IRIS
SPIGA, OTTAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 11.200
EU - Europa 10.014
AS - Asia 5.085
SA - Sud America 972
AF - Africa 279
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 8
Totale 27.575
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Nazione #
US - Stati Uniti d'America 11.060
IT - Italia 2.162
GB - Regno Unito 1.973
RU - Federazione Russa 1.908
SG - Singapore 1.560
CN - Cina 1.535
IE - Irlanda 1.088
BR - Brasile 817
VN - Vietnam 582
DE - Germania 570
FR - Francia 557
SE - Svezia 535
HK - Hong Kong 433
UA - Ucraina 426
FI - Finlandia 304
KR - Corea 288
IN - India 177
ZA - Sudafrica 129
NL - Olanda 84
TR - Turchia 75
ES - Italia 73
CA - Canada 72
BD - Bangladesh 58
AR - Argentina 55
JP - Giappone 55
PL - Polonia 53
EE - Estonia 52
IQ - Iraq 49
AT - Austria 47
BE - Belgio 47
KE - Kenya 42
MX - Messico 41
NG - Nigeria 32
PK - Pakistan 32
ID - Indonesia 30
IR - Iran 28
SA - Arabia Saudita 26
EC - Ecuador 25
CZ - Repubblica Ceca 20
CH - Svizzera 18
CL - Cile 16
AU - Australia 15
CI - Costa d'Avorio 15
IL - Israele 15
LT - Lituania 15
UZ - Uzbekistan 15
JO - Giordania 13
BO - Bolivia 12
EG - Egitto 12
VE - Venezuela 12
AE - Emirati Arabi Uniti 11
DZ - Algeria 11
MY - Malesia 11
AZ - Azerbaigian 10
KZ - Kazakistan 10
MA - Marocco 10
OM - Oman 10
PE - Perù 10
PT - Portogallo 10
UY - Uruguay 10
AL - Albania 9
HU - Ungheria 9
RO - Romania 9
TN - Tunisia 9
DK - Danimarca 8
CO - Colombia 7
JM - Giamaica 7
PH - Filippine 7
PY - Paraguay 7
TW - Taiwan 7
GE - Georgia 6
GR - Grecia 6
LB - Libano 6
LV - Lettonia 6
NP - Nepal 6
SY - Repubblica araba siriana 6
BH - Bahrain 5
ET - Etiopia 5
EU - Europa 5
RS - Serbia 5
DO - Repubblica Dominicana 4
PA - Panama 4
SK - Slovacchia (Repubblica Slovacca) 4
AO - Angola 3
CR - Costa Rica 3
NO - Norvegia 3
QA - Qatar 3
TH - Thailandia 3
AM - Armenia 2
BY - Bielorussia 2
CG - Congo 2
CY - Cipro 2
HR - Croazia 2
IM - Isola di Man 2
LA - Repubblica Popolare Democratica del Laos 2
MD - Moldavia 2
MN - Mongolia 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PR - Porto Rico 2
Totale 27.547
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Città #
Dallas 1.963
Southend 1.705
Fairfield 1.109
Dublin 1.074
Singapore 870
Ashburn 789
Chandler 623
Siena 593
Moscow 531
Santa Clara 509
Woodbridge 461
Hong Kong 409
Seattle 397
Houston 379
Beijing 370
Jacksonville 342
Wilmington 341
Cambridge 337
Hefei 316
San Jose 300
Seoul 271
Ann Arbor 259
Los Angeles 250
Milan 221
The Dalles 221
Munich 202
Princeton 182
Helsinki 177
Florence 176
Menlo Park 171
Ho Chi Minh City 161
Lauterbourg 151
New York 149
Hanoi 147
Council Bluffs 142
Johannesburg 112
Rome 110
Nanjing 101
Boardman 98
Shanghai 72
São Paulo 70
San Mateo 68
Buffalo 66
Fremont 64
San Diego 61
Bengaluru 60
Columbus 50
Nanchang 49
Brussels 46
Tokyo 46
Chicago 45
Redondo Beach 45
Izmir 41
London 41
Dearborn 40
Orem 39
Málaga 37
Nuremberg 35
Turku 35
Warsaw 35
Lappeenranta 31
Vienna 31
Abuja 30
Haiphong 30
Dong Ket 29
Redwood City 29
Frankfurt am Main 28
Norwalk 28
Da Nang 27
Shenyang 27
Tianjin 27
Changsha 26
Rio de Janeiro 26
Belo Horizonte 25
Denver 25
San Francisco 25
Washington 25
Brescia 24
Guangzhou 24
Phoenix 24
Lancaster 23
Toronto 23
Atlanta 22
Düsseldorf 22
Jiaxing 21
Montreal 21
Portsmouth 21
Baghdad 20
Chennai 20
Hebei 20
Stockholm 20
Boston 19
Kunming 19
Amsterdam 18
Paris 16
Abidjan 15
Brasília 15
Brno 15
Jinan 15
Manchester 15
Totale 18.685
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Nome #
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population 573
Association of toll-like receptor 7 variants with life-threatening COVID-19 disease in males: Findings from a nested case-control study 499
A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria 482
Modello molecolare tridimensionale del peplomero del coronavirus della SARS come base razionale per la progettazione di farmaci e kit diagnostici 453
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity 452
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria 401
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males 386
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium 354
Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon 350
Omic Approach in Non-Smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine 344
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 343
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 335
A structurally driven analysis of thiol reactivity in mammalian albumins 320
Revealing the complexity of a monogenic disease: rett syndrome exome sequencing 304
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization 297
A combined ML and DFT strategy for the prediction of dye candidates for indoor DSSCs 293
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow-induced chemoresistance in acute leukemias 290
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 287
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 287
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins 283
Evidence of a new phosphoryl transfer system in nucleotide metabolism 281
An Introduction to Personalized Nutrition 281
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies 273
Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease 270
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 269
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease 266
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria 264
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human 262
Omicron variants of SARS CoV-2 indicate a new antiviral strategy: Interfere with spike glycoprotein trimerization 260
Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease 259
Applications of in silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions 257
ProCoCoA: A quantitative approach for analyzing protein core composition 245
Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU 241
AKUImg: A database of cartilage images of Alkaptonuria patients 238
A structural genomics approach to sars coronavirus infection 234
Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations 227
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 227
Alkaptonuria 224
Towards an integrated interactive database for the search of stratification biomarkers in Alkaptonuria 223
Flavonoids and hERG channels: Friends or foes? 216
Computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases 214
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 212
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 212
Searching for protein binding sites from Molecular Dynamics simulations and paramagnetic fragment-based NMR studies 207
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 205
Bioinformatics approaches to predict mutation effects in the binding site of the proangiogenic molecule {CD}93 203
Probing protein surface accessibility with solvent and paramagnetic molecules 202
Artificial intelligence approaches in drug discovery: towards the laboratory of the future 201
Personalized nutrition and omics technologies 201
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 200
A structural genomics approach to sars coronavirus infection 199
Cell and tissue models of alkaptonuria 199
Three-dimensional computation of atom depth in complex molecular structures 196
Vasorelaxing activity of R-(-)-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 Channels 196
NMR studies of lysozyme surface accessibility by using different paramagnetic relaxation probes 195
Structural investigation of Rett-inducing MeCP2 mutations 194
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein 193
Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite 193
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model 192
Peptide-protein interactions studied by surface plasmon and nuclear magnetic resonances 188
Coumarins Isolated from Murraya paniculata in Vietnam and Their Inhibitory Effects against Enzyme Soluble Epoxide Hydrolase (sEH) 186
On the dynamics of water molecules at the protein solute interfaces. 185
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors 185
Omics-based technologies for food authentication and traceability 183
Towards a precision medicine approach based on machine learning for tailoring medical treatment in Alkaptonuria 182
ApreciseKUre: an approach of Precision Medicine in a Rare Disease 181
NMR studies of protein hydration and TEMPOL accessibility 180
Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a 178
Prediction of quaternary assembly of SARS coronavirus peplomer 178
NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide 177
NMR studies of protein surface accessibility 177
Metal ion complexation and folding of linear peptides 176
Proteomic profiling reveals mitochondrial alterations in Rett syndrome 175
The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers 174
Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy 174
Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model 174
Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe 174
Structural bioinformatic survey of protein-small molecule interfaces delineates the role of glycine in surface pocket formation 174
Tertiary structure prediction of SARS coronavirus helicase 172
FOXG1 is responsible for the congenital variant of Rett syndrome. 171
Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract 170
Structure and function correlations between the rat liver threonine deaminase and aminotransferases 170
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 166
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) [Cribado virtual de antraquinonas procedentes de Prismatomeris memecyloides como inhibidores noveles de fosfodiesterasa tipo 5 (PDE-5Is)] 166
Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies 165
Pharmacological and in silico analysis of oat avenanthramides as EGFR inhibitors: effects on EGF-induced lung cancer cell growth and migration 165
NMR and MD studies on the interaction between ligand peptides and alpha-bungarotoxin 164
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes 163
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus 160
Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage 159
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 159
NMR studies of the inclusion complex between β-cyclodextrin and paroxetine 158
Computational approaches integrated in a digital ecosystem platform for a rare disease 157
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? 157
NMR studies of BPTI aggregation by using paramagnetic relaxation reagents 155
NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor 152
NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes 152
Probing the protein space for extending the detection of weak homology folds 152
Multi-omics model applied to cancer genetics 150
Structural Bioinformatics to unveil weaknesses of coronavirus spike glycoprotein stability 149
Totale 23.097
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Categoria #
all - tutte 81.519
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 81.519
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021742 0 0 0 0 0 0 0 0 0 314 269 159
2021/20222.060 201 250 175 136 108 104 129 78 136 197 197 349
2022/20232.356 154 236 292 300 212 428 104 181 223 71 96 59
2023/20242.027 92 66 203 85 101 503 588 39 13 32 93 212
2024/20254.453 101 172 384 292 500 302 271 311 395 240 485 1.000
2025/20269.584 789 1.537 1.673 1.156 1.759 408 1.135 346 344 437 0 0
Totale 28.010