IRIS
SPIGA, OTTAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 10.439
EU - Europa 9.632
AS - Asia 4.106
SA - Sud America 880
AF - Africa 94
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 8
Totale 25.174
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Nazione #
US - Stati Uniti d'America 10.322
IT - Italia 2.069
GB - Regno Unito 1.937
RU - Federazione Russa 1.905
CN - Cina 1.443
SG - Singapore 1.262
IE - Irlanda 1.086
BR - Brasile 759
DE - Germania 548
SE - Svezia 534
UA - Ucraina 419
FR - Francia 417
HK - Hong Kong 371
FI - Finlandia 286
KR - Corea 285
VN - Vietnam 232
IN - India 137
ES - Italia 67
TR - Turchia 66
NL - Olanda 62
CA - Canada 61
EE - Estonia 52
BE - Belgio 47
AR - Argentina 46
BD - Bangladesh 45
JP - Giappone 45
AT - Austria 42
PL - Polonia 42
MX - Messico 36
IR - Iran 27
ZA - Sudafrica 27
IQ - Iraq 24
ID - Indonesia 23
PK - Pakistan 23
CZ - Repubblica Ceca 20
EC - Ecuador 19
SA - Arabia Saudita 17
CH - Svizzera 16
CI - Costa d'Avorio 14
IL - Israele 14
LT - Lituania 14
AU - Australia 13
CL - Cile 12
KE - Kenya 11
PT - Portogallo 10
UZ - Uzbekistan 10
AE - Emirati Arabi Uniti 9
BO - Bolivia 9
DZ - Algeria 9
KZ - Kazakistan 9
PE - Perù 9
VE - Venezuela 9
AL - Albania 8
HU - Ungheria 8
DK - Danimarca 7
MA - Marocco 7
RO - Romania 7
TN - Tunisia 7
TW - Taiwan 7
AZ - Azerbaigian 6
CO - Colombia 6
EG - Egitto 6
JM - Giamaica 6
JO - Giordania 6
LV - Lettonia 6
UY - Uruguay 6
BH - Bahrain 5
EU - Europa 5
GE - Georgia 5
OM - Oman 5
PY - Paraguay 5
ET - Etiopia 4
GR - Grecia 4
MY - Malesia 4
PH - Filippine 4
RS - Serbia 4
CR - Costa Rica 3
DO - Repubblica Dominicana 3
LB - Libano 3
NP - Nepal 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
HR - Croazia 2
LA - Repubblica Popolare Democratica del Laos 2
MN - Mongolia 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PR - Porto Rico 2
QA - Qatar 2
SN - Senegal 2
TH - Thailandia 2
UG - Uganda 2
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A2 - ???statistics.table.value.countryCode.A2??? 1
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BS - Bahamas 1
Totale 25.158
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Città #
Dallas 1.948
Southend 1.705
Fairfield 1.109
Dublin 1.072
Ashburn 726
Singapore 721
Chandler 623
Siena 593
Moscow 531
Santa Clara 498
Woodbridge 461
Seattle 396
Houston 378
Beijing 367
Hong Kong 363
Jacksonville 341
Wilmington 341
Cambridge 337
Hefei 271
Seoul 271
Ann Arbor 259
Los Angeles 205
Munich 202
Milan 189
Princeton 182
Menlo Park 171
Florence 168
Helsinki 159
New York 135
The Dalles 122
Rome 103
Nanjing 101
Boardman 98
Shanghai 69
San Mateo 68
São Paulo 65
Fremont 64
Ho Chi Minh City 64
Buffalo 62
Bengaluru 60
San Diego 60
Council Bluffs 54
Hanoi 52
Columbus 50
Nanchang 49
Brussels 46
Redondo Beach 45
Chicago 42
Dearborn 40
Izmir 40
London 40
Tokyo 39
Málaga 37
Turku 35
Nuremberg 32
Lappeenranta 31
Lauterbourg 30
Dong Ket 29
Redwood City 29
Vienna 29
Norwalk 28
Shenyang 27
Warsaw 27
Tianjin 26
Changsha 25
Denver 25
San Francisco 25
Brescia 24
Phoenix 24
Washington 24
Guangzhou 23
Lancaster 23
Rio de Janeiro 23
Atlanta 22
Belo Horizonte 22
Düsseldorf 22
Jiaxing 21
Portsmouth 21
Hebei 20
Kunming 19
Montreal 19
Stockholm 19
Toronto 19
Boston 17
Brno 15
Jinan 15
Johannesburg 15
Abidjan 14
Perugia 14
Rocca Di Neto 14
Brasília 13
Brooklyn 13
Frankfurt am Main 13
Hangzhou 13
Lucca 13
Prato 13
San Jose 13
Monteriggioni 12
Jeddah 11
Orem 11
Totale 17.164
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Nome #
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population 549
Association of toll-like receptor 7 variants with life-threatening COVID-19 disease in males: Findings from a nested case-control study 458
A new integrated and interactive tool applicable to inborn errors of metabolism: Application to alkaptonuria 454
Modello molecolare tridimensionale del peplomero del coronavirus della SARS come base razionale per la progettazione di farmaci e kit diagnostici 438
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity 417
Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria 377
Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium 341
Beer promotes differentiation and mineralization of human osteoblastic cells: Role of silicon 333
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males 331
Omic Approach in Non-Smoker Female with Lung Squamous Cell Carcinoma Pinpoints to Germline Susceptibility and Personalized Medicine 328
From in silico to in vitro: A trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel 322
Negative chronotropism, positive inotropism and lusitropism of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on rat heart preparations occur through reduction of RyR2 Ca2+ leak 320
A structurally driven analysis of thiol reactivity in mammalian albumins 299
Revealing the complexity of a monogenic disease: rett syndrome exome sequencing 291
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow-induced chemoresistance in acute leukemias 276
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 274
A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization 268
Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A 267
An Introduction to Personalized Nutrition 265
Evidence of a new phosphoryl transfer system in nucleotide metabolism 264
Cav1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: Electrophysiological, functional, and molecular docking studies 264
Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins 258
The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels 254
Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease 254
A combined ML and DFT strategy for the prediction of dye candidates for indoor DSSCs 246
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease 244
Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria 242
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human 241
Applications of in silico Methods for Design and Development of Drugs Targeting Protein-Protein Interactions 239
Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease 239
Omicron variants of SARS CoV-2 indicate a new antiviral strategy: Interfere with spike glycoprotein trimerization 237
ProCoCoA: A quantitative approach for analyzing protein core composition 234
Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU 228
Hydration studies on the archaeal protein Sso7d using NMR measurements and MD simulations 220
AKUImg: A database of cartilage images of Alkaptonuria patients 216
A structural genomics approach to sars coronavirus infection 212
Towards an integrated interactive database for the search of stratification biomarkers in Alkaptonuria 206
A multitarget semi-synthetic derivative of the flavonoid morin with improved in vitro vasorelaxant activity: Role of CaV1.2 and KCa1.1 channels 203
Flavonoids and hERG channels: Friends or foes? 202
Computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases 200
Design, synthesis and pharmacological evaluation of ester-based quercetin derivatives as selective vascular KCa1.1 channel stimulators 198
The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels 197
Searching for protein binding sites from Molecular Dynamics simulations and paramagnetic fragment-based NMR studies 193
Alkaptonuria 191
Probing protein surface accessibility with solvent and paramagnetic molecules 190
The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells 187
Cell and tissue models of alkaptonuria 187
2-Hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl(E)-3-(4-hydroxy-3-methoxyphenyl)acrylate: synthesis, in silico analysis and in vitro pharmacological evaluation 187
Protein-thiol substitution or protein dethiolation by thiol/disulfide exchange reactions: the albumin model 184
Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite 184
Personalized nutrition and omics technologies 184
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein 183
Vasorelaxing activity of R-(-)-3'-Hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 Channels 183
Bioinformatics approaches to predict mutation effects in the binding site of the proangiogenic molecule {CD}93 182
Structural investigation of Rett-inducing MeCP2 mutations 182
Three-dimensional computation of atom depth in complex molecular structures 181
Peptide-protein interactions studied by surface plasmon and nuclear magnetic resonances 181
A structural genomics approach to sars coronavirus infection 180
NMR studies of lysozyme surface accessibility by using different paramagnetic relaxation probes 180
On the dynamics of water molecules at the protein solute interfaces. 176
NMR studies of protein hydration and TEMPOL accessibility 175
Artificial intelligence approaches in drug discovery: towards the laboratory of the future 173
Coumarins Isolated from Murraya paniculata in Vietnam and Their Inhibitory Effects against Enzyme Soluble Epoxide Hydrolase (sEH) 169
NMR studies of protein surface accessibility 169
Omics-based technologies for food authentication and traceability 169
Identification of Inhibitors Binding Site of Ebola L Polymerase Based on its Homology Model 167
NMR studies on Ni(II) induced cyclization of a histidine-tagged peptide 166
Prediction of quaternary assembly of SARS coronavirus peplomer 165
Metal ion complexation and folding of linear peptides 165
Structural bioinformatic survey of protein-small molecule interfaces delineates the role of glycine in surface pocket formation 164
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors 163
Structure and function correlations between the rat liver threonine deaminase and aminotransferases 162
ApreciseKUre: an approach of Precision Medicine in a Rare Disease 160
Tertiary structure prediction of SARS coronavirus helicase 158
Towards a precision medicine approach based on machine learning for tailoring medical treatment in Alkaptonuria 157
FOXG1 is responsible for the congenital variant of Rett syndrome. 155
On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus 153
NMR studies of the inclusion complex between β-cyclodextrin and paroxetine 152
NMR and MD studies on the interaction between ligand peptides and alpha-bungarotoxin 152
Probing the surface of a sweet protein: NMR study of MNEI with a paramagnetic probe 152
In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) [Cribado virtual de antraquinonas procedentes de Prismatomeris memecyloides como inhibidores noveles de fosfodiesterasa tipo 5 (PDE-5Is)] 152
Proteomic profiling reveals mitochondrial alterations in Rett syndrome 152
Fine tuning by protein kinases of CaV1.2 channel current in rat tail artery myocytes 151
Pharmacological and in silico analysis of oat avenanthramides as EGFR inhibitors: effects on EGF-induced lung cancer cell growth and migration 148
Mycobacterium tuberculosis chaperonin 10 is secreted in the macrophage phagosome: is secretion due to dissociation and adoption of a partially helical structure at the membrane? 148
NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor 148
NMR studies on the surface accessibility of the archaeal protein Sso7d by using TEMPOL and Gd(III)(DTPA-BMA) as paramagnetic probes 146
NMR studies of BPTI aggregation by using paramagnetic relaxation reagents 146
The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers 144
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators 144
Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage 143
Computational approaches integrated in a digital ecosystem platform for a rare disease 142
Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a 142
Phytochemical Composition, Anti-Inflammatory Property, and Anti-Atopic Effect of Chaetomorpha linum Extract 141
Functional, electrophysiology, and molecular dynamics analysis of quercetin-induced contraction of rat vascular musculature 140
Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies 137
Histidyl tags and structural stabilization of linear peptides 136
Probing the protein space for extending the detection of weak homology folds 135
Structural Bioinformatics to unveil weaknesses of coronavirus spike glycoprotein stability 135
Multi-omics model applied to cancer genetics 134
Totale 21.331
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Categoria #
all - tutte 77.361
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 77.361
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.727 0 0 0 0 0 265 162 321 237 314 269 159
2021/20222.060 201 250 175 136 108 104 129 78 136 197 197 349
2022/20232.356 154 236 292 300 212 428 104 181 223 71 96 59
2023/20242.027 92 66 203 85 101 503 588 39 13 32 93 212
2024/20254.453 101 172 384 292 500 302 271 311 395 240 485 1.000
2025/20267.181 789 1.537 1.673 1.156 1.759 267 0 0 0 0 0 0
Totale 25.607