IRIS
DOCQUIER, JEAN DENIS
 Distribuzione geografica
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Continente #
EU - Europa 6.657
NA - Nord America 5.876
AS - Asia 1.081
AF - Africa 48
OC - Oceania 19
Continente sconosciuto - Info sul continente non disponibili 16
SA - Sud America 13
Totale 13.710
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Nazione #
US - Stati Uniti d'America 5.849
GB - Regno Unito 1.920
IE - Irlanda 1.281
IT - Italia 1.052
CN - Cina 810
UA - Ucraina 639
SE - Svezia 492
FR - Francia 381
DE - Germania 321
RU - Federazione Russa 211
FI - Finlandia 184
SG - Singapore 118
CI - Costa d'Avorio 42
VN - Vietnam 41
BE - Belgio 37
NL - Olanda 34
TR - Turchia 34
CA - Canada 23
CZ - Repubblica Ceca 23
PL - Polonia 21
IN - India 18
AU - Australia 17
EU - Europa 15
ES - Italia 14
RO - Romania 14
HK - Hong Kong 10
JP - Giappone 8
GR - Grecia 7
KR - Corea 7
BR - Brasile 6
CH - Svizzera 5
AR - Argentina 4
IL - Israele 4
PH - Filippine 4
HU - Ungheria 3
IQ - Iraq 3
MD - Moldavia 3
NG - Nigeria 3
SA - Arabia Saudita 3
AL - Albania 2
AM - Armenia 2
HR - Croazia 2
IR - Iran 2
KZ - Kazakistan 2
LA - Repubblica Popolare Democratica del Laos 2
MK - Macedonia 2
NZ - Nuova Zelanda 2
PA - Panama 2
PT - Portogallo 2
TH - Thailandia 2
UZ - Uzbekistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BD - Bangladesh 1
BG - Bulgaria 1
BO - Bolivia 1
BT - Bhutan 1
BY - Bielorussia 1
CL - Cile 1
CR - Costa Rica 1
EC - Ecuador 1
EE - Estonia 1
EG - Egitto 1
GE - Georgia 1
IM - Isola di Man 1
KE - Kenya 1
KG - Kirghizistan 1
LU - Lussemburgo 1
MT - Malta 1
MX - Messico 1
NO - Norvegia 1
NP - Nepal 1
PK - Pakistan 1
TW - Taiwan 1
ZA - Sudafrica 1
Totale 13.710
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Città #
Southend 1.770
Dublin 1.273
Chandler 651
Fairfield 574
Jacksonville 509
Menlo Park 481
Ann Arbor 358
Ashburn 356
Siena 350
Wilmington 295
Woodbridge 285
Princeton 236
Seattle 226
Houston 186
Cambridge 184
Nanjing 168
Beijing 147
Fremont 145
Boardman 130
Helsinki 93
New York 88
Florence 72
Nanchang 67
Singapore 67
San Diego 62
Moscow 60
Shanghai 58
Milan 57
San Mateo 56
Rome 43
Abidjan 42
Shenyang 42
Düsseldorf 40
Dong Ket 38
Tianjin 37
Brussels 35
Sesto Fiorentino 30
Venezia 27
Izmir 26
Amsterdam 25
Jiaxing 25
Kunming 25
London 24
Changsha 20
Hebei 18
Jinan 16
West Jordan 16
Dearborn 15
Guangzhou 15
Ningbo 15
Norwalk 14
Nuremberg 14
Gdynia 13
Brno 12
Falls Church 12
Hangzhou 12
Los Angeles 11
Málaga 11
Philadelphia 11
San Francisco 11
Zhengzhou 11
Chicago 10
Redwood City 10
Taizhou 10
Timisoara 10
Kilburn 9
Lancaster 9
Bologna 8
Padova 8
Paris 8
Prato 8
Torino 8
Anguillara Sabazia 7
Hanover 7
Munich 7
Toronto 7
Auburn Hills 6
Hong Kong 6
Islington 6
Olomouc 6
Pisa 6
Turin 6
Bari 5
Changchun 5
Chengdu 5
Hefei 5
Melbourne 5
Montreal 5
Naples 5
New Bedfont 5
Shenzhen 5
Tappahannock 5
Acton 4
Brescia 4
Cagliari 4
Canberra 4
Carmignano 4
Edinburgh 4
Falkenstein 4
Kocaeli 4
Totale 9.954
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Nome #
1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases 378
Antibiotico-resistenza e Batteri ambientali 232
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 226
Linear guanidine derivatives, methods of preparation and uses thereof 210
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 206
Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily 201
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 197
An update on β-lactamase inhibitor discovery and development 191
Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece 183
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 182
Immunization with Toscana virus N-Gc proteins protects mice against virus challenge 181
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 179
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 178
Discovery of a Novel Metallo-β-Lactamase Inhibitor that Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae 171
Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. 167
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 163
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 156
Structure-Function Relationships of Class D Carbapenemases 153
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 149
Resistenza ai carbapenemi in Pseudomonas aeruginosa: ruolo delle metallo-beta-lattamasi acquisite. 143
Characterization of a Functional Metallo-β-Lactamase from the Marine Bacterium Haliangium ochraceum 143
X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40 Class D Carbapenemase Inhibited by NXL104 142
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 139
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 136
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 133
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 131
Preparation of new macrocyclic amidinourea derivatives as chitinase inhibitors 131
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 131
null 130
Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in Sequence Type 621 129
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases 129
Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics 127
Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity 123
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 122
null 121
null 120
Structure-fucntion relationship of the NDM-1 metallo-beta-lactamase: Importance of Trp-87 in enzyme structure, function and stability. 113
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 112
Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC  beta-Lactamases 112
FIM-1, a new acquired metallo-beta-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy 112
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 111
null 111
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases 109
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 109
Editorial overview: Anti-infectives: Towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need 108
Purification and characterization of PBP4a, a new low-molecular-weight penicillin-binding protein from Bacillus subtilis 107
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates 107
High-Resolution Crystal Structure of the Subclass B3 Metallo-beta-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides 105
Crystal structure and mutational analysis of FUS-1 (OXA-85), a class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum 104
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases 103
null 103
Carbapenemases in microbial drug resistance. 102
Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa producing the VIM-1 metallo-beta-lactamase from different Italian hospitals 100
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 100
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 100
Purification and biochemical characterization of IMP-13 metallo-beta-lactamase. 97
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa 96
IMP-12, a plasmid-encoded metallo-beta-lactamase of the IMP-type from a Pseudomonas putida clinical isolate. 96
Microbiological analysis of hospital wastewaters: impact of water treatment on microbial biodiversity and antimicrobial resistance. 96
null 94
Metallo-β-lactamase producers in environmental microbiota: New molecular class B enzyme in Janthinobacterium lividum 93
Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes 92
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 92
Structure of the extended-spectrum beta-lactamase TEM-72 inhibited by citrate 91
Interaction of Ceftaroline with Clinically-Relevant β-Lactamases 91
Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum 90
4-(N-alkyl-and-acyl-amino)-1,2,4-triazole-3-thione analogs as metallo-β-lactamase inhibitors: Impact of 4-linker on potency and spectrum of inhibition 90
null 90
Structural and functional characterization of two new class D beta-lactamases: OXA-46 and OXA-48 89
null 89
Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4 89
Purification and biochemical characterization of the VIM-1 metallo-β-lactamase 88
Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea 88
Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes 87
Antibiotic Resistance, Medical Need and Development of Novel Antibacterials 86
Mimicking the Ala220 Duplication of OXA-146 (an OXA-23 variant) in OXA-40 and OXA-48 Highlights Mechanistic Differences among Class D Carbapenemases. 85
Characterization of a novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron 85
[Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms]. 84
Molecular and biochemical characterization of cmy-16 from Proteus mirabilis. 84
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design. 83
Functional diversity among metallo-β-lactamases: characterization of the CAR-1 enzyme of Erwinia Carotovora 82
Probing the role of R2-loop deletions and substituions on the functional properties of the acquired AmpC-type β-lactamase CMY-2. 82
Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA 81
Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase 79
Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding 79
Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-beta-lactamases 78
CENTA as a chromogenic substrate for studying β-lactamases 78
Inducible class C beta-lactamases produced by psychrophilic bacteria 78
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors 77
The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form 77
Clonal relatedness of Pseudomonas aeruginosa producine the VIM-1 metallo-beta-lactamase from different italina hospitals. 77
Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-beta-lactamase encoded by a conjugative plasmid 76
Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues 76
IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso 73
Postgenomic scan of metallo-beta-lactamase homologues in rhizobacteria: identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum 72
Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak 72
OXA-46, a new class D beta-lactamase of narrow substrate specificity, encoded by a blaVIM-1-containing integron from a Pseudomonas aeruginosa clinical isolate 72
Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase 71
Epidemiology of infections caused by multiresistant gram-negatives: ESBLs, MBLs, panresistant strains 70
Structure and function of metallo-β-lactamases. Meet-the-Experts session “Structure, Function and Genetics of Metallo-β-Lactamases”. 70
Totale 11.726
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Categoria #
all - tutte 47.522
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.522
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.647 0 0 159 359 89 91 120 263 172 183 48 163
2020/20212.129 74 202 29 168 95 328 169 316 231 205 152 160
2021/20221.703 92 174 118 114 120 60 73 75 99 201 198 379
2022/20232.383 151 208 296 343 250 473 50 215 256 28 67 46
2023/20242.260 89 40 232 92 118 483 714 65 5 106 74 242
2024/2025424 185 239 0 0 0 0 0 0 0 0 0 0
Totale 14.002