Starting from 5-(pyrrol-1-yl)pyrazole derivatives, the synthesis of triazole-based compounds by isosteric replacement of pyrrole and pyrazole was studied. The amido derivatives were obtained by organocatalyzed cycloaddition reactions between aryl azides and 0-ketoamides or 0-ketoesters. The synthesis of the second series of compounds, namely 5-(triazol-1-yl)pyrazole derivatives, involved the preparation of 5-azido-1H- pyrazole derivatives to be subjected to cycloaddition with alkynes.

Avigliano, M., Francesco, D.D., Brizzi, A., Paolino, M., Corelli, F., Mugnaini, C. (2023). Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates. ARKIVOC, 2023(7), 1-11 [10.24820/ark.5550190.p011.966].

Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates

Avigliano, Marialuce;Francesco, Debora De;Brizzi, Antonella;Paolino, Marco;Corelli, Federico
;
Mugnaini, Claudia
2023-01-01

Abstract

Starting from 5-(pyrrol-1-yl)pyrazole derivatives, the synthesis of triazole-based compounds by isosteric replacement of pyrrole and pyrazole was studied. The amido derivatives were obtained by organocatalyzed cycloaddition reactions between aryl azides and 0-ketoamides or 0-ketoesters. The synthesis of the second series of compounds, namely 5-(triazol-1-yl)pyrazole derivatives, involved the preparation of 5-azido-1H- pyrazole derivatives to be subjected to cycloaddition with alkynes.
2023
Avigliano, M., Francesco, D.D., Brizzi, A., Paolino, M., Corelli, F., Mugnaini, C. (2023). Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates. ARKIVOC, 2023(7), 1-11 [10.24820/ark.5550190.p011.966].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1276550