IRIS
VALOTI, MASSIMO
 Distribuzione geografica
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Continente #
NA - Nord America 7.987
EU - Europa 6.819
AS - Asia 1.561
SA - Sud America 265
AF - Africa 32
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 6
Totale 16.678
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Nazione #
US - Stati Uniti d'America 7.942
GB - Regno Unito 1.900
IE - Irlanda 1.102
IT - Italia 857
CN - Cina 854
SE - Svezia 613
UA - Ucraina 605
RU - Federazione Russa 474
SG - Singapore 449
FR - Francia 393
DE - Germania 379
BR - Brasile 242
FI - Finlandia 203
TR - Turchia 94
ES - Italia 81
BE - Belgio 44
VN - Vietnam 40
CA - Canada 33
CZ - Repubblica Ceca 33
AT - Austria 29
HK - Hong Kong 29
NL - Olanda 22
GR - Grecia 13
IN - India 13
IR - Iran 10
CI - Costa d'Avorio 9
HU - Ungheria 9
MA - Marocco 8
AU - Australia 7
BG - Bulgaria 7
CL - Cile 7
EE - Estonia 7
IQ - Iraq 7
MX - Messico 7
PK - Pakistan 7
RO - Romania 7
AR - Argentina 6
BD - Bangladesh 6
LT - Lituania 6
TW - Taiwan 6
AZ - Azerbaigian 5
EG - Egitto 5
EU - Europa 5
JP - Giappone 5
PL - Polonia 5
CH - Svizzera 4
PH - Filippine 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
EC - Ecuador 3
HR - Croazia 3
JO - Giordania 3
PT - Portogallo 3
UZ - Uzbekistan 3
ZA - Sudafrica 3
AE - Emirati Arabi Uniti 2
BO - Bolivia 2
CY - Cipro 2
DZ - Algeria 2
ID - Indonesia 2
IL - Israele 2
IM - Isola di Man 2
JM - Giamaica 2
KE - Kenya 2
KR - Corea 2
LK - Sri Lanka 2
LU - Lussemburgo 2
LV - Lettonia 2
MY - Malesia 2
NG - Nigeria 2
OM - Oman 2
QA - Qatar 2
VE - Venezuela 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BY - Bielorussia 1
CO - Colombia 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
KH - Cambogia 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MD - Moldavia 1
NO - Norvegia 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PA - Panama 1
PE - Perù 1
PY - Paraguay 1
SA - Arabia Saudita 1
SV - El Salvador 1
TH - Thailandia 1
Totale 16.678
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Città #
Southend 1.748
Fairfield 1.133
Dublin 1.088
Chandler 682
Ashburn 586
Woodbridge 540
Jacksonville 493
Wilmington 458
Seattle 443
Cambridge 404
Houston 400
Santa Clara 394
Ann Arbor 361
Siena 340
Princeton 198
Beijing 175
Nanjing 173
Singapore 171
Menlo Park 136
Fremont 106
Dearborn 93
Helsinki 84
San Diego 84
Boardman 79
Izmir 78
Málaga 76
Nanchang 74
Milan 71
New York 70
Shanghai 63
San Mateo 58
Florence 57
Council Bluffs 52
Moscow 52
Brussels 44
Dong Ket 38
Los Angeles 37
Hebei 35
Shenyang 34
Tianjin 31
Munich 28
Hong Kong 27
Jiaxing 26
Vienna 25
Brno 24
London 22
Changsha 21
Jinan 21
Lappeenranta 21
Washington 21
Redwood City 19
Frankfurt am Main 16
São Paulo 16
Zhengzhou 16
Kunming 15
Rome 15
San Francisco 15
Norwalk 14
Toronto 12
Düsseldorf 11
Lauterbourg 11
Ottawa 11
Taizhou 11
The Dalles 10
Guangzhou 9
Hangzhou 9
Lancaster 9
Ningbo 9
Abidjan 8
Brescia 8
Kilburn 8
Nuremberg 8
Olomouc 8
Venezia 8
Amsterdam 7
Calci 7
Changchun 7
Columbus 7
Hefei 7
Nottingham 7
Portsmouth 7
Silver Spring 7
Tappahannock 7
Arezzo 6
Belo Horizonte 6
Eboli 6
Falls Church 6
Lanzhou 6
Santo André 6
Trieste 6
Berlin 5
Brasília 5
Budapest 5
Dallas 5
Falkenstein 5
Harbin 5
Saint Petersburg 5
Andover 4
Bacoli 4
Baghdad 4
Totale 11.903
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Nome #
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 297
Prodrugs of pyrazolo[3,4-d]pyrimidines: from library synthesis to evaluation as potential anticancer agents in an orthotopic glioblastoma model 283
In vitro toxicity evaluation of lomefloxacin-loaded MCM-41 mesoporous silica nanoparticles 264
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor 238
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: Nanosystem approaches for drug delivery 235
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems 229
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 219
Antihypertensive, cardio-and neuroprotective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats 215
Folate-targeted liposomal nitrooxy-doxorubicin: an effective tool against P-glycoprotein-positive and folate receptor-positive tumors 214
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold 209
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction 209
Gold nanoparticles potentiate CaVchannel currents in rat tail artery myocytes 206
β-Naphtoflavone and Ethanol Induce Cytochrome P450 and Protect towards MPP⁺ Toxicity in Human Neuroblastoma SH-SY5Y Cells 203
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 200
Chemical characterization and antihypertensive effects of locular gel and serum of Lycopersicum esculentum L. var. “Camone” tomato in spontaneously hypertensive rats 198
Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery 191
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study 190
The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder 184
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters 182
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents 180
CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes 179
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability 178
Cyclooxygenase activity of hemoglobin. 176
Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system 174
Physiopathological Effects of the NO Donor 3-Morpholinosydnonimine on Rat Cortical Synaptosomes 173
Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species 170
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors 170
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices 169
Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine 168
Flavonoids and hERG channels: Friends or foes? 168
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents 168
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 167
Effects of Autologous, Cross-Linked Erythrocytes on Isolated Hypoperfused Rabbit Heart Dynamics 167
Interactions of taurine and structurally related analogues with GABAergic system and taurine binding sites of rabbit brain 167
Merging computational modelling and experimental metabolite identification for toxicity prediction 166
Toxicity assessment on trophoblast cells for some environment polluting chemicals and 17β-estradiol 165
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision cut slices 164
Calcium antagonist and antiperoxidant properties of some hindered phenols 162
Acacia catechu willd. Extract protects neuronal cells from oxidative stress-induced damage 162
Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite 160
A specific taurine recognition site in the rabbit brain is responsible for taurine effects on thermoregulation 160
Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits 156
On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings 155
N,N-bis(cyclohexanol)amine aryl esters inhibit P-glycoprotein as transport substrates 155
Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis 153
DP7, a novel dihydropyridine multidrug resistance reverter, shows only weak inhibitory activity on human CYP3A enzyme(s) 153
Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol 152
Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans 150
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration 148
Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol 147
N-Dealkylation of chlorimipramine and chlorpromazine by rat liver microsomal cytochrome P450 isoenzymes 146
Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives 145
Interactions of human P-glycoprotein transport substrates and inhibitors at the drug binding domain: Functional and molecular docking analyses 144
Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision-cut slices 143
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus 141
Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits after intracerebroventricular injection of hemoglobin 141
Effects of taurine and some structurally related analogues on the central mechanism of thermoregulation: a structure-activity relationship study 141
Protection by taurine of rat brain cortical slices against oxygen glucose deprivation- and reoxygenation-induced damage 140
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder 139
Neuroprotection afforded by some hindered phenols and a-tocopherol in guinea-pig detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions. 138
Vanadate as an inhibitor of plant and mammalian peroxidases 137
Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells 137
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds 136
Synthesis and biological evaluation of amidine, guanidine, and thiourea derivatives of 2-amino(6-trifluoromethoxy)benzothiazole as neuroprotective agents potentially useful in brain diseases 136
Effect of loxiglumide (CR 1505) on CCK-induced contractions and 3H-acetylcholine release from guinea-pig gallbladder 136
2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta 136
Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits 136
HPLC determination of inorganic cation levels in CSF and plasma of conscious rabbits 134
Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds 134
Gender-related neuronal and smooth muscle damage of guinea pig isolated urinary bladder from anoxia-glucopenia and reperfusion injury and its relationship to glycogen content 134
β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration 133
In vitro cytotoxicity evaluation of functional PEG-PDMA block copolymer in liver HEPG2 cells 131
Neuroprotection afforded by GABA against oxygen-glucose deprivation-induced injury in rat cortical brain slices: an hormetic dose-response effect 131
Functionalized mesoporous silica nanoparticles for oral delivery of budesonide 128
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy 126
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen-glucose deprivation-induced damage. Amino Acids 123
2,4,6-trinitrotoluene (TNT) with xenobiotic biotransformation system in European eel Anguilla anguilla (Linnaeus, 1758) 122
Peroxidase catalysed formation of prostaglandins from arachidonic acid 122
Synthesis and antiperoxidant activity of new phenolic O-glycosides 120
Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase 119
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes 118
Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle 117
GABA-mediated effects of some taurine derivatives injected i.c.v. on rabbit rectal temperature and gross motor behaviour 117
Distribution and peroxidative oxidation of 2-t-butyl-4-methoxyphenol in rat tissues after a single intraperitoneal dose 117
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations 117
BENZENE BONE MARROW TOXICITY AND EFFECTS ON LIVER ENZYMES OF C57BL/6 MICE 116
Purification and characterization of rat intestinal peroxidase. Its activity towards 2-t-butyl-4-methoxyphenol (BHA) 115
Effects on C57/BL mice of subchronic treatment with benzene [Effetto del trattamento subcronico con benzene in topi C57/Bl] 114
The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress 112
Synthetic approach, regio- and stereochemical characterisation and differentiation of new potential antioxidant C- and O- arylglycosides 112
Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds 112
Thin layer chromatography in the quantitative analysis of pharmaceuticals. Comparison of layers in the analysis of complex mixtures of phenothiazine derivatives 111
Pharmacokinetics of chlorimipramine, chlorpromazine and their N-dealkylated metabolites in plasma of healthy volunteers after a single oral dose of the parent compounds 111
Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injectionof GABA, GABAA and GABAB agonists and antagonists 110
3,5-Di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+-ATPase 109
Dehalogenation and N-dealkylation of chlorpromazine as revealed by plasma concentrations of metabolites in a population of chronically medicated schizophrenics 109
Gold nanoparticles toxicity in rat precision-cut liver slices: a preliminary study 109
Measurement of synthetic phenolic antioxidants in human tissues by high-performance liquid chromatography with coulometric electrochemical detection 109
Evidence of a coupled mechanism between monoamine oxidase and peroxidase in the metabolism of tyramine by rat intestinal mitochondria 107
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl 104
Totale 15.523
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Categoria #
all - tutte 58.535
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 58.535
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020236 0 0 0 0 0 0 0 0 0 0 65 171
2020/20212.395 135 225 54 250 149 327 108 322 261 230 180 154
2021/20221.869 165 222 138 161 96 62 117 96 77 209 183 343
2022/20232.501 151 219 337 386 196 443 61 220 265 108 74 41
2023/20241.780 85 32 157 112 69 484 584 60 4 35 36 122
2024/20252.284 106 164 320 207 419 199 122 238 307 148 54 0
Totale 16.934