The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC(50)=12 microM.
Mugnaini, C., Rajamaki, S., Tintori, C., Corelli, F., Massa, S., Witvrouw, M., et al. (2007). Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17, 5370-5373 [10.1016/j.bmcl.2007.08.005].
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.
MUGNAINI, CLAUDIA;TINTORI, CRISTINA;CORELLI, FEDERICO;MASSA, SILVIO;BOTTA, MAURIZIO
2007-01-01
Abstract
The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC(50)=12 microM.
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https://hdl.handle.net/11365/21021
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