The development of a straightforward synthesis of 4-amino-6-benzyl-6H-pyrrolo[3,4-d]pyrimidine and 7-amino-2-benzyl-2H-pyrazolo[4,3-d]pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays.
Semeraro, T., Mugnaini, C., Manetti, F., Pasquini, S., Corelli, F. (2008). Practical synthesis of novel purine analogues as Hsp90 inhibitors. TETRAHEDRON, 64(49), 11249-11255 [10.1016/j.tet.2008.09.030].
Practical synthesis of novel purine analogues as Hsp90 inhibitors.
MUGNAINI, CLAUDIA;MANETTI, FABRIZIO;CORELLI, FEDERICO
2008-01-01
Abstract
The development of a straightforward synthesis of 4-amino-6-benzyl-6H-pyrrolo[3,4-d]pyrimidine and 7-amino-2-benzyl-2H-pyrazolo[4,3-d]pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays.
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https://hdl.handle.net/11365/2996
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