The pyrimidine linker (4) was prepared by solid phase synthesis starting from Merrifield resin. Acylation of 4 with different acyl chlorides gave polymerbound 4-acyloxypyrimidines (2a-c), which proved to be useful solid-supported reagents for the selective acylation of amines. Their use in solution combinatorial chemistry has been also envisaged. (author abst.)
Botta, M., Corelli, F., Petricci, E., Seri, C. (2002). New solid-supported reagents (SSRs) for selective acylation of amines. HETEROCYCLES, 56(1-2), 369-377 [10.3987/COM-01-S(K)50].
New solid-supported reagents (SSRs) for selective acylation of amines
BOTTA, MAURIZIO;CORELLI, FEDERICO;PETRICCI, ELENA;
2002-01-01
Abstract
The pyrimidine linker (4) was prepared by solid phase synthesis starting from Merrifield resin. Acylation of 4 with different acyl chlorides gave polymerbound 4-acyloxypyrimidines (2a-c), which proved to be useful solid-supported reagents for the selective acylation of amines. Their use in solution combinatorial chemistry has been also envisaged. (author abst.)File in questo prodotto:
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https://hdl.handle.net/11365/26771
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