IRIS
SPIGA, OTTAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 11.532
EU - Europa 10.094
AS - Asia 5.178
SA - Sud America 972
AF - Africa 281
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 8
Totale 28.082
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Nazione #
US - Stati Uniti d'America 11.369
IT - Italia 2.231
GB - Regno Unito 1.975
RU - Federazione Russa 1.908
SG - Singapore 1.588
CN - Cina 1.561
IE - Irlanda 1.088
BR - Brasile 817
VN - Vietnam 582
DE - Germania 570
FR - Francia 558
SE - Svezia 535
HK - Hong Kong 435
UA - Ucraina 426
FI - Finlandia 304
KR - Corea 289
IN - India 177
ZA - Sudafrica 129
BD - Bangladesh 92
NL - Olanda 88
CA - Canada 86
TR - Turchia 75
ES - Italia 73
AR - Argentina 55
JP - Giappone 55
PL - Polonia 53
EE - Estonia 52
IQ - Iraq 50
AT - Austria 47
BE - Belgio 47
MX - Messico 44
KE - Kenya 42
NG - Nigeria 32
PK - Pakistan 32
ID - Indonesia 30
IR - Iran 28
SA - Arabia Saudita 26
EC - Ecuador 25
CZ - Repubblica Ceca 20
CH - Svizzera 18
CL - Cile 16
AU - Australia 15
CI - Costa d'Avorio 15
IL - Israele 15
LT - Lituania 15
UZ - Uzbekistan 15
JO - Giordania 13
BO - Bolivia 12
EG - Egitto 12
JM - Giamaica 12
VE - Venezuela 12
AE - Emirati Arabi Uniti 11
DZ - Algeria 11
MY - Malesia 11
AZ - Azerbaigian 10
KZ - Kazakistan 10
MA - Marocco 10
OM - Oman 10
PE - Perù 10
PT - Portogallo 10
RO - Romania 10
UY - Uruguay 10
AL - Albania 9
HU - Ungheria 9
TN - Tunisia 9
DK - Danimarca 8
CO - Colombia 7
PH - Filippine 7
PY - Paraguay 7
TW - Taiwan 7
GE - Georgia 6
GR - Grecia 6
LB - Libano 6
LV - Lettonia 6
NP - Nepal 6
SY - Repubblica araba siriana 6
BH - Bahrain 5
ET - Etiopia 5
EU - Europa 5
RS - Serbia 5
DO - Repubblica Dominicana 4
NO - Norvegia 4
PA - Panama 4
SK - Slovacchia (Repubblica Slovacca) 4
UG - Uganda 4
AO - Angola 3
BG - Bulgaria 3
CR - Costa Rica 3
NI - Nicaragua 3
QA - Qatar 3
TH - Thailandia 3
AM - Armenia 2
BY - Bielorussia 2
CG - Congo 2
CY - Cipro 2
HR - Croazia 2
IM - Isola di Man 2
KW - Kuwait 2
LA - Repubblica Popolare Democratica del Laos 2
MD - Moldavia 2
Totale 28.052
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Città #
Dallas 1.966
Southend 1.705
Fairfield 1.109
Dublin 1.074
Singapore 877
Ashburn 810
Chandler 623
Siena 593
Moscow 531
Santa Clara 517
Woodbridge 461
San Jose 427
Hong Kong 410
Seattle 397
Houston 381
Beijing 371
Jacksonville 342
Wilmington 341
Cambridge 337
Hefei 316
Seoul 271
Ann Arbor 259
Los Angeles 258
Milan 230
The Dalles 221
Munich 202
Princeton 182
Florence 181
Helsinki 177
Menlo Park 171
New York 163
Ho Chi Minh City 161
Lauterbourg 151
Council Bluffs 148
Hanoi 147
Rome 123
Johannesburg 112
Nanjing 101
Boardman 98
Shanghai 72
São Paulo 70
Buffalo 68
San Mateo 68
Fremont 64
San Diego 61
Bengaluru 60
Columbus 51
Chicago 50
Nanchang 49
Brussels 46
Tokyo 46
Redondo Beach 45
Izmir 41
London 41
Dearborn 40
Orem 40
Málaga 37
Nuremberg 35
Turku 35
Warsaw 35
Lappeenranta 31
Vienna 31
Abuja 30
Haiphong 30
Dong Ket 29
Redwood City 29
Toronto 29
Frankfurt am Main 28
Norwalk 28
Da Nang 27
Shenyang 27
Tianjin 27
Washington 27
Changsha 26
Rio de Janeiro 26
San Francisco 26
Belo Horizonte 25
Brescia 25
Denver 25
Phoenix 25
Atlanta 24
Guangzhou 24
Lancaster 24
Montreal 24
Düsseldorf 22
Jiaxing 21
Portsmouth 21
Baghdad 20
Boston 20
Chennai 20
Hebei 20
Stockholm 20
Kunming 19
Amsterdam 18
Bologna 16
Paris 16
Abidjan 15
Brasília 15
Brno 15
Jinan 15
Totale 18.938
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Nome #
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population 577
Association of toll-like receptor 7 variants with life-threatening COVID-19 disease in males: Findings from a nested case-control study 504
A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria 485
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity 463
Modello molecolare tridimensionale del peplomero del coronavirus della SARS come base razionale per la progettazione di farmaci e kit diagnostici 461
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males 418
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria 403
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium 362
Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon 354
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 349
Omic Approach in Non-Smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine 346
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 339
A structurally driven analysis of thiol reactivity in mammalian albumins 324
Revealing the complexity of a monogenic disease: rett syndrome exome sequencing 306
A combined ML and DFT strategy for the prediction of dye candidates for indoor DSSCs 301
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization 298
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow-induced chemoresistance in acute leukemias 291
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 291
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 289
Evidence of a new phosphoryl transfer system in nucleotide metabolism 284
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins 284
An Introduction to Personalized Nutrition 284
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies 276
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease 273
Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease 272
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 270
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria 267
Omicron variants of SARS CoV-2 indicate a new antiviral strategy: Interfere with spike glycoprotein trimerization 265
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human 264
Applications of in silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions 262
Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease 261
ProCoCoA: A quantitative approach for analyzing protein core composition 247
Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU 244
AKUImg: A database of cartilage images of Alkaptonuria patients 243
A structural genomics approach to sars coronavirus infection 240
Alkaptonuria 230
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 230
Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations 228
Towards an integrated interactive database for the search of stratification biomarkers in Alkaptonuria 224
Flavonoids and hERG channels: Friends or foes? 217
Computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases 215
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 213
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 212
Searching for protein binding sites from Molecular Dynamics simulations and paramagnetic fragment-based NMR studies 210
Artificial intelligence approaches in drug discovery: towards the laboratory of the future 208
Exploring the Antioxidant and Anti-Inflammatory Potential of Saffron (Crocus sativus) Tepals Extract within the Circular Bioeconomy 208
Bioinformatics approaches to predict mutation effects in the binding site of the proangiogenic molecule {CD}93 205
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 205
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model 204
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 204
Personalized nutrition and omics technologies 204
Probing protein surface accessibility with solvent and paramagnetic molecules 203
A structural genomics approach to sars coronavirus infection 202
Vasorelaxing activity of R-(-)-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 Channels 200
Cell and tissue models of alkaptonuria 200
Structural investigation of Rett-inducing MeCP2 mutations 198
NMR studies of lysozyme surface accessibility by using different paramagnetic relaxation probes 198
Omics-based technologies for food authentication and traceability 197
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein 196
Three-dimensional computation of atom depth in complex molecular structures 196
Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite 194
The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers 191
Peptide-protein interactions studied by surface plasmon and nuclear magnetic resonances 188
Coumarins Isolated from Murraya paniculata in Vietnam and Their Inhibitory Effects against Enzyme Soluble Epoxide Hydrolase (sEH) 187
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors 187
On the dynamics of water molecules at the protein solute interfaces. 185
Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract 184
Towards a precision medicine approach based on machine learning for tailoring medical treatment in Alkaptonuria 184
ApreciseKUre: an approach of Precision Medicine in a Rare Disease 184
NMR studies of protein hydration and TEMPOL accessibility 181
Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a 180
Prediction of quaternary assembly of SARS coronavirus peplomer 178
NMR studies of protein surface accessibility 178
NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide 177
Metal ion complexation and folding of linear peptides 177
Proteomic profiling reveals mitochondrial alterations in Rett syndrome 177
Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model 175
Structural bioinformatic survey of protein-small molecule interfaces delineates the role of glycine in surface pocket formation 175
Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies 174
FOXG1 is responsible for the congenital variant of Rett syndrome. 174
Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe 174
Tertiary structure prediction of SARS coronavirus helicase 173
Structure and function correlations between the rat liver threonine deaminase and aminotransferases 171
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 168
NMR and MD studies on the interaction between ligand peptides and alpha-bungarotoxin 167
Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage 167
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) [Cribado virtual de antraquinonas procedentes de Prismatomeris memecyloides como inhibidores noveles de fosfodiesterasa tipo 5 (PDE-5Is)] 166
Pharmacological and in silico analysis of oat avenanthramides as EGFR inhibitors: effects on EGF-induced lung cancer cell growth and migration 165
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes 164
Computational approaches integrated in a digital ecosystem platform for a rare disease 160
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus 160
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 160
NMR studies of the inclusion complex between β-cyclodextrin and paroxetine 159
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? 158
NMR studies of BPTI aggregation by using paramagnetic relaxation reagents 157
Probing the protein space for extending the detection of weak homology folds 155
NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor 153
Multi-omics model applied to cancer genetics 152
NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes 152
Structural Bioinformatics to unveil weaknesses of coronavirus spike glycoprotein stability 150
Totale 23.465
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Categoria #
all - tutte 84.859
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 84.859
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021159 0 0 0 0 0 0 0 0 0 0 0 159
2021/20222.060 201 250 175 136 108 104 129 78 136 197 197 349
2022/20232.356 154 236 292 300 212 428 104 181 223 71 96 59
2023/20242.027 92 66 203 85 101 503 588 39 13 32 93 212
2024/20254.453 101 172 384 292 500 302 271 311 395 240 485 1.000
2025/202610.093 789 1.537 1.673 1.156 1.759 408 1.135 346 344 526 275 145
Totale 28.519