SAPONARA, SIMONA
SAPONARA, SIMONA
Dipartimento di Scienze della Vita
(+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells
2006-01-01 Saponara, Simona; Testai, L.; Iozzi, D.; Martinotti, E.; Martelli, A.; Chericoni, S.; Sgaragli, G.; Fusi, Fabio; Calderone, V.
2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation
2001-01-01 Fusi, Fabio; Saponara, Simona; Gagov, H.; Sgaragli, G. P.
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation
2021-01-01 Brizzi, A.; Trezza, A.; Spiga, O.; Maramai, S.; Scorzelli, F.; Saponara, S.; Fusi, F.
3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility
2004-01-01 Saponara, Simona; Kawase, M.; Shak, A.; Motohashi, N.; Molnar, J.; Ugocsai, K.; Sgaragli, Gian Pietro; Fusi, Fabio
3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart
2007-01-01 Saponara, Simona; Ferrara, A; Gorelli, B; Shah, A; Kawase, M; Motohashi, N; Molnar, J; Sgaragli, GIAN PIETRO; Fusi, Fabio
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors
2022-01-01 Alov, Petko; Al Sharif, Merilin; Aluani, Denitsa; Chegaev, Konstantin; Dinic, Jelena; Divac Rankov, Aleksandra; Fernandes, Miguel X; Fusi, Fabio; García-Sosa, Alfonso T; Juvonen, Risto; Kondeva-Burdina, Magdalena; Padrón, José M; Pajeva, Ilza; Pencheva, Tania; Puerta, Adrián; Raunio, Hannu; Riganti, Chiara; Tsakovska, Ivanka; Tzankova, Virginia; Yordanov, Yordan; Saponara, Simona
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels
2021-01-01 Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F.
A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound
2024-01-01 Salaroglio, Iris C.; Stefanova, Denitsa; Teixeira, Ricardo G.; Oliveira, Nuno F. B.; Ahmed, Amer; Fusi, Fabio; Tzankova, Virginia; Yordanov, Yordan; Machuqueiro, Miguel; Saponara, Simona; Valente, Andreia; Riganti, Chiara
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation
2003-01-01 Frosini, M.; Sesti, C.; Saponara, S.; Ricci, L.; Valoti, M.; Palmi, M.; Machetti, F.; Sgaragli, G. P.
Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile
2009-01-01 Bova, S; Saponara, Simona; Rampa, A; Gobbi, S; Cima, L; Fusi, Fabio; Sgaragli, GIAN PIETRO; Cavalli, M; DE LOS RIOS, C; Striessnig, J; Bisi, A.
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats
2020-01-01 Pessina, F.; Frosini, M.; Marcolongo, P.; Fusi, F.; Saponara, S.; Gamberucci, A.; Valoti, M.; Giustarini, D.; Fiorenzani, P.; Gorelli, B.; Francardi, V.; Botta, M.; Dreassi, E.
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues
2018-01-01 Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: synthesis and biological evaluation
2023-01-01 Carullo, G.; Falbo, F.; Ahmed, A.; Trezza, A.; Gianibbi, B.; Nicolotti, O.; Campiani, G.; Aiello, F.; Saponara, S.; Fusi, F.
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability
2022-01-01 Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G.
Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes
2002-01-01 Fusi, Fabio; Saponara, Simona; Sgaragli, Gian Pietro; Cargnelli, G; Bova, S.
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives
2006-01-01 Fusi, F.; Saponara, S.; Valoti, M.; Dragoni, S.; D'Elia, P.; Sgaragli, T.; Alderighi, D.; Sgaragli, G. P.
Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes
2010-01-01 Fusi, Fabio; Cavalli, M; Mulholland, D; CROUCH N., R; Coombes, P; Dawson, G; Bova, S; Sgaragli, G.; Saponara, Simona
Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery
2001-01-01 Petkov G., V.; Fusi, Fabio; Saponara, Simona; Gagov, H.; Sgaragli, Gian Pietro; Boev, K. K.
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators
2020-01-01 Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F.
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain
2016-01-01 Brindisi, Margherita; Maramai, Samuele; Gemma, Sandra; Brogi, Simone; Grillo, Alessandro; Di Cesare Mannelli, Lorenzo; Gabellieri, Emanuele; Lamponi, Stefania; Saponara, Simona; Gorelli, Beatrice; Tedesco, Daniele; Bonfiglio, Tommaso; Landry, Christophe; Jung, Kwang Mook; Armirotti, Andrea; Luongo, Livio; Ligresti, Alessia; Piscitelli, Fabiana; Bertucci, Carlo; Dehouck, Marie Pierre; Campiani, Giuseppe; Maione, Sabatino; Ghelardini, Carla; Pittaluga, Anna; Piomelli, Daniele; Di Marzo, Vincenzo; Butini, Stefania
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| (+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells | 1-gen-2006 | Saponara, Simona; Testai, L.; Iozzi, D.; Martinotti, E.; Martelli, A.; Chericoni, S.; Sgaragli, G.; Fusi, Fabio; Calderone, V. | - | |
| 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation | 1-gen-2001 | Fusi, Fabio; Saponara, Simona; Gagov, H.; Sgaragli, G. P. | - | |
| 2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation | 1-gen-2021 | Brizzi, A.; Trezza, A.; Spiga, O.; Maramai, S.; Scorzelli, F.; Saponara, S.; Fusi, F. | - | |
| 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility | 1-gen-2004 | Saponara, Simona; Kawase, M.; Shak, A.; Motohashi, N.; Molnar, J.; Ugocsai, K.; Sgaragli, Gian Pietro; Fusi, Fabio | - | |
| 3,5-dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effects on Langendorff-perfused rat heart | 1-gen-2007 | Saponara, Simona; Ferrara, A; Gorelli, B; Shah, A; Kawase, M; Motohashi, N; Molnar, J; Sgaragli, GIAN PIETRO; Fusi, Fabio | - | |
| A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors | 1-gen-2022 | Alov, Petko; Al Sharif, Merilin; Aluani, Denitsa; Chegaev, Konstantin; Dinic, Jelena; Divac Rankov, Aleksandra; Fernandes, Miguel X; Fusi, Fabio; García-Sosa, Alfonso T; Juvonen, Risto; Kondeva-Burdina, Magdalena; Padrón, José M; Pajeva, Ilza; Pencheva, Tania; Puerta, Adrián; Raunio, Hannu; Riganti, Chiara; Tsakovska, Ivanka; Tzankova, Virginia; Yordanov, Yordan; Saponara, Simona | - | |
| A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels | 1-gen-2021 | Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F. | - | |
| A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound | 1-gen-2024 | Salaroglio, Iris C.; Stefanova, Denitsa; Teixeira, Ricardo G.; Oliveira, Nuno F. B.; Ahmed, Amer; Fusi, Fabio; Tzankova, Virginia; Yordanov, Yordan; Machuqueiro, Miguel; Saponara, Simona; Valente, Andreia; Riganti, Chiara | - | |
| A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation | 1-gen-2003 | Frosini, M.; Sesti, C.; Saponara, S.; Ricci, L.; Valoti, M.; Palmi, M.; Machetti, F.; Sgaragli, G. P. | - | |
| Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile | 1-gen-2009 | Bova, S; Saponara, Simona; Rampa, A; Gobbi, S; Cima, L; Fusi, Fabio; Sgaragli, GIAN PIETRO; Cavalli, M; DE LOS RIOS, C; Striessnig, J; Bisi, A. | - | |
| Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats | 1-gen-2020 | Pessina, F.; Frosini, M.; Marcolongo, P.; Fusi, F.; Saponara, S.; Gamberucci, A.; Valoti, M.; Giustarini, D.; Fiorenzani, P.; Gorelli, B.; Francardi, V.; Botta, M.; Dreassi, E. | - | |
| Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues | 1-gen-2018 | Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - | |
| Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: synthesis and biological evaluation | 1-gen-2023 | Carullo, G.; Falbo, F.; Ahmed, A.; Trezza, A.; Gianibbi, B.; Nicolotti, O.; Campiani, G.; Aiello, F.; Saponara, S.; Fusi, F. | - | |
| Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability | 1-gen-2022 | Federico, S.; Khan, T.; Fontana, A.; Brogi, S.; Benedetti, R.; Sarno, F.; Carullo, G.; Pezzotta, A.; Saraswati, A. P.; Passaro, E.; Pozzetti, L.; Papa, A.; Relitti, N.; Gemma, S.; Butini, S.; Pistocchi, A.; Ramunno, A.; Vincenzi, F.; Varani, K.; Tatangelo, V.; Patrussi, L.; Baldari, C. T.; Saponara, S.; Gorelli, B.; Lamponi, S.; Valoti, M.; Saccoccia, F.; Giannaccari, M.; Ruberti, G.; Herp, D.; Jung, M.; Altucci, L.; Campiani, G. | - | |
| Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes | 1-gen-2002 | Fusi, Fabio; Saponara, Simona; Sgaragli, Gian Pietro; Cargnelli, G; Bova, S. | - | |
| Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives | 1-gen-2006 | Fusi, F.; Saponara, S.; Valoti, M.; Dragoni, S.; D'Elia, P.; Sgaragli, T.; Alderighi, D.; Sgaragli, G. P. | - | |
| Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes | 1-gen-2010 | Fusi, Fabio; Cavalli, M; Mulholland, D; CROUCH N., R; Coombes, P; Dawson, G; Bova, S; Sgaragli, G.; Saponara, Simona | - | |
| Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery | 1-gen-2001 | Petkov G., V.; Fusi, Fabio; Saponara, Simona; Gagov, H.; Sgaragli, Gian Pietro; Boev, K. K. | - | |
| Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators | 1-gen-2020 | Carullo, G.; Ahmed, A.; Trezza, A.; Spiga, O.; Brizzi, A.; Saponara, S.; Fusi, F.; Aiello, F. | - | |
| Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain | 1-gen-2016 | Brindisi, Margherita; Maramai, Samuele; Gemma, Sandra; Brogi, Simone; Grillo, Alessandro; Di Cesare Mannelli, Lorenzo; Gabellieri, Emanuele; Lamponi, Stefania; Saponara, Simona; Gorelli, Beatrice; Tedesco, Daniele; Bonfiglio, Tommaso; Landry, Christophe; Jung, Kwang Mook; Armirotti, Andrea; Luongo, Livio; Ligresti, Alessia; Piscitelli, Fabiana; Bertucci, Carlo; Dehouck, Marie Pierre; Campiani, Giuseppe; Maione, Sabatino; Ghelardini, Carla; Pittaluga, Anna; Piomelli, Daniele; Di Marzo, Vincenzo; Butini, Stefania | - |