In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC(50) values in the micromolar range.
Mugnaini, C., Petricci, E., Botta, M., Corelli, F., Mastromarino, P., Giorgi, G. (2007). Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 42(2), 256-262 [10.1016/j.ejmech.2006.09.002].
Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as a new ribella virus inhibitors
MUGNAINI, CLAUDIA;PETRICCI, ELENA;BOTTA, MAURIZIO;CORELLI, FEDERICO;GIORGI, GIANLUCA
2007-01-01
Abstract
In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC(50) values in the micromolar range.
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https://hdl.handle.net/11365/3453
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