IRIS
VALOTI, MASSIMO
 Distribuzione geografica
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Continente #
NA - Nord America 7.423
EU - Europa 6.605
AS - Asia 1.230
AF - Africa 18
SA - Sud America 12
OC - Oceania 7
Continente sconosciuto - Info sul continente non disponibili 6
Totale 15.301
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Nazione #
US - Stati Uniti d'America 7.392
GB - Regno Unito 1.893
IE - Irlanda 1.101
CN - Cina 818
IT - Italia 769
SE - Svezia 613
UA - Ucraina 603
RU - Federazione Russa 465
FR - Francia 380
DE - Germania 348
SG - Singapore 223
FI - Finlandia 188
TR - Turchia 88
ES - Italia 80
VN - Vietnam 40
BE - Belgio 38
CZ - Repubblica Ceca 32
CA - Canada 28
AT - Austria 17
GR - Grecia 13
IN - India 11
IR - Iran 10
NL - Olanda 10
HU - Ungheria 9
CI - Costa d'Avorio 8
AU - Australia 7
RO - Romania 7
CL - Cile 6
TW - Taiwan 6
AZ - Azerbaigian 5
BG - Bulgaria 5
EU - Europa 5
JP - Giappone 5
PL - Polonia 5
BR - Brasile 4
EG - Egitto 4
SK - Slovacchia (Repubblica Slovacca) 4
CH - Svizzera 3
EE - Estonia 3
HK - Hong Kong 3
HR - Croazia 3
PT - Portogallo 3
RS - Serbia 3
AE - Emirati Arabi Uniti 2
AR - Argentina 2
ID - Indonesia 2
IM - Isola di Man 2
KR - Corea 2
LK - Sri Lanka 2
LV - Lettonia 2
MA - Marocco 2
MY - Malesia 2
NG - Nigeria 2
PH - Filippine 2
PK - Pakistan 2
ZA - Sudafrica 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
BD - Bangladesh 1
BY - Bielorussia 1
DK - Danimarca 1
IL - Israele 1
IQ - Iraq 1
JM - Giamaica 1
LU - Lussemburgo 1
MD - Moldavia 1
MX - Messico 1
NO - Norvegia 1
OM - Oman 1
PA - Panama 1
QA - Qatar 1
SA - Arabia Saudita 1
TH - Thailandia 1
Totale 15.301
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Città #
Southend 1.748
Fairfield 1.133
Dublin 1.087
Chandler 682
Ashburn 578
Woodbridge 540
Jacksonville 493
Wilmington 458
Seattle 443
Cambridge 404
Houston 400
Ann Arbor 361
Siena 338
Princeton 198
Nanjing 173
Beijing 171
Singapore 162
Menlo Park 136
Fremont 106
Dearborn 93
San Diego 84
Boardman 78
Izmir 78
Málaga 76
Nanchang 74
Helsinki 72
New York 70
Shanghai 63
San Mateo 58
Moscow 49
Florence 45
Brussels 38
Dong Ket 38
Milan 36
Hebei 35
Shenyang 34
Tianjin 30
Jiaxing 26
Los Angeles 25
Brno 24
Munich 23
London 22
Changsha 21
Washington 21
Jinan 20
Lappeenranta 20
Redwood City 19
Vienna 16
Kunming 15
San Francisco 15
Norwalk 14
Zhengzhou 14
Frankfurt am Main 12
Rome 11
Taizhou 11
Hangzhou 9
Lancaster 9
Ningbo 9
Ottawa 9
Toronto 9
Abidjan 8
Kilburn 8
Olomouc 8
Venezia 8
Calci 7
Changchun 7
Columbus 7
Guangzhou 7
Hefei 7
Nottingham 7
Silver Spring 7
Tappahannock 7
Arezzo 6
Eboli 6
Falls Church 6
Lanzhou 6
Amsterdam 5
Berlin 5
Budapest 5
Dallas 5
Düsseldorf 5
Saint Petersburg 5
Andover 4
Bacoli 4
Bonndorf 4
Leawood 4
Mestre 4
Montréal 4
Padova 4
Parma 4
Phoenix 4
Pisa 4
Pátrai 4
Ventimiglia 4
Zanjan 4
Auburn Hills 3
Belgrade 3
Cedar Knolls 3
Chicago 3
Chiswick 3
Totale 11.245
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Nome #
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 282
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 267
In vitro toxicity evaluation of lomefloxacin-loaded MCM-41 mesoporous silica nanoparticles 256
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 225
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 219
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 212
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 208
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 207
Gold nanoparticles potentiate CaVchannel currents in rat tail artery myocytes 198
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold 194
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 194
β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP⁺ Toxicity in Human Neuroblastoma SH-SY5Y Cells 190
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 189
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 187
Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery 184
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 178
Chemical characterization and antihypertensive effects of locular gel and serum of Lycopersicum esculentum L. var. “Camone” tomato in spontaneously hypertensive rats 176
The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder 173
Physiopathological Effects of the NO Donor 3-Morpholinosydnonimine on Rat Cortical Synaptosomes 168
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters 168
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 165
Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species 162
Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine 161
Cyclooxygenase activity of hemoglobin. 160
CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes 159
Toxicity assessment on trophoblast cells for some environment polluting chemicals and 17β-estradiol 158
Merging computational modelling and experimental metabolite identification for toxicity prediction 157
Flavonoids and hERG channels: Friends or foes? 157
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 156
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices 156
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 156
Effects of Autologous, Cross-Linked Erythrocytes on Isolated Hypoperfused Rabbit Heart Dynamics 155
Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite 152
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 152
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 151
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision cut slices 150
Calcium antagonist and antiperoxidant properties of some hindered phenols 148
N,N-bis(cyclohexanol)amine aryl esters inhibit P-glycoprotein as transport substrates 148
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 147
On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings 143
Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits 142
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 142
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration 142
Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans 141
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis 141
DP7, a novel dihydropyridine multidrug resistance reverter, shows only weak inhibitory activity on human CYP3A enzyme(s) 141
Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol 140
N-Dealkylation of chlorimipramine and chlorpromazine by rat liver microsomal cytochrome P450 isoenzymes 137
Interactions of taurine and structurally related analogues with GABAergic system and taurine binding sites of rabbit brain 137
Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits after intracerebroventricular injection of hemoglobin 136
Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol 136
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus 135
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 135
Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses 135
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision-cut slices 133
Vanadate as an inhibitor of plant and mammalian peroxidases 131
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds 129
Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells 129
Neuroprotection afforded by some hindered phenols and a-tocopherol in guinea-pig detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions. 128
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 128
Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage 128
Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds 127
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder 127
Effect of loxiglumide (CR 1505) on CCK-induced contractions and 3H-acetylcholine release from guinea-pig gallbladder 127
Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits 127
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases 125
2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta 125
β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration 125
Gender-related neuronal and smooth muscle damage of guinea pig isolated urinary bladder from anoxia-glucopenia and reperfusion injury and its relationship to glycogen content 121
Functionalized mesoporous silica nanoparticles for oral delivery of budesonide 120
HPLC determination of inorganic cation levels in CSF and plasma of conscious rabbits 119
In vitro cytotoxicity evaluation of functional PEG-PDMA block copolymer in liver HEPG2 cells 119
Neuroprotection afforded by GABA against oxygen-glucose deprivation-induced injury in rat cortical brain slices: an hormetic dose-response effect 118
Synthesis and antiperoxidant activity of new phenolic O-glycosides 114
Peroxidase catalysed formation of prostaglandins from arachidonic acid 114
Acacia catechu willd. Extract protects neuronal cells from oxidative stress-induced damage 113
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes 111
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations 111
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage. Amino Acids 110
Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle 110
Purification and characterization of rat intestinal peroxidase. Its activity towards 2-t-butyl-4-methoxyphenol (BHA) 109
Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase 109
2,4,6-trinitrotoluene (TNT) with xenobiotic biotransformation system in European eel Anguilla anguilla (Linnaeus, 1758) 108
Distribution and peroxidative oxidation of 2-t-butyl-4-methoxyphenol in rat tissues after a single intraperitoneal dose 108
BENZENE BONE MARROW TOXICITY AND EFFECTS ON LIVER ENZYMES OF C57BL/6 MICE 107
Thin layer chromatography in the quantitative analysis of pharmaceuticals. Comparison of layers in the analysis of complex mixtures of phenothiazine derivatives 106
Pharmacokinetics of chlorimipramine, chlorpromazine and their N-dealkylated metabolites in plasma of healthy volunteers after a single oral dose of the parent compounds 106
The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress 105
Synthetic approach, regio- and stereochemical characterisation and differentiation of new potential antioxidant C- and O- arylglycosides 105
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 105
Effects on C57/BL mice of subchronic treatment with benzene [Effetto del trattamento subcronico con benzene in topi C57/Bl] 104
Evidence of a coupled mechanism between monoamine oxidase and peroxidase in the metabolism of tyramine by rat intestinal mitochondria 104
Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds 104
Measurement of synthetic phenolic antioxidants in human tissues by high-performance liquid chromatography with coulometric electrochemical detection 102
Gold nanoparticles toxicity in rat precision-cut liver slices: a preliminary study 99
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 96
Dehalogenation and N-dealkylation of chlorpromazine as revealed by plasma concentrations of metabolites in a population of chronically medicated schizophrenics 96
The interaction of antioxidants and structurally related compounds with mitochondrial oxidative phosphorylation 96
3,5-Di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+-ATPase 95
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injectionof GABA, GABAA and GABAB agonists and antagonists 95
Totale 14.336
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Categoria #
all - tutte 51.618
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.618
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.944 0 0 0 0 260 289 292 380 264 223 65 171
2020/20212.395 135 225 54 250 149 327 108 322 261 230 180 154
2021/20221.869 165 222 138 161 96 62 117 96 77 209 183 343
2022/20232.501 151 219 337 386 196 443 61 220 265 108 74 41
2023/20241.780 85 32 157 112 69 484 584 60 4 35 36 122
2024/2025895 106 164 320 207 98 0 0 0 0 0 0 0
Totale 15.545