S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.
Mugnaini, C., Manetti, F., EST J., A., CLOTET CODINA, I., Maga, G., Cancio, R., et al. (2006). Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16, 3541-3544 [10.1016/j.bmcl.2006.03.080].
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors
MUGNAINI, CLAUDIA;MANETTI, FABRIZIO;BOTTA, MAURIZIO;CORELLI, FEDERICO
2006-01-01
Abstract
S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.
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https://hdl.handle.net/11365/20981
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