IRIS
POZZI, CECILIA
 Distribuzione geografica
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Continente #
NA - Nord America 21.441
EU - Europa 6.305
AS - Asia 3.717
SA - Sud America 828
AF - Africa 166
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 7
Totale 32.478
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Nazione #
US - Stati Uniti d'America 21.324
IT - Italia 1.484
RU - Federazione Russa 1.264
CN - Cina 1.136
SG - Singapore 1.075
GB - Regno Unito 955
IE - Irlanda 861
BR - Brasile 674
VN - Vietnam 468
SE - Svezia 441
HK - Hong Kong 365
FR - Francia 308
UA - Ucraina 283
DE - Germania 247
FI - Finlandia 146
IN - India 140
KR - Corea 139
BD - Bangladesh 91
ZA - Sudafrica 89
CA - Canada 62
AR - Argentina 56
NL - Olanda 56
PL - Polonia 40
AT - Austria 39
TR - Turchia 38
ES - Italia 37
IQ - Iraq 32
JP - Giappone 30
BE - Belgio 29
PK - Pakistan 26
MX - Messico 25
CZ - Repubblica Ceca 24
ID - Indonesia 23
EC - Ecuador 22
SA - Arabia Saudita 21
GR - Grecia 18
CH - Svizzera 17
CL - Cile 17
UZ - Uzbekistan 17
VE - Venezuela 17
CI - Costa d'Avorio 14
CO - Colombia 14
IR - Iran 14
EG - Egitto 13
KE - Kenya 13
PY - Paraguay 13
AU - Australia 11
KZ - Kazakistan 10
NG - Nigeria 10
PT - Portogallo 10
JO - Giordania 9
PH - Filippine 9
AE - Emirati Arabi Uniti 8
AZ - Azerbaigian 8
IL - Israele 8
LT - Lituania 8
MA - Marocco 8
TN - Tunisia 7
UY - Uruguay 7
JM - Giamaica 6
KG - Kirghizistan 6
MY - Malesia 6
NP - Nepal 6
RO - Romania 5
TW - Taiwan 5
BG - Bulgaria 4
BO - Bolivia 4
CR - Costa Rica 4
DZ - Algeria 4
EU - Europa 4
GT - Guatemala 4
HU - Ungheria 4
NO - Norvegia 4
OM - Oman 4
PE - Perù 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AL - Albania 3
AO - Angola 3
BY - Bielorussia 3
LB - Libano 3
LV - Lettonia 3
MD - Moldavia 3
TH - Thailandia 3
TM - Turkmenistan 3
BA - Bosnia-Erzegovina 2
BB - Barbados 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
GE - Georgia 2
HN - Honduras 2
IM - Isola di Man 2
NZ - Nuova Zelanda 2
PA - Panama 2
PR - Porto Rico 2
QA - Qatar 2
RS - Serbia 2
TT - Trinidad e Tobago 2
AM - Armenia 1
BH - Bahrain 1
BN - Brunei Darussalam 1
Totale 32.460
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Città #
Dallas 15.103
Dublin 859
Southend 782
Singapore 607
Fairfield 577
Ashburn 523
Santa Clara 404
Moscow 350
San Jose 332
Chandler 323
Beijing 319
Milan 312
Siena 285
Hong Kong 283
Woodbridge 270
Wilmington 241
Seattle 233
Jacksonville 226
Council Bluffs 220
Houston 201
Cambridge 199
Ann Arbor 187
Hefei 166
Princeton 141
Seoul 136
New York 133
Los Angeles 124
Ho Chi Minh City 114
Dong Ket 112
The Dalles 100
Florence 99
Rome 88
Helsinki 87
Fremont 86
Lauterbourg 85
Boardman 83
Nanjing 83
Hanoi 75
Johannesburg 75
Munich 68
San Mateo 55
São Paulo 53
Orem 48
Shanghai 48
Bengaluru 47
Chicago 43
Buffalo 41
San Diego 41
Redondo Beach 37
Sesto Fiorentino 35
Columbus 30
Frankfurt am Main 29
London 29
Amsterdam 28
Figino 28
Nanchang 28
Warsaw 27
Brussels 25
Dearborn 25
Menlo Park 25
Shenyang 25
Vienna 24
Nuremberg 23
Phoenix 23
Tokyo 23
Toronto 22
Chennai 20
Atlanta 19
Brooklyn 19
Denver 19
Trofarello 19
Belo Horizonte 18
Bologna 18
Changsha 18
Kunming 18
Lappeenranta 18
Prato 17
Stockholm 17
Guangzhou 16
Naples 16
Redwood City 16
Tashkent 16
Tianjin 16
Brno 15
Da Nang 15
Turin 15
Abidjan 14
Jiaxing 14
Montreal 14
Ningbo 14
Brasília 13
Hebei 13
Jinan 13
Kensington 13
Poplar 13
San Francisco 13
Boston 12
Düsseldorf 12
Paris 12
Rio de Janeiro 12
Totale 26.080
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Nome #
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.477
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.364
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 372
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 288
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase, a validated target towards Alzheimer disease 287
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 287
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 281
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster 280
Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein 280
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity 275
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs 270
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 267
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery 261
Iron binding to human heavy-chain ferritin 261
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative 260
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 259
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 258
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 256
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 253
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives 248
Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R 242
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 238
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors 235
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 232
Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites 231
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs 228
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase for the treatment of Alzheimer disease 228
Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase 226
Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin 223
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 223
In silico identification and in vitro evaluation of natural inhibitors of leishmania major pteridine reductase I 219
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance. 218
Assembly of a Functional Triiron(III) Cluster in L-Ferritin 218
Structural and functional characterization of the human thymidylate synthase (hTS) interface variant R175C, new perspectives for the development of hTS inhibitors 215
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS) 214
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 214
Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells 213
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 213
Dynamic interplay between copper toxicity and mitochondrial dysfunction in Alzheimer’s disease 213
X-ray Crystallography Contributions to Drug Discovery Against Parasite 212
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity 211
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor 210
Structural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases 208
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini 206
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 206
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders 205
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 203
Exploiting the bile acid binding protein as transporter of a Cholic Acid/Mirin bioconjugate for potential applications in liver cancer therapy 203
Loop electrostatics modulates the intersubunit interactions in ferritin 199
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 194
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors 193
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. 188
Crystal structure of Enterococcus faecalis Thymidylate synthase 185
Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilities 184
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases 180
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase 178
Morita−Baylis−Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands 176
The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease 172
Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes 171
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 169
Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design 168
Structural and mechanistic insights into iron processing and biomineralization by vertebrate ferritins 165
Editorial for the special issue: “targeting β- lactamases to fight bacterial resistance to β-Lactam antibiotics” 165
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin 163
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 163
Structural insight into iron pathways in ferritin 162
CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND 160
Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening 157
Metal ion binding to human Glutaminyl Cyclase: a structural perspective 155
Structural insight into iron pathways in ferritin 155
Structural characterization of human heat shock protein 90 N-Terminal domain and its variants K112R and K112A in complex with a potent 1,2,3-Triazole-based inhibitor 154
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 153
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 151
Assisted assembly and growth of iron-oxide mineral particles in human L-ferritin, new insight to unveil the biomineralization process 151
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates 145
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective 142
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 140
Structural and functional characterization of new human thymidylate synthase interface variants 135
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin 133
Structural and functional characterization of new human thymidylate synthase interface variants 132
Structural and mechanistic insights into the iron processing by vertebrate ferritins 127
High resolution iron derivative of bullfrog M ferritin: structural insight into ferroxidase process 126
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. 125
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 123
Structural comparison between Enterococcus faecalis and human thymidylate synthase provides hints about enzyme conformational variabilities 121
Validation of recombinant chicken liver bile acid binding protein as a tool for cholic acid hosting 121
Crystallographic studies of new human Thymidylate synthase inhibitors 119
Crystallographic studies of new human Thymidylate synthase inhibitors. 118
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations 117
Staphylococcus aureus-associated skin and soft tissue infections: Anatomical localization, epidemiology, therapy and potential prophylaxis 116
Structural and mechanistic insights into the iron processing by vertebrate ferritins 114
Crystallographic studies of new human Thymidylate synthase inhibitors 112
Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules 104
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 63
null 52
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 39
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach 31
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 29
Totale 32.886
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Categoria #
all - tutte 70.549
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 70.549
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.252 49 137 110 136 89 42 53 67 58 126 150 235
2022/20231.433 100 103 222 143 154 309 40 117 148 25 39 33
2023/20241.553 56 34 112 67 74 349 535 30 14 40 36 206
2024/20252.970 127 130 273 153 373 168 143 194 215 151 380 663
2025/202621.103 455 4.457 11.316 1.064 1.269 251 662 200 307 371 244 507
2026/2027273 273 0 0 0 0 0 0 0 0 0 0 0
Totale 32.886