Reaction of 3-amino-1H-pyrazole-4-carbonitrile with 2,4-pentanedione yielded 5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-carbonitrile, which was easily and efficiently transformed into a small library of amido derivatives. This procedure opens the way to new compounds potentially endowed with interesting biological activities.
Mugnaini, C., Pasculini, L., Pagli, C., Brizzi, A., Paolino, M., Gianibbi, B., et al. (2022). Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold. ARKIVOC, 2022(2), 22-29 [10.24820/ark.5550190.p011.628].
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold
Claudia Mugnaini;Antonella Brizzi;Marco Paolino;Beatrice Gianibbi;Federico Corelli
2022-01-01
Abstract
Reaction of 3-amino-1H-pyrazole-4-carbonitrile with 2,4-pentanedione yielded 5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-carbonitrile, which was easily and efficiently transformed into a small library of amido derivatives. This procedure opens the way to new compounds potentially endowed with interesting biological activities.
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https://hdl.handle.net/11365/1173089