IRIS
SPIGA, OTTAVIA
 Distribuzione geografica
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Continente #
EU - Europa 7.166
NA - Nord America 6.871
AS - Asia 969
SA - Sud America 25
AF - Africa 17
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 6
Totale 15.067
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Nazione #
US - Stati Uniti d'America 6.843
GB - Regno Unito 1.880
IT - Italia 1.707
IE - Irlanda 1.097
CN - Cina 575
SE - Svezia 520
RU - Federazione Russa 450
UA - Ucraina 421
FR - Francia 364
DE - Germania 332
SG - Singapore 225
FI - Finlandia 171
ES - Italia 50
TR - Turchia 46
BE - Belgio 44
VN - Vietnam 30
NL - Olanda 28
IN - India 26
AT - Austria 24
CA - Canada 19
CZ - Repubblica Ceca 17
IR - Iran 15
PL - Polonia 14
CI - Costa d'Avorio 13
AU - Australia 11
BR - Brasile 9
JP - Giappone 9
PK - Pakistan 9
CH - Svizzera 6
CL - Cile 6
HU - Ungheria 6
DK - Danimarca 5
EU - Europa 5
HK - Hong Kong 5
MX - Messico 5
PT - Portogallo 5
RO - Romania 5
IL - Israele 4
PE - Perù 4
RS - Serbia 4
SA - Arabia Saudita 4
AR - Argentina 3
LT - Lituania 3
LV - Lettonia 3
MY - Malesia 3
SY - Repubblica araba siriana 3
GR - Grecia 2
KR - Corea 2
KZ - Kazakistan 2
NZ - Nuova Zelanda 2
PH - Filippine 2
PR - Porto Rico 2
QA - Qatar 2
SK - Slovacchia (Repubblica Slovacca) 2
UG - Uganda 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BG - Bulgaria 1
BO - Bolivia 1
EC - Ecuador 1
EE - Estonia 1
EG - Egitto 1
HR - Croazia 1
IM - Isola di Man 1
JO - Giordania 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
LK - Sri Lanka 1
LU - Lussemburgo 1
MS - Montserrat 1
MT - Malta 1
PA - Panama 1
TH - Thailandia 1
TN - Tunisia 1
UY - Uruguay 1
Totale 15.067
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Città #
Southend 1.729
Fairfield 1.128
Dublin 1.083
Chandler 630
Siena 585
Ashburn 553
Woodbridge 470
Seattle 394
Houston 369
Jacksonville 345
Cambridge 343
Wilmington 340
Ann Arbor 262
Santa Clara 214
Princeton 184
Menlo Park 171
Singapore 158
Florence 126
Beijing 118
Helsinki 109
Nanjing 101
Boardman 96
New York 75
San Mateo 68
Shanghai 66
Fremont 64
San Diego 61
Rome 57
Los Angeles 52
Milan 49
Nanchang 48
Brussels 44
Moscow 44
Dearborn 43
Izmir 41
Munich 39
Málaga 38
Dong Ket 29
Redwood City 29
London 28
Norwalk 28
Shenyang 26
Washington 24
Lancaster 21
Tianjin 21
Vienna 21
Changsha 20
Hebei 20
Jiaxing 20
Guangzhou 18
Kunming 18
Brno 15
Columbus 14
Rocca Di Neto 14
Toronto 14
Abidjan 13
Chicago 13
Lucca 13
Jinan 12
Monteriggioni 12
Dallas 11
Comun Nuovo 10
Hangzhou 10
Messina 9
Nuremberg 9
Perugia 9
Prato 9
San Francisco 9
Arezzo 8
Curtarolo 8
Figline Valdarno 8
Kilburn 8
Ningbo 8
Paris 8
Philadelphia 8
Phoenix 8
Pisa 8
Poggibonsi 8
Taizhou 8
Bologna 7
Casaleggio Novara 7
Grosseto 7
Hounslow 7
Naples 7
Torino 7
Verona 7
Zhengzhou 7
Campi Bisenzio 6
Hanover 6
Hefei 6
Nice 6
Palermo 6
Venezia 6
Brescia 5
Catania 5
Citta 5
Eboli 5
Falkenstein 5
Lappeenranta 5
Livorno 5
Totale 11.031
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Nome #
Modello molecolare tridimensionale del peplomero del coronavirus della SARS come base razionale per la progettazione di farmaci e kit diagnostici 379
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria 290
Omic Approach in Non-Smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine 266
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium 264
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 263
A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria 243
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 236
Revealing the complexity of a monogenic disease: rett syndrome exome sequencing 228
Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon 227
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 225
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins 217
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow-induced chemoresistance in acute leukemias 213
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 204
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population 201
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 198
Evidence of a new phosphoryl transfer system in nucleotide metabolism 197
A structurally driven analysis of thiol reactivity in mammalian albumins 192
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies 192
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human 185
Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU 173
Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations 172
Hot spot mapping of protein surfaces with TEMPOL: Bovine pancreatic RNase A as a model system 172
An Introduction to Personalized Nutrition 172
Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease 171
Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease 170
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease 167
ProCoCoA: A quantitative approach for analyzing protein core composition. 165
Applications of in silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions 162
Towards an integrated interactive database for the search of stratification biomarkers in Alkaptonuria 160
Flavonoids and hERG channels: Friends or foes? 159
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 158
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males 158
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization 153
Computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases 150
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria 146
Peptide-protein interactions studied by surface plasmon and nuclear magnetic resonances 142
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 141
NMR studies of lysozyme surface accessibility by using different paramagnetic relaxation probes 141
Association of toll-like receptor 7 variants with life-threatening COVID-19 disease in males: Findings from a nested case-control study 140
Searching for protein binding sites from Molecular Dynamics simulations and paramagnetic fragment-based NMR studies 139
Three-dimensional computation of atom depth in complex molecular structures 138
Structural investigation of Rett-inducing MeCP2 mutations 136
Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite 135
On the dynamics of water molecules at the protein solute interfaces. 134
Personalized nutrition and omics technologies 134
Metal ion complexation and folding of linear peptides 133
Structure and function correlations between the rat liver threonine deaminase and aminotransferases 133
Probing protein surface accessibility with solvent and paramagnetic molecules 132
Coumarins Isolated from Murraya paniculata in Vietnam and Their Inhibitory Effects against Enzyme Soluble Epoxide Hydrolase (sEH) 131
NMR studies of protein surface accessibility 131
Omics-based technologies for food authentication and traceability 128
Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model 126
NMR studies of protein hydration and TEMPOL accessibility 123
null 123
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein 121
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) [Cribado virtual de antraquinonas procedentes de Prismatomeris memecyloides como inhibidores noveles de fosfodiesterasa tipo 5 (PDE-5Is)] 121
Cell and tissue models of alkaptonuria 121
Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe 120
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? 117
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model 117
Tertiary structure prediction of SARS coronavirus helicase 117
FOXG1 is responsible for the congenital variant of Rett syndrome. 116
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus 116
Vasorelaxing activity of R-(-)-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 Channels 116
NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide 115
Structural bioinformatic survey of protein-small molecule interfaces delineates the role of glycine in surface pocket formation 115
null 113
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 113
NMR studies of BPTI aggregation by using paramagnetic relaxation reagents 112
Towards a precision medicine approach based on machine learning for tailoring medical treatment in Alkaptonuria 111
A structural genomics approach to sars coronavirus infection 108
null 106
Structural Bioinformatics to unveil weaknesses of coronavirus spike glycoprotein stability 106
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 105
Prediction of quaternary assembly of SARS coronavirus peplomer 103
Transient Pockets and Surface Hotspots Prediction. 103
AKUImg: A database of cartilage images of Alkaptonuria patients 103
Histidyl tags and structural stabilization of linear peptides 100
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes 100
Probing the protein space for extending the detection of weak homology folds. 99
A structural genomics approach to sars coronavirus infection 99
NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes 98
NMR studies of the inclusion complex between β-cyclodextrin and paroxetine 92
NMR and MD studies on the interaction between ligand peptides and alpha-bungarotoxin 92
Leveraging proteomics in orphan disease research: pitfalls and potential 90
NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor 89
Proteomic profiling reveals mitochondrial alterations in Rett syndrome 88
Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies 87
Bioinformatics approaches to predict mutation effects in the binding site of the proangiogenic molecule {CD}93 86
NMR studies of the interaction of alpha-bungarotoxin with a mimotope of the nicotinic acetylcholine receptor 86
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 85
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors 83
Artificial intelligence approaches in drug discovery: towards the laboratory of the future 82
Omicron variants of SARS CoV-2 indicate a new antiviral strategy: Interfere with spike glycoprotein trimerization 82
Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus 76
ApreciseKUre: an approach of Precision Medicine in a Rare Disease 75
Transient pockets as mediators of gas molecules routes inside proteins: the case study of dioxygen pathway in homogentisate 1,2-dioxygenase and its implication in Alkaptonuria development 73
Structural bioinformatics survey on disease-inducing missense mutations 73
Modeling the structure of SARS-CoV spike glycoprotein 71
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 71
Totale 14.140
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Categoria #
all - tutte 51.763
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.763
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.733 0 0 0 0 210 216 245 323 253 207 97 182
2020/20212.680 103 218 107 222 289 266 164 324 241 315 271 160
2021/20222.068 202 250 175 136 108 105 129 78 136 199 198 352
2022/20232.377 155 237 296 304 213 433 105 182 224 73 96 59
2023/20242.041 92 67 204 85 101 506 595 39 13 32 93 214
2024/20251.324 101 174 384 293 372 0 0 0 0 0 0 0
Totale 15.464