IRIS
MANGANI, STEFANO
 Distribuzione geografica
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Continente #
NA - Nord America 31.796
EU - Europa 13.686
AS - Asia 7.691
SA - Sud America 1.412
Continente sconosciuto - Info sul continente non disponibili 438
AF - Africa 269
OC - Oceania 26
Totale 55.318
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Nazione #
US - Stati Uniti d'America 31.547
GB - Regno Unito 3.132
CN - Cina 2.757
RU - Federazione Russa 2.346
SG - Singapore 2.257
IT - Italia 1.945
IE - Irlanda 1.833
BR - Brasile 1.172
SE - Svezia 1.138
UA - Ucraina 1.087
HK - Hong Kong 756
FR - Francia 724
VN - Vietnam 679
DE - Germania 640
FI - Finlandia 414
KR - Corea 351
IN - India 215
CA - Canada 129
ZA - Sudafrica 116
BD - Bangladesh 114
AR - Argentina 92
IQ - Iraq 83
TR - Turchia 73
NL - Olanda 71
JP - Giappone 62
PL - Polonia 61
ES - Italia 53
MX - Messico 53
ID - Indonesia 50
PK - Pakistan 40
AT - Austria 39
BE - Belgio 33
CZ - Repubblica Ceca 33
NG - Nigeria 33
SA - Arabia Saudita 33
EC - Ecuador 29
VE - Venezuela 28
GR - Grecia 27
UZ - Uzbekistan 26
CL - Cile 25
CO - Colombia 25
KE - Kenya 22
AU - Australia 21
PH - Filippine 21
CI - Costa d'Avorio 20
EG - Egitto 18
IR - Iran 18
MY - Malesia 18
CH - Svizzera 16
JM - Giamaica 16
EU - Europa 15
JO - Giordania 15
AZ - Azerbaigian 14
IL - Israele 14
MA - Marocco 12
NP - Nepal 12
PY - Paraguay 12
RO - Romania 12
LT - Lituania 11
TN - Tunisia 11
UY - Uruguay 11
BG - Bulgaria 10
KZ - Kazakistan 10
PE - Perù 10
PT - Portogallo 10
AE - Emirati Arabi Uniti 9
AL - Albania 9
DZ - Algeria 9
ET - Etiopia 9
LB - Libano 9
DO - Repubblica Dominicana 8
TW - Taiwan 8
BO - Bolivia 7
TH - Thailandia 7
CR - Costa Rica 6
EE - Estonia 6
KG - Kirghizistan 6
PA - Panama 6
TT - Trinidad e Tobago 6
GT - Guatemala 5
NI - Nicaragua 5
OM - Oman 5
PR - Porto Rico 5
PS - Palestinian Territory 5
BY - Bielorussia 4
HR - Croazia 4
LU - Lussemburgo 4
NZ - Nuova Zelanda 4
QA - Qatar 4
RS - Serbia 4
ZM - Zambia 4
AO - Angola 3
HN - Honduras 3
KW - Kuwait 3
LV - Lettonia 3
LY - Libia 3
MD - Moldavia 3
SN - Senegal 3
SV - El Salvador 3
A2 - ???statistics.table.value.countryCode.A2??? 2
Totale 54.854
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Città #
Dallas 16.071
Southend 2.676
Dublin 1.826
Fairfield 1.724
Singapore 1.317
Ashburn 1.253
Chandler 994
Jacksonville 893
Woodbridge 815
Santa Clara 774
Wilmington 683
Seattle 662
Hong Kong 659
Cambridge 625
Beijing 619
Moscow 612
Houston 605
San Jose 564
Council Bluffs 555
Milan 452
Ann Arbor 412
Siena 382
Hefei 373
Seoul 349
Princeton 323
Nanjing 306
The Dalles 285
Helsinki 223
New York 221
Los Angeles 212
Lauterbourg 200
Boardman 190
Fremont 182
Ho Chi Minh City 180
San Mateo 165
Hanoi 150
Rome 144
Columbus 126
San Diego 122
Shanghai 107
Buffalo 103
Dong Ket 103
São Paulo 102
Menlo Park 101
Nanchang 97
Florence 93
Johannesburg 93
Munich 91
London 90
Redondo Beach 70
Bengaluru 67
Orem 60
Tianjin 58
Shenyang 54
Hebei 52
Tokyo 52
Kunming 51
San Francisco 49
Changsha 48
Lancaster 48
Figino 44
Frankfurt am Main 42
Düsseldorf 41
Toronto 41
Chicago 37
Brooklyn 36
Sesto Fiorentino 36
Zhengzhou 36
Atlanta 35
Warsaw 35
Denver 34
Jiaxing 34
Venezia 34
Guangzhou 33
Amsterdam 31
Kensington 31
Jinan 30
Rio de Janeiro 30
Brussels 29
Chennai 29
Montreal 29
Norwalk 29
Baghdad 28
Dearborn 28
Ningbo 28
Abuja 27
Nuremberg 27
Poplar 27
Boston 26
Phoenix 26
Curitiba 25
Mestre 25
Tashkent 25
Bologna 24
Hangzhou 24
Belo Horizonte 23
Jakarta 23
Turin 23
Vienna 23
Da Nang 22
Totale 41.723
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Nome #
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.486
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.377
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 376
An update on β-lactamase inhibitor discovery and development 337
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 292
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase, a validated target towards Alzheimer disease 289
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 289
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 286
Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein 285
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster 283
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity 279
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs 276
X-ray absorption spectroscopy study of native and phenylphosphorodiamidate-inhibited Bacillus pasteurii urease 274
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery 272
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 269
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 266
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 265
Iron binding to human heavy-chain ferritin 265
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 258
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 254
A structure-based proposal for the catalytic mechanism of the bacterial acid phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases 254
A hint for the function of human Sco1 from different structures 253
4-Chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: crystallization and preliminary crystallographic analysis 251
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives 250
A ternary complex of carbonic anhydrase: X-ray crystallographic structure of the adduct of human carbonic anhydrase II with the activator phenylalanine and the inhibitor azide 249
Crystal and molecular structure of the ternary complex Zn(II)–ATP–2,2′-bipyridyl 246
Crystal and molecular structure of the ternary complex bis[(adenosine 5'-triphosphato)(2,2'-bipyridine)zinc(II)] tetrahydrate 246
Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R 244
An Italian contribution to structural genomics: Understanding metalloproteins 241
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 241
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors 239
Differences in the Binding of Copper(I) to α- and β-Synuclein 238
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 238
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 234
Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites 233
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs 231
Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates 230
Crystallization and preliminary crystallographic analysis of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E: a novel dioxygenase involved in the biodegradation of polychlorinated aromatic compounds 230
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase for the treatment of Alzheimer disease 229
Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase 228
X-ray Crystal Structure of the Acinetobacter baumannii OXA-24/40 Class D Carbapenemase Inhibited by NXL104 228
Crystal structure of AphA class B acid phosphatase/phosphotransferase from E. coli 226
On nature's strategy for assigning genetic code multiplicity 226
Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin 226
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 226
X-ray-diffraction Studies On Carboxypeptidase-a Complexes - the Zinc Stereochemistry 225
Homodimeric Enzymes as Drug Targets 221
Characterization of the metallocenter of rabbit skeletal muscle AMP deaminase. Evidence for a dinuclear zinc site 221
Assembly of a Functional Triiron(III) Cluster in L-Ferritin 220
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance. 219
A redox switch in CopC: An intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites 218
Identification of copper(II) binding sites in the aminoglycosidic antibiotic Neomycin B 217
Crystal-structure of the Complex Between Human Carbonic Anhydrase-ii and the Aromatic Inhibitor 1,2,4-triazole 217
Copper(I)-alkyl sulfide and -cysteine tri-nuclear clusters as models for metallo proteins: a structural density functional analysis 217
X-ray, Nmr and Molecular-dynamics Studies On Reduced Bovine Superoxide-dismutase - Implications For the Mechanism 217
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS) 217
Structural and functional characterization of the human thymidylate synthase (hTS) interface variant R175C, new perspectives for the development of hTS inhibitors 217
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 217
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 216
Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases 215
X-ray-diffraction Study of the Interaction Between Carboxypeptidase-a and (s)-(+)-1-amino-2-phenylethyl Phosphonic Acid 214
A prokaryotic superoxide dismutase paralog lacking two Cu ligands: From largely unstructured in solution to ordered in the crystal 214
X-ray Crystallography Contributions to Drug Discovery Against Parasite 214
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity 213
X-ray-absorption Studies On Catechol 2,3-dioxygenase From Pseudomonas-putida Mt2 212
Structure-Function Relationships of Class D Carbapenemases 212
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor 212
Crystal-structure of the Ternary Complex Between Carboxypeptidase-a, L-phenylalanine, and the Azide Ion 211
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini 209
A hint for the function of human Sco1 from different structures (vol 103, pg 8595, 2006) 208
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 208
Anion Coordination Chemistry .2. Electrochemical, Thermodynamic, and Structural Studies On Supercomplex Formation Between Large Polyammonium Cycloalkanes and the 2 Complex Anions Hexacyanoferrate(ii) and Hexacyanocobaltate(iii) 207
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders 207
XAS of dilute biological samples 204
A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis casts two nickels 204
Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction? 198
Crystal structure and mutational analysis of FUS-1 (OXA-85), a class D beta-lactamase from Fusobacterium nucleatum subsp. polymorphum 198
Crystallographic determination of reduced bovine superoxide dismutase at pH 5.0 and of anion binding to its active site 197
The first structure of a bacterial class B acid phosphatase reveals further structural heterogeneity among phosphatases of the haloacid dehalogenase fold 197
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 197
Characterization of the metallocenter of rabbit skeletal muscle AMP deaminase. A new model for substrate interactions at a dinuclear cocatalytic Zn site 196
Anion Coordination Chemistry - Crystal-structure of the Super Complex - [h81,4,7,10,13,16,19,22,25,28-deca-azacyclotriacontane][co(cn)6]2cl2.10h 2o 196
Dynamic properties of bovine Cu,Zn superoxide dismutase from crystallographic data 195
Carbonic-anhydrase - An Example of How the Cavity Governs the Reactivity At the Zinc Ion 195
Crystal-structure of the Complex Between Carboxypeptidase-a and the Biproduct Analog Inhibitor L-benzylsuccinate At 2.0-a Resolution 194
Polynuclear Zinc(ii) Complexes With Large Polyazacycloalkanes - Equilibrium Studies and Crystal-structure of the Binuclear [zn2([30]anen10)(ncs)](clo4)3 Complex 194
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors 194
Crystal and Molecular Structure of a Photoisomer of an Oxodipyrro-methene: The E-Isomer of 3,4-Dimethyl-2,2'-pyrromethen-5(1H)-one 192
Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms 192
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. 190
Crystal structure of Enterococcus faecalis Thymidylate synthase 189
A copper(I) protein possibly involved in the assembly of Cu-A center of bacterial cytochrome c oxidase 189
Characterization of the zinc-binding site of the histidine-proline-rich glycoprotein associated with rabbit skeletal muscle AMP deaminase 187
Thermal-stability of Some Potassium Dibenzo-18-crown-6 Solid Compounds - Kx(db18c6) (x = Ncs, Br, I, No3) - Differential Scanning Calorimetry and X-ray-investigations 187
Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilities 187
Crystallization of soluble proteins in vapor diffusion for x-ray crystallography 186
X-ray studies of the binding of small anionic inhibitors at the carboxypeptidase A active site 185
The solution structure of a monomeric, reduced form of human copper, zinc superoxide dismutase bearing the same charge as the native protein 185
Interaction of Carboxypeptidase-a With Anions - Crystal-structure of the Complex With the Hpo(2-) Anion 184
Structure and properties of copper-zinc superoxide dismutases 184
Totale 37.126
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Categoria #
all - tutte 143.691
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 143.691
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.695 0 448 254 250 129 111 146 106 105 304 292 550
2022/20233.710 252 211 497 487 402 794 79 324 428 43 106 87
2023/20242.882 141 72 192 107 240 669 1.009 46 14 54 49 289
2024/20255.559 223 301 438 295 672 275 210 433 449 205 604 1.454
2025/202626.402 1.008 5.441 12.060 1.421 2.156 505 1.183 336 539 620 271 862
2026/20271.047 673 374 0 0 0 0 0 0 0 0 0 0
Totale 55.318