
null 172
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development 170
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 168
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 167
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 164
Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies 157
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts 157
New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations 150
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy 147
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 143
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 142
In vitro assessement of tariquidar toxicity towards vasculature 140
Failure Effect Analysis of Patch-Clamp Electronic Instrumentation in Electrophysiology Experiments 138
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 136
Mitochondrial-targeting nitrooxy-doxorubicin: effects on P-glycoprotein and assessment of their vascular effects 135
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 134
In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies 133
Interference measurements and failure analysis of patch-clamp laboratory instrumentation for electrophysiology tests 131
Flavonoids and hERG channels: Friends or foes? 126
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 125
The multi-factorial nature of clinical multidrug resistance in cancer 124
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 118
MC225, a novel probe for P-glycoprotein PET Imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation 117
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation. 113
Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. 111
2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation. 109
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility. 109
Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes. 109
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile 107
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. 107
null 106
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart. 105
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study. 105
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 104
L-type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage 104
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 104
null 103
(+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells 103
Synthesis and antiperoxidant activity of new phenolic O-glycosides. 102
Mechanism of myricetin stimulation of vascular L-type Ca2+ current. 101
The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects 100
Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles. 100
Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells 99
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery. 98
Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells. 98
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker 96
Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current 95
The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels 93
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 93
Playing with opening and closing of heterocycles: using the Cusmano-Ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors. 92
L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles. 90
Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels 89
Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles. 87
Repurposing old drugs to fight multidrug resistant cancers 81
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 78
Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans 75
Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv 74
Mechanism of osthole inhibition of vascular Cav1.2 current 72
In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin 70
Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. 68
null 67
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 67
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 66
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 66
Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels 65
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 63
Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes 61
Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart 55
null 51
Inhibition of iron-dependent decomposition of H2O2 as a method for assessing the free-radical-scavenging activity of novel antioxidants in a hydrophilic environment. 50
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 42
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature 40
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 33
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors 31
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions 29
Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance 26
Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. 25
Nitrobenzoxadiazole derivatives of the rat selective toxicant norbormide as fluorescent probes for live cell imaging 24
2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 23
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 20
Hypoxia as a driver of resistance to immunotherapy 20
Screening for potential hazardous effects of an H2S-donating anthracycline on the cardiovascular system. 18
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels 13
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 12
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation 9
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity 3
Totale 9042
Categoria #
all - tutte 16142
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 16142

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018112 0000 00 00 1377022
2018/20191177 469011 25106 8270 41183297262
2019/20202192 26191115308 208219 194256 19118353113
2020/20211979 109152109167 219210 98217 163270144121
2021/20221489 104188117101 6560 10755 109163155265
2022/20231639 111158252266 125322 73160 172000
Totale 9042