RecentstudiesdemonstratedthatactivationoftheGABABreceptor,eitherbymeansoforthostericagonistsorpositiveallostericmodulators(PAMs),inhibiteddifferentnicotine-relatedbehaviors,includingintravenousself-administrationandconditionedplaceprefer-ence,inrodents.Thepresentstudyinvestigatedwhethertheanti-nicotineeffectsoftheGABABreceptoragonist,baclofen,andGABABPAMs,CGP7930,andGS39783,extendtonicotinestimulanteffects.Tothisend,CD1micewereinitiallytreatedwithbaclofen(0,1.25,and2.5mg/kg,i.p.),CGP7930(0,25,and50mg/kg,i.g.),orGS39783(0,25,and50mg/kg,i.g.),thentreatedwithnicotine(0and0.05mg/kg,s.c.),andfinallyexposedtoanautomatedapparatusforrecordingoflocomotoractivity.Pretreatmentwithdosesofbaclofen,CGP7930,orGS39783thatdidnotalterlocomotoractivitywhengivenwithnico-tinevehiclefullypreventedhyperlocomotioninducedby0.05mg/kgnicotine.ThesedataextendtonicotinestimulanteffectsthecapacityofbaclofenandGABABPAMstoblockthereinforcing,motivational,andrewardingpropertiesofnicotine.ThesedatastrengthenthehypothesisthatactivationoftheGABABreceptormayrepresentapotentiallyuseful,anti-smokingtherapeuticstrategy.
Lobina, C., Carai, M.A.M., Froestl, W., Mugnaini, C., Pasquini, S., Corelli, F., et al. (2011). Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice. FRONTIERS IN PSYCHIATRY, 2 [10.3389/fpsyt.2011.00076].
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice
MUGNAINI, CLAUDIA;PASQUINI, SERENA;CORELLI, FEDERICO;
2011-01-01
Abstract
RecentstudiesdemonstratedthatactivationoftheGABABreceptor,eitherbymeansoforthostericagonistsorpositiveallostericmodulators(PAMs),inhibiteddifferentnicotine-relatedbehaviors,includingintravenousself-administrationandconditionedplaceprefer-ence,inrodents.Thepresentstudyinvestigatedwhethertheanti-nicotineeffectsoftheGABABreceptoragonist,baclofen,andGABABPAMs,CGP7930,andGS39783,extendtonicotinestimulanteffects.Tothisend,CD1micewereinitiallytreatedwithbaclofen(0,1.25,and2.5mg/kg,i.p.),CGP7930(0,25,and50mg/kg,i.g.),orGS39783(0,25,and50mg/kg,i.g.),thentreatedwithnicotine(0and0.05mg/kg,s.c.),andfinallyexposedtoanautomatedapparatusforrecordingoflocomotoractivity.Pretreatmentwithdosesofbaclofen,CGP7930,orGS39783thatdidnotalterlocomotoractivitywhengivenwithnico-tinevehiclefullypreventedhyperlocomotioninducedby0.05mg/kgnicotine.ThesedataextendtonicotinestimulanteffectsthecapacityofbaclofenandGABABPAMstoblockthereinforcing,motivational,andrewardingpropertiesofnicotine.ThesedatastrengthenthehypothesisthatactivationoftheGABABreceptormayrepresentapotentiallyuseful,anti-smokingtherapeuticstrategy.
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https://hdl.handle.net/11365/23271
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