A synthetic route for the preparation of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones characterized by a decorated benzyl moiety at different positions of the five-membered ring has been developed, and some compounds have been tested as Hsp90 ligands. One of them displayed IC50 = 50 μM representing an interesting starting point for further investigations. © 2008 Elsevier Ltd. All rights reserved.
Semeraro, T., Mugnaini, C., Corelli, F. (2008). Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands. TETRAHEDRON LETTERS, 49(41), 5965-5967 [10.1016/j.tetlet.2008.07.158].
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands
Semeraro, Teresa;Mugnaini, Claudia;Corelli, Federico
2008-01-01
Abstract
A synthetic route for the preparation of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones characterized by a decorated benzyl moiety at different positions of the five-membered ring has been developed, and some compounds have been tested as Hsp90 ligands. One of them displayed IC50 = 50 μM representing an interesting starting point for further investigations. © 2008 Elsevier Ltd. All rights reserved.
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https://hdl.handle.net/11365/3329
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