The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.
Landini, G., DI MAGGIO, T., Sergio, F., Docquier, J.D., Rossolini, G.M., Pallecchi, L. (2016). Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(12), 7513-7517 [10.1128/AAC.01334-16].
Effect of high N-acetylcysteine concentrations on antibiotic activity against a large collection of respiratory pathogens
LANDINI, GIULIA;DI MAGGIO, TIZIANA;DOCQUIER, JEAN DENIS;ROSSOLINI, GIAN MARIA;PALLECCHI, LUCIA
2016-01-01
Abstract
The effect of high N-acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.
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https://hdl.handle.net/11365/1008817
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