Synthesis of some novel 1-aryl-1H-1,2,3-triazole-4-carboxamides and ethyl 1-aryl-5-(1,2,3-triazol-1-yl)-1H-pyrazole-4-carboxylates

Starting from 5-(pyrrol-1-yl)pyrazole derivatives, the synthesis of triazole-based compounds by isosteric replacement of pyrrole and pyrazole was studied. The amido derivatives were obtained by organocatalyzed cycloaddition reactions between aryl azides and 0-ketoamides or 0-ketoesters. The synthesis of the second series of compounds, namely 5-(triazol-1-yl)pyrazole derivatives, involved the preparation of 5-azido-1H- pyrazole derivatives to be subjected to cycloaddition with alkynes.