The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.
Bernini, A., Spiga, O., Ciutti, A., Chiellini, S., Bracci, L., Yan, X., et al. (2004). Prediction of quaternary assembly of SARS coronavirus peplomer. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 325(4), 1210-1214 [10.1016/j.bbrc.2004.10.156].
Prediction of quaternary assembly of SARS coronavirus peplomer
Bernini, A.;Spiga, Ottavia;Bracci, Luisa;Niccolai, Neri
2004-01-01
Abstract
The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.File | Dimensione | Formato | |
---|---|---|---|
BBRC_2004.pdf
non disponibili
Tipologia:
PDF editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
754.65 kB
Formato
Adobe PDF
|
754.65 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/19147
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo