IRIS
VALOTI, MASSIMO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 12.623
EU - Europa 9.153
AS - Asia 4.687
SA - Sud America 835
Continente sconosciuto - Info sul continente non disponibili 267
AF - Africa 179
OC - Oceania 21
Totale 27.765
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 12.441
GB - Regno Unito 2.003
CN - Cina 1.695
RU - Federazione Russa 1.688
SG - Singapore 1.500
IT - Italia 1.459
IE - Irlanda 1.105
BR - Brasile 670
SE - Svezia 633
UA - Ucraina 617
FR - Francia 531
DE - Germania 456
VN - Vietnam 371
HK - Hong Kong 350
FI - Finlandia 268
KR - Corea 219
TR - Turchia 112
IN - India 108
ES - Italia 106
CA - Canada 85
ZA - Sudafrica 77
BD - Bangladesh 65
AR - Argentina 48
MX - Messico 47
BE - Belgio 46
JP - Giappone 37
NL - Olanda 37
CZ - Repubblica Ceca 35
AT - Austria 33
CO - Colombia 31
PL - Polonia 31
NG - Nigeria 30
IQ - Iraq 27
EC - Ecuador 23
ID - Indonesia 23
SA - Arabia Saudita 23
PK - Pakistan 22
CL - Cile 19
VE - Venezuela 18
AU - Australia 16
MA - Marocco 16
KE - Kenya 15
EG - Egitto 14
LT - Lituania 14
GR - Grecia 13
AZ - Azerbaigian 12
PE - Perù 12
IR - Iran 11
UZ - Uzbekistan 11
CI - Costa d'Avorio 10
JM - Giamaica 10
NP - Nepal 10
RO - Romania 10
AE - Emirati Arabi Uniti 9
HU - Ungheria 9
JO - Giordania 9
MY - Malesia 9
PH - Filippine 9
BG - Bulgaria 8
CR - Costa Rica 8
TW - Taiwan 8
EE - Estonia 7
PY - Paraguay 7
GT - Guatemala 6
LB - Libano 6
CH - Svizzera 5
EU - Europa 5
IL - Israele 5
KZ - Kazakistan 5
OM - Oman 5
TT - Trinidad e Tobago 5
AL - Albania 4
GE - Georgia 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
PT - Portogallo 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
UY - Uruguay 4
AO - Angola 3
BB - Barbados 3
BO - Bolivia 3
BY - Bielorussia 3
CM - Camerun 3
CY - Cipro 3
HN - Honduras 3
HR - Croazia 3
NI - Nicaragua 3
TH - Thailandia 3
TN - Tunisia 3
BZ - Belize 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GA - Gabon 2
GD - Grenada 2
IM - Isola di Man 2
LK - Sri Lanka 2
LU - Lussemburgo 2
MD - Moldavia 2
Totale 27.473
Salva come PNG Salva come JPEG
Città #
Southend 1.748
Fairfield 1.134
Dallas 1.093
Dublin 1.092
Ashburn 928
Singapore 853
Chandler 683
Woodbridge 542
San Jose 511
Jacksonville 496
Santa Clara 477
Wilmington 460
Moscow 455
Seattle 453
Houston 423
Cambridge 404
Beijing 402
Milan 374
Ann Arbor 361
Siena 340
Hong Kong 332
Council Bluffs 282
Hefei 220
Seoul 217
Princeton 200
The Dalles 191
Nanjing 173
Los Angeles 163
Menlo Park 136
New York 127
Helsinki 114
Lauterbourg 112
Fremont 107
Rome 105
Ho Chi Minh City 97
Dearborn 93
San Diego 89
Boardman 83
Hanoi 82
Izmir 78
Málaga 76
Florence 74
Nanchang 74
Columbus 73
Munich 73
Johannesburg 70
Shanghai 70
São Paulo 66
Buffalo 59
San Mateo 58
Brussels 45
Orem 39
Dong Ket 38
London 37
Tianjin 37
Frankfurt am Main 36
Hebei 35
Shenyang 35
Bengaluru 34
Brooklyn 34
Redondo Beach 33
San Francisco 33
Turku 31
Tokyo 30
Chicago 29
Abuja 28
Lappeenranta 27
Washington 27
Jiaxing 26
Atlanta 25
Changsha 25
Vienna 25
Brno 24
Turin 23
Denver 22
Jinan 22
Phoenix 22
Warsaw 22
Figino 20
Rio de Janeiro 20
Guangzhou 19
Redwood City 19
Zhengzhou 19
Toronto 18
Brasília 17
Montreal 17
Stockholm 17
Belo Horizonte 16
Boston 16
Chennai 16
Da Nang 16
Kunming 16
Mexico City 15
Naples 15
Norwalk 15
Philadelphia 15
Haiphong 14
Manchester 14
Hangzhou 13
Nairobi 13
Totale 18.127
Salva come PNG Salva come JPEG
Nome #
Effects on C57/BL mice of subchronic treatment with benzene [Effetto del trattamento subcronico con benzene in topi C57/Bl] 1.083
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 408
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 374
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 372
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 342
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 334
Chemical characterization and antihypertensive effects of locular gel and serum of Lycopersicum esculentum L. var. “Camone” tomato in spontaneously hypertensive rats 328
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 324
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 323
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 315
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 311
In vitro toxicity evaluation of lomefloxacin-loaded MCM-41 mesoporous silica nanoparticles 311
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 307
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 307
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold 297
Acacia catechu willd. Extract protects neuronal cells from oxidative stress-induced damage 292
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 289
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 289
β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP⁺ Toxicity in Human Neuroblastoma SH-SY5Y Cells 288
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters 288
2,4,6-trinitrotoluene (TNT) with xenobiotic biotransformation system in European eel Anguilla anguilla (Linnaeus, 1758) 276
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 276
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 275
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 273
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 271
Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite 269
Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species 269
Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine 268
Physiopathological Effects of the NO Donor 3-Morpholinosydnonimine on Rat Cortical Synaptosomes 266
Calcium antagonist and antiperoxidant properties of some hindered phenols 266
Cyclooxygenase activity of hemoglobin 265
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 264
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 263
Gold nanoparticles potentiate CaVchannel currents in rat tail artery myocytes 263
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision cut slices 262
2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta 262
On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings 260
CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes 260
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 255
Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol 253
Effects of Autologous, Cross-Linked Erythrocytes on Isolated Hypoperfused Rabbit Heart Dynamics 250
Interactions of taurine and structurally related analogues with GABAergic system and taurine binding sites of rabbit brain 249
Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans 248
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 248
Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery 247
DP7, a novel dihydropyridine multidrug resistance reverter, shows only weak inhibitory activity on human CYP3A enzyme(s) 243
Toxicity assessment on trophoblast cells for some environment polluting chemicals and 17β-estradiol 243
Merging computational modelling and experimental metabolite identification for toxicity prediction 241
N,N-bis(cyclohexanol)amine aryl esters inhibit P-glycoprotein as transport substrates 240
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis 239
Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol 238
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 232
Flavonoids and hERG channels: Friends or foes? 231
The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder 230
Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits 229
Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses 228
HPLC determination of inorganic cation levels in CSF and plasma of conscious rabbits 222
Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells 221
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision-cut slices 219
3,5-Di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+-ATPase 214
Effect of loxiglumide (CR 1505) on CCK-induced contractions and 3H-acetylcholine release from guinea-pig gallbladder 214
Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage 214
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder 213
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes 209
N-Dealkylation of chlorimipramine and chlorpromazine by rat liver microsomal cytochrome P450 isoenzymes 209
BENZENE BONE MARROW TOXICITY AND EFFECTS ON LIVER ENZYMES OF C57BL/6 MICE 209
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 207
β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration 207
Pharmacokinetic of diphenydramine in young volunteers with a dimenhydrinate 25 mg chewing gum formulation 206
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases 206
Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds 201
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices 201
Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits 201
Vanadate as an inhibitor of plant and mammalian peroxidases 199
Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle 198
Gender-related neuronal and smooth muscle damage of guinea pig isolated urinary bladder from anoxia-glucopenia and reperfusion injury and its relationship to glycogen content 198
Dehalogenation and N-dealkylation of chlorpromazine as revealed by plasma concentrations of metabolites in a population of chronically medicated schizophrenics 197
In vitro cytotoxicity evaluation of functional PEG-PDMA block copolymer in liver HEPG2 cells 195
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage. Amino Acids 194
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injectionof GABA, GABAA and GABAB agonists and antagonists 193
The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress 192
Neuroprotection afforded by some hindered phenols and a-tocopherol in guinea-pig detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions. 192
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration 192
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds 191
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl 190
Neuroprotection afforded by GABA against oxygen-glucose deprivation-induced injury in rat cortical brain slices: an hormetic dose-response effect 186
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus 185
Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro 185
Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits after intracerebroventricular injection of hemoglobin 183
Peroxidase catalysed formation of prostaglandins from arachidonic acid 180
Synthesis and antiperoxidant activity of new phenolic O-glycosides 178
Functionalized mesoporous silica nanoparticles for oral delivery of budesonide 177
Evidence of a coupled mechanism between monoamine oxidase and peroxidase in the metabolism of tyramine by rat intestinal mitochondria 176
Heteroaryl-substituted phenols as potential antioxidants 173
Purification and characterization of rat intestinal peroxidase. Its activity towards 2-t-butyl-4-methoxyphenol (BHA) 173
Reversible monoacylglycerol lipase inhibitors: discovery of a new class of benzylpiperidine derivatives 170
Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase 168
Synthetic approach, regio- and stereochemical characterisation and differentiation of new potential antioxidant C- and O- arylglycosides 167
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations 167
Gold nanoparticles toxicity in rat precision-cut liver slices: a preliminary study 165
Totale 24.871
Salva come PNG Salva come JPEG
Categoria #
all - tutte 84.011
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 84.011
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.482 0 0 138 161 96 62 117 96 77 209 183 343
2022/20232.501 151 219 337 386 196 443 61 220 265 108 74 41
2023/20241.780 85 32 157 112 69 484 584 60 4 35 36 122
2024/20253.440 106 164 320 207 419 199 122 238 307 148 361 849
2025/20268.739 596 1.100 841 840 1.554 298 838 244 315 396 1.069 648
2026/2027936 363 241 332 0 0 0 0 0 0 0 0 0
Totale 27.765