IRIS
NACCI, VITO
 Distribuzione geografica
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Continente #
NA - Nord America 6.109
EU - Europa 4.585
AS - Asia 2.448
SA - Sud America 360
AF - Africa 88
Continente sconosciuto - Info sul continente non disponibili 57
OC - Oceania 11
AN - Antartide 1
Totale 13.659
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Nazione #
US - Stati Uniti d'America 6.046
GB - Regno Unito 1.049
CN - Cina 972
RU - Federazione Russa 872
SG - Singapore 730
IE - Irlanda 660
IT - Italia 423
UA - Ucraina 385
SE - Svezia 383
DE - Germania 300
BR - Brasile 293
FR - Francia 269
VN - Vietnam 184
HK - Hong Kong 178
KR - Corea 136
FI - Finlandia 109
IN - India 64
ES - Italia 40
TR - Turchia 40
CA - Canada 37
BD - Bangladesh 34
ZA - Sudafrica 32
AR - Argentina 24
IQ - Iraq 20
PL - Polonia 18
NL - Olanda 17
VE - Venezuela 17
NG - Nigeria 16
CI - Costa d'Avorio 15
CZ - Repubblica Ceca 14
JP - Giappone 13
MX - Messico 12
KE - Kenya 10
CL - Cile 9
PK - Pakistan 9
RO - Romania 8
AZ - Azerbaigian 7
UZ - Uzbekistan 7
AU - Australia 6
CO - Colombia 6
SA - Arabia Saudita 6
BE - Belgio 5
EC - Ecuador 5
GR - Grecia 5
ID - Indonesia 5
IL - Israele 5
TN - Tunisia 5
HU - Ungheria 4
JM - Giamaica 4
LT - Lituania 4
MA - Marocco 4
NZ - Nuova Zelanda 4
BY - Bielorussia 3
GE - Georgia 3
IR - Iran 3
KG - Kirghizistan 3
KZ - Kazakistan 3
LA - Repubblica Popolare Democratica del Laos 3
MY - Malesia 3
PA - Panama 3
PS - Palestinian Territory 3
QA - Qatar 3
AM - Armenia 2
AT - Austria 2
BG - Bulgaria 2
DZ - Algeria 2
EE - Estonia 2
JO - Giordania 2
LU - Lussemburgo 2
LV - Lettonia 2
MM - Myanmar 2
PE - Perù 2
PH - Filippine 2
PT - Portogallo 2
PY - Paraguay 2
UY - Uruguay 2
AE - Emirati Arabi Uniti 1
AO - Angola 1
AQ - Antartide 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BS - Bahamas 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
ET - Etiopia 1
GP - Guadalupe 1
HN - Honduras 1
KH - Cambogia 1
LB - Libano 1
LY - Libia 1
MD - Moldavia 1
MN - Mongolia 1
NC - Nuova Caledonia 1
NO - Norvegia 1
NP - Nepal 1
SK - Slovacchia (Repubblica Slovacca) 1
SV - El Salvador 1
SY - Repubblica araba siriana 1
Totale 13.602
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Città #
Southend 946
Fairfield 731
Dublin 660
Dallas 512
Ashburn 469
Singapore 415
Chandler 339
Jacksonville 324
Woodbridge 313
Santa Clara 307
Wilmington 264
Houston 260
Seattle 246
Cambridge 233
Beijing 221
Moscow 219
San Jose 192
Hefei 175
Milan 175
Hong Kong 167
Ann Arbor 165
Seoul 136
Princeton 106
Nanjing 105
Council Bluffs 95
Los Angeles 89
The Dalles 89
Ho Chi Minh City 73
Lauterbourg 58
Rome 56
New York 52
Hanoi 50
Nanchang 49
Boardman 45
Fremont 44
Munich 41
Shanghai 39
Buffalo 33
Helsinki 33
São Paulo 33
Johannesburg 30
Düsseldorf 29
Venezia 27
Málaga 26
Izmir 25
San Diego 24
Menlo Park 22
Bengaluru 19
Hebei 19
Jiaxing 17
Shenyang 17
Warsaw 17
Chicago 16
Figino 16
Tianjin 16
Abidjan 15
Chennai 15
Montreal 15
Changsha 14
Kunming 14
Abuja 13
Lancaster 13
Ningbo 13
Siena 13
Orem 12
Redwood City 12
San Mateo 12
Tokyo 12
Turin 12
Atlanta 11
Frankfurt am Main 11
Kensington 11
London 11
Denver 10
Hanover 10
Rende 10
San Francisco 10
Toronto 9
Washington 9
Amsterdam 8
Boston 8
Da Nang 8
Hangzhou 8
Jinan 8
Norwalk 8
Redondo Beach 8
Brno 7
Dhaka 7
Guangzhou 7
Haiphong 7
Philadelphia 7
Phoenix 7
Tashkent 7
Baghdad 6
Baku 6
Belo Horizonte 6
Bologna 6
Caracas 6
Dearborn 6
Nairobi 6
Totale 9.313
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Nome #
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 417
A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors 325
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 288
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 285
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 282
A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor 282
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 271
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 265
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 258
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 250
Pyrrolobenzoxazepinone Derivatives as Non-Nucleoside HIV-1 RT Inhibitors: Further Structure-Activity Relationship Studies and Identification of More Potent Broad-Spectrum HIV-1 RT Inhibitors with Antiviral Activity 247
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 244
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 243
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 243
New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure 242
An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity 242
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 241
New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site 238
A rational approach to the design of selective substrates and potent non-transportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). New glutamate and aspartate analogues as potential neuroprotective agents 231
Pyrrolo[2,1-c][1,4]benzothiazines: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Cardiovascular Activity 228
Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent 226
Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies 225
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 224
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 223
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 221
Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site 220
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 218
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 212
Activation of the c-Jun NH2 Terminal Kinase (JNK) Signalling Pathway is Essential During PBOX-6-Induced Apoptosis in Chronic Myelogenous leukemia (CML) Cells 209
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases 205
Characterisation of 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties 204
Synthesis and biological evaluation of conformationally restricted analogs of tolmetin and ketorolac 201
Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21 200
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6 199
Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia 198
Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists 197
Novel and Highly Potent 5-HT3 Receptor Agonists Based on a Pyrroloquinoxaline Structure 195
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 195
Thiazolothiazepine Inhibitors of HIV-1 Integrase 194
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity 193
Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones:  Novel and Specific Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors with Antiviral Activity 193
Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one 192
Pyrrolo[1,3]benzothiazepine-Based Serotonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure-Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents 191
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral-type benzodiazepine receptors (PBR) 188
Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents 187
Polycondensed heterocycles. VI. A new efficient synthesis of 4H-pyrrolo[2,1-c][1,4]benzothiazines 186
Polycondensed heterocycles. V. Synthesis of 5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepine 183
Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation 180
Polycondensed heterocycles. IV. Synthesis of 1,4-Dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazine 179
Polycondensed heterocycles. III. Synthesis of 5,11-dioxo-1,2,3,11a-tetrahydro-5H,11H- and 5-oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzothiazepine 177
Polycondensed heterocycles. VIII. Synthesis of 11-aryl-5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepines by Pummerer rearrangement-cyclization reaction 176
Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands 175
Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular mitsunobu cyclisation 173
Polycondensed Heterocycles. Part 11: Preparation and Regioselective Reductions of 5-Phenyl-4H-pyrrolo[1,2-a][1]benzazepin-4-one 172
Polycondensed heterocycles. VII. A convenient synthesis of pyrrolo[1,2-a]quinoxaline derivatives by intramolecular aromatic nucleophilic displacement 168
Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents 168
Polycondensed heterocycles. IX. Pyrrolo[2,1-c][1,4]benzothiazepines. Synthesis of 3-(dimethylamino)methyl derivatives 163
Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors: Past, Present, and Future Perspectives 159
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL 155
The pyrrolo-1,5-benzoxazepine,PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumor growth in vivo 154
Pyrrolo-1,5-benzoxazepines Induce Apoptosis in HL-60, Jurkart, and Hut-78 Cells: A New Class of Apoptotic Agents 153
Pyrrolo-1,5-benzoxazepines Induce Apoptosis in Chronic Myelogenous Leukemia Cells (CML) by Bypassing the Apoptotic Suppressor Bcr-Abl 138
The Stereoselective Targeting of a Specific Enzyme-Substrate Complex is the Molecular Mechanism for the Synergic Inhibition of HIV-1 Reverse Transcriptase by (R)-(-)PPO464, a Novel Generation of Non-Nucleoside Inhibitors 134
Thioanalogues of Antitumor Antibiotics. 1. Synthesis of 7,8-disubstituted 5,11-Dioxo-1,2,3,11a-tetrahydro-5H,11H- and 5-Oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzothiazepine 117
Synthesis and Anticholinesterase Activity of Huperzine A Analogues Containing Phenol and Catechol Replacements for the Pyridone Ring 115
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Totale 13.659
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Categoria #
all - tutte 41.814
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.814
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022688 0 146 24 35 60 2 59 30 29 75 76 152
2022/20231.312 77 112 189 184 136 265 29 111 118 35 30 26
2023/2024891 34 19 69 36 33 250 339 22 3 25 8 53
2024/20251.639 17 89 189 65 241 68 26 48 170 42 152 532
2025/20263.843 323 602 342 418 700 188 391 110 129 200 73 367
2026/2027445 167 278 0 0 0 0 0 0 0 0 0 0
Totale 13.659