IRIS
DOCQUIER, JEAN DENIS
 Distribuzione geografica
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Continente #
NA - Nord America 37.942
EU - Europa 9.687
AS - Asia 5.311
SA - Sud America 1.044
AF - Africa 332
OC - Oceania 26
Continente sconosciuto - Info sul continente non disponibili 17
Totale 54.359
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Nazione #
US - Stati Uniti d'America 37.777
GB - Regno Unito 2.075
RU - Federazione Russa 1.844
CN - Cina 1.826
IT - Italia 1.556
SG - Singapore 1.479
IE - Irlanda 1.283
BR - Brasile 869
UA - Ucraina 639
FR - Francia 599
VN - Vietnam 544
SE - Svezia 515
DE - Germania 497
HK - Hong Kong 483
KR - Corea 296
FI - Finlandia 234
ZA - Sudafrica 176
IN - India 168
CA - Canada 84
NL - Olanda 82
TR - Turchia 79
AR - Argentina 71
PL - Polonia 67
ES - Italia 66
BD - Bangladesh 58
IQ - Iraq 55
PK - Pakistan 47
BE - Belgio 46
CI - Costa d'Avorio 43
MX - Messico 43
JP - Giappone 40
NG - Nigeria 37
EC - Ecuador 27
CZ - Repubblica Ceca 26
ID - Indonesia 26
AT - Austria 25
PT - Portogallo 24
SA - Arabia Saudita 24
CO - Colombia 22
AU - Australia 21
KE - Kenya 20
UZ - Uzbekistan 19
JO - Giordania 18
VE - Venezuela 18
CH - Svizzera 16
RO - Romania 16
EU - Europa 15
NP - Nepal 15
AE - Emirati Arabi Uniti 14
CL - Cile 13
EG - Egitto 13
IR - Iran 13
GR - Grecia 12
PH - Filippine 12
TN - Tunisia 12
IL - Israele 11
MY - Malesia 11
ET - Etiopia 9
LT - Lituania 9
KZ - Kazakistan 8
BO - Bolivia 7
HN - Honduras 7
JM - Giamaica 7
MA - Marocco 7
OM - Oman 7
PA - Panama 7
PY - Paraguay 7
AL - Albania 6
GE - Georgia 6
AZ - Azerbaigian 5
BA - Bosnia-Erzegovina 5
CR - Costa Rica 5
DZ - Algeria 5
KG - Kirghizistan 5
LA - Repubblica Popolare Democratica del Laos 5
LV - Lettonia 5
PE - Perù 5
TW - Taiwan 5
UY - Uruguay 5
AM - Armenia 4
HU - Ungheria 4
MD - Moldavia 4
NI - Nicaragua 4
NO - Norvegia 4
NZ - Nuova Zelanda 4
SI - Slovenia 4
TH - Thailandia 4
BG - Bulgaria 3
BH - Bahrain 3
BY - Bielorussia 3
CY - Cipro 3
HR - Croazia 3
KW - Kuwait 3
LB - Libano 3
MK - Macedonia 3
SN - Senegal 3
AO - Angola 2
CG - Congo 2
DK - Danimarca 2
EE - Estonia 2
Totale 54.325
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Città #
Dallas 29.451
Southend 1.758
Dublin 1.275
Singapore 824
Chandler 643
Fairfield 573
Ashburn 572
Moscow 541
Jacksonville 506
Santa Clara 484
Menlo Park 477
Hong Kong 460
Siena 412
Beijing 390
Ann Arbor 358
Hefei 320
San Jose 302
Wilmington 294
Woodbridge 285
Seoul 281
Princeton 234
Seattle 230
The Dalles 223
Houston 191
Los Angeles 190
Cambridge 185
Nanjing 167
Johannesburg 162
Ho Chi Minh City 153
Milan 145
Fremont 144
Lauterbourg 141
New York 136
Boardman 132
Hanoi 118
Helsinki 113
Florence 111
Council Bluffs 105
São Paulo 85
Munich 84
Buffalo 72
Rome 71
San Diego 71
Shanghai 69
Nanchang 66
Düsseldorf 56
San Mateo 56
London 51
Nuremberg 48
Orem 48
Bengaluru 46
Columbus 45
Shenyang 45
Abidjan 43
Redondo Beach 43
Brussels 42
Tianjin 39
Warsaw 39
Dong Ket 38
Frankfurt am Main 38
Amsterdam 37
Chennai 34
Chicago 34
Tokyo 34
Sesto Fiorentino 32
Abuja 31
Izmir 29
Rio de Janeiro 29
Coslada 28
Da Nang 28
Montreal 28
Guangzhou 26
Kensington 26
Kunming 26
Poplar 26
Venezia 26
Changsha 25
Jiaxing 25
Toronto 22
San Francisco 21
Haiphong 20
Jinan 20
Atlanta 19
Hangzhou 19
Phoenix 19
Baghdad 18
Brasília 18
Brooklyn 18
Hebei 18
Mexico City 18
Tashkent 18
Brescia 17
Denver 17
Istanbul 17
Porto Alegre 17
Turku 17
Amman 16
Ningbo 16
Stockholm 16
West Jordan 16
Totale 45.202
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Nome #
1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases 7.634
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.462
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.351
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors 7.306
Antibiotico-resistenza e Batteri ambientali 371
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 370
Linear guanidine derivatives, methods of preparation and uses thereof 359
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 348
Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste 340
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 327
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 326
An update on β-lactamase inhibitor discovery and development 326
Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily 317
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 284
Immunization with Toscana virus N-Gc proteins protects mice against virus challenge 270
Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece 269
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 269
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 266
Characterization of a Functional Metallo-β-Lactamase from the Marine Bacterium Haliangium ochraceum 263
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 258
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 251
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 249
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 244
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 243
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 243
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 242
Discovery of a Novel Metallo-β-Lactamase Inhibitor that Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae 241
Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. 233
X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40 Class D Carbapenemase Inhibited by NXL104 223
[Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms]. 221
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 220
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 216
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 216
Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA 216
Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy 215
4-(N-alkyl-and-acyl-amino)-1,2,4-triazole-3-thione analogs as metallo-β-lactamase inhibitors: Impact of 4-linker on potency and spectrum of inhibition 212
FIM-1, a new acquired metallo-beta-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy 209
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases 207
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates 207
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 207
Structure-Function Relationships of Class D Carbapenemases 206
Structure-fucntion relationship of the NDM-1 metallo-beta-lactamase: Importance of Trp-87 in enzyme structure, function and stability. 204
Resistenza ai carbapenemi in Pseudomonas aeruginosa: ruolo delle metallo-beta-lattamasi acquisite. 203
Preparation of new macrocyclic amidinourea derivatives as chitinase inhibitors 202
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases 202
Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics 195
Crystal structure and mutational analysis of FUS-1 (OXA-85), a class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum 194
Carbapenemases in microbial drug resistance 185
Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in Sequence Type 621 183
Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity 182
Efficient inactivation of sars-cov-2 and other rna or dna viruses with blue led light 182
IMP-12, a plasmid-encoded metallo-beta-lactamase of the IMP-type from a Pseudomonas putida clinical isolate. 181
Purification and characterization of PBP4a, a new low-molecular-weight penicillin-binding protein from Bacillus subtilis 174
Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC  beta-Lactamases 173
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases 170
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 166
An update on antibacterial AlkylGuanidino Ureas: Design of new derivatives, synergism with colistin and data analysis of the whole library 166
Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors 165
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors 164
Interaction of Ceftaroline with Clinically-Relevant β-Lactamases 162
Structural and functional characterization of two new class D beta-lactamase: OXA-46 and OXA-48 162
High-Resolution Crystal Structure of the Subclass B3 Metallo-beta-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides 160
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa 159
Structure of the extended-spectrum beta-lactamase TEM-72 inhibited by citrate 158
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 155
Antibiotic Resistance, Medical Need and Development of Novel Antibacterials 154
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 151
A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics 151
Structural and functional characterization of two new class D beta-lactamases: OXA-46 and OXA-48 150
Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals. 150
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 149
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 148
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 148
Microbiological analysis of hospital wastewaters: impact of water treatment on microbial biodiversity and antimicrobial resistance. 148
Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum 147
A standard numbering scheme for class C β-lactamases 147
Epidemiology of infections caused by multiresistant gram-negatives: ESBLs, MBLs, panresistant strains 146
Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies 146
The impact of counterions in biological activity: case study of antibacterial alkylguanidino ureas 144
A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors 144
Purification and biochemical characterization of IMP-13 metallo-beta-lactamase. 143
Mimicking the Ala220 Duplication of OXA-146 (an OXA-23 variant) in OXA-40 and OXA-48 Highlights Mechanistic Differences among Class D Carbapenemases. 143
Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes 141
Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak 141
Editorial overview: Anti-infectives: Towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need 141
Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4 140
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates 139
Lunaemycins, New Cyclic Hexapeptide Antibiotics from the Cave Moonmilk-Dweller Streptomyces lunaelactis MM109T 138
Functional diversity among metallo-β-lactamases: characterization of the CAR-1 enzyme of Erwinia Carotovora 138
Probing the role of R2-loop deletions and substituions on the functional properties of the acquired AmpC-type β-lactamase CMY-2. 138
The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form 136
Purification and biochemical characterization of the VIM-1 metallo-β-lactamase 135
CENTA as a chromogenic substrate for studying β-lactamases 135
Metallo-β-lactamase producers in environmental microbiota: New molecular class B enzyme in Janthinobacterium lividum 135
Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase 134
Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea 134
Genetic and biochemical characterization of FUS-1 (OXA-85), a narrow-spectrum class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum 131
Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding 131
Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-beta-lactamases 131
Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships 130
Totale 48.641
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Categoria #
all - tutte 110.903
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 110.903
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021309 0 0 0 0 0 0 0 0 0 0 149 160
2021/20221.695 91 173 118 113 120 60 73 75 98 200 198 376
2022/20232.364 150 208 295 340 246 469 50 212 254 28 66 46
2023/20242.254 88 40 231 92 118 482 711 65 5 106 74 242
2024/20254.266 185 238 377 260 497 224 203 273 313 232 404 1.060
2025/202636.942 728 8.295 21.952 1.470 1.711 428 990 368 379 456 165 0
Totale 54.711