IRIS
SPIGA, OTTAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 12.585
EU - Europa 10.712
AS - Asia 5.245
SA - Sud America 1.015
Continente sconosciuto - Info sul continente non disponibili 445
AF - Africa 282
OC - Oceania 17
Totale 30.301
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Nazione #
US - Stati Uniti d'America 12.389
IT - Italia 2.828
GB - Regno Unito 1.979
RU - Federazione Russa 1.908
SG - Singapore 1.611
CN - Cina 1.565
IE - Irlanda 1.088
BR - Brasile 833
VN - Vietnam 586
DE - Germania 572
FR - Francia 558
SE - Svezia 541
HK - Hong Kong 442
UA - Ucraina 426
FI - Finlandia 304
KR - Corea 289
IN - India 180
ZA - Sudafrica 130
CA - Canada 102
BD - Bangladesh 100
NL - Olanda 89
TR - Turchia 76
ES - Italia 75
AR - Argentina 60
JP - Giappone 56
PL - Polonia 55
EE - Estonia 52
IQ - Iraq 50
MX - Messico 48
AT - Austria 47
BE - Belgio 47
KE - Kenya 42
ID - Indonesia 35
PK - Pakistan 33
NG - Nigeria 32
EC - Ecuador 30
IR - Iran 28
SA - Arabia Saudita 27
CZ - Repubblica Ceca 21
CH - Svizzera 18
CO - Colombia 18
CL - Cile 17
VE - Venezuela 17
JM - Giamaica 16
AU - Australia 15
CI - Costa d'Avorio 15
IL - Israele 15
LT - Lituania 15
UZ - Uzbekistan 15
JO - Giordania 14
BO - Bolivia 12
EG - Egitto 12
MY - Malesia 12
AE - Emirati Arabi Uniti 11
DZ - Algeria 11
KZ - Kazakistan 11
PT - Portogallo 11
AZ - Azerbaigian 10
MA - Marocco 10
OM - Oman 10
PE - Perù 10
PH - Filippine 10
RO - Romania 10
UY - Uruguay 10
AL - Albania 9
HU - Ungheria 9
TN - Tunisia 9
DK - Danimarca 8
LB - Libano 7
LV - Lettonia 7
NP - Nepal 7
PY - Paraguay 7
TW - Taiwan 7
GE - Georgia 6
GR - Grecia 6
SY - Repubblica araba siriana 6
BH - Bahrain 5
DO - Repubblica Dominicana 5
ET - Etiopia 5
EU - Europa 5
NI - Nicaragua 5
RS - Serbia 5
SK - Slovacchia (Repubblica Slovacca) 5
NO - Norvegia 4
PA - Panama 4
TH - Thailandia 4
UG - Uganda 4
AO - Angola 3
BG - Bulgaria 3
CR - Costa Rica 3
HN - Honduras 3
QA - Qatar 3
AM - Armenia 2
BB - Barbados 2
BY - Bielorussia 2
CG - Congo 2
CY - Cipro 2
HR - Croazia 2
IM - Isola di Man 2
KW - Kuwait 2
Totale 29.829
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Città #
Dallas 1.970
Southend 1.705
Fairfield 1.109
Dublin 1.074
Ashburn 893
Singapore 892
Chandler 624
Siena 593
Santa Clara 569
San Jose 552
Milan 547
Moscow 531
Woodbridge 461
Hong Kong 416
Seattle 402
Houston 382
Beijing 371
Jacksonville 343
Wilmington 341
Cambridge 337
Council Bluffs 325
Hefei 316
Los Angeles 272
Seoul 271
Ann Arbor 259
Rome 224
The Dalles 222
Munich 202
Florence 189
Princeton 182
Helsinki 177
New York 175
Menlo Park 171
Ho Chi Minh City 163
Lauterbourg 151
Hanoi 147
Johannesburg 112
Nanjing 101
Boardman 100
Columbus 85
Buffalo 73
Shanghai 73
São Paulo 72
San Mateo 68
Fremont 64
Bengaluru 61
San Diego 61
Chicago 59
Nanchang 49
Tokyo 47
Brussels 46
Redondo Beach 45
Dearborn 42
Izmir 41
London 41
Orem 40
Málaga 37
Warsaw 37
Nuremberg 35
Turku 35
Phoenix 33
Lappeenranta 31
Vienna 31
Abuja 30
Haiphong 30
Toronto 30
Washington 30
Atlanta 29
Dong Ket 29
Redwood City 29
Brescia 28
Frankfurt am Main 28
Montreal 28
Norwalk 28
Da Nang 27
Rio de Janeiro 27
Shenyang 27
Tianjin 27
Changsha 26
San Francisco 26
Belo Horizonte 25
Denver 25
Boston 24
Guangzhou 24
Lancaster 24
Turin 23
Bologna 22
Düsseldorf 22
Chennai 21
Jiaxing 21
Portsmouth 21
Baghdad 20
Brooklyn 20
Hebei 20
Stockholm 20
Kunming 19
Amsterdam 18
Philadelphia 18
Naples 16
Paris 16
Totale 19.975
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Nome #
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population 594
Association of toll-like receptor 7 variants with life-threatening COVID-19 disease in males: Findings from a nested case-control study 512
A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria 496
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity 483
Modello molecolare tridimensionale del peplomero del coronavirus della SARS come base razionale per la progettazione di farmaci e kit diagnostici 466
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males 442
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria 418
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium 374
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 370
Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies 367
Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon 364
Omic Approach in Non-Smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine 359
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 347
A structurally driven analysis of thiol reactivity in mammalian albumins 338
Revealing the complexity of a monogenic disease: rett syndrome exome sequencing 322
A combined ML and DFT strategy for the prediction of dye candidates for indoor DSSCs 318
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization 309
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 309
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow-induced chemoresistance in acute leukemias 306
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 301
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins 297
An Introduction to Personalized Nutrition 297
Evidence of a new phosphoryl transfer system in nucleotide metabolism 287
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 286
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease 285
Omicron variants of SARS CoV-2 indicate a new antiviral strategy: Interfere with spike glycoprotein trimerization 284
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies 281
Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease 280
Applications of in silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions 274
Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease 274
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria 274
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human 270
ProCoCoA: A quantitative approach for analyzing protein core composition 265
Alkaptonuria 255
Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU 254
AKUImg: A database of cartilage images of Alkaptonuria patients 249
A structural genomics approach to sars coronavirus infection 245
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 242
Towards an integrated interactive database for the search of stratification biomarkers in Alkaptonuria 240
Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations 236
Searching for protein binding sites from Molecular Dynamics simulations and paramagnetic fragment-based NMR studies 232
Flavonoids and hERG channels: Friends or foes? 231
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 228
Computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases 224
Artificial intelligence approaches in drug discovery: towards the laboratory of the future 222
Bioinformatics approaches to predict mutation effects in the binding site of the proangiogenic molecule {CD}93 222
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 221
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 221
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model 219
Vasorelaxing activity of R-(-)-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 Channels 217
Probing protein surface accessibility with solvent and paramagnetic molecules 215
A structural genomics approach to sars coronavirus infection 215
Cell and tissue models of alkaptonuria 214
Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy 213
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 210
Structural investigation of Rett-inducing MeCP2 mutations 209
Personalized nutrition and omics technologies 208
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein 206
The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers 205
NMR studies of lysozyme surface accessibility by using different paramagnetic relaxation probes 203
Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite 201
On the dynamics of water molecules at the protein solute interfaces. 201
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors 201
Omics-based technologies for food authentication and traceability 201
Tertiary structure prediction of SARS coronavirus helicase 200
Three-dimensional computation of atom depth in complex molecular structures 200
Peptide-protein interactions studied by surface plasmon and nuclear magnetic resonances 198
Prediction of quaternary assembly of SARS coronavirus peplomer 196
ApreciseKUre: an approach of Precision Medicine in a Rare Disease 195
Coumarins Isolated from Murraya paniculata in Vietnam and Their Inhibitory Effects against Enzyme Soluble Epoxide Hydrolase (sEH) 192
NMR studies of protein hydration and TEMPOL accessibility 192
Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a 191
Proteomic profiling reveals mitochondrial alterations in Rett syndrome 190
Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract 189
NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide 186
Towards a precision medicine approach based on machine learning for tailoring medical treatment in Alkaptonuria 186
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 185
NMR studies of the inclusion complex between β-cyclodextrin and paroxetine 185
Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe 185
NMR studies of protein surface accessibility 185
Metal ion complexation and folding of linear peptides 185
Structural bioinformatic survey of protein-small molecule interfaces delineates the role of glycine in surface pocket formation 185
FOXG1 is responsible for the congenital variant of Rett syndrome. 184
NMR and MD studies on the interaction between ligand peptides and alpha-bungarotoxin 182
Pharmacological and in silico analysis of oat avenanthramides as EGFR inhibitors: effects on EGF-induced lung cancer cell growth and migration 180
Structure and function correlations between the rat liver threonine deaminase and aminotransferases 180
Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model 179
Probing the protein space for extending the detection of weak homology folds 174
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes 173
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) [Cribado virtual de antraquinonas procedentes de Prismatomeris memecyloides como inhibidores noveles de fosfodiesterasa tipo 5 (PDE-5Is)] 173
Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage 171
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? 170
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus 168
Computational approaches integrated in a digital ecosystem platform for a rare disease 165
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 165
NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes 163
NMR studies of BPTI aggregation by using paramagnetic relaxation reagents 163
Leveraging proteomics in orphan disease research: pitfalls and potential 163
Multi-omics model applied to cancer genetics 162
NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor 160
Totale 24.809
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Categoria #
all - tutte 90.463
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 90.463
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.609 0 0 175 136 108 104 129 78 136 197 197 349
2022/20232.356 154 236 292 300 212 428 104 181 223 71 96 59
2023/20242.027 92 66 203 85 101 503 588 39 13 32 93 212
2024/20254.453 101 172 384 292 500 302 271 311 395 240 485 1.000
2025/202610.861 789 1.537 1.673 1.156 1.759 408 1.135 346 344 526 275 913
2026/20271.014 390 315 309 0 0 0 0 0 0 0 0 0
Totale 30.301