The synthesis of the boronated dinucleotide (2) starting from commercially available building blocks was accomplished according to the phosphoramidite approach. The dimer, which can be used in the construction of oligonucleotide sequences, is itself interesting for its potential applications in Boron Neutron Capture Therapy and as a possible inhibitor of HIV-1 integrase. Computational studies were also performed showing its preferential C3'-endo (RNA-like) conformation
Stasi, L.P., Mugnaini, C., Alcaro, S., Corelli, F., Botta, M. (2003). Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences. HETEROCYCLES, 61, 403-416 [10.3987/com-03-s56].
Synthesis and conformational studies of 3’-(2’-aminoborane-2’-deoxyuridyl)-5’-thymidilyl hydrogen phospate to be used in the construction of oligonucleotide sequences
Mugnaini, Claudia;Corelli, Federico;Botta, Maurizio
2003-01-01
Abstract
The synthesis of the boronated dinucleotide (2) starting from commercially available building blocks was accomplished according to the phosphoramidite approach. The dimer, which can be used in the construction of oligonucleotide sequences, is itself interesting for its potential applications in Boron Neutron Capture Therapy and as a possible inhibitor of HIV-1 integrase. Computational studies were also performed showing its preferential C3'-endo (RNA-like) conformation
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/18634
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo