The present invention relates to a crystal of the protein thymidylate synthase (TS), in particular human TS, in the presence of a ligand, methods of crystallization thereof and uses thereof. The invention also relates to the three- dimensional structure of a new binding site located in the dimerization interface region of TS protein and applications thereof in the design and obtainment of new inhibitors with pharmacological activity, in particular antitumour activity.
Pozzi, C., Mangani, S., Costi, M.P., Ferrari, S., Guaitoli, G. (2011)CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND. . Brevetto No. WO/2011/067715.
CRYSTAL STRUCTURE OF A COMPLEX OF THYMIDYLATE SYNTHASE (TS) WITH A LIGAND
Cecilia Pozzi;Stefano Mangani;Maria Paola Costi;
2011-01-01
Abstract
The present invention relates to a crystal of the protein thymidylate synthase (TS), in particular human TS, in the presence of a ligand, methods of crystallization thereof and uses thereof. The invention also relates to the three- dimensional structure of a new binding site located in the dimerization interface region of TS protein and applications thereof in the design and obtainment of new inhibitors with pharmacological activity, in particular antitumour activity.
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https://hdl.handle.net/11365/1071993
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