A modified Mitsunobu reaction of 2-hydroxymethylpyrrole and suitable thiophenol derivatives lead to intermediates which can be easily elaborated and eventually cyclised to the title compounds. The cyclisation step consists of another Mitsunobu reaction variation by which an 'activated' pyrrole is N- alkylated intramolecularly, under very mild conditions.
Garofalo, A., Campiani, G., Fiorini, I., Nacci, V. (1999). Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular mitsunobu cyclisation. TETRAHEDRON, 55(5), 1479-1490 [10.1016/S0040-4020(98)01127-2].
Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular mitsunobu cyclisation
Campiani, Giuseppe;Fiorini, Isabella;Nacci, Vito
1999-01-01
Abstract
A modified Mitsunobu reaction of 2-hydroxymethylpyrrole and suitable thiophenol derivatives lead to intermediates which can be easily elaborated and eventually cyclised to the title compounds. The cyclisation step consists of another Mitsunobu reaction variation by which an 'activated' pyrrole is N- alkylated intramolecularly, under very mild conditions.
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https://hdl.handle.net/11365/30170
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