IRIS
POZZI, CECILIA
 Distribuzione geografica
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Continente #
NA - Nord America 20.340
EU - Europa 5.542
AS - Asia 3.059
SA - Sud America 719
AF - Africa 61
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 7
Totale 29.742
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Nazione #
US - Stati Uniti d'America 20.272
RU - Federazione Russa 1.263
CN - Cina 1.045
IT - Italia 996
GB - Regno Unito 924
SG - Singapore 902
IE - Irlanda 858
BR - Brasile 622
SE - Svezia 405
HK - Hong Kong 342
VN - Vietnam 292
UA - Ucraina 280
DE - Germania 222
FR - Francia 207
KR - Corea 138
FI - Finlandia 134
IN - India 104
AR - Argentina 39
AT - Austria 37
NL - Olanda 35
PL - Polonia 35
CA - Canada 34
TR - Turchia 32
ES - Italia 30
BD - Bangladesh 27
BE - Belgio 27
ZA - Sudafrica 24
CZ - Repubblica Ceca 23
JP - Giappone 21
MX - Messico 19
ID - Indonesia 17
GR - Grecia 15
IQ - Iraq 15
SA - Arabia Saudita 15
EC - Ecuador 14
PK - Pakistan 14
IR - Iran 13
CH - Svizzera 12
CI - Costa d'Avorio 12
CO - Colombia 12
PY - Paraguay 12
UZ - Uzbekistan 12
AU - Australia 11
PT - Portogallo 9
EG - Egitto 8
KZ - Kazakistan 8
IL - Israele 7
LT - Lituania 7
CL - Cile 6
KG - Kirghizistan 6
AE - Emirati Arabi Uniti 5
AZ - Azerbaigian 5
PH - Filippine 5
RO - Romania 5
BO - Bolivia 4
CR - Costa Rica 4
EU - Europa 4
TW - Taiwan 4
VE - Venezuela 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BG - Bulgaria 3
DZ - Algeria 3
JO - Giordania 3
KE - Kenya 3
LV - Lettonia 3
MA - Marocco 3
NP - Nepal 3
OM - Oman 3
PE - Perù 3
TM - Turkmenistan 3
UY - Uruguay 3
AL - Albania 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
IM - Isola di Man 2
JM - Giamaica 2
LB - Libano 2
MD - Moldavia 2
MY - Malesia 2
NZ - Nuova Zelanda 2
PA - Panama 2
QA - Qatar 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
AM - Armenia 1
BB - Barbados 1
BH - Bahrain 1
BN - Brunei Darussalam 1
CY - Cipro 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
ET - Etiopia 1
GE - Georgia 1
GT - Guatemala 1
HN - Honduras 1
LA - Repubblica Popolare Democratica del Laos 1
LK - Sri Lanka 1
MK - Macedonia 1
MN - Mongolia 1
NG - Nigeria 1
Totale 29.732
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Città #
Dallas 15.087
Dublin 856
Southend 782
Fairfield 577
Singapore 517
Ashburn 447
Santa Clara 383
Moscow 349
Chandler 323
Beijing 308
Siena 285
Woodbridge 270
Hong Kong 269
Wilmington 240
Seattle 231
Jacksonville 223
Cambridge 199
Houston 197
Ann Arbor 187
Hefei 145
Princeton 141
Seoul 136
New York 117
Dong Ket 112
Los Angeles 89
Fremont 86
Nanjing 83
Boardman 82
Florence 81
Milan 78
Helsinki 77
Munich 68
Ho Chi Minh City 63
San Mateo 55
São Paulo 48
Bengaluru 45
Shanghai 45
San Diego 38
Chicago 37
Redondo Beach 37
Sesto Fiorentino 35
The Dalles 34
Buffalo 33
Council Bluffs 28
Hanoi 28
Nanchang 28
Rome 27
Columbus 26
London 26
Warsaw 26
Brussels 25
Dearborn 25
Menlo Park 25
Shenyang 25
Vienna 23
Phoenix 22
Nuremberg 20
Brooklyn 19
Trofarello 19
Changsha 18
Belo Horizonte 17
Kunming 17
Lappeenranta 16
Redwood City 16
Tokyo 16
Brno 15
Denver 15
Prato 15
Tianjin 15
Toronto 15
Guangzhou 14
Jiaxing 14
Ningbo 14
Stockholm 14
Amsterdam 13
Brasília 13
Hebei 13
Jinan 13
Abidjan 12
Boston 12
Düsseldorf 12
Poplar 12
San Francisco 12
Arezzo 11
Brescia 11
Chennai 11
Montreal 11
Salt Lake City 11
Tashkent 11
Turku 11
Bologna 10
Frankfurt am Main 10
Johannesburg 10
Orem 10
Zhengzhou 10
Atlanta 9
Biên Hòa 9
Izmir 9
Portsmouth 9
Rio de Janeiro 9
Totale 24.402
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Nome #
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.410
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.321
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 322
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 262
Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein 250
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase, a validated target towards Alzheimer disease 245
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 244
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 243
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster 242
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs 239
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity 236
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 236
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 232
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives 230
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 227
Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R 225
Iron binding to human heavy-chain ferritin 222
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 220
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery 217
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 216
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors 207
Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin 203
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative 202
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance. 198
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 198
Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase 197
X-ray Crystallography Contributions to Drug Discovery Against Parasite 197
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS) 196
Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites 195
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase for the treatment of Alzheimer disease 195
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 195
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 194
Assembly of a Functional Triiron(III) Cluster in L-Ferritin 193
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 191
Structural and functional characterization of the human thymidylate synthase (hTS) interface variant R175C, new perspectives for the development of hTS inhibitors 191
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs 189
Dynamic interplay between copper toxicity and mitochondrial dysfunction in Alzheimer’s disease 189
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 188
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity 187
In silico identification and in vitro evaluation of natural inhibitors of leishmania major pteridine reductase I 187
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 183
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini 182
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor 182
Loop electrostatics modulates the intersubunit interactions in ferritin 182
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders 180
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 180
Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells 179
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 175
Crystal structure of Enterococcus faecalis Thymidylate synthase 173
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. 172
Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilities 169
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors 166
The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease 156
Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes 152
Editorial for the special issue: “targeting β- lactamases to fight bacterial resistance to β-Lactam antibiotics” 152
Structural insight into iron pathways in ferritin 149
Structural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases 146
Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening 145
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 142
CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND 142
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases 141
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 137
Exploiting the bile acid binding protein as transporter of a Cholic Acid/Mirin bioconjugate for potential applications in liver cancer therapy 137
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin 136
Structural insight into iron pathways in ferritin 135
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 134
Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design 132
Structural and mechanistic insights into iron processing and biomineralization by vertebrate ferritins 131
Assisted assembly and growth of iron-oxide mineral particles in human L-ferritin, new insight to unveil the biomineralization process 130
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 126
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase 125
Structural and functional characterization of new human thymidylate synthase interface variants 122
Structural and functional characterization of new human thymidylate synthase interface variants 121
Structural characterization of human heat shock protein 90 N-Terminal domain and its variants K112R and K112A in complex with a potent 1,2,3-Triazole-based inhibitor 119
High resolution iron derivative of bullfrog M ferritin: structural insight into ferroxidase process 115
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin 114
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective 113
Structural and mechanistic insights into the iron processing by vertebrate ferritins 113
Metal ion binding to human Glutaminyl Cyclase: a structural perspective 112
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates 111
Morita−Baylis−Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands 110
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. 109
Structural comparison between Enterococcus faecalis and human thymidylate synthase provides hints about enzyme conformational variabilities 109
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 107
Crystallographic studies of new human Thymidylate synthase inhibitors. 103
Crystallographic studies of new human Thymidylate synthase inhibitors 103
Crystallographic studies of new human Thymidylate synthase inhibitors 101
Structural and mechanistic insights into the iron processing by vertebrate ferritins 98
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 97
Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules 91
Staphylococcus aureus-associated skin and soft tissue infections: Anatomical localization, epidemiology, therapy and potential prophylaxis 88
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations 87
Validation of recombinant chicken liver bile acid binding protein as a tool for cholic acid hosting 83
null 52
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 20
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 19
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach 13
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 13
Totale 30.145
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Categoria #
all - tutte 63.700
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.700
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.026 0 0 0 0 0 217 58 222 96 194 56 183
2021/20221.252 49 137 110 136 89 42 53 67 58 126 150 235
2022/20231.433 100 103 222 143 154 309 40 117 148 25 39 33
2023/20241.553 56 34 112 67 74 349 535 30 14 40 36 206
2024/20252.970 127 130 273 153 373 168 143 194 215 151 380 663
2025/202618.635 455 4.457 11.316 1.064 1.269 74 0 0 0 0 0 0
Totale 30.145