IRIS
MUGNAINI, CLAUDIA
 Distribuzione geografica
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Continente #
NA - Nord America 7.447
EU - Europa 5.817
AS - Asia 3.431
SA - Sud America 603
AF - Africa 164
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 2
Totale 17.474
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Nazione #
US - Stati Uniti d'America 7.339
GB - Regno Unito 1.225
CN - Cina 1.076
RU - Federazione Russa 1.057
SG - Singapore 1.036
IT - Italia 971
IE - Irlanda 745
BR - Brasile 504
FR - Francia 386
SE - Svezia 381
UA - Ucraina 374
VN - Vietnam 332
DE - Germania 282
HK - Hong Kong 271
KR - Corea 196
FI - Finlandia 175
IN - India 119
BD - Bangladesh 106
TR - Turchia 81
ZA - Sudafrica 73
AR - Argentina 46
MX - Messico 46
CA - Canada 41
ES - Italia 38
JP - Giappone 38
PL - Polonia 28
NL - Olanda 27
CI - Costa d'Avorio 23
IQ - Iraq 21
NG - Nigeria 19
PK - Pakistan 19
AT - Austria 16
BE - Belgio 16
CZ - Repubblica Ceca 15
SA - Arabia Saudita 15
ID - Indonesia 13
TW - Taiwan 13
EG - Egitto 11
RO - Romania 11
AE - Emirati Arabi Uniti 10
AU - Australia 10
EC - Ecuador 10
LT - Lituania 10
CH - Svizzera 9
CO - Colombia 9
JO - Giordania 9
PY - Paraguay 9
MY - Malesia 8
PT - Portogallo 8
CL - Cile 7
KE - Kenya 7
MA - Marocco 7
NP - Nepal 7
TN - Tunisia 7
UZ - Uzbekistan 7
AL - Albania 6
BG - Bulgaria 6
DZ - Algeria 6
RS - Serbia 6
IL - Israele 5
IR - Iran 5
KZ - Kazakistan 5
PE - Perù 5
UY - Uruguay 5
DO - Repubblica Dominicana 4
ET - Etiopia 4
GE - Georgia 4
HN - Honduras 4
LB - Libano 4
LV - Lettonia 4
PH - Filippine 4
SN - Senegal 4
VE - Venezuela 4
AM - Armenia 3
CR - Costa Rica 3
GR - Grecia 3
KW - Kuwait 3
LK - Sri Lanka 3
MD - Moldavia 3
OM - Oman 3
SK - Slovacchia (Repubblica Slovacca) 3
AZ - Azerbaigian 2
BH - Bahrain 2
BO - Bolivia 2
EE - Estonia 2
HR - Croazia 2
HU - Ungheria 2
JM - Giamaica 2
MM - Myanmar 2
PA - Panama 2
PS - Palestinian Territory 2
SI - Slovenia 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
AO - Angola 1
BF - Burkina Faso 1
BM - Bermuda 1
BY - Bielorussia 1
CY - Cipro 1
Totale 17.461
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Città #
Southend 1.074
Dallas 995
Dublin 744
Fairfield 743
Singapore 585
Ashburn 479
Menlo Park 426
Woodbridge 365
Santa Clara 329
Chandler 319
Jacksonville 299
Wilmington 294
Beijing 288
Houston 283
Moscow 281
Seattle 277
Cambridge 269
Hong Kong 261
Siena 261
San Jose 256
Hefei 213
Seoul 190
Ann Arbor 169
The Dalles 151
Princeton 124
Ho Chi Minh City 119
Los Angeles 109
Milan 97
Helsinki 93
Nanjing 90
Florence 88
Hanoi 75
Lauterbourg 75
New York 73
Johannesburg 66
Boardman 61
Council Bluffs 59
Izmir 56
Fremont 54
Buffalo 51
São Paulo 47
Rome 45
San Diego 42
San Mateo 42
Munich 40
Nanchang 36
Bengaluru 33
Dearborn 33
Shanghai 31
London 30
Frankfurt am Main 29
Shenyang 28
Tokyo 28
Chicago 25
Abidjan 23
Tianjin 23
Columbus 22
Turku 22
Chennai 21
Orem 20
Rio de Janeiro 18
San Francisco 18
Abuja 17
Düsseldorf 17
Haiphong 17
Mumbai 17
Anguillara Sabazia 16
Redondo Beach 16
Hebei 15
Brooklyn 14
Brussels 14
Guangzhou 14
Jiaxing 13
Jinan 13
Mexico City 13
Vienna 13
Atlanta 12
Cardiff 12
Montreal 12
Paris 12
Redwood City 12
Warsaw 12
Bari 11
Belo Horizonte 11
Brno 11
Changsha 11
Da Nang 11
Kunming 11
Norwalk 11
Phoenix 11
Zhengzhou 11
Guarulhos 10
L’Aquila 10
Málaga 10
Naples 10
Amsterdam 9
Boston 9
Brasília 9
Denver 9
Mogliano 9
Totale 11.962
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Nome #
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: preliminary in vitro studies with analogues of immucillin-G 360
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold 355
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor 317
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 314
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease 307
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 298
Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists 277
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains 275
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice 274
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 270
Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening 262
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors 254
Synthesis, 1 structural properties, and pharmacological evaluation of 2-(acylamino)thiophene-3-carboxamides and analogues thereof 251
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 251
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 247
A new linker for anchoring/masking primary amines on solid support 247
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 245
NUOVA TERAPIA PER IL TRATTAMENTO DELL'IPERURICEMIA NELLA SINDROME DI LESCH-NYHAN 245
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 245
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol. 243
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 242
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands 239
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions 239
Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle 236
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 235
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 235
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors 235
Chiral Azole Derivatives, 3. Synthesis of the Enantiomers of the Potent Aromatase Inhibitor 1-[2-Benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole 234
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo 232
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors 228
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice 228
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors 227
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure-Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo 226
Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives 221
Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure 217
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists 214
Solution-phase parallel synthesis of S-DABO analogues 214
COR758, a negative allosteric modulator of GABAB receptors 210
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies 208
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands 208
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 204
Chiral Azole Derivatives. 4. Enantiomers of Bifonazole and Related Antifungal Agents: Stereoselective Synthesis, Configuration Assignment, and Biological Evaluation 202
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues 202
Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 201
The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry 199
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor 198
Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats 198
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity 198
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors 194
Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen 192
Rational design and synthesis of homochiral azole antifungal agents 189
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands 187
Practical synthesis of novel purine analogues as Hsp90 inhibitors. 187
null 186
Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase 184
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 183
Parallel Solution-Phase and Microwave-Assisted Synthesis of New S-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity 181
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 179
The bioisosteric concept applied to cannabinoid ligands 175
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors 174
Chemistry of GABAB receptor ligands: focus on agonists and antagonists 171
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 167
Microwave-assisted acylation of amines, alcohols and phenols by the use of solid-supported reagents (SSRs) 164
Total Synthesis of δ-Sanshool and Analogues Thereof 160
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress 159
USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO 159
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse 159
Synthesis and biological evaluation of thiophene-based cannabinoid receptor type 2 radiotracers for PET imaging 148
Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates 147
Precise structure activity relationships in asymmetric catalysis using carbohydrate scaffolds to allow ready fine tuning: dialkylzinc-aldehyde additions 147
Research on L-Nucleosides. Synthesis and Biological Evaluation of a Series of L- and D-2’,3’-Dideoxy-3’-[Tris(methylthio)methyl]-β-Pentofuranosyl Nucleosides 147
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 146
Simplified Analogs Of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 146
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors 144
Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists 143
Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences 142
The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective 142
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands 140
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats 136
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor 124
In silico multi-target approach revealed potential lead compounds as scaffold for the synthesis of chemical analogues targeting SARS-CoV-2 122
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats 116
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 113
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 112
Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. 104
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators 100
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition 97
Targeting TRPA1 with Novel Synthetic Compounds Based on Different Scaffolds to Reduce Acute and Chronic Pain 5
Light-Controlled Modulation of the Endocannabinoid System: Photoswitchable Ligands for Cannabinoid and TRPV1 Receptors 4
GABAB Receptor signaling in CA1 Pyramidal Cells is not Regulated by Aging in the APP/PS1 Mouse Model of Amyloid Pathology 4
A sesquiterpene-rich essential oil from Cannabis sativa L. attenuates symptoms and neuroinflammation in experimental autoimmune encephalomyelitis model through a CB2-mediated signalling 4
Totale 17.650
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Categoria #
all - tutte 54.000
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.000
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202178 0 0 0 0 0 0 0 0 0 0 0 78
2021/20221.030 87 136 78 104 29 42 57 39 39 119 90 210
2022/20231.398 97 94 205 171 136 297 44 121 128 34 52 19
2023/20241.256 71 24 83 101 50 268 418 35 11 19 28 148
2024/20252.459 56 134 237 141 279 136 94 149 240 123 230 640
2025/20265.724 478 1.150 618 633 1.000 218 642 190 198 273 191 133
Totale 17.650