IRIS
SPIGA, OTTAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 6.537
EU - Europa 6.519
AS - Asia 770
SA - Sud America 14
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 6
AF - Africa 3
Totale 13.861
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Nazione #
US - Stati Uniti d'America 6.518
GB - Regno Unito 1.868
IT - Italia 1.555
IE - Irlanda 1.095
CN - Cina 548
SE - Svezia 519
UA - Ucraina 421
FR - Francia 362
DE - Germania 298
FI - Finlandia 152
SG - Singapore 71
RU - Federazione Russa 51
ES - Italia 47
TR - Turchia 45
BE - Belgio 40
VN - Vietnam 30
AT - Austria 22
NL - Olanda 22
IN - India 20
CZ - Repubblica Ceca 18
IR - Iran 15
CA - Canada 13
PL - Polonia 11
AU - Australia 10
JP - Giappone 9
PK - Pakistan 9
HK - Hong Kong 7
CH - Svizzera 6
HU - Ungheria 6
CL - Cile 5
EU - Europa 5
MX - Messico 5
PT - Portogallo 5
RO - Romania 5
DK - Danimarca 4
PE - Perù 4
RS - Serbia 4
SA - Arabia Saudita 4
AR - Argentina 3
IL - Israele 3
BR - Brasile 2
GR - Grecia 2
KR - Corea 2
KZ - Kazakistan 2
NZ - Nuova Zelanda 2
QA - Qatar 2
SK - Slovacchia (Repubblica Slovacca) 2
UG - Uganda 2
A2 - ???statistics.table.value.countryCode.A2??? 1
EG - Egitto 1
HR - Croazia 1
IM - Isola di Man 1
LB - Libano 1
LV - Lettonia 1
MS - Montserrat 1
MT - Malta 1
PH - Filippine 1
TH - Thailandia 1
Totale 13.861
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Città #
Southend 1.729
Fairfield 1.128
Dublin 1.081
Chandler 630
Ashburn 546
Siena 507
Woodbridge 470
Seattle 394
Houston 369
Jacksonville 345
Cambridge 340
Wilmington 340
Ann Arbor 262
Princeton 184
Menlo Park 171
Beijing 118
Florence 117
Nanjing 100
Boardman 97
Helsinki 95
New York 72
San Mateo 68
Fremont 64
San Diego 61
Shanghai 61
Rome 51
Nanchang 48
Moscow 44
Dearborn 43
Los Angeles 42
Singapore 42
Izmir 41
Brussels 40
Milan 40
Málaga 38
Dong Ket 29
Redwood City 29
Norwalk 28
Shenyang 26
London 25
Washington 24
Lancaster 21
Tianjin 21
Vienna 21
Hebei 20
Jiaxing 20
Changsha 19
Kunming 18
Guangzhou 17
Brno 15
Rocca Di Neto 14
Chicago 13
Lucca 13
Munich 13
Jinan 12
Monteriggioni 12
Comun Nuovo 10
Hangzhou 10
Toronto 10
Perugia 9
Prato 9
Arezzo 8
Curtarolo 8
Figline Valdarno 8
Kilburn 8
Messina 8
Ningbo 8
Philadelphia 8
Phoenix 8
Pisa 8
Poggibonsi 8
San Francisco 8
Taizhou 8
Bologna 7
Casaleggio Novara 7
Grosseto 7
Hounslow 7
Paris 7
Torino 7
Verona 7
Zhengzhou 7
Campi Bisenzio 6
Hanover 6
Hefei 6
Nice 6
Venezia 6
Brescia 5
Catania 5
Citta 5
Eboli 5
Falkenstein 5
Metzingen 5
Montemurlo 5
Napoli 5
Padova 5
Parma 5
Tappahannock 5
Zanjan 5
Asciano 4
Belgrade 4
Totale 10.486
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Nome #
Modello molecolare tridimensionale del peplomero del coronavirus della SARS come base razionale per la progettazione di farmaci e kit diagnostici 369
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria 278
Omic Approach in Non-Smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine 256
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 253
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium 252
A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria 224
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 223
Revealing the complexity of a monogenic disease: rett syndrome exome sequencing 218
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 215
Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon 212
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins 211
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow-induced chemoresistance in acute leukemias 202
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 200
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 190
Evidence of a new phosphoryl transfer system in nucleotide metabolism 187
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies 185
A structurally driven analysis of thiol reactivity in mammalian albumins 181
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population 180
Hot spot mapping of protein surfaces with TEMPOL: Bovine pancreatic RNase A as a model system 167
Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations. 166
Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU 165
An Introduction to Personalized Nutrition 161
Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease 160
Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease 159
ProCoCoA: A quantitative approach for analyzing protein core composition. 156
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human 156
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease 156
Towards an integrated interactive database for the search of stratification biomarkers in Alkaptonuria 155
Applications of in silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions 154
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 151
Flavonoids and hERG channels: Friends or foes? 148
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization 144
Computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases 142
Peptide-protein interactions studied by surface plasmon and nuclear magnetic resonances 137
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 137
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria 134
Searching for protein binding sites from Molecular Dynamics simulations and paramagnetic fragment-based NMR studies 133
NMR studies of lysozyme surface accessibility by using different paramagnetic relaxation probes 133
Structural investigation of Rett-inducing MeCP2 mutations 132
Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite 130
Three-dimensional computation of atom depth in complex molecular structures 129
On the dynamics of water molecules at the protein solute interfaces. 129
Metal ion complexation and folding of linear peptides 128
Structure and function correlations between the rat liver threonine deaminase and aminotransferases 128
Probing protein surface accessibility with solvent and paramagnetic molecules 127
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males 127
NMR studies of protein surface accessibility 126
Coumarins Isolated from Murraya paniculata in Vietnam and Their Inhibitory Effects against Enzyme Soluble Epoxide Hydrolase (sEH) 124
Personalized nutrition and omics technologies 124
null 123
Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model 122
Omics-based technologies for food authentication and traceability 122
Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe 117
Cell and tissue models of alkaptonuria 117
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) [Cribado virtual de antraquinonas procedentes de Prismatomeris memecyloides como inhibidores noveles de fosfodiesterasa tipo 5 (PDE-5Is)] 116
NMR studies of protein hydration and TEMPOL accessibility 115
null 115
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? 113
Tertiary structure prediction of SARS coronavirus helicase 113
null 113
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus 112
Vasorelaxing activity of R-(-)-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 Channels 112
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein 111
NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide 109
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model. 109
FOXG1 is responsible for the congenital variant of Rett syndrome. 109
NMR studies of BPTI aggregation by using paramagnetic relaxation reagents 107
null 106
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 106
Structural bioinformatic survey of protein-small molecule interfaces delineates the role of glycine in surface pocket formation 102
Towards a precision medicine approach based on machine learning for tailoring medical treatment in Alkaptonuria 101
Transient Pockets and Surface Hotspots Prediction. 99
Histidyl tags and structural stabilization of linear peptides 98
Structural Bioinformatics to unveil weaknesses of coronavirus spike glycoprotein stability 98
A structural genomics approach to sars coronavirus infection 96
Prediction of quaternary assembly of SARS coronavirus peplomer 95
NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes 95
Probing the protein space for extending the detection of weak homology folds. 95
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes 93
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 93
A structural genomics approach to sars coronavirus infection 89
NMR studies of the inclusion complex between β-cyclodextrin and paroxetine 87
AKUImg: A database of cartilage images of Alkaptonuria patients 87
NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor 86
NMR and MD studies on the interaction between ligand peptides and alpha-bungarotoxin 84
Leveraging proteomics in orphan disease research: pitfalls and potential 81
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 80
NMR studies of the interaction of alpha-bungarotoxin with a mimotope of the nicotinic acetylcholine receptor 79
Proteomic profiling reveals mitochondrial alterations in Rett syndrome 79
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 78
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors 74
Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus 70
Bioinformatics approaches to predict mutation effects in the binding site of the proangiogenic molecule {CD}93 69
Omicron variants of SARS CoV-2 indicate a new antiviral strategy: Interfere with spike glycoprotein trimerization 68
Transient pockets as mediators of gas molecules routes inside proteins: the case study of dioxygen pathway in homogentisate 1,2-dioxygenase and its implication in Alkaptonuria development 68
Structural bioinformatics survey on disease-inducing missense mutations 67
Artificial intelligence approaches in drug discovery: towards the laboratory of the future 65
Modeling the structure of SARS-CoV spike glycoprotein 65
MD and NMR studies of alpha-bungarotoxin surface accessibility 63
Surface accessibility of hew lysozyme 63
Totale 13.288
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Categoria #
all - tutte 44.965
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.965
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.649 307 94 155 360 210 216 245 323 253 207 97 182
2020/20212.680 103 218 107 222 289 266 164 324 241 315 271 160
2021/20222.068 202 250 175 136 108 105 129 78 136 199 198 352
2022/20232.377 155 237 296 304 213 433 105 182 224 73 96 59
2023/20242.050 92 67 204 85 101 506 595 41 13 33 96 217
2024/202565 65 0 0 0 0 0 0 0 0 0 0 0
Totale 14.214