SAPONARA, SIMONA
 Distribuzione geografica
Continente #
NA - Nord America 5.322
EU - Europa 4.516
AS - Asia 636
SA - Sud America 11
AF - Africa 8
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 6
Totale 10.505
Nazione #
US - Stati Uniti d'America 5.300
GB - Regno Unito 1.306
IE - Irlanda 841
IT - Italia 827
CN - Cina 518
SE - Svezia 415
UA - Ucraina 364
FR - Francia 290
DE - Germania 201
FI - Finlandia 139
TR - Turchia 48
ES - Italia 38
VN - Vietnam 30
BE - Belgio 21
CA - Canada 21
AT - Austria 15
NL - Olanda 9
IN - India 8
IR - Iran 7
RU - Federazione Russa 7
AU - Australia 6
PL - Polonia 6
RS - Serbia 6
SG - Singapore 6
EU - Europa 5
JP - Giappone 5
PT - Portogallo 5
BR - Brasile 4
EG - Egitto 4
GR - Grecia 4
HK - Hong Kong 4
BG - Bulgaria 3
DK - Danimarca 3
KR - Corea 3
NO - Norvegia 3
RO - Romania 3
AR - Argentina 2
CL - Cile 2
HU - Ungheria 2
ID - Indonesia 2
IL - Israele 2
LU - Lussemburgo 2
MA - Marocco 2
MD - Moldavia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
CH - Svizzera 1
CO - Colombia 1
CZ - Repubblica Ceca 1
EE - Estonia 1
FK - Isole Falkland (Malvinas) 1
GH - Ghana 1
IM - Isola di Man 1
KZ - Kazakistan 1
MY - Malesia 1
PA - Panama 1
PE - Perù 1
ZA - Sudafrica 1
Totale 10.505
Città #
Southend 1.217
Fairfield 880
Dublin 828
Ashburn 602
Chandler 402
Woodbridge 354
Siena 353
Seattle 346
Houston 340
Jacksonville 295
Cambridge 292
Wilmington 285
Ann Arbor 258
Princeton 132
Beijing 130
Nanjing 108
Helsinki 84
Fremont 65
Washington 65
San Mateo 54
New York 52
Florence 50
San Diego 49
Boardman 47
Shanghai 47
Izmir 45
Menlo Park 40
Dearborn 39
Milan 37
Nanchang 35
Málaga 33
Los Angeles 30
Dong Ket 29
Hebei 26
Tianjin 25
London 22
Brussels 21
Shenyang 21
Redwood City 16
Vienna 15
Guangzhou 14
San Francisco 14
Jinan 13
Torino 13
Norwalk 12
Rome 12
Hangzhou 11
Jiaxing 11
Kunming 9
Ningbo 9
Tappahannock 9
Ottawa 8
Taizhou 8
Toronto 8
Hefei 7
Naples 7
Prato 7
Zhengzhou 7
Changsha 6
Citta 6
Düsseldorf 6
Falkenstein 6
Lancaster 6
Arezzo 5
Cerreto Guidi 5
Frankfurt am Main 5
Kilburn 5
Lamezia Terme 5
Lappeenranta 5
Lisbon 5
Phoenix 5
Ambrogio 4
Bacoli 4
Belgrade 4
Cairo 4
Hanover 4
Hong Kong 4
Lanzhou 4
Latina 4
Queens 4
Salerno 4
Scandicci 4
Ventimiglia 4
Zanjan 4
Amsterdam 3
Andover 3
Bari 3
Bologna 3
Camparada 3
Changchun 3
Fontaneto d'Agogna 3
Groningen 3
Hounslow 3
Inverigo 3
Mestre 3
Modena 3
Oslo 3
Padova 3
Pisa 3
Redmond 3
Totale 8.118
Nome #
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 251
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues 246
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain 235
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 222
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 198
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 198
Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies 192
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development 188
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 187
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 178
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 174
Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts 172
Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies 168
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 167
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling 165
New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: in vitro and in vivo evaluations 164
In vitro assessement of tariquidar toxicity towards vasculature 161
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy 160
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 156
Failure Effect Analysis of Patch-Clamp Electronic Instrumentation in Electrophysiology Experiments 152
In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies 152
Mitochondrial-targeting nitrooxy-doxorubicin: effects on P-glycoprotein and assessment of their vascular effects 150
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 150
Flavonoids and hERG channels: Friends or foes? 147
Interference measurements and failure analysis of patch-clamp laboratory instrumentation for electrophysiology tests 144
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 143
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 140
MC225, a novel probe for P-glycoprotein PET Imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation 138
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 136
The multi-factorial nature of clinical multidrug resistance in cancer 136
Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes 132
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 132
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart. 131
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors 130
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile 128
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery 128
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 128
(+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells 126
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility. 126
2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation. 125
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 125
Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. 124
L-type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage 123
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 120
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. 117
Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles. 115
The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects 114
Synthesis and antiperoxidant activity of new phenolic O-glycosides 111
Mechanism of myricetin stimulation of vascular L-type Ca2+ current. 110
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker 110
Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells 110
Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells 109
Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current 108
L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles 106
null 106
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 105
Proton pump inhibitors directly block hERG-potassium channel and independently increase the risk of QTc prolongation in a large cohort of US Veterans 105
Repurposing old drugs to fight multidrug resistant cancers 104
null 103
Playing with opening and closing of heterocycles: using the Cusmano-Ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors. 103
Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca(2+) channels 102
The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels 101
Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles 97
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 90
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 87
Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels 85
In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin 85
Mechanism of osthole inhibition of vascular Cav1.2 current 81
Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes 80
Sdox, a H2S releasing anthracycline, with a safer profile than doxorubicin toward vasculature 80
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 79
Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart 78
Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv 78
Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. 75
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 73
null 67
Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma 58
Inhibition of iron-dependent decomposition of H2O2 as a method for assessing the free-radical-scavenging activity of novel antioxidants in a hydrophilic environment. 55
2-hydroxy-4-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 54
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors 53
null 51
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 49
Screening for potential hazardous effects of an H2S-donating anthracycline on the cardiovascular system. 44
In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents 42
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels 41
Effects of quercetin and rutin on vascular preparations: a comparison between mechanical and electrophysiological phenomena. 38
Off-label use of hydroxychloroquine in COVID-19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance 37
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions 36
Hypoxia as a driver of resistance to immunotherapy 33
Nitrobenzoxadiazole derivatives of the rat selective toxicant norbormide as fluorescent probes for live cell imaging 33
Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment 28
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity 26
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation 26
Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical 20
null 16
The Enigma of Norbormide, a Rattus-Selective Toxicant 3
Totale 10.765
Categoria #
all - tutte 34.203
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.203


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019559 0 0 0 0 0 0 0 0 0 0 297 262
2019/20202.192 261 91 115 308 208 219 194 256 191 183 53 113
2020/20211.979 109 152 109 167 219 210 98 217 163 270 144 121
2021/20221.489 104 188 117 101 65 60 107 55 109 163 155 265
2022/20231.773 110 158 251 263 124 318 69 153 175 55 67 30
2023/20241.589 79 33 195 83 115 494 471 33 8 44 34 0
Totale 10.765