IRIS
CORELLI, FEDERICO
 Distribuzione geografica
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Continente #
NA - Nord America 16.975
EU - Europa 13.144
AS - Asia 7.396
SA - Sud America 1.278
AF - Africa 283
Continente sconosciuto - Info sul continente non disponibili 237
OC - Oceania 28
Totale 39.341
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Nazione #
US - Stati Uniti d'America 16.745
GB - Regno Unito 2.891
CN - Cina 2.632
SG - Singapore 2.208
IT - Italia 2.178
RU - Federazione Russa 2.130
IE - Irlanda 1.626
BR - Brasile 1.052
UA - Ucraina 1.049
FR - Francia 935
SE - Svezia 859
DE - Germania 714
VN - Vietnam 638
HK - Hong Kong 571
KR - Corea 432
FI - Finlandia 373
IN - India 222
BD - Bangladesh 170
TR - Turchia 115
ZA - Sudafrica 115
CA - Canada 108
AR - Argentina 74
MX - Messico 74
JP - Giappone 69
ES - Italia 67
IQ - Iraq 51
PL - Polonia 50
NL - Olanda 49
NG - Nigeria 39
PK - Pakistan 36
CI - Costa d'Avorio 35
EC - Ecuador 35
ID - Indonesia 34
BE - Belgio 31
CZ - Repubblica Ceca 28
CL - Cile 27
AU - Australia 25
SA - Arabia Saudita 25
CO - Colombia 24
AT - Austria 23
PY - Paraguay 21
VE - Venezuela 20
UZ - Uzbekistan 19
MA - Marocco 18
EG - Egitto 17
JO - Giordania 17
RO - Romania 17
AE - Emirati Arabi Uniti 16
KE - Kenya 16
MY - Malesia 15
LT - Lituania 14
AL - Albania 13
CH - Svizzera 13
TN - Tunisia 12
TW - Taiwan 12
IL - Israele 11
UY - Uruguay 11
GR - Grecia 10
SN - Senegal 10
EE - Estonia 9
KZ - Kazakistan 9
NP - Nepal 9
PH - Filippine 9
PT - Portogallo 9
TH - Thailandia 9
CR - Costa Rica 8
IR - Iran 8
JM - Giamaica 8
PE - Perù 8
RS - Serbia 8
AZ - Azerbaigian 6
DK - Danimarca 6
GE - Georgia 6
SI - Slovenia 6
TT - Trinidad e Tobago 6
BG - Bulgaria 5
BH - Bahrain 5
HN - Honduras 5
HU - Ungheria 5
LB - Libano 5
LK - Sri Lanka 5
NO - Norvegia 5
AM - Armenia 4
DO - Repubblica Dominicana 4
DZ - Algeria 4
ET - Etiopia 4
EU - Europa 4
LV - Lettonia 4
OM - Oman 4
PS - Palestinian Territory 4
SV - El Salvador 4
SY - Repubblica araba siriana 4
AO - Angola 3
GT - Guatemala 3
GY - Guiana 3
HR - Croazia 3
IM - Isola di Man 3
KG - Kirghizistan 3
KW - Kuwait 3
MD - Moldavia 3
Totale 39.064
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Città #
Southend 2.586
Dallas 2.174
Dublin 1.623
Fairfield 1.487
Menlo Park 1.476
Singapore 1.230
Ashburn 1.038
Jacksonville 849
Chandler 818
Woodbridge 712
Santa Clara 692
Wilmington 638
Beijing 637
Moscow 580
Houston 556
Hong Kong 545
Milan 528
Seattle 505
Cambridge 489
Hefei 455
San Jose 450
Seoul 425
Council Bluffs 383
Siena 350
Ann Arbor 345
The Dalles 301
Princeton 295
Nanjing 288
Ho Chi Minh City 219
Los Angeles 216
Rome 204
Lauterbourg 178
Helsinki 166
Boardman 149
Hanoi 146
New York 144
Nanchang 125
Buffalo 112
Florence 107
San Diego 97
Johannesburg 95
San Mateo 91
São Paulo 90
Fremont 86
Columbus 82
Bengaluru 68
Shenyang 68
Tianjin 63
Shanghai 62
Izmir 61
Munich 59
London 58
Hebei 52
Tokyo 52
Düsseldorf 49
Orem 49
Changsha 43
Frankfurt am Main 43
Dearborn 41
Norwalk 40
Rio de Janeiro 40
Venezia 40
Chicago 38
Chennai 36
Abidjan 35
Naples 35
Abuja 34
Guangzhou 34
San Francisco 34
Turin 33
Kunming 32
Haiphong 31
Jiaxing 31
Turku 30
Figino 29
Lancaster 29
Atlanta 28
Brussels 28
Mumbai 28
Redondo Beach 28
Warsaw 28
Hangzhou 25
Brooklyn 24
Montreal 24
Redwood City 24
Belo Horizonte 23
Mexico City 23
Stockholm 23
Da Nang 22
Jinan 22
Málaga 22
Zhengzhou 22
Bologna 21
Washington 21
Anguillara Sabazia 20
Boston 20
Phoenix 20
Ningbo 19
Baghdad 18
Campinas 18
Totale 26.662
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Nome #
Ligandi TRPV1 519
Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress 413
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 and CB2 receptor ligands 364
Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold 363
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA B receptor 331
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury 328
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease 314
Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach 313
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 284
New fluoroquinolones active against fluoroquinolones-resistant Mycobacterium tuberculosis strains 284
Computational studies of competitive inhibitors of nitric oxide synthase (NOS) enzymes: towards the development of powerful and isoform-selective inhibitors 282
Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists 282
Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice 280
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 278
6-Vinyl pyrimidine and pyrimidinone derivatives and the use thereof 274
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 272
A Novel Route to Calix[4]arenes. 2. Solution- and Solid-State Structural Analyses and Molecular Modeling Studies 271
Synthesis, 1 structural properties, and pharmacological evaluation of 2-(acylamino)thiophene-3-carboxamides and analogues thereof 263
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 260
Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: Involvement of the GABAB and cannabinoid CB1 receptors 257
A new linker for anchoring/masking primary amines on solid support 256
A combinatorial approach for the solid phase synthesis of 5,6-disubstituted pyrimidinones and pyrimidine derivatives 255
An improved synthesis of solid-supported reagents (SSRs) for selective acylation of amines by microwave irradiation 255
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 254
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 254
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility 254
Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor 253
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 252
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 252
Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol. 251
Alpha1-Adrenoceptor Antagonists. 4. Pharmacophore-based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives 250
NUOVA TERAPIA PER IL TRATTAMENTO DELL'IPERURICEMIA NELLA SINDROME DI LESCH-NYHAN 250
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure-Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands 249
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 248
Synthesis and biological evaluation of New N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands 246
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 246
Chiral Azole Derivatives, 3. Synthesis of the Enantiomers of the Potent Aromatase Inhibitor 1-[2-Benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole 244
Regioselective functionalization of quinolin-4(1H)-ones via sequential palladium-catalyzed reactions 243
Combinatorial chemistry as a tool for targeting different stages of the replicative HIV-1 cycle 242
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones 242
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 1. Synthesis and Structure-Activity Relationship of a Class of Human Immunodeficiency Virus type 1 Integrase Inhibitors 241
Design, synthesis, and physicochemical and pharmacological profiling of 7‐Hydroxy-5-oxopyrazolo[4,3‐b]pyridine-6-carboxamide derivatives with antiosteoarthritic activity in vivo 241
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 240
Parallel solution phase synthesis of 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines 240
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 240
A novel highly selective cannabinoid CB2 agonist reduces in vitro growth and TGF-beta release of human glial cell tumors 238
A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent 237
Synthesis of an original oxygenated taxuspine X analogue: a versatile non-natural natural product with remarkable P-gp modulating activity 237
New Resorcinol-Anandamide "Hybrids" as Potent Cannabinoid Receptor Ligands Endowed with antinociceptive activity in vivo 236
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice 236
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists 233
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 2. Synthesis and Structure-Activity Relationship of Potent and Selective Cannabinoid-2 Receptor Agonists Endowed with Analgesic Activity in Vivo 232
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 231
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 230
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides 229
Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors 229
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists 228
Solid phase synthesis of 5,6-disubstituted pyrimidinone and pyrimidindione derivatives 228
Antifungal Agents. 11.N-Substituted Derivatives of 1-[(Aryl)(4-aryl-1H-pyrrol-3yl)methyl]-1H-imidazole: Synthesis, Anti-Candida Activity, and QSAR Studies 227
Solution-phase parallel synthesis of S-DABO analogues 225
Pyrrolobenzodiazepines and related systems. 2. Synthesis and biological properties of isonoraptazepine derivatives 223
5,6-Dihydro-5-[4-[4-(2-methoxyphenyl)-1- piperazinyl]butyl]-4H- pyrrolo[1,2-a][1,4]benzodiazepine-4,6-dione and Related Compounds as New 5-HT1A Receptor Ligands 223
Microwave-assisted ethylene-alkyne cross-metathesis: synthesis of chiral 2-(N-1-acetyl-1-arylmethyl)-1,3-butadienes 222
Reduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure 221
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes 221
COR758, a negative allosteric modulator of GABAB receptors 219
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies 217
Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol (2-AG) Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 (CB1) Receptor 216
The 4-Quinolone-3-carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry 216
Synthesis, Cannabinoid Receptor Affinity, and Molecular Modeling Studies of Substituted 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides 215
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 214
Synthetic bioactive olivetol-related amides: the influence of the phenolic group in cannabinoid receptor activity 212
Chiral Azole Derivatives. 4. Enantiomers of Bifonazole and Related Antifungal Agents: Stereoselective Synthesis, Configuration Assignment, and Biological Evaluation 211
Human Tuberculosis. III. Current and Prospective Approaches in Anti-Tubercular Therapy 211
Solid-phase synthesis (SPS) of substituted uracils via Oxone® cleavage methodology 209
Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands 209
Synthesis, molecular modeling studies, and pharmacological activity of selective A1 receptor antagonists 209
Efficient synthesis of iminoctadine, a potent antifungal agent and polyamine oxidase inhibitor (PAO) 208
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor 208
Anti-addictive properties of COR659 – Additional pharmacological evidence and comparison with a series of novel analogues 208
Three-Dimensional Quantitative Structure-Selectivity Relationships (3D-QSSR) Analysis Guided Rational Design of a Highly Selective Ligand for the Cannabinoid Receptor 2 206
A model for the interaction of the sulfonic distamycin A derivatives, angiogenesis-modulating agents, with recombinant human basic fibroblast growth factor (bFGF) 205
Rational design and synthesis of homochiral azole antifungal agents 203
Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats 203
Probing the substrate specificity for lipases. II. Kinetic and Modeling Studies on the Molecular Recognition of 2-Arylpropionic Esters by Candida rugosa and Rhizomucor miehei Lipases 203
Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors 203
Synthesis and biological evaluation of conformationally restricted analogs of tolmetin and ketorolac 201
Practical synthesis of novel purine analogues as Hsp90 inhibitors. 200
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist 200
Inhibition of alcohol self-administration by positive allosteric modulators of the GABA(B) receptor in rats: lack of tolerance and potentiation of baclofen 200
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands 197
Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents 196
The tetramerization of 2,4-dimethoxycinnamates. A novel route to calixarenes 196
Fibroblast growth factors and their inhibitors 193
Pharmacophore Based Receptor Modeling: The Case of Adenosine A3 Receptor Antagonists. An Approach to the Optimization of Protein Models 193
Stereoselective synthesis of advanced intermediates en route to Taxuspine U and X: a study of macrocyclization via ring closing metathesis to highly constrained twelve-membered rings 192
Probing the substrate specificity for lipases. A CoMFA approach for predicting the hydrolysis rates of 2-arylpropionic esters catalyzed by Candida rugosa lipase 192
Stereoselective synthesis of α-aryl-2-benzofuranmethanamines and α-aryl-1H-indole-2-methanamines through palladium-mediated annulation of chiral α-arylpropargylamines 190
New solid-supported reagents (SSRs) for selective acylation of amines 189
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides 188
Totale 24.148
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Categoria #
all - tutte 119.183
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 119.183
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.091 0 333 146 218 59 71 133 81 86 263 206 495
2022/20233.403 225 226 470 489 332 713 71 278 354 69 106 70
2023/20242.408 127 41 169 143 89 583 852 73 13 42 38 238
2024/20254.944 96 292 461 281 548 261 132 299 433 263 488 1.390
2025/202612.014 979 2.357 1.297 1.205 1.916 432 1.175 362 396 580 310 1.005
2026/2027895 565 330 0 0 0 0 0 0 0 0 0 0
Totale 39.341