The effect of freeze-dried red wine (FDRW) on cardiac function and electrocardiogram (ECG) in Langendorff-isolated rat hearts was investigated. FDRW significantly decreased left ventricular pressure and coronary perfusion pressure, the latter being dependent on the activation of both phosphatidylinositol 3-kinase and eNOS. FDRW did not affect the QRS and QT interval in the ECG, although at 56 μg of gallic acid equivalents/mL, it prolonged PQ interval and induced a second-degree atrioventricular block in 3 out of 6 hearts. This is the first study demonstrating that at concentrations resembling a moderate consumption of red wine, FDRW exhibited negative inotropic and coronary vasodilating activity leaving unaltered ECG, whereas at very high concentrations, it induced arrhythmogenic effects.

Ferrara, A., Fusi, F., Gorelli, B., Sgaragli, G.P., & Saponara, S. (2014). Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 92(2), 171-174 [10.1139/cjpp-2013-0262].

Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart

FERRARA, ANTONELLA;FUSI, FABIO;GORELLI, BEATRICE;SGARAGLI, GIAN PIETRO;SAPONARA, SIMONA
2014

Abstract

The effect of freeze-dried red wine (FDRW) on cardiac function and electrocardiogram (ECG) in Langendorff-isolated rat hearts was investigated. FDRW significantly decreased left ventricular pressure and coronary perfusion pressure, the latter being dependent on the activation of both phosphatidylinositol 3-kinase and eNOS. FDRW did not affect the QRS and QT interval in the ECG, although at 56 μg of gallic acid equivalents/mL, it prolonged PQ interval and induced a second-degree atrioventricular block in 3 out of 6 hearts. This is the first study demonstrating that at concentrations resembling a moderate consumption of red wine, FDRW exhibited negative inotropic and coronary vasodilating activity leaving unaltered ECG, whereas at very high concentrations, it induced arrhythmogenic effects.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/45813
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