IRIS
MUGNAINI, CLAUDIA
 Distribuzione geografica
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Continente #
NA - Nord America 4.716
EU - Europa 4.044
AS - Asia 585
OC - Oceania 7
AF - Africa 6
SA - Sud America 6
Continente sconosciuto - Info sul continente non disponibili 1
Totale 9.365
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Nazione #
US - Stati Uniti d'America 4.702
GB - Regno Unito 1.154
IE - Irlanda 744
IT - Italia 668
CN - Cina 433
SE - Svezia 370
UA - Ucraina 362
FR - Francia 284
DE - Germania 204
FI - Finlandia 120
TR - Turchia 61
SG - Singapore 50
RU - Federazione Russa 43
ES - Italia 16
CZ - Repubblica Ceca 13
BE - Belgio 12
IN - India 11
CA - Canada 10
RO - Romania 10
PL - Polonia 9
AU - Australia 7
NL - Olanda 7
AT - Austria 6
BG - Bulgaria 5
EG - Egitto 4
HK - Hong Kong 4
PK - Pakistan 4
KR - Corea 3
MX - Messico 3
SA - Arabia Saudita 3
VN - Vietnam 3
CL - Cile 2
EE - Estonia 2
HU - Ungheria 2
JP - Giappone 2
LK - Sri Lanka 2
LV - Lettonia 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
AM - Armenia 1
AR - Argentina 1
BD - Bangladesh 1
BO - Bolivia 1
BR - Brasile 1
CH - Svizzera 1
DK - Danimarca 1
DZ - Algeria 1
EU - Europa 1
IL - Israele 1
IR - Iran 1
JM - Giamaica 1
KZ - Kazakistan 1
MD - Moldavia 1
NG - Nigeria 1
NO - Norvegia 1
OM - Oman 1
PE - Perù 1
PT - Portogallo 1
RS - Serbia 1
SY - Repubblica araba siriana 1
TW - Taiwan 1
Totale 9.365
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Città #
Southend 1.074
Dublin 743
Fairfield 743
Menlo Park 426
Woodbridge 365
Ashburn 345
Chandler 319
Jacksonville 296
Wilmington 294
Houston 280
Seattle 273
Cambridge 269
Siena 239
Ann Arbor 169
Princeton 124
Beijing 114
Nanjing 89
Boardman 61
Helsinki 61
Izmir 56
Fremont 52
Florence 48
San Mateo 42
San Diego 40
Nanchang 36
Dearborn 33
Moscow 33
Rome 33
New York 32
Singapore 31
Milan 27
Shenyang 27
Shanghai 21
London 19
Tianjin 18
Anguillara Sabazia 16
Hebei 15
Düsseldorf 13
Jiaxing 13
Jinan 13
Redwood City 12
Brno 11
Brussels 11
Chicago 11
Kunming 11
Norwalk 11
Málaga 10
Changsha 9
Mogliano 9
Munich 9
Paris 9
San Francisco 9
Urlati 9
Candiolo 8
Hangzhou 8
Zhengzhou 8
Aligarh 7
Cardiff 7
Lancaster 7
Ningbo 7
Bari 6
Galatone 6
Guangzhou 6
Mestre 6
Venezia 6
Vienna 6
Certaldo 5
Changchun 5
Hefei 5
Lanzhou 5
Mestrino 5
Naples 5
Sofia 5
Valencia 5
Arconate 4
Como 4
Fucecchio 4
Lastra a Signa 4
Latina 4
Livorno 4
Melbourne 4
Port Talbot 4
Toronto 4
Turku 4
Atlanta 3
Berlin 3
Bonndorf 3
Cagliari 3
Chiswick 3
Edinburgh 3
Empoli 3
Falkenstein 3
Groningen 3
Ho Chi Minh City 3
Islington 3
Kilburn 3
Krakow 3
Montemiletto 3
Ottawa 3
Sesto Fiorentino 3
Totale 7.249
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Nome #
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: preliminary in vitro studies with analogues of immucillin-G 241
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease 217
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 198
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 197
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors 188
null 186
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 177
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor 170
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains 165
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 161
Synthesis, 1 structural properties, and pharmacological evaluation of 2-(acylamino)thiophene-3-carboxamides and analogues thereof 159
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 158
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 155
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 149
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol. 147
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors 145
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands 144
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 143
NUOVA TERAPIA PER IL TRATTAMENTO DELL'IPERURICEMIA NELLA SINDROME DI LESCH-NYHAN 142
Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives 141
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors 141
Chiral Azole Derivatives, 3. Synthesis of the Enantiomers of the Potent Aromatase Inhibitor 1-[2-Benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole 141
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity 141
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 140
Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen 140
Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle 139
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions 136
Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening 136
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice 134
Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists 134
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies 133
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 130
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice 130
Solution-phase parallel synthesis of S-DABO analogues 127
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor 127
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands 126
Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure 126
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure-Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo 124
Rational design and synthesis of homochiral azole antifungal agents 123
Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 121
Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase 121
A new linker for anchoring/masking primary amines on solid support 121
The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry 120
Total Synthesis of δ-Sanshool and Analogues Thereof 119
Practical synthesis of novel purine analogues as Hsp90 inhibitors. 118
The bioisosteric concept applied to cannabinoid ligands 118
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 115
Parallel Solution-Phase and Microwave-Assisted Synthesis of New S-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity 113
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors 111
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands 109
Microwave-assisted acylation of amines, alcohols and phenols by the use of solid-supported reagents (SSRs) 106
Synthesis and biological evaluation of thiophene-based cannabinoid receptor type 2 radiotracers for PET imaging 105
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors 103
Precise structure activity relationships in asymmetric catalysis using carbohydrate scaffolds to allow ready fine tuning: dialkylzinc-aldehyde additions 96
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold 96
USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO 94
Research on L-Nucleosides. Synthesis and Biological Evaluation of a Series of L- and D-2’,3’-Dideoxy-3’-[Tris(methylthio)methyl]-β-Pentofuranosyl Nucleosides 94
Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats 93
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists 91
Simplified Analogs Of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 91
Chiral Azole Derivatives. 4. Enantiomers of Bifonazole and Related Antifungal Agents: Stereoselective Synthesis, Configuration Assignment, and Biological Evaluation 88
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors 87
The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective 87
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues 86
COR758, a negative allosteric modulator of GABAB receptors 84
Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences 80
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 77
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse 76
Chemistry of GABAB receptor ligands: focus on agonists and antagonists 75
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo 73
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors 71
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats 68
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands 65
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress 58
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats 58
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 52
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators 52
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 44
Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. 30
In silico multi-target approach revealed potential lead compounds as scaffold for the synthesis of chemical analogues targeting SARS-CoV-2 24
Totale 9.501
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Categoria #
all - tutte 29.998
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.998
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.007 253 78 104 294 178 159 144 226 172 174 95 130
2020/20211.644 71 144 27 180 104 175 124 217 160 229 135 78
2021/20221.030 87 136 78 104 29 42 57 39 39 119 90 210
2022/20231.398 97 94 205 171 136 297 44 121 128 34 52 19
2023/20241.256 71 24 83 101 50 268 418 35 11 19 28 148
2024/202534 34 0 0 0 0 0 0 0 0 0 0 0
Totale 9.501