IRIS
SAPONARA, SIMONA
 Distribuzione geografica
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Continente #
NA - Nord America 5.435
EU - Europa 5.018
AS - Asia 839
SA - Sud America 17
AF - Africa 14
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 6
Totale 11.337
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Nazione #
US - Stati Uniti d'America 5.402
GB - Regno Unito 1.317
IT - Italia 900
IE - Irlanda 819
CN - Cina 552
SE - Svezia 412
UA - Ucraina 366
RU - Federazione Russa 356
FR - Francia 304
DE - Germania 235
SG - Singapore 158
FI - Finlandia 147
TR - Turchia 48
ES - Italia 41
CA - Canada 30
VN - Vietnam 30
BE - Belgio 23
CZ - Repubblica Ceca 19
AT - Austria 15
NL - Olanda 11
IN - India 8
AU - Australia 7
IR - Iran 7
PL - Polonia 7
BR - Brasile 6
HK - Hong Kong 6
JP - Giappone 6
RS - Serbia 6
CI - Costa d'Avorio 5
EU - Europa 5
PT - Portogallo 5
BG - Bulgaria 4
EG - Egitto 4
GR - Grecia 4
HU - Ungheria 4
LT - Lituania 4
RO - Romania 4
AE - Emirati Arabi Uniti 3
CL - Cile 3
DK - Danimarca 3
KR - Corea 3
MY - Malesia 3
NO - Norvegia 3
PE - Perù 3
PK - Pakistan 3
AR - Argentina 2
ID - Indonesia 2
IL - Israele 2
LK - Sri Lanka 2
LU - Lussemburgo 2
LV - Lettonia 2
MA - Marocco 2
MD - Moldavia 2
PA - Panama 2
ZA - Sudafrica 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AZ - Azerbaigian 1
CH - Svizzera 1
CO - Colombia 1
EE - Estonia 1
FK - Isole Falkland (Malvinas) 1
GH - Ghana 1
HN - Honduras 1
IM - Isola di Man 1
KZ - Kazakistan 1
NZ - Nuova Zelanda 1
PH - Filippine 1
QA - Qatar 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
UY - Uruguay 1
Totale 11.337
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Città #
Southend 1.217
Fairfield 880
Dublin 807
Ashburn 602
Chandler 395
Siena 375
Woodbridge 354
Seattle 346
Houston 340
Jacksonville 295
Cambridge 292
Wilmington 285
Ann Arbor 258
Princeton 132
Beijing 130
Nanjing 108
Singapore 108
Helsinki 85
Boardman 66
Fremont 65
Washington 64
San Mateo 54
Florence 50
New York 50
Shanghai 50
San Diego 49
Izmir 45
Moscow 42
Los Angeles 40
Menlo Park 40
Dearborn 39
Milan 37
Nanchang 35
Málaga 33
Dong Ket 29
Hebei 26
London 25
Tianjin 25
Munich 24
Brussels 23
Shenyang 21
San Francisco 19
Dallas 18
Guangzhou 16
Redwood City 16
Rome 15
Vienna 15
Jinan 14
Torino 13
Toronto 13
Columbus 12
Norwalk 12
Hangzhou 11
Jiaxing 11
Ottawa 11
Brno 10
Prato 10
Kunming 9
Ningbo 9
Tappahannock 9
Zhengzhou 9
Frankfurt am Main 8
Olomouc 8
Taizhou 8
Düsseldorf 7
Hefei 7
Bari 6
Changsha 6
Citta 6
Espoo 6
Falkenstein 6
Lancaster 6
Lappeenranta 6
Naples 6
Abidjan 5
Amsterdam 5
Arezzo 5
Cerreto Guidi 5
Kilburn 5
Lamezia Terme 5
Lisbon 5
Phoenix 5
Santa Clara 5
Ambrogio 4
Bacoli 4
Belgrade 4
Bologna 4
Cairo 4
Hong Kong 4
Lanzhou 4
Latina 4
Palermo 4
Poggibonsi 4
Queens 4
Salerno 4
Scandicci 4
Turin 4
Ventimiglia 4
Zanjan 4
Andover 3
Totale 8.391
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Nome #
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 263
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 262
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 249
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 234
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 207
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 203
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 200
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 197
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development 193
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 189
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 183
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 181
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts 179
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 178
Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies 178
New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations 175
In vitro assessement of tariquidar toxicity towards vasculature 172
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 164
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy 163
In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies 161
Failure Effect Analysis of Patch-Clamp Electronic Instrumentation in Electrophysiology Experiments 157
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 157
Flavonoids and hERG channels: Friends or foes? 157
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 156
Mitochondrial-targeting nitrooxy-doxorubicin: effects on P-glycoprotein and assessment of their vascular effects 155
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 152
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 151
MC225, a novel probe for P-glycoprotein PET Imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation 150
Interference measurements and failure analysis of patch-clamp laboratory instrumentation for electrophysiology tests 149
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 147
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart 144
The multi-factorial nature of clinical multidrug resistance in cancer 144
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 142
Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes 142
2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation 141
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile 141
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 140
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility 139
(+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells 138
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery 137
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 135
L-type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage 132
Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells 129
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 128
Repurposing old drugs to fight multidrug resistant cancers 125
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives 124
Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans 124
Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles 122
The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects 120
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker 118
Mechanism of myricetin stimulation of vascular L-type Ca2+ current 117
Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells 117
Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells 114
Synthesis and antiperoxidant activity of new phenolic O-glycosides 114
Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current 113
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 111
L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles 110
Playing with opening and closing of heterocycles: using the Cusmano-Ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors. 109
The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels 107
Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels 106
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Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 103
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature 103
Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles 102
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 96
In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin 96
Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes 92
Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels 91
Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv 88
Mechanism of osthole inhibition of vascular Cav1.2 current 87
Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart 86
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 86
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 84
Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. 77
Tyrosine kinase inhibitor Si409 has in vitro and in vivo anti-tumor activity against diffuse large B-cell lymphoma 72
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 69
null 67
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors 63
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 60
Inhibition of iron-dependent decomposition of H2O2 as a method for assessing the free-radical-scavenging activity of novel antioxidants in a hydrophilic environment. 59
Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. 57
Screening for potential hazardous effects of an H2S-donating anthracycline on the cardiovascular system. 56
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 55
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels 52
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions 50
Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance 43
Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical 40
Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment 39
Hypoxia as a driver of resistance to immunotherapy 38
Nitrobenzoxadiazole derivatives of the rat selective toxicant norbormide as fluorescent probes for live cell imaging 36
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: synthesis and biological evaluation 35
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity 30
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 18
The Enigma of Norbormide, a Rattus-Selective Toxicant 15
Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols 7
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies 7
A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound 6
Totale 11.619
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Categoria #
all - tutte 40.234
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.234
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.417 0 0 0 0 208 219 194 256 191 183 53 113
2020/20211.979 109 152 109 167 219 210 98 217 163 270 144 121
2021/20221.489 104 188 117 101 65 60 107 55 109 163 155 265
2022/20231.747 109 154 248 258 121 313 69 152 174 55 66 28
2023/20241.689 78 30 183 80 114 480 457 31 6 44 42 144
2024/2025780 81 138 267 189 105 0 0 0 0 0 0 0
Totale 11.619