IRIS
MUGNAINI, CLAUDIA
 Distribuzione geografica
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Continente #
NA - Nord America 7.243
EU - Europa 5.757
AS - Asia 3.327
SA - Sud America 603
AF - Africa 163
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 2
Totale 17.105
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Nazione #
US - Stati Uniti d'America 7.151
GB - Regno Unito 1.225
CN - Cina 1.067
RU - Federazione Russa 1.057
SG - Singapore 1.024
IT - Italia 912
IE - Irlanda 745
BR - Brasile 504
FR - Francia 386
SE - Svezia 381
UA - Ucraina 374
VN - Vietnam 332
DE - Germania 282
HK - Hong Kong 262
KR - Corea 196
FI - Finlandia 175
IN - India 119
TR - Turchia 81
ZA - Sudafrica 73
AR - Argentina 46
MX - Messico 41
ES - Italia 37
JP - Giappone 37
CA - Canada 35
BD - Bangladesh 34
PL - Polonia 28
NL - Olanda 27
CI - Costa d'Avorio 23
IQ - Iraq 21
NG - Nigeria 19
PK - Pakistan 19
AT - Austria 16
BE - Belgio 16
CZ - Repubblica Ceca 15
SA - Arabia Saudita 15
ID - Indonesia 13
TW - Taiwan 13
EG - Egitto 11
RO - Romania 11
AE - Emirati Arabi Uniti 10
AU - Australia 10
EC - Ecuador 10
LT - Lituania 10
CH - Svizzera 9
CO - Colombia 9
JO - Giordania 9
PY - Paraguay 9
PT - Portogallo 8
CL - Cile 7
KE - Kenya 7
MA - Marocco 7
MY - Malesia 7
NP - Nepal 7
UZ - Uzbekistan 7
AL - Albania 6
BG - Bulgaria 6
DZ - Algeria 6
RS - Serbia 6
TN - Tunisia 6
IL - Israele 5
IR - Iran 5
KZ - Kazakistan 5
PE - Perù 5
UY - Uruguay 5
DO - Repubblica Dominicana 4
ET - Etiopia 4
GE - Georgia 4
LB - Libano 4
LV - Lettonia 4
PH - Filippine 4
SN - Senegal 4
VE - Venezuela 4
AM - Armenia 3
GR - Grecia 3
HN - Honduras 3
KW - Kuwait 3
LK - Sri Lanka 3
MD - Moldavia 3
OM - Oman 3
SK - Slovacchia (Repubblica Slovacca) 3
AZ - Azerbaigian 2
BH - Bahrain 2
BO - Bolivia 2
CR - Costa Rica 2
EE - Estonia 2
HR - Croazia 2
HU - Ungheria 2
MM - Myanmar 2
PA - Panama 2
PS - Palestinian Territory 2
SI - Slovenia 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
AO - Angola 1
BF - Burkina Faso 1
BM - Bermuda 1
BY - Bielorussia 1
CY - Cipro 1
DK - Danimarca 1
EU - Europa 1
Totale 17.093
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Città #
Southend 1.074
Dallas 990
Dublin 743
Fairfield 743
Singapore 582
Ashburn 466
Menlo Park 426
Woodbridge 365
Chandler 319
Santa Clara 316
Jacksonville 299
Wilmington 294
Beijing 286
Houston 283
Moscow 281
Seattle 277
Cambridge 269
Siena 261
Hong Kong 252
Hefei 213
San Jose 193
Seoul 190
Ann Arbor 169
The Dalles 151
Princeton 124
Ho Chi Minh City 119
Los Angeles 101
Helsinki 93
Nanjing 89
Florence 85
Milan 81
Hanoi 75
Lauterbourg 75
Johannesburg 66
Boardman 61
Council Bluffs 59
New York 58
Izmir 56
Fremont 54
Buffalo 47
São Paulo 47
San Diego 42
San Mateo 42
Munich 40
Rome 39
Nanchang 36
Bengaluru 33
Dearborn 33
Shanghai 31
London 30
Frankfurt am Main 29
Shenyang 28
Tokyo 28
Chicago 25
Abidjan 23
Tianjin 23
Columbus 22
Turku 22
Chennai 21
Orem 20
Rio de Janeiro 18
Abuja 17
Düsseldorf 17
Haiphong 17
Mumbai 17
San Francisco 17
Anguillara Sabazia 16
Redondo Beach 16
Hebei 15
Brooklyn 14
Brussels 14
Guangzhou 14
Jiaxing 13
Jinan 13
Vienna 13
Atlanta 12
Cardiff 12
Paris 12
Redwood City 12
Warsaw 12
Belo Horizonte 11
Brno 11
Changsha 11
Da Nang 11
Kunming 11
Montreal 11
Norwalk 11
Phoenix 11
Zhengzhou 11
Bari 10
Guarulhos 10
L’Aquila 10
Málaga 10
Naples 10
Amsterdam 9
Boston 9
Brasília 9
Denver 9
Mexico City 9
Mogliano 9
Totale 11.793
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Nome #
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: preliminary in vitro studies with analogues of immucillin-G 357
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor 316
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 311
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease 300
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 296
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold 285
Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists 274
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains 272
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice 270
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 269
Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening 261
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors 252
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 250
Synthesis, 1 structural properties, and pharmacological evaluation of 2-(acylamino)thiophene-3-carboxamides and analogues thereof 247
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 246
A new linker for anchoring/masking primary amines on solid support 246
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol. 243
NUOVA TERAPIA PER IL TRATTAMENTO DELL'IPERURICEMIA NELLA SINDROME DI LESCH-NYHAN 243
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 242
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 239
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions 237
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 237
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands 235
Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle 235
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 234
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors 234
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 233
Chiral Azole Derivatives, 3. Synthesis of the Enantiomers of the Potent Aromatase Inhibitor 1-[2-Benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole 231
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo 228
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors 225
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors 224
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice 223
Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives 221
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure-Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo 220
Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure 215
Solution-phase parallel synthesis of S-DABO analogues 212
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists 209
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies 205
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands 205
COR758, a negative allosteric modulator of GABAB receptors 204
Chiral Azole Derivatives. 4. Enantiomers of Bifonazole and Related Antifungal Agents: Stereoselective Synthesis, Configuration Assignment, and Biological Evaluation 201
Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 199
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity 198
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor 197
Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats 197
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues 196
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors 194
Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen 192
Rational design and synthesis of homochiral azole antifungal agents 187
null 186
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands 185
Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase 184
Practical synthesis of novel purine analogues as Hsp90 inhibitors. 183
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 183
The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry 180
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 178
Parallel Solution-Phase and Microwave-Assisted Synthesis of New S-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity 176
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 175
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors 174
The bioisosteric concept applied to cannabinoid ligands 172
Chemistry of GABAB receptor ligands: focus on agonists and antagonists 169
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 163
Microwave-assisted acylation of amines, alcohols and phenols by the use of solid-supported reagents (SSRs) 162
Total Synthesis of δ-Sanshool and Analogues Thereof 160
USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO 158
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress 155
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse 154
Synthesis and biological evaluation of thiophene-based cannabinoid receptor type 2 radiotracers for PET imaging 148
Precise structure activity relationships in asymmetric catalysis using carbohydrate scaffolds to allow ready fine tuning: dialkylzinc-aldehyde additions 147
Simplified Analogs Of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 146
Research on L-Nucleosides. Synthesis and Biological Evaluation of a Series of L- and D-2’,3’-Dideoxy-3’-[Tris(methylthio)methyl]-β-Pentofuranosyl Nucleosides 144
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors 143
Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates 141
The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective 141
Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences 139
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands 137
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats 135
Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists 134
In silico multi-target approach revealed potential lead compounds as scaffold for the synthesis of chemical analogues targeting SARS-CoV-2 121
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor 118
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 115
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats 115
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 112
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 101
Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. 100
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators 99
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition 93
Totale 17.273
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Categoria #
all - tutte 51.901
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.901
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021442 0 0 0 0 0 0 0 0 0 229 135 78
2021/20221.030 87 136 78 104 29 42 57 39 39 119 90 210
2022/20231.398 97 94 205 171 136 297 44 121 128 34 52 19
2023/20241.256 71 24 83 101 50 268 418 35 11 19 28 148
2024/20252.459 56 134 237 141 279 136 94 149 240 123 230 640
2025/20265.347 478 1.150 618 633 1.000 218 642 190 198 220 0 0
Totale 17.273