IRIS
VALOTI, MASSIMO
 Distribuzione geografica
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Continente #
NA - Nord America 10.612
EU - Europa 8.618
AS - Asia 4.573
SA - Sud America 785
AF - Africa 178
OC - Oceania 21
Continente sconosciuto - Info sul continente non disponibili 7
Totale 24.794
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Nazione #
US - Stati Uniti d'America 10.481
GB - Regno Unito 1.996
RU - Federazione Russa 1.687
CN - Cina 1.663
SG - Singapore 1.470
IE - Irlanda 1.105
IT - Italia 943
BR - Brasile 652
SE - Svezia 629
UA - Ucraina 616
FR - Francia 530
DE - Germania 456
VN - Vietnam 365
HK - Hong Kong 343
FI - Finlandia 268
KR - Corea 218
TR - Turchia 111
IN - India 107
ES - Italia 104
ZA - Sudafrica 77
CA - Canada 63
BD - Bangladesh 49
BE - Belgio 46
AR - Argentina 43
MX - Messico 39
NL - Olanda 37
CZ - Repubblica Ceca 35
JP - Giappone 35
AT - Austria 33
NG - Nigeria 30
PL - Polonia 30
IQ - Iraq 27
SA - Arabia Saudita 23
EC - Ecuador 21
PK - Pakistan 21
CL - Cile 17
ID - Indonesia 17
AU - Australia 16
MA - Marocco 16
KE - Kenya 15
CO - Colombia 14
EG - Egitto 14
LT - Lituania 14
VE - Venezuela 14
GR - Grecia 13
AZ - Azerbaigian 12
IR - Iran 11
PE - Perù 11
UZ - Uzbekistan 11
CI - Costa d'Avorio 10
HU - Ungheria 9
JO - Giordania 9
NP - Nepal 9
BG - Bulgaria 8
PH - Filippine 8
RO - Romania 8
AE - Emirati Arabi Uniti 7
EE - Estonia 7
PY - Paraguay 7
TW - Taiwan 7
LB - Libano 6
MY - Malesia 6
CH - Svizzera 5
CR - Costa Rica 5
EU - Europa 5
IL - Israele 5
JM - Giamaica 5
KZ - Kazakistan 5
OM - Oman 5
AL - Albania 4
GE - Georgia 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
PT - Portogallo 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
AO - Angola 3
BB - Barbados 3
BO - Bolivia 3
BY - Bielorussia 3
CM - Camerun 3
CY - Cipro 3
HR - Croazia 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
DK - Danimarca 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
GA - Gabon 2
GT - Guatemala 2
HN - Honduras 2
IM - Isola di Man 2
LK - Sri Lanka 2
LU - Lussemburgo 2
MD - Moldavia 2
NI - Nicaragua 2
NO - Norvegia 2
PS - Palestinian Territory 2
QA - Qatar 2
Totale 24.770
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Città #
Southend 1.748
Fairfield 1.133
Dublin 1.090
Dallas 1.086
Singapore 842
Ashburn 777
Chandler 682
Woodbridge 540
Jacksonville 495
Wilmington 459
Moscow 455
Seattle 447
Santa Clara 423
Houston 409
Cambridge 404
Beijing 396
Ann Arbor 361
Siena 340
Hong Kong 327
San Jose 277
Hefei 220
Seoul 217
Princeton 198
The Dalles 191
Nanjing 173
Los Angeles 142
Menlo Park 136
Helsinki 114
Lauterbourg 112
New York 107
Fremont 106
Council Bluffs 102
Ho Chi Minh City 97
Dearborn 93
San Diego 86
Boardman 82
Hanoi 80
Izmir 78
Milan 78
Málaga 76
Nanchang 74
Munich 73
Johannesburg 70
Florence 69
Shanghai 68
São Paulo 65
San Mateo 58
Buffalo 57
Columbus 51
Brussels 45
Dong Ket 38
Orem 38
Tianjin 37
Frankfurt am Main 36
London 36
Hebei 35
Shenyang 35
Bengaluru 34
Redondo Beach 33
Turku 31
Tokyo 30
Abuja 28
Rome 28
Lappeenranta 27
Jiaxing 26
Changsha 25
San Francisco 25
Vienna 25
Brno 24
Washington 23
Jinan 22
Warsaw 22
Brooklyn 19
Denver 19
Guangzhou 19
Redwood City 19
Rio de Janeiro 19
Zhengzhou 19
Atlanta 17
Brasília 17
Phoenix 17
Stockholm 17
Belo Horizonte 16
Chennai 16
Kunming 16
Montreal 15
Chicago 14
Da Nang 14
Haiphong 14
Manchester 14
Norwalk 14
Toronto 14
Mexico City 13
Nairobi 13
Poplar 13
Amsterdam 12
Hangzhou 12
Nuremberg 12
Taizhou 12
Baghdad 11
Totale 16.894
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Nome #
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 382
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 358
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 355
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 331
Chemical characterization and antihypertensive effects of locular gel and serum of Lycopersicum esculentum L. var. “Camone” tomato in spontaneously hypertensive rats 313
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 311
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 310
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 309
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 303
In vitro toxicity evaluation of lomefloxacin-loaded MCM-41 mesoporous silica nanoparticles 302
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 296
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 287
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 287
Acacia catechu willd. Extract protects neuronal cells from oxidative stress-induced damage 284
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold 281
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 271
β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP⁺ Toxicity in Human Neuroblastoma SH-SY5Y Cells 271
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 269
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters 269
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 265
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 263
2,4,6-trinitrotoluene (TNT) with xenobiotic biotransformation system in European eel Anguilla anguilla (Linnaeus, 1758) 262
Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species 262
Calcium antagonist and antiperoxidant properties of some hindered phenols 256
Gold nanoparticles potentiate CaVchannel currents in rat tail artery myocytes 255
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 255
Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine 254
Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite 253
Physiopathological Effects of the NO Donor 3-Morpholinosydnonimine on Rat Cortical Synaptosomes 251
Cyclooxygenase activity of hemoglobin. 250
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 250
2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta 249
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 248
CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes 247
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision cut slices 239
On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings 239
Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol 237
Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans 235
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 234
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 233
Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery 232
DP7, a novel dihydropyridine multidrug resistance reverter, shows only weak inhibitory activity on human CYP3A enzyme(s) 230
Toxicity assessment on trophoblast cells for some environment polluting chemicals and 17β-estradiol 230
Effects of Autologous, Cross-Linked Erythrocytes on Isolated Hypoperfused Rabbit Heart Dynamics 230
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy 229
Interactions of taurine and structurally related analogues with GABAergic system and taurine binding sites of rabbit brain 229
Merging computational modelling and experimental metabolite identification for toxicity prediction 227
Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits 222
N,N-bis(cyclohexanol)amine aryl esters inhibit P-glycoprotein as transport substrates 222
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis 221
The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder 221
Flavonoids and hERG channels: Friends or foes? 216
Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol 215
Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses 212
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 210
Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells 209
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision-cut slices 206
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder 205
HPLC determination of inorganic cation levels in CSF and plasma of conscious rabbits 203
3,5-Di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+-ATPase 199
Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage 199
N-Dealkylation of chlorimipramine and chlorpromazine by rat liver microsomal cytochrome P450 isoenzymes 197
Effect of loxiglumide (CR 1505) on CCK-induced contractions and 3H-acetylcholine release from guinea-pig gallbladder 196
BENZENE BONE MARROW TOXICITY AND EFFECTS ON LIVER ENZYMES OF C57BL/6 MICE 194
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices 192
β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration 192
Pharmacokinetic of diphenydramine in young volunteers with a dimenhydrinate 25 mg chewing gum formulation 191
Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits 190
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 189
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases 189
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes 187
Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds 187
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration 186
In vitro cytotoxicity evaluation of functional PEG-PDMA block copolymer in liver HEPG2 cells 185
Gender-related neuronal and smooth muscle damage of guinea pig isolated urinary bladder from anoxia-glucopenia and reperfusion injury and its relationship to glycogen content 185
Vanadate as an inhibitor of plant and mammalian peroxidases 184
Neuroprotection afforded by some hindered phenols and a-tocopherol in guinea-pig detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions. 183
The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress 182
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds 182
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injectionof GABA, GABAA and GABAB agonists and antagonists 181
Dehalogenation and N-dealkylation of chlorpromazine as revealed by plasma concentrations of metabolites in a population of chronically medicated schizophrenics 180
Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle 179
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus 177
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage. Amino Acids 177
Neuroprotection afforded by GABA against oxygen-glucose deprivation-induced injury in rat cortical brain slices: an hormetic dose-response effect 177
Effects on C57/BL mice of subchronic treatment with benzene [Effetto del trattamento subcronico con benzene in topi C57/Bl] 173
Peroxidase catalysed formation of prostaglandins from arachidonic acid 168
Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits after intracerebroventricular injection of hemoglobin 167
Heteroaryl-substituted phenols as potential antioxidants 165
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl 164
Synthesis and antiperoxidant activity of new phenolic O-glycosides 163
Functionalized mesoporous silica nanoparticles for oral delivery of budesonide 163
Evidence of a coupled mechanism between monoamine oxidase and peroxidase in the metabolism of tyramine by rat intestinal mitochondria 159
Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro 158
Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase 158
Purification and characterization of rat intestinal peroxidase. Its activity towards 2-t-butyl-4-methoxyphenol (BHA) 157
Synthetic approach, regio- and stereochemical characterisation and differentiation of new potential antioxidant C- and O- arylglycosides 155
Gold nanoparticles toxicity in rat precision-cut liver slices: a preliminary study 155
Thin layer chromatography in the quantitative analysis of pharmaceuticals. Comparison of layers in the analysis of complex mixtures of phenothiazine derivatives 154
Distribution and peroxidative oxidation of 2-t-butyl-4-methoxyphenol in rat tissues after a single intraperitoneal dose 153
Totale 22.467
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Categoria #
all - tutte 75.815
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 75.815
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021564 0 0 0 0 0 0 0 0 0 230 180 154
2021/20221.869 165 222 138 161 96 62 117 96 77 209 183 343
2022/20232.501 151 219 337 386 196 443 61 220 265 108 74 41
2023/20241.780 85 32 157 112 69 484 584 60 4 35 36 122
2024/20253.440 106 164 320 207 419 199 122 238 307 148 361 849
2025/20266.963 596 1.100 841 840 1.554 298 838 244 315 337 0 0
Totale 25.053