14-3-3 is a family of highly conserved regulatory proteins which is attracting a significant interest due to its potential role as target for pharmacological intervention against cancer and neurodegenerative disorders. Although modulating protein-protein interactions (PPI) is still conceived as a challenging task in drug discovery, in past few years peptide inhibitors and small molecular modulators of 14-3-3 PPI have been described. Here we examine structural and biological features of 14-3-3 and propose an overview on techniques used for discovering small molecular inhibitors and stabilizers of 14-3-3 PPI.
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|Titolo:||Small molecules modulation of 14-3-3 protein–protein interactions|
|Citazione:||Mori, M., Vignaroli, G., & Botta, M. (2013). Small molecules modulation of 14-3-3 protein–protein interactions. DRUG DISCOVERY TODAY: TECHNOLOGIES, 10, e541-e547.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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