IRIS
POZZI, CECILIA
 Distribuzione geografica
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Continente #
NA - Nord America 4.317
EU - Europa 4.099
AS - Asia 945
SA - Sud America 24
AF - Africa 19
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 7
Totale 9.424
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Nazione #
US - Stati Uniti d'America 4.302
IE - Irlanda 863
GB - Regno Unito 856
IT - Italia 815
CN - Cina 499
SE - Svezia 390
RU - Federazione Russa 336
UA - Ucraina 274
FR - Francia 184
SG - Singapore 167
DE - Germania 136
VN - Vietnam 113
FI - Finlandia 107
HK - Hong Kong 74
BE - Belgio 24
CZ - Repubblica Ceca 22
NL - Olanda 18
IN - India 17
BR - Brasile 16
TR - Turchia 15
CA - Canada 13
CI - Costa d'Avorio 12
ES - Italia 12
AU - Australia 11
GR - Grecia 11
PL - Polonia 11
AT - Austria 10
CH - Svizzera 9
IR - Iran 9
IL - Israele 6
UZ - Uzbekistan 6
PT - Portogallo 5
EG - Egitto 4
EU - Europa 4
KG - Kirghizistan 4
KZ - Kazakistan 4
RO - Romania 4
A2 - ???statistics.table.value.countryCode.A2??? 3
CO - Colombia 3
JP - Giappone 3
PH - Filippine 3
SA - Arabia Saudita 3
TW - Taiwan 3
AZ - Azerbaigian 2
BO - Bolivia 2
IM - Isola di Man 2
IQ - Iraq 2
KR - Corea 2
LV - Lettonia 2
MY - Malesia 2
NZ - Nuova Zelanda 2
PK - Pakistan 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
AR - Argentina 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
DZ - Algeria 1
EC - Ecuador 1
ID - Indonesia 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
MD - Moldavia 1
MK - Macedonia 1
MN - Mongolia 1
NO - Norvegia 1
PA - Panama 1
PE - Perù 1
QA - Qatar 1
RS - Serbia 1
TH - Thailandia 1
TJ - Tagikistan 1
TN - Tunisia 1
ZA - Sudafrica 1
Totale 9.424
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Città #
Dublin 861
Southend 782
Fairfield 577
Santa Clara 374
Chandler 323
Ashburn 317
Siena 285
Woodbridge 270
Wilmington 236
Seattle 226
Jacksonville 223
Cambridge 199
Houston 192
Ann Arbor 187
Princeton 141
Singapore 118
Beijing 112
Dong Ket 112
Fremont 86
Nanjing 83
New York 82
Boardman 77
Helsinki 76
Moscow 56
San Mateo 55
Florence 54
Shanghai 42
San Diego 37
Sesto Fiorentino 35
Nanchang 28
Milan 27
Dearborn 25
Menlo Park 25
Munich 25
Brussels 24
Shenyang 23
Trofarello 19
Changsha 18
Rome 18
Kunming 17
Redwood City 16
Brno 15
London 15
Jiaxing 14
Hebei 13
Jinan 13
Los Angeles 13
Ningbo 13
Tianjin 13
Abidjan 12
Phoenix 12
Prato 12
Toronto 12
Arezzo 11
Amsterdam 10
Guangzhou 10
Vienna 10
Zhengzhou 10
Chicago 9
Gdynia 8
Izmir 8
Norwalk 8
Pisa 8
West Jordan 8
Bologna 7
Columbus 7
Paris 7
Zurich 7
Bari 6
Hefei 6
Madrid 6
Olomouc 6
San Francisco 6
Zanjan 6
Canberra 5
Livorno 5
Martellago 5
Redmond 5
Tappahannock 5
Tashkent 5
Bishkek 4
Eboli 4
Fuzhou 4
Genoa 4
Hanover 4
Kolkata 4
Modena 4
Nuremberg 4
Prescot 4
Stockholm 4
Venezia 4
Verona 4
Berlin 3
Bogotá 3
Cairo 3
Chengdu 3
Chongqing 3
Empoli 3
Fort Worth 3
Fucecchio 3
Totale 6.906
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Nome #
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 243
Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein 209
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs 185
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 181
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 179
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster 170
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity 163
Iron binding to human heavy-chain ferritin 163
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 162
Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase 157
Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites 157
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors 156
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative 156
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 155
X-ray Crystallography Contributions to Drug Discovery Against Parasite 154
Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin 153
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery 152
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives 150
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase, a validated target towards Alzheimer disease 147
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS) 145
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 144
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 144
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 142
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 140
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity 137
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders 137
Structural and functional characterization of the human thymidylate synthase (hTS) interface variant R175C, new perspectives for the development of hTS inhibitors 137
Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R 137
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. 135
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 134
Assembly of a Functional Triiron(III) Cluster in L-Ferritin 134
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini 134
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 132
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 131
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 128
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 126
In silico identification and in vitro evaluation of natural inhibitors of leishmania major pteridine reductase I 121
Loop electrostatics modulates the intersubunit interactions in ferritin 120
The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease 118
Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes 117
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 117
Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilities 116
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors 115
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 114
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 114
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 114
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance. 113
Structural insight into iron pathways in ferritin 112
Structural insight into iron pathways in ferritin 110
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 109
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 107
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs 105
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor 105
Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening 100
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase for the treatment of Alzheimer disease 99
Dynamic interplay between copper toxicity and mitochondrial dysfunction in Alzheimer’s disease 98
Crystal structure of Enterococcus faecalis Thymidylate synthase 95
Structural and mechanistic insights into iron processing and biomineralization by vertebrate ferritins 93
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 91
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 88
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin 87
High resolution iron derivative of bullfrog M ferritin: structural insight into ferroxidase process 85
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 83
Crystallographic studies of new human Thymidylate synthase inhibitors 78
CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND 76
Crystallographic studies of new human Thymidylate synthase inhibitors 74
Crystallographic studies of new human Thymidylate synthase inhibitors. 71
Structural and mechanistic insights into the iron processing by vertebrate ferritins 67
Structural and mechanistic insights into the iron processing by vertebrate ferritins 67
Assisted assembly and growth of iron-oxide mineral particles in human L-ferritin, new insight to unveil the biomineralization process 67
Structural and functional characterization of new human thymidylate synthase interface variants 67
Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells 65
Structural and functional characterization of new human thymidylate synthase interface variants 65
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. 64
Structural comparison between Enterococcus faecalis and human thymidylate synthase provides hints about enzyme conformational variabilities 62
null 52
Structural characterization of human heat shock protein 90 N-Terminal domain and its variants K112R and K112A in complex with a potent 1,2,3-Triazole-based inhibitor 51
Editorial for the special issue: “targeting β- lactamases to fight bacterial resistance to β-Lactam antibiotics” 50
Staphylococcus aureus-associated skin and soft tissue infections: Anatomical localization, epidemiology, therapy and potential prophylaxis 49
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 48
Validation of recombinant chicken liver bile acid binding protein as a tool for cholic acid hosting 46
Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design 40
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations 37
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase 36
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates 36
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases 33
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin 31
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS) 28
Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules 25
Metal ion binding to human Glutaminyl Cyclase: a structural perspective 21
Exploiting the bile acid binding protein as transporter of a Cholic Acid/Mirin bioconjugate for potential applications in liver cancer therapy 16
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective 9
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 8
Totale 9.794
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Categoria #
all - tutte 34.545
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.545
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020833 0 0 0 0 0 0 159 179 154 167 65 109
2020/20211.492 44 115 30 143 134 217 58 222 96 194 56 183
2021/20221.252 49 137 110 136 89 42 53 67 58 126 150 235
2022/20231.439 100 103 222 143 156 309 40 118 150 25 40 33
2023/20241.566 56 35 113 69 75 353 538 30 15 40 36 206
2024/20251.235 128 130 275 153 377 170 2 0 0 0 0 0
Totale 9.794