IRIS
NACCI, VITO
 Distribuzione geografica
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Continente #
NA - Nord America 3.997
EU - Europa 3.171
AS - Asia 505
OC - Oceania 8
AF - Africa 3
SA - Sud America 1
Totale 7.685
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Nazione #
US - Stati Uniti d'America 3.988
GB - Regno Unito 1.003
IE - Irlanda 657
CN - Cina 444
UA - Ucraina 381
SE - Svezia 379
DE - Germania 239
FR - Francia 192
IT - Italia 112
FI - Finlandia 95
RU - Federazione Russa 45
TR - Turchia 32
ES - Italia 28
SG - Singapore 13
CZ - Repubblica Ceca 9
CA - Canada 8
RO - Romania 8
NL - Olanda 6
AU - Australia 5
BE - Belgio 5
HU - Ungheria 4
GR - Grecia 3
IN - India 3
IR - Iran 3
NZ - Nuova Zelanda 3
JP - Giappone 2
NG - Nigeria 2
SA - Arabia Saudita 2
AZ - Azerbaigian 1
BG - Bulgaria 1
BR - Brasile 1
EE - Estonia 1
HK - Hong Kong 1
ID - Indonesia 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
PA - Panama 1
PK - Pakistan 1
PL - Polonia 1
SK - Slovacchia (Repubblica Slovacca) 1
ZA - Sudafrica 1
Totale 7.685
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Città #
Southend 946
Fairfield 731
Dublin 657
Chandler 339
Ashburn 333
Jacksonville 324
Woodbridge 313
Wilmington 263
Houston 256
Seattle 244
Cambridge 233
Ann Arbor 165
Princeton 106
Nanjing 103
Beijing 102
Nanchang 49
Boardman 45
Fremont 44
Moscow 33
Shanghai 32
Düsseldorf 28
Venezia 27
Málaga 26
Helsinki 25
Izmir 25
San Diego 24
Menlo Park 22
Hebei 19
Shenyang 17
Jiaxing 16
New York 14
Tianjin 14
Kunming 13
Lancaster 13
Ningbo 13
Siena 13
Redwood City 12
San Mateo 12
Changsha 11
Hanover 10
Rende 10
Jinan 8
Norwalk 8
Washington 8
Hangzhou 7
Dearborn 6
Philadelphia 6
Singapore 6
Brno 5
Brussels 5
Lappeenranta 5
Las Vegas 5
London 5
San Francisco 5
Changchun 4
Guangzhou 4
Lanzhou 4
Mestre 4
Saint Petersburg 4
Taizhou 4
Amsterdam 3
Bucharest 3
Edinburgh 3
Haikou 3
Leawood 3
Rome 3
Timisoara 3
Toronto 3
Zhengzhou 3
Andover 2
Berlin 2
Chiswick 2
Enna 2
Frankfurt am Main 2
Hounslow 2
Istanbul 2
Kilburn 2
Lagos 2
Los Angeles 2
Madrid 2
Melbourne 2
Montreal 2
Montréal 2
Olomouc 2
Prague 2
Prato 2
Prescot 2
St Petersburg 2
Zanjan 2
Acton 1
Auburn Hills 1
Bonndorf 1
Boston 1
Bratislava 1
Budapest 1
Canberra 1
Cardiff 1
Castiglion Fibocchi 1
Central 1
Chongqing 1
Totale 5.863
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Nome #
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 175
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 164
Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies 161
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 159
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 156
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 153
Pyrrolo[2,1-c][1,4]benzothiazines: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Cardiovascular Activity 150
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. 150
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. 142
New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure 142
A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor 142
A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors 142
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 141
Pyrrolobenzoxazepinone Derivatives as Non-Nucleoside HIV-1 RT Inhibitors: Further Structure-Activity Relationship Studies and Identification of More Potent Broad-Spectrum HIV-1 RT Inhibitors with Antiviral Activity 140
Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent 140
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 139
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 136
An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity 135
Polycondensed heterocycles. IV. Synthesis of 1,4-Dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazine 135
Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists 133
Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one 132
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 131
Polycondensed heterocycles. V. Synthesis of 5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepine 131
Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands 131
Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones:  Novel and Specific Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors with Antiviral Activity 130
Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21 129
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 128
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships. 128
Novel and Highly Potent 5-HT3 Receptor Agonists Based on a Pyrroloquinoxaline Structure 123
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases 123
Synthesis and biological evaluation of conformationally restricted analogs of tolmetin and ketorolac 122
Polycondensed heterocycles. III. Synthesis of 5,11-dioxo-1,2,3,11a-tetrahydro-5H,11H- and 5-oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzothiazepine 122
Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents 121
Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site 121
New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site 120
Thiazolothiazepine Inhibitors of HIV-1 Integrase 116
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6 116
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 115
Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular mitsunobu cyclisation 114
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 113
Polycondensed heterocycles. VI. A new efficient synthesis of 4H-pyrrolo[2,1-c][1,4]benzothiazines 113
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral-type benzodiazepine receptors (PBR) 111
Polycondensed heterocycles. VII. A convenient synthesis of pyrrolo[1,2-a]quinoxaline derivatives by intramolecular aromatic nucleophilic displacement 111
Polycondensed Heterocycles. Part 11: Preparation and Regioselective Reductions of 5-Phenyl-4H-pyrrolo[1,2-a][1]benzazepin-4-one 111
A rational approach to the design of selective substrates and potent non-transportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). New glutamate and aspartate analogues as potential neuroprotective agents 109
Polycondensed heterocycles. IX. Pyrrolo[2,1-c][1,4]benzothiazepines. Synthesis of 3-(dimethylamino)methyl derivatives 109
Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia 109
Polycondensed heterocycles. VIII. Synthesis of 11-aryl-5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepines by Pummerer rearrangement-cyclization reaction 108
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 107
Pyrrolo[1,3]benzothiazepine-Based Serotonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure-Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents 107
Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents 105
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies. 103
Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors: Past, Present, and Future Perspectives 102
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials. 99
Activation of the c-Jun NH2 Terminal Kinase (JNK) Signalling Pathway is Essential During PBOX-6-Induced Apoptosis in Chronic Myelogenous leukemia (CML) Cells 96
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity 89
Characterisation of 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties 88
Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation 88
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL 79
Pyrrolo-1,5-benzoxazepines Induce Apoptosis in Chronic Myelogenous Leukemia Cells (CML) by Bypassing the Apoptotic Suppressor Bcr-Abl 79
Pyrrolo-1,5-benzoxazepines Induce Apoptosis in HL-60, Jurkart, and Hut-78 Cells: A New Class of Apoptotic Agents 78
The pyrrolo-1,5-benzoxazepine,PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumor growth in vivo 73
Thioanalogues of Antitumor Antibiotics. 1. Synthesis of 7,8-disubstituted 5,11-Dioxo-1,2,3,11a-tetrahydro-5H,11H- and 5-Oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzothiazepine 66
The Stereoselective Targeting of a Specific Enzyme-Substrate Complex is the Molecular Mechanism for the Synergic Inhibition of HIV-1 Reverse Transcriptase by (R)-(-)PPO464, a Novel Generation of Non-Nucleoside Inhibitors 58
Synthesis and Anticholinesterase Activity of Huperzine A Analogues Containing Phenol and Catechol Replacements for the Pyridone Ring 39
null 2
Totale 7.740
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Categoria #
all - tutte 23.817
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.817
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.741 218 60 107 313 111 148 153 219 143 140 26 103
2020/20211.094 57 126 35 106 42 177 55 159 149 38 104 46
2021/2022737 49 146 24 35 60 2 59 30 29 75 76 152
2022/20231.312 77 112 189 184 136 265 29 111 118 35 30 26
2023/2024891 34 19 69 36 33 250 339 22 3 25 8 53
2024/20258 8 0 0 0 0 0 0 0 0 0 0 0
Totale 7.740