IRIS
DOCQUIER, JEAN DENIS
 Distribuzione geografica
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Continente #
NA - Nord America 37.079
EU - Europa 9.191
AS - Asia 4.465
SA - Sud America 942
AF - Africa 110
OC - Oceania 22
Continente sconosciuto - Info sul continente non disponibili 17
Totale 51.826
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Nazione #
US - Stati Uniti d'America 36.943
GB - Regno Unito 2.014
RU - Federazione Russa 1.842
CN - Cina 1.688
IT - Italia 1.429
IE - Irlanda 1.282
SG - Singapore 1.270
BR - Brasile 797
UA - Ucraina 636
SE - Svezia 509
DE - Germania 466
FR - Francia 437
HK - Hong Kong 435
KR - Corea 294
VN - Vietnam 270
FI - Finlandia 215
IN - India 119
TR - Turchia 67
CA - Canada 66
NL - Olanda 66
AR - Argentina 63
PL - Polonia 61
BE - Belgio 46
BD - Bangladesh 42
CI - Costa d'Avorio 42
JP - Giappone 38
IQ - Iraq 37
ES - Italia 36
MX - Messico 35
PK - Pakistan 34
CZ - Repubblica Ceca 26
AT - Austria 23
EC - Ecuador 22
ZA - Sudafrica 21
ID - Indonesia 20
SA - Arabia Saudita 19
AU - Australia 18
CO - Colombia 16
PT - Portogallo 16
VE - Venezuela 16
EU - Europa 15
RO - Romania 15
UZ - Uzbekistan 15
IR - Iran 13
IL - Israele 11
AE - Emirati Arabi Uniti 10
GR - Grecia 10
KE - Kenya 9
CH - Svizzera 8
CL - Cile 8
EG - Egitto 8
TN - Tunisia 8
BO - Bolivia 7
ET - Etiopia 7
HN - Honduras 7
JO - Giordania 7
LT - Lituania 7
NP - Nepal 7
OM - Oman 7
PH - Filippine 7
AL - Albania 6
JM - Giamaica 6
KZ - Kazakistan 6
NG - Nigeria 6
PA - Panama 6
LA - Repubblica Popolare Democratica del Laos 5
LV - Lettonia 5
PE - Perù 5
TW - Taiwan 5
UY - Uruguay 5
AM - Armenia 4
AZ - Azerbaigian 4
CR - Costa Rica 4
MD - Moldavia 4
NI - Nicaragua 4
NZ - Nuova Zelanda 4
TH - Thailandia 4
BA - Bosnia-Erzegovina 3
BG - Bulgaria 3
BY - Bielorussia 3
CY - Cipro 3
GE - Georgia 3
HU - Ungheria 3
KG - Kirghizistan 3
LB - Libano 3
NO - Norvegia 3
PY - Paraguay 3
SI - Slovenia 3
AO - Angola 2
BH - Bahrain 2
DK - Danimarca 2
DZ - Algeria 2
EE - Estonia 2
HR - Croazia 2
KW - Kuwait 2
LU - Lussemburgo 2
MA - Marocco 2
MK - Macedonia 2
MY - Malesia 2
PR - Porto Rico 2
Totale 51.802
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Città #
Dallas 29.445
Southend 1.758
Dublin 1.274
Singapore 712
Chandler 643
Fairfield 573
Moscow 540
Ashburn 526
Jacksonville 505
Menlo Park 477
Santa Clara 477
Hong Kong 430
Siena 410
Beijing 381
Ann Arbor 358
Wilmington 294
Woodbridge 285
Seoul 281
Hefei 267
Princeton 234
Seattle 230
Houston 187
Cambridge 185
Nanjing 167
Los Angeles 148
Fremont 144
Boardman 132
New York 125
Milan 124
Florence 97
Helsinki 96
Munich 83
The Dalles 77
Ho Chi Minh City 74
São Paulo 73
Buffalo 70
Nanchang 66
Shanghai 65
San Diego 64
Rome 56
San Mateo 56
Düsseldorf 55
Hanoi 54
Nuremberg 47
Bengaluru 45
Shenyang 45
London 43
Redondo Beach 43
Abidjan 42
Brussels 42
Columbus 41
Tianjin 39
Dong Ket 38
Council Bluffs 36
Warsaw 35
Tokyo 34
Sesto Fiorentino 32
Amsterdam 29
Chicago 29
Izmir 28
Kunming 26
Poplar 26
Venezia 26
Changsha 25
Guangzhou 25
Jiaxing 25
Rio de Janeiro 23
Montreal 22
Jinan 20
San Francisco 20
Brasília 18
Brooklyn 18
Chennai 18
Hangzhou 18
Hebei 18
Brescia 17
Frankfurt am Main 17
Porto Alegre 17
Toronto 17
Turku 17
Baghdad 16
Denver 16
Ningbo 16
West Jordan 16
Dearborn 15
Phoenix 15
Stockholm 15
Tashkent 15
Verona 15
Zhengzhou 15
Belo Horizonte 14
Brno 14
Istanbul 14
Lappeenranta 14
Norwalk 14
Prato 14
Atlanta 13
Bologna 13
Gdynia 13
Lancaster 13
Totale 43.649
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Nome #
1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases 7.584
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.413
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.324
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors 7.281
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 349
Linear guanidine derivatives, methods of preparation and uses thereof 340
Antibiotico-resistenza e Batteri ambientali 337
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 322
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 307
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 303
An update on β-lactamase inhibitor discovery and development 295
Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily 292
Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste 259
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 253
Immunization with Toscana virus N-Gc proteins protects mice against virus challenge 250
Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece 250
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 249
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 246
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 236
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 233
Characterization of a Functional Metallo-β-Lactamase from the Marine Bacterium Haliangium ochraceum 231
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 229
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 228
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 227
Discovery of a Novel Metallo-β-Lactamase Inhibitor that Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae 224
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 218
Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. 217
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 216
X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40 Class D Carbapenemase Inhibited by NXL104 215
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 199
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 196
Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA 195
Structure-Function Relationships of Class D Carbapenemases 194
[Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms]. 194
FIM-1, a new acquired metallo-beta-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy 193
Resistenza ai carbapenemi in Pseudomonas aeruginosa: ruolo delle metallo-beta-lattamasi acquisite. 191
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates 191
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 191
4-(N-alkyl-and-acyl-amino)-1,2,4-triazole-3-thione analogs as metallo-β-lactamase inhibitors: Impact of 4-linker on potency and spectrum of inhibition 190
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases 188
Preparation of new macrocyclic amidinourea derivatives as chitinase inhibitors 188
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases 188
Structure-fucntion relationship of the NDM-1 metallo-beta-lactamase: Importance of Trp-87 in enzyme structure, function and stability. 185
Crystal structure and mutational analysis of FUS-1 (OXA-85), a class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum 183
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 183
Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in Sequence Type 621 174
Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics 171
Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy 170
Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity 168
Carbapenemases in microbial drug resistance. 163
Purification and characterization of PBP4a, a new low-molecular-weight penicillin-binding protein from Bacillus subtilis 162
Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC  beta-Lactamases 158
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases 156
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa 155
Efficient inactivation of sars-cov-2 and other rna or dna viruses with blue led light 152
High-Resolution Crystal Structure of the Subclass B3 Metallo-beta-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides 148
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 146
Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals. 143
Interaction of Ceftaroline with Clinically-Relevant β-Lactamases 143
Structural and functional characterization of two new class D beta-lactamases: OXA-46 and OXA-48 142
Structure of the extended-spectrum beta-lactamase TEM-72 inhibited by citrate 142
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 142
Antibiotic Resistance, Medical Need and Development of Novel Antibacterials 142
Structural and functional characterization of two new class D beta-lactamase: OXA-46 and OXA-48 142
Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors 140
A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics 140
Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum 140
IMP-12, a plasmid-encoded metallo-beta-lactamase of the IMP-type from a Pseudomonas putida clinical isolate. 138
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 138
Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes 137
Epidemiology of infections caused by multiresistant gram-negatives: ESBLs, MBLs, panresistant strains 137
Microbiological analysis of hospital wastewaters: impact of water treatment on microbial biodiversity and antimicrobial resistance. 136
Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies 136
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors 135
Editorial overview: Anti-infectives: Towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need 135
A standard numbering scheme for class C β-lactamases 135
An update on antibacterial AlkylGuanidino Ureas: Design of new derivatives, synergism with colistin and data analysis of the whole library 130
null 130
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 129
The impact of counterions in biological activity: case study of antibacterial alkylguanidino ureas 129
Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak 129
Purification and biochemical characterization of IMP-13 metallo-beta-lactamase. 129
Mimicking the Ala220 Duplication of OXA-146 (an OXA-23 variant) in OXA-40 and OXA-48 Highlights Mechanistic Differences among Class D Carbapenemases. 129
Functional diversity among metallo-β-lactamases: characterization of the CAR-1 enzyme of Erwinia Carotovora 128
A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors 128
Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4 126
Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase 125
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 124
Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-beta-lactamases 124
Metallo-β-lactamase producers in environmental microbiota: New molecular class B enzyme in Janthinobacterium lividum 123
Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding 122
null 121
Lunaemycins, New Cyclic Hexapeptide Antibiotics from the Cave Moonmilk-Dweller Streptomyces lunaelactis MM109T 120
Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase 120
CENTA as a chromogenic substrate for studying β-lactamases 120
Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes 120
null 120
Purification and biochemical characterization of the VIM-1 metallo-β-lactamase 119
CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome 118
Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens 117
Totale 46.723
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Categoria #
all - tutte 105.000
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.000
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.552 0 0 0 0 0 326 169 314 229 205 149 160
2021/20221.695 91 173 118 113 120 60 73 75 98 200 198 376
2022/20232.364 150 208 295 340 246 469 50 212 254 28 66 46
2023/20242.254 88 40 231 92 118 482 711 65 5 106 74 242
2024/20254.266 185 238 377 260 497 224 203 273 313 232 404 1.060
2025/202634.409 728 8.295 21.952 1.470 1.711 253 0 0 0 0 0 0
Totale 52.178