We investigated whether heat-stress induced hyperthermia could enhance release of both endogenous taurine and GABA from nerve cells into the extracellular compartment thus acting like endogenous cryogens. Conscious rabbits were exposed for 1 hr to 40 degreesC (heat stress) while cerebrospinal fluid (CSF) and plasma osmolality and the CSF concentrations of some cations, proteins as well as those of taurine and GABA were determined. Heat stress-induced hyperthermia was accompanied by a significant rise in CSF and plasma osmolality, CSF calcium, taurine and GABA levels. It is suggested that during heat stress taurine and GABA are released in the extracellular space of brain tissues in higher amounts, as compared to control conditions, to counteract the resulting hyperthermia, thus acting as cryogenic agents.
Frosini, M., Sesti, C., Palmi, M., Valoti, M., Fusi, F., Mantovani, P., et al. (2000). The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress. In Taurine 4: taurine and excitable tissues (pp. 335-344). Cham : Springer [10.1007/0-306-46838-7_38].
The possible role of taurine and GABA as endogenous cryogens in the rabbit: changes in CSF levels in heat-stress
FROSINI, MARIA;PALMI, MITRI;VALOTI, MASSIMO;FUSI, FABIO;MANTOVANI, PIERO;SGARAGLI, GIAN PIETRO
2000-01-01
Abstract
We investigated whether heat-stress induced hyperthermia could enhance release of both endogenous taurine and GABA from nerve cells into the extracellular compartment thus acting like endogenous cryogens. Conscious rabbits were exposed for 1 hr to 40 degreesC (heat stress) while cerebrospinal fluid (CSF) and plasma osmolality and the CSF concentrations of some cations, proteins as well as those of taurine and GABA were determined. Heat stress-induced hyperthermia was accompanied by a significant rise in CSF and plasma osmolality, CSF calcium, taurine and GABA levels. It is suggested that during heat stress taurine and GABA are released in the extracellular space of brain tissues in higher amounts, as compared to control conditions, to counteract the resulting hyperthermia, thus acting as cryogenic agents.File | Dimensione | Formato | |
---|---|---|---|
2000 ADVEXPMEDBIOL HEAT STRESS .pdf
non disponibili
Tipologia:
PDF editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
240.79 kB
Formato
Adobe PDF
|
240.79 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/450295
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo