IRIS
DOCQUIER, JEAN DENIS
 Distribuzione geografica
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Continente #
NA - Nord America 40.056
EU - Europa 10.712
AS - Asia 5.459
SA - Sud America 1.112
Continente sconosciuto - Info sul continente non disponibili 389
AF - Africa 347
OC - Oceania 27
Totale 58.102
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Nazione #
US - Stati Uniti d'America 39.745
IT - Italia 2.377
GB - Regno Unito 2.115
RU - Federazione Russa 1.882
CN - Cina 1.849
SG - Singapore 1.503
IE - Irlanda 1.285
BR - Brasile 896
UA - Ucraina 642
FR - Francia 604
SE - Svezia 593
VN - Vietnam 548
DE - Germania 504
HK - Hong Kong 490
KR - Corea 296
FI - Finlandia 234
ZA - Sudafrica 176
IN - India 172
CA - Canada 152
BD - Bangladesh 94
NL - Olanda 93
AR - Argentina 84
TR - Turchia 80
ES - Italia 71
PL - Polonia 71
IQ - Iraq 55
MX - Messico 49
PK - Pakistan 47
BE - Belgio 46
JP - Giappone 44
CI - Costa d'Avorio 43
CO - Colombia 41
NG - Nigeria 37
ID - Indonesia 34
IL - Israele 32
EC - Ecuador 31
CZ - Repubblica Ceca 27
AT - Austria 25
SA - Arabia Saudita 25
PT - Portogallo 24
AU - Australia 21
KE - Kenya 20
VE - Venezuela 20
UZ - Uzbekistan 19
CR - Costa Rica 18
JO - Giordania 18
CH - Svizzera 17
MY - Malesia 16
NP - Nepal 16
PH - Filippine 16
RO - Romania 16
EU - Europa 15
AE - Emirati Arabi Uniti 14
HN - Honduras 14
SC - Seychelles 14
CL - Cile 13
EG - Egitto 13
IR - Iran 13
JM - Giamaica 13
GR - Grecia 12
TN - Tunisia 12
GT - Guatemala 11
LT - Lituania 11
BO - Bolivia 9
ET - Etiopia 9
KZ - Kazakistan 8
NI - Nicaragua 8
PA - Panama 8
PY - Paraguay 8
SV - El Salvador 8
BB - Barbados 7
GE - Georgia 7
MA - Marocco 7
OM - Oman 7
PR - Porto Rico 7
TT - Trinidad e Tobago 7
AL - Albania 6
BG - Bulgaria 6
AM - Armenia 5
AZ - Azerbaigian 5
BA - Bosnia-Erzegovina 5
CY - Cipro 5
DZ - Algeria 5
GP - Guadalupe 5
KG - Kirghizistan 5
LA - Repubblica Popolare Democratica del Laos 5
LV - Lettonia 5
NO - Norvegia 5
PE - Perù 5
TH - Thailandia 5
TW - Taiwan 5
UY - Uruguay 5
EE - Estonia 4
HU - Ungheria 4
MD - Moldavia 4
NZ - Nuova Zelanda 4
SI - Slovenia 4
BH - Bahrain 3
BY - Bielorussia 3
DK - Danimarca 3
Totale 57.679
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Città #
Dallas 29.478
Southend 1.758
Dublin 1.275
Ashburn 946
Singapore 839
Chandler 644
Fairfield 574
Santa Clara 561
San Jose 553
Moscow 541
Milan 531
Jacksonville 509
Menlo Park 477
Hong Kong 464
Siena 413
Beijing 398
Ann Arbor 358
Council Bluffs 337
Hefei 320
Wilmington 294
Woodbridge 288
Seoul 281
Seattle 236
Princeton 234
The Dalles 233
Los Angeles 231
Houston 195
Rome 187
Cambridge 185
New York 184
Nanjing 167
Johannesburg 162
Ho Chi Minh City 154
Fremont 144
Lauterbourg 141
Boardman 140
Florence 130
Hanoi 119
Helsinki 113
São Paulo 93
Columbus 88
Buffalo 84
Munich 84
San Diego 71
Shanghai 70
Nanchang 66
San Mateo 57
Chicago 56
Düsseldorf 56
London 53
Orem 53
Nuremberg 48
Bengaluru 46
Shenyang 45
Abidjan 43
Redondo Beach 43
Brussels 42
Amsterdam 41
Warsaw 40
Frankfurt am Main 39
Montreal 39
Tianjin 39
Dong Ket 38
Figino 38
Tokyo 35
Chennai 34
Phoenix 33
Sesto Fiorentino 32
Abuja 31
Toronto 31
Da Nang 30
Rio de Janeiro 30
Izmir 29
North Bergen 29
Coslada 28
Turin 28
Brooklyn 27
Brescia 26
Guangzhou 26
Kensington 26
Kunming 26
Poplar 26
Venezia 26
Changsha 25
Jiaxing 25
Atlanta 24
Denver 24
San Francisco 23
Naples 21
Brasília 20
Haiphong 20
Jinan 20
Mexico City 20
Philadelphia 20
Bologna 19
Hangzhou 19
Baghdad 18
Hebei 18
Porto Alegre 18
Tashkent 18
Totale 47.071
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Nome #
1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-β-lactamases 7.662
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.506
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.408
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors 7.340
Antibiotico-resistenza e Batteri ambientali 398
New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors 393
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 391
Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste 382
Linear guanidine derivatives, methods of preparation and uses thereof 379
An update on β-lactamase inhibitor discovery and development 352
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization 351
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents 344
Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily 335
Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound 313
Immunization with Toscana virus N-Gc proteins protects mice against virus challenge 312
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 298
Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol 292
Characterization of a Functional Metallo-β-Lactamase from the Marine Bacterium Haliangium ochraceum 283
Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece 283
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 280
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 273
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 271
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 270
Screen of unfocused libraries identified compounds with direct or synergistic antibacterial activity 265
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 264
Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy 261
Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. 257
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 256
Discovery of a Novel Metallo-β-Lactamase Inhibitor that Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae 253
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors 251
[Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms]. 249
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 249
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates 243
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 243
4-(N-alkyl-and-acyl-amino)-1,2,4-triazole-3-thione analogs as metallo-β-lactamase inhibitors: Impact of 4-linker on potency and spectrum of inhibition 243
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 241
Perturbation and resilience of the gut microbiome up to 3 months after β-lactams exposure in healthy volunteers suggest an important role of microbial β-lactamases 240
FIM-1, a new acquired metallo-beta-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy 237
X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40 Class D Carbapenemase Inhibited by NXL104 237
Preparation of new macrocyclic amidinourea derivatives as chitinase inhibitors 229
Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA 228
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases 225
Structure-fucntion relationship of the NDM-1 metallo-beta-lactamase: Importance of Trp-87 in enzyme structure, function and stability. 223
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases 217
Structure-Function Relationships of Class D Carbapenemases 215
Carbapenemases in microbial drug resistance 214
Resistenza ai carbapenemi in Pseudomonas aeruginosa: ruolo delle metallo-beta-lattamasi acquisite. 213
IMP-12, a plasmid-encoded metallo-beta-lactamase of the IMP-type from a Pseudomonas putida clinical isolate. 209
Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity 208
Crystal structure and mutational analysis of FUS-1 (OXA-85), a class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum 208
Deciphering multifactorial resistance phenotypes in acinetobacter baumannii by genomics and targeted label-free proteomics 202
An update on antibacterial AlkylGuanidino Ureas: Design of new derivatives, synergism with colistin and data analysis of the whole library 199
Efficient inactivation of sars-cov-2 and other rna or dna viruses with blue led light 199
Intercontinental dissemination of IMP-13-producing Pseudomonas aeruginosa belonging in Sequence Type 621 196
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases 194
Purification and characterization of PBP4a, a new low-molecular-weight penicillin-binding protein from Bacillus subtilis 192
Interaction of Ceftaroline with Clinically-Relevant β-Lactamases 189
Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors 188
Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC  beta-Lactamases 188
Structural and functional characterization of two new class D beta-lactamase: OXA-46 and OXA-48 187
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors 186
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 184
Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii 183
High-Resolution Crystal Structure of the Subclass B3 Metallo-beta-Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides 183
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 182
Microbiological analysis of hospital wastewaters: impact of water treatment on microbial biodiversity and antimicrobial resistance. 181
A Clinical Study Provides the First Direct Evidence That Interindividual Variations in Fecal β-Lactamase Activity Affect the Gut Mycobiota Dynamics in Response to β-Lactam Antibiotics 178
A standard numbering scheme for class C β-lactamases 176
Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals. 175
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates 174
BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa 174
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties 173
Structure of the extended-spectrum beta-lactamase TEM-72 inhibited by citrate 173
Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes 169
Antibiotic Resistance, Medical Need and Development of Novel Antibacterials 169
A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors 169
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 168
Structural and functional characterization of two new class D beta-lactamases: OXA-46 and OXA-48 167
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 166
Amino acid replacement at position 228 induces fluctuation in the Ω-loop of KPC-3 and reduces the affinity against oxyimino cephalosporins: Kinetic and molecular dynamics studies 165
The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form 164
The impact of counterions in biological activity: case study of antibacterial alkylguanidino ureas 163
Epidemiology of infections caused by multiresistant gram-negatives: ESBLs, MBLs, panresistant strains 163
Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum 163
Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4 163
Lunaemycins, New Cyclic Hexapeptide Antibiotics from the Cave Moonmilk-Dweller Streptomyces lunaelactis MM109T 158
Editorial overview: Anti-infectives: Towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need 158
Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding 157
Purification and biochemical characterization of IMP-13 metallo-beta-lactamase. 156
Purification and biochemical characterization of the VIM-1 metallo-β-lactamase 156
CENTA as a chromogenic substrate for studying β-lactamases 156
Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak 155
Mimicking the Ala220 Duplication of OXA-146 (an OXA-23 variant) in OXA-40 and OXA-48 Highlights Mechanistic Differences among Class D Carbapenemases. 155
Probing the role of R2-loop deletions and substituions on the functional properties of the acquired AmpC-type β-lactamase CMY-2. 152
Functional diversity among metallo-β-lactamases: characterization of the CAR-1 enzyme of Erwinia Carotovora 151
Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase 151
Expression, purification, crystallization and preliminary X-ray characterization of the class B acid phosphatase (AphA) from Escherichia coli 151
Overproduction and biochemical characterization of the Chryseobacterium meningosepticum BlaB metallo-beta-lactamase 150
Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea 149
Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens 148
Totale 51.042
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Categoria #
all - tutte 123.347
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 123.347
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.200 0 0 0 0 120 60 73 75 98 200 198 376
2022/20232.364 150 208 295 340 246 469 50 212 254 28 66 46
2023/20242.254 88 40 231 92 118 482 711 65 5 106 74 242
2024/20254.266 185 238 377 260 497 224 203 273 313 232 404 1.060
2025/202637.846 728 8.295 21.952 1.470 1.711 428 990 368 379 456 242 827
2026/20272.487 539 370 820 624 134 0 0 0 0 0 0 0
Totale 58.102