The preparation of 4a-g, conformationally rigid calcium channel blockers related to Diltiazem, is described starting from tricyclic compounds 5a-c. On radioreceptor assay and preliminary biochemical tests some compounds show high affinity for Calcium Channel Receptors (CCRs) and calcium antagonistic activity comparable or superior to that of Diltiazem. © 1992.
Campiani, G., Nacci, V., Garofalo, A., Botta, M., Fiorini, I., Tafi, A., et al. (1992). Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2(10), 1193-1198 [10.1016/S0960-894X(00)80212-7].
Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists
Campiani G.;Nacci V.;Botta M.;Fiorini I.;Tafi A.;
1992-01-01
Abstract
The preparation of 4a-g, conformationally rigid calcium channel blockers related to Diltiazem, is described starting from tricyclic compounds 5a-c. On radioreceptor assay and preliminary biochemical tests some compounds show high affinity for Calcium Channel Receptors (CCRs) and calcium antagonistic activity comparable or superior to that of Diltiazem. © 1992.
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https://hdl.handle.net/11365/28232
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