IRIS
NACCI, VITO
 Distribuzione geografica
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Continente #
NA - Nord America 4.168
EU - Europa 3.408
AS - Asia 609
AF - Africa 18
OC - Oceania 9
SA - Sud America 1
Totale 8.213
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Nazione #
US - Stati Uniti d'America 4.157
GB - Regno Unito 1.006
IE - Irlanda 658
CN - Cina 445
UA - Ucraina 381
SE - Svezia 380
RU - Federazione Russa 258
DE - Germania 242
FR - Francia 192
IT - Italia 115
SG - Singapore 110
FI - Finlandia 97
TR - Turchia 32
ES - Italia 29
CI - Costa d'Avorio 15
CZ - Repubblica Ceca 12
CA - Canada 9
RO - Romania 8
NL - Olanda 7
AU - Australia 5
BE - Belgio 5
HU - Ungheria 4
NZ - Nuova Zelanda 4
AZ - Azerbaigian 3
GR - Grecia 3
IN - India 3
IR - Iran 3
LA - Repubblica Popolare Democratica del Laos 3
EE - Estonia 2
JP - Giappone 2
NG - Nigeria 2
PA - Panama 2
SA - Arabia Saudita 2
AE - Emirati Arabi Uniti 1
BG - Bulgaria 1
BR - Brasile 1
BY - Bielorussia 1
DK - Danimarca 1
HK - Hong Kong 1
ID - Indonesia 1
KG - Kirghizistan 1
KH - Cambogia 1
LT - Lituania 1
LV - Lettonia 1
NO - Norvegia 1
PK - Pakistan 1
PL - Polonia 1
PT - Portogallo 1
SK - Slovacchia (Repubblica Slovacca) 1
ZA - Sudafrica 1
Totale 8.213
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Città #
Southend 946
Fairfield 731
Dublin 658
Chandler 339
Ashburn 336
Jacksonville 324
Woodbridge 313
Wilmington 263
Houston 256
Seattle 244
Cambridge 233
Ann Arbor 165
Santa Clara 130
Princeton 106
Nanjing 103
Beijing 102
Singapore 79
Nanchang 49
Boardman 45
Fremont 44
Moscow 33
Shanghai 32
Düsseldorf 28
Helsinki 27
Venezia 27
Málaga 26
Izmir 25
San Diego 24
Menlo Park 22
Hebei 19
Shenyang 17
Jiaxing 16
Abidjan 15
New York 14
Tianjin 14
Kunming 13
Lancaster 13
Ningbo 13
Siena 13
Redwood City 12
San Mateo 12
Changsha 11
Hanover 10
Rende 10
Los Angeles 9
Jinan 8
Norwalk 8
Washington 8
Brno 7
Hangzhou 7
Dearborn 6
Philadelphia 6
Brussels 5
Dallas 5
Lappeenranta 5
Las Vegas 5
London 5
San Francisco 5
Changchun 4
Frankfurt am Main 4
Guangzhou 4
Lanzhou 4
Mestre 4
Saint Petersburg 4
Taizhou 4
Toronto 4
Amsterdam 3
Bucharest 3
Edinburgh 3
Haikou 3
Leawood 3
Prague 3
Rome 3
Timisoara 3
Vientiane 3
Zhengzhou 3
Andover 2
Baku 2
Berlin 2
Chiswick 2
Enna 2
Hounslow 2
Istanbul 2
Kilburn 2
Lagos 2
Madrid 2
Melbourne 2
Montreal 2
Montréal 2
Olomouc 2
Prato 2
Prescot 2
St Petersburg 2
Tallinn 2
Zanjan 2
Acton 1
Auburn Hills 1
Auckland 1
Bishkek 1
Bonndorf 1
Totale 6.106
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Nome #
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine d3 and serotonin 5-HT 1A and 5-HT2A receptors: Design, synthesis, and effects on behavior 191
Pyrrolo 1,3 benzothiazepine-based Atypical Antipsychotic Agents. Synthesis, Structure-Activity Relationship, Molecular Modeling, and Biological Studies 171
Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR):  From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers 170
Exploiting Protein Fluctuations at the Active-Site Gorge of Human Cholinesterases: Further Optimization of the Design Strategy to Develop Extremely Potent Inhibitors 167
Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies 167
Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore 167
Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT3 Receptor Agonists: Synthesis, Further Structure-Activity Relationships, and Biological Studies 159
Pyrrolo[2,1-c][1,4]benzothiazines: Synthesis, Structure-Activity Relationships, Molecular Modeling Studies, and Cardiovascular Activity 155
A Concerted Study Using Binding Measurements, X-ray Structural Data, and Molecular Modeling on the Stereochemical Features Responsible for the Affinity of 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines toward Mitochondrial Benzodiazepine Receptors 155
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents 153
New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure 153
A Comparative Molecular Field Analysis Model for 6-Arylpyrrolo[2,1-d][1,5]benzothiazepines Binding Selectively to the Mitochondrial Benzodiazepine Receptor 152
Pyrrolobenzoxazepinone Derivatives as Non-Nucleoside HIV-1 RT Inhibitors: Further Structure-Activity Relationship Studies and Identification of More Potent Broad-Spectrum HIV-1 RT Inhibitors with Antiviral Activity 151
Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent 151
A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring 150
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors 149
Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663 145
An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity 145
Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target 143
Discovery of Huperzine A/Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Mid-gorge Recognition Sites 140
Polycondensed heterocycles. IV. Synthesis of 1,4-Dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazine 139
Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands 139
Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21 138
Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation and Structure Activity Relationships 138
Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists 137
Polycondensed heterocycles. V. Synthesis of 5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepine 137
Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one 137
Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones:  Novel and Specific Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors with Antiviral Activity 134
Neuronal high affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases 132
Synthesis and biological evaluation of conformationally restricted analogs of tolmetin and ketorolac 130
New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site 130
Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site 129
Novel and Highly Potent 5-HT3 Receptor Agonists Based on a Pyrroloquinoxaline Structure 128
'Polycondensed heterocycles. Part 12: an approach to the synthesis of 2-acetyl-1'-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-pyrrolidine]-2'-one 126
Polycondensed heterocycles. III. Synthesis of 5,11-dioxo-1,2,3,11a-tetrahydro-5H,11H- and 5-oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzothiazepine 126
Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents 125
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6 125
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies 124
Thiazolothiazepine Inhibitors of HIV-1 Integrase 122
Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular mitsunobu cyclisation 120
Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia 120
Polycondensed Heterocycles. Part 11: Preparation and Regioselective Reductions of 5-Phenyl-4H-pyrrolo[1,2-a][1]benzazepin-4-one 119
A rational approach to the design of selective substrates and potent non-transportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). New glutamate and aspartate analogues as potential neuroprotective agents 118
Polycondensed heterocycles. VI. A new efficient synthesis of 4H-pyrrolo[2,1-c][1,4]benzothiazines 118
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behaviour and the Role of Dopamine D3/D2Receptors 116
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, Biological and Structure-Activity Relationship Studies 116
Polycondensed heterocycles. VII. A convenient synthesis of pyrrolo[1,2-a]quinoxaline derivatives by intramolecular aromatic nucleophilic displacement 116
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral-type benzodiazepine receptors (PBR) 115
Polycondensed heterocycles. IX. Pyrrolo[2,1-c][1,4]benzothiazepines. Synthesis of 3-(dimethylamino)methyl derivatives 114
Polycondensed heterocycles. VIII. Synthesis of 11-aryl-5H,11H-Pyrrolo[2,1-c][1,4]benzothiazepines by Pummerer rearrangement-cyclization reaction 113
Combining 4-Aminoquinoline- and Clotrimazole-based Pharmacophores towards Innovative and Potent Hybrid Antimalarials 112
Pyrrolo[1,3]benzothiazepine-Based Serotonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure-Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents 112
Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents 109
Activation of the c-Jun NH2 Terminal Kinase (JNK) Signalling Pathway is Essential During PBOX-6-Induced Apoptosis in Chronic Myelogenous leukemia (CML) Cells 107
Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors: Past, Present, and Future Perspectives 105
Characterisation of 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties 98
Benzothiazine and Benzothiazepine derivatives: synthesis and preliminary biological evaluation 97
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity 97
Pyrrolo-1,5-benzoxazepines Induce Apoptosis in HL-60, Jurkart, and Hut-78 Cells: A New Class of Apoptotic Agents 85
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL 85
Pyrrolo-1,5-benzoxazepines Induce Apoptosis in Chronic Myelogenous Leukemia Cells (CML) by Bypassing the Apoptotic Suppressor Bcr-Abl 85
The pyrrolo-1,5-benzoxazepine,PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumor growth in vivo 78
Thioanalogues of Antitumor Antibiotics. 1. Synthesis of 7,8-disubstituted 5,11-Dioxo-1,2,3,11a-tetrahydro-5H,11H- and 5-Oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzothiazepine 71
The Stereoselective Targeting of a Specific Enzyme-Substrate Complex is the Molecular Mechanism for the Synergic Inhibition of HIV-1 Reverse Transcriptase by (R)-(-)PPO464, a Novel Generation of Non-Nucleoside Inhibitors 63
Synthesis and Anticholinesterase Activity of Huperzine A Analogues Containing Phenol and Catechol Replacements for the Pyridone Ring 47
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Totale 8.268
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Categoria #
all - tutte 26.501
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.501
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.043 0 0 0 0 111 148 153 219 143 140 26 103
2020/20211.094 57 126 35 106 42 177 55 159 149 38 104 46
2021/2022737 49 146 24 35 60 2 59 30 29 75 76 152
2022/20231.312 77 112 189 184 136 265 29 111 118 35 30 26
2023/2024891 34 19 69 36 33 250 339 22 3 25 8 53
2024/2025536 17 89 189 65 176 0 0 0 0 0 0 0
Totale 8.268