IRIS
POZZI, CECILIA
 Distribuzione geografica
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Continente #
NA - Nord America 20.972
EU - Europa 5.834
AS - Asia 3.600
SA - Sud America 821
AF - Africa 163
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 7
Totale 31.411
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Nazione #
US - Stati Uniti d'America 20.879
RU - Federazione Russa 1.264
CN - Cina 1.107
IT - Italia 1.050
SG - Singapore 1.041
GB - Regno Unito 955
IE - Irlanda 861
BR - Brasile 669
VN - Vietnam 468
SE - Svezia 411
HK - Hong Kong 365
FR - Francia 307
UA - Ucraina 282
DE - Germania 247
FI - Finlandia 146
KR - Corea 139
IN - India 138
ZA - Sudafrica 89
AR - Argentina 55
NL - Olanda 55
CA - Canada 50
BD - Bangladesh 43
AT - Austria 39
PL - Polonia 39
TR - Turchia 38
ES - Italia 36
IQ - Iraq 32
BE - Belgio 29
JP - Giappone 27
PK - Pakistan 26
CZ - Repubblica Ceca 24
ID - Indonesia 23
MX - Messico 23
EC - Ecuador 22
SA - Arabia Saudita 21
CH - Svizzera 17
CL - Cile 17
GR - Grecia 17
UZ - Uzbekistan 17
VE - Venezuela 17
CI - Costa d'Avorio 14
IR - Iran 14
CO - Colombia 13
KE - Kenya 13
PY - Paraguay 13
AU - Australia 11
EG - Egitto 11
KZ - Kazakistan 10
NG - Nigeria 10
PT - Portogallo 10
JO - Giordania 9
PH - Filippine 9
AE - Emirati Arabi Uniti 8
AZ - Azerbaigian 8
IL - Israele 8
LT - Lituania 8
MA - Marocco 8
TN - Tunisia 7
UY - Uruguay 7
KG - Kirghizistan 6
MY - Malesia 6
NP - Nepal 6
RO - Romania 5
TW - Taiwan 5
BG - Bulgaria 4
BO - Bolivia 4
CR - Costa Rica 4
DZ - Algeria 4
EU - Europa 4
HU - Ungheria 4
NO - Norvegia 4
OM - Oman 4
PE - Perù 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AL - Albania 3
AO - Angola 3
JM - Giamaica 3
LB - Libano 3
LV - Lettonia 3
MD - Moldavia 3
TM - Turkmenistan 3
BA - Bosnia-Erzegovina 2
BY - Bielorussia 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
GE - Georgia 2
GT - Guatemala 2
HN - Honduras 2
IM - Isola di Man 2
NZ - Nuova Zelanda 2
PA - Panama 2
QA - Qatar 2
RS - Serbia 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
AM - Armenia 1
BB - Barbados 1
BH - Bahrain 1
BN - Brunei Darussalam 1
CY - Cipro 1
Totale 31.397
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Città #
Dallas 15.090
Dublin 859
Southend 782
Singapore 603
Fairfield 577
Ashburn 479
Santa Clara 387
Moscow 350
Chandler 323
Beijing 317
Siena 285
Hong Kong 283
Woodbridge 270
Wilmington 240
San Jose 234
Seattle 231
Jacksonville 224
Cambridge 199
Houston 197
Ann Arbor 187
Hefei 166
Council Bluffs 165
Princeton 141
Seoul 136
New York 124
Ho Chi Minh City 114
Dong Ket 112
Los Angeles 110
The Dalles 100
Helsinki 87
Milan 87
Fremont 86
Lauterbourg 85
Florence 84
Boardman 83
Nanjing 83
Hanoi 75
Johannesburg 75
Munich 68
San Mateo 55
São Paulo 51
Orem 48
Bengaluru 47
Shanghai 47
Chicago 42
San Diego 40
Redondo Beach 37
Buffalo 35
Sesto Fiorentino 35
Rome 30
Frankfurt am Main 29
London 29
Amsterdam 28
Nanchang 28
Warsaw 27
Columbus 26
Brussels 25
Dearborn 25
Menlo Park 25
Shenyang 25
Nuremberg 23
Vienna 23
Phoenix 22
Tokyo 22
Chennai 20
Toronto 20
Brooklyn 19
Trofarello 19
Belo Horizonte 18
Changsha 18
Lappeenranta 18
Kunming 17
Prato 17
Stockholm 17
Denver 16
Guangzhou 16
Redwood City 16
Tashkent 16
Brno 15
Da Nang 15
Tianjin 15
Abidjan 14
Atlanta 14
Jiaxing 14
Ningbo 14
Brasília 13
Hebei 13
Jinan 13
Kensington 13
Montreal 13
Poplar 13
Boston 12
Düsseldorf 12
Paris 12
Rio de Janeiro 12
San Francisco 12
Zurich 12
Arezzo 11
Brescia 11
Manchester 11
Totale 25.453
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Nome #
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors 7.459
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity 7.350
VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- And metallo-β-lactamases, restores activity of cefepime in enterobacterales and Pseudomonas aeruginosa 339
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase, a validated target towards Alzheimer disease 278
Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein 274
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 273
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster 267
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem 264
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs 263
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 263
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity 261
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam 257
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction 250
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors 250
Crystal structure of the extended-spectrum β-lactamase BEL-1, in native form and in complex with imipenem and moxalactam. 249
Iron binding to human heavy-chain ferritin 247
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative 246
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery 245
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives 243
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design 239
Evidence of destabilization of the human thymidylate synthase (hTS) dimeric structure induced by the interface mutation Q62R 236
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors 227
Amino-thiadiazole as innovative inhibitors of human glutaminyl cyclase for the treatment of Alzheimer disease 219
Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites 218
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii 218
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model 215
Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin 214
Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase 213
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance. 213
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs 213
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae 213
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS) 210
Assembly of a Functional Triiron(III) Cluster in L-Ferritin 208
X-ray Crystallography Contributions to Drug Discovery Against Parasite 208
Dynamic interplay between copper toxicity and mitochondrial dysfunction in Alzheimer’s disease 206
Structural and functional characterization of the human thymidylate synthase (hTS) interface variant R175C, new perspectives for the development of hTS inhibitors 205
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 205
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections 204
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart 200
Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells 199
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity 199
In silico identification and in vitro evaluation of natural inhibitors of leishmania major pteridine reductase I 199
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini 198
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor 198
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders 197
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 196
Structural characterization of a synthetic mimic of the Photoactive Yellow Protein 192
Loop electrostatics modulates the intersubunit interactions in ferritin 191
Crystal structure of Enterococcus faecalis Thymidylate synthase 181
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. 181
Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilities 180
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors 177
Structural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases 174
The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease 171
Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes 167
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases 164
Editorial for the special issue: “targeting β- lactamases to fight bacterial resistance to β-Lactam antibiotics” 162
Exploiting the bile acid binding protein as transporter of a Cholic Acid/Mirin bioconjugate for potential applications in liver cancer therapy 162
Structural insight into iron pathways in ferritin 155
CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND 154
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 154
Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design 153
Morita−Baylis−Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands 153
Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening 152
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin 152
Structural and mechanistic insights into iron processing and biomineralization by vertebrate ferritins 151
Structural insight into iron pathways in ferritin 148
Evolution to carbapenem -hydrolyzing activity in noncarbapenemase class D beta-lactamase OXA-10 by rational protein design 148
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design 148
Structural characterization of human heat shock protein 90 N-Terminal domain and its variants K112R and K112A in complex with a potent 1,2,3-Triazole-based inhibitor 147
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase 147
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 147
Metal ion binding to human Glutaminyl Cyclase: a structural perspective 142
Assisted assembly and growth of iron-oxide mineral particles in human L-ferritin, new insight to unveil the biomineralization process 139
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates 136
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective 130
Structural and functional characterization of new human thymidylate synthase interface variants 130
Structural and functional characterization of new human thymidylate synthase interface variants 129
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 128
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin 126
Structural and mechanistic insights into the iron processing by vertebrate ferritins 126
High resolution iron derivative of bullfrog M ferritin: structural insight into ferroxidase process 124
Probing the role of Arg97 in the parasite Leishmania braziliensis Hsp90 through site directed mutagenesis on the human counterpart 117
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism. 114
Structural comparison between Enterococcus faecalis and human thymidylate synthase provides hints about enzyme conformational variabilities 113
Crystallographic studies of new human Thymidylate synthase inhibitors 111
Structural and mechanistic insights into the iron processing by vertebrate ferritins 110
Crystallographic studies of new human Thymidylate synthase inhibitors. 110
Crystallographic studies of new human Thymidylate synthase inhibitors 110
Staphylococcus aureus-associated skin and soft tissue infections: Anatomical localization, epidemiology, therapy and potential prophylaxis 106
Validation of recombinant chicken liver bile acid binding protein as a tool for cholic acid hosting 105
Structural Basis of Parasitic HSP90 ATPase Inhibition by Small Molecules 101
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations 98
null 52
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 31
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 30
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach 22
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 16
Totale 31.815
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Categoria #
all - tutte 66.791
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 66.791
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021433 0 0 0 0 0 0 0 0 0 194 56 183
2021/20221.252 49 137 110 136 89 42 53 67 58 126 150 235
2022/20231.433 100 103 222 143 154 309 40 117 148 25 39 33
2023/20241.553 56 34 112 67 74 349 535 30 14 40 36 206
2024/20252.970 127 130 273 153 373 168 143 194 215 151 380 663
2025/202620.305 455 4.457 11.316 1.064 1.269 251 662 200 307 324 0 0
Totale 31.815