IRIS
MUGNAINI, CLAUDIA
 Distribuzione geografica
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Continente #
NA - Nord America 5.096
EU - Europa 4.409
AS - Asia 730
AF - Africa 29
SA - Sud America 24
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 1
Totale 10.297
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Nazione #
US - Stati Uniti d'America 5.076
GB - Regno Unito 1.155
IE - Irlanda 744
IT - Italia 723
CN - Cina 447
SE - Svezia 370
UA - Ucraina 362
RU - Federazione Russa 308
FR - Francia 285
DE - Germania 217
SG - Singapore 158
FI - Finlandia 131
TR - Turchia 61
CI - Costa d'Avorio 23
ES - Italia 16
BE - Belgio 14
CZ - Repubblica Ceca 14
BR - Brasile 13
CA - Canada 13
IN - India 12
NL - Olanda 11
RO - Romania 10
PL - Polonia 9
AU - Australia 8
AT - Austria 7
JP - Giappone 7
HK - Hong Kong 6
KR - Corea 6
PK - Pakistan 6
PT - Portogallo 6
BG - Bulgaria 5
TW - Taiwan 5
AR - Argentina 4
EG - Egitto 4
VN - Vietnam 4
AE - Emirati Arabi Uniti 3
CH - Svizzera 3
CL - Cile 3
LV - Lettonia 3
MX - Messico 3
SA - Arabia Saudita 3
SK - Slovacchia (Repubblica Slovacca) 3
BO - Bolivia 2
EE - Estonia 2
HU - Ungheria 2
LK - Sri Lanka 2
LT - Lituania 2
MY - Malesia 2
PE - Perù 2
SI - Slovenia 2
AL - Albania 1
AM - Armenia 1
BD - Bangladesh 1
CR - Costa Rica 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
EU - Europa 1
GE - Georgia 1
IL - Israele 1
IR - Iran 1
JM - Giamaica 1
KZ - Kazakistan 1
MD - Moldavia 1
NG - Nigeria 1
NO - Norvegia 1
OM - Oman 1
PA - Panama 1
RS - Serbia 1
SY - Repubblica araba siriana 1
Totale 10.297
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Città #
Southend 1.074
Dublin 743
Fairfield 743
Menlo Park 426
Woodbridge 365
Ashburn 349
Chandler 319
Santa Clara 298
Jacksonville 296
Wilmington 294
Houston 280
Seattle 273
Cambridge 269
Siena 261
Ann Arbor 169
Princeton 124
Beijing 115
Singapore 114
Nanjing 89
Helsinki 72
Boardman 61
Izmir 56
Florence 55
Fremont 53
San Mateo 42
San Diego 40
Nanchang 36
New York 34
Dearborn 33
Moscow 33
Rome 33
Milan 27
Shenyang 27
Abidjan 23
Shanghai 21
London 20
Munich 18
Tianjin 18
Anguillara Sabazia 16
Hebei 15
Brussels 13
Düsseldorf 13
Jiaxing 13
Jinan 13
Redwood City 12
Brno 11
Chicago 11
Kunming 11
Norwalk 11
San Francisco 11
Changsha 10
Málaga 10
Paris 10
Mogliano 9
Urlati 9
Candiolo 8
Hangzhou 8
Los Angeles 8
Zhengzhou 8
Aligarh 7
Bari 7
Cardiff 7
Lancaster 7
Naples 7
Ningbo 7
Vienna 7
Galatone 6
Guangzhou 6
Mestre 6
Venezia 6
Certaldo 5
Changchun 5
Clifton 5
Columbus 5
Hefei 5
Lanzhou 5
Lisbon 5
Mestrino 5
Ottawa 5
Sofia 5
Toronto 5
Valencia 5
Arconate 4
Como 4
Frankfurt am Main 4
Fucecchio 4
Ho Chi Minh City 4
Hong Kong 4
Lastra a Signa 4
Latina 4
Livorno 4
Melbourne 4
Port Talbot 4
Tokyo 4
Turku 4
Atlanta 3
Berlin 3
Bonndorf 3
Bratislava 3
Cagliari 3
Totale 7.733
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Nome #
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: preliminary in vitro studies with analogues of immucillin-G 255
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease 228
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 212
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 205
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors 194
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 191
null 186
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 184
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor 184
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains 178
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 173
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 173
Synthesis, 1 structural properties, and pharmacological evaluation of 2-(acylamino)thiophene-3-carboxamides and analogues thereof 168
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 160
NUOVA TERAPIA PER IL TRATTAMENTO DELL'IPERURICEMIA NELLA SINDROME DI LESCH-NYHAN 159
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol. 158
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors 156
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands 155
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors 153
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity 153
Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives 151
Chiral Azole Derivatives, 3. Synthesis of the Enantiomers of the Potent Aromatase Inhibitor 1-[2-Benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole 151
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 150
Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle 149
Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen 149
Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening 148
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice 148
Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists 148
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions 147
Towards new methodologies for the synthesis of biologically interesting 6-substituted pyrimidines and 4(3H)-pyrimidinones 147
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies 146
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice 144
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 143
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands 139
Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure 138
Solution-phase parallel synthesis of S-DABO analogues 137
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor 136
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure-Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo 133
A new linker for anchoring/masking primary amines on solid support 133
Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 132
Rational design and synthesis of homochiral azole antifungal agents 132
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold 130
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 129
The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry 128
Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase 126
The bioisosteric concept applied to cannabinoid ligands 125
Total Synthesis of δ-Sanshool and Analogues Thereof 125
Practical synthesis of novel purine analogues as Hsp90 inhibitors. 123
Parallel Solution-Phase and Microwave-Assisted Synthesis of New S-DABO Derivatives Endowed with Subnanomolar Anti-HIV-1 Activity 119
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists 117
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands 117
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors 116
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors 116
Microwave-assisted acylation of amines, alcohols and phenols by the use of solid-supported reagents (SSRs) 112
Synthesis and biological evaluation of thiophene-based cannabinoid receptor type 2 radiotracers for PET imaging 111
USO DI DERIVATI DELL’ACIDO 2-AMMINOTIOFEN-3- CARBOSSILICO PER IL TRATTAMENTO DELLE DIPENDENZE DA CIBO 107
Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats 105
Precise structure activity relationships in asymmetric catalysis using carbohydrate scaffolds to allow ready fine tuning: dialkylzinc-aldehyde additions 104
Research on L-Nucleosides. Synthesis and Biological Evaluation of a Series of L- and D-2’,3’-Dideoxy-3’-[Tris(methylthio)methyl]-β-Pentofuranosyl Nucleosides 102
Chiral Azole Derivatives. 4. Enantiomers of Bifonazole and Related Antifungal Agents: Stereoselective Synthesis, Configuration Assignment, and Biological Evaluation 100
Simplified Analogs Of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 98
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues 97
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors 95
COR758, a negative allosteric modulator of GABAB receptors 95
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 94
The allosteric modulation of the GABAB receptor: a medicinal chemistry perspective 94
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors 89
Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences 88
Chemistry of GABAB receptor ligands: focus on agonists and antagonists 88
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo 85
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse 85
New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands 80
Operant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats 73
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress 72
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 71
Suppressing effect of CMPPE, a new positive allosteric modulator of the GABAB receptor, on alcohol self-administration and reinstatement of alcohol seeking in rats 63
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators 59
The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives 51
Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. 38
In silico multi-target approach revealed potential lead compounds as scaffold for the synthesis of chemical analogues targeting SARS-CoV-2 31
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor 19
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 14
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 14
Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates 13
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition 6
Totale 10.450
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Categoria #
all - tutte 34.910
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.910
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020941 0 0 0 0 0 0 144 226 172 174 95 130
2020/20211.644 71 144 27 180 104 175 124 217 160 229 135 78
2021/20221.030 87 136 78 104 29 42 57 39 39 119 90 210
2022/20231.398 97 94 205 171 136 297 44 121 128 34 52 19
2023/20241.256 71 24 83 101 50 268 418 35 11 19 28 148
2024/2025983 56 134 237 141 279 136 0 0 0 0 0 0
Totale 10.450