14-3-3 is a family of highly conserved regulatory proteins which is attracting a significant interest due to its potential role as target for pharmacological intervention against cancer and neurodegenerative disorders. Although modulating protein-protein interactions (PPI) is still conceived as a challenging task in drug discovery, in past few years peptide inhibitors and small molecular modulators of 14-3-3 PPI have been described. Here we examine structural and biological features of 14-3-3 and propose an overview on techniques used for discovering small molecular inhibitors and stabilizers of 14-3-3 PPI.

Mori, M., Vignaroli, G., Botta, M. (2013). Small molecules modulation of 14-3-3 protein–protein interactions. DRUG DISCOVERY TODAY: TECHNOLOGIES, 10, e541-e547 [10.1016/j.ddtec.2012.10.001].

Small molecules modulation of 14-3-3 protein–protein interactions

MORI, MATTIA;VIGNAROLI, GIULIA;BOTTA, MAURIZIO
2013-01-01

Abstract

14-3-3 is a family of highly conserved regulatory proteins which is attracting a significant interest due to its potential role as target for pharmacological intervention against cancer and neurodegenerative disorders. Although modulating protein-protein interactions (PPI) is still conceived as a challenging task in drug discovery, in past few years peptide inhibitors and small molecular modulators of 14-3-3 PPI have been described. Here we examine structural and biological features of 14-3-3 and propose an overview on techniques used for discovering small molecular inhibitors and stabilizers of 14-3-3 PPI.
Mori, M., Vignaroli, G., Botta, M. (2013). Small molecules modulation of 14-3-3 protein–protein interactions. DRUG DISCOVERY TODAY: TECHNOLOGIES, 10, e541-e547 [10.1016/j.ddtec.2012.10.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/46372
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