Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously threatens our capability to treat bacterial diseases, including potentially deadly hospital-acquired infections. This growing issue certainly requires multiple adequate responses, including the improvement of both diagnosis methods and use of antibacterial agents, and obviously the development of novel antibacterial drugs, especially active against Gram-negative pathogens, which represent an urgent medical need. Considering the clinical relevance of both Î²-lactam antibiotics and Î²-lactamase-mediated resistance, the discovery and development of combinations including a Î²-lactamase inhibitor seems to be particularly attractive, despite being extremely challenging due to the enormous diversity, both structurally and mechanistically, of the potential Î²-lactamase targets. This review will cover the evolution of currently available Î²-lactamase inhibitors along with the most recent research leading to new Î²-lactamase inhibitors of potential clinical interest or already in the stage of clinical development.
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|Titolo:||An update on Î²-lactamase inhibitor discovery and development|
|Appare nelle tipologie:||1.1 Articolo in rivista|