IRIS
MANETTI, FABRIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 31.906
EU - Europa 18.553
AS - Asia 10.439
SA - Sud America 1.946
AF - Africa 426
OC - Oceania 37
Continente sconosciuto - Info sul continente non disponibili 21
AN - Antartide 2
Totale 63.330
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Nazione #
US - Stati Uniti d'America 31.597
GB - Regno Unito 4.634
CN - Cina 3.896
RU - Federazione Russa 3.115
SG - Singapore 3.067
IE - Irlanda 2.281
IT - Italia 2.214
BR - Brasile 1.618
UA - Ucraina 1.533
FR - Francia 1.389
SE - Svezia 1.257
DE - Germania 946
VN - Vietnam 877
HK - Hong Kong 820
KR - Corea 642
FI - Finlandia 507
IN - India 295
CA - Canada 161
TR - Turchia 153
ZA - Sudafrica 148
BD - Bangladesh 120
NL - Olanda 110
AR - Argentina 102
ES - Italia 102
MX - Messico 86
IQ - Iraq 82
JP - Giappone 77
PL - Polonia 72
NG - Nigeria 64
ID - Indonesia 63
EC - Ecuador 62
PK - Pakistan 62
AT - Austria 61
BE - Belgio 61
CI - Costa d'Avorio 61
CZ - Repubblica Ceca 55
RO - Romania 54
VE - Venezuela 44
CO - Colombia 36
KE - Kenya 34
AU - Australia 32
SA - Arabia Saudita 32
EG - Egitto 31
CL - Cile 30
UZ - Uzbekistan 27
MA - Marocco 25
GR - Grecia 24
TN - Tunisia 24
PH - Filippine 23
CH - Svizzera 22
AE - Emirati Arabi Uniti 21
JO - Giordania 21
MY - Malesia 20
EU - Europa 19
PY - Paraguay 18
LT - Lituania 17
AZ - Azerbaigian 15
NP - Nepal 14
UY - Uruguay 14
CR - Costa Rica 13
EE - Estonia 11
BG - Bulgaria 10
DK - Danimarca 10
DZ - Algeria 10
GE - Georgia 10
IL - Israele 10
KZ - Kazakistan 10
PE - Perù 10
TH - Thailandia 10
DO - Repubblica Dominicana 9
IR - Iran 9
OM - Oman 9
AL - Albania 8
ET - Etiopia 8
HU - Ungheria 8
JM - Giamaica 8
PA - Panama 7
RS - Serbia 7
BA - Bosnia-Erzegovina 6
BO - Bolivia 6
HR - Croazia 6
LB - Libano 6
TT - Trinidad e Tobago 6
BH - Bahrain 5
KG - Kirghizistan 5
NZ - Nuova Zelanda 5
PS - Palestinian Territory 5
PT - Portogallo 5
BB - Barbados 4
BS - Bahamas 4
GY - Guiana 4
IM - Isola di Man 4
KH - Cambogia 4
LU - Lussemburgo 4
LV - Lettonia 4
SK - Slovacchia (Repubblica Slovacca) 4
SN - Senegal 4
TW - Taiwan 4
AM - Armenia 3
AO - Angola 3
Totale 63.265
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Città #
Dallas 9.963
Southend 4.195
Menlo Park 3.988
Dublin 2.263
Fairfield 2.096
Singapore 1.721
Ashburn 1.394
Chandler 1.281
Jacksonville 1.255
Woodbridge 998
Beijing 867
Wilmington 862
Moscow 812
Houston 796
Seattle 786
Hong Kong 778
Cambridge 738
Hefei 721
Siena 702
Santa Clara 651
Seoul 634
San Jose 568
Ann Arbor 561
Princeton 455
Nanjing 433
The Dalles 407
Los Angeles 323
Ho Chi Minh City 280
Lauterbourg 272
Helsinki 238
Boardman 225
New York 201
Hanoi 199
Council Bluffs 185
Nanchang 167
Florence 160
Milan 156
San Diego 143
São Paulo 142
San Mateo 137
Buffalo 128
Bengaluru 116
Johannesburg 113
Shenyang 111
Dearborn 104
Rome 103
Shanghai 87
Izmir 84
London 84
Hebei 76
Tianjin 76
Columbus 73
Dong Ket 73
Fremont 73
Orem 72
Changsha 71
Kunming 62
Abidjan 61
Abuja 61
Tokyo 60
Hangzhou 55
Amsterdam 54
Málaga 53
Brussels 51
Toronto 51
Düsseldorf 50
Frankfurt am Main 49
Jiaxing 49
San Francisco 48
Redondo Beach 47
Warsaw 47
Lancaster 46
Montreal 46
Munich 46
Rio de Janeiro 44
Chicago 43
Jinan 40
Bologna 38
Vienna 38
Norwalk 37
Nuremberg 37
Zhengzhou 37
Da Nang 35
Guangzhou 35
Chennai 34
Denver 34
Brooklyn 33
Redwood City 33
Stockholm 32
Timisoara 32
Venezia 31
Baghdad 30
Guayaquil 30
Mexico City 30
Belo Horizonte 28
Philadelphia 28
Atlanta 27
Haiphong 27
Ningbo 27
Paris 27
Totale 46.000
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.499
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 530
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 488
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 418
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases 402
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 387
N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY 382
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma 374
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria 365
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 359
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 358
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 355
Dérivé de quinolinone 355
N-Acylthourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 350
Gli1 inhibitors and uses thereof 349
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 343
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 331
Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog 329
Novel acylguanidine derivatives targeting smoothened induce antiproliferative and pro-apoptotic effects in chronic myeloid leukemia cells 319
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo 312
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 300
Stereoselective Synthesis of Sofosbuvir through Nucleoside Phosphorylation Controlled by Kinetic Resolution 299
Valutazione della specificità di substrato delle lipasi da Candida rugosa e Rhizomucor miehei 298
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 294
Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators 294
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 288
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 288
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 272
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 271
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 265
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 265
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design 264
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 258
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 257
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria 256
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth 255
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog 255
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 250
Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts 250
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 248
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 248
Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials 246
Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design 244
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 243
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria 243
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 241
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 240
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 240
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 239
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 239
Alpha1-Adrenoceptor Antagonists. 4. Pharmacophore-based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives 236
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication 236
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 235
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 235
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis 233
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 233
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 233
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 231
A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent 230
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 229
3D QSAR model on a set of selective A1 adenosine receptor (A1AR) antagonists 227
Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold 226
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 225
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones 224
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 223
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway 222
3-Arilpiperazinilalchilpirrolo[3,2-d]pirimidin-2,4-dione: una nuova classe di ligandi potenti ed altamente selettivi per i recettori alfa1 adrenergici 221
TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 221
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 220
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 220
A drop of enantioselectivity in the Pseudomonas cepacia lipase-catalyzed ester hydrolysis is influenced by the chain length of the fatty acid 219
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 219
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 217
Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress 216
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 214
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor 214
Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extracts 213
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 213
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds 212
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 211
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 211
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes 209
Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria 208
Application of pharmacophore models in medicinal chemistry 207
COR758, a negative allosteric modulator of GABAB receptors 207
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as Smoothened antagonists 205
Hypothesis on Serenoa repens (Bartram) small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure 205
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. 202
A model for the interaction of the sulfonic distamycin A derivatives, angiogenesis-modulating agents, with recombinant human basic fibroblast growth factor (bFGF) 201
Quinolinone derivatives 198
Treatment of alkaptonuria and tyrosinemia type I 198
A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions 198
Synthesis, molecular modeling studies, and pharmacological activity of selective A1 receptor antagonists 198
Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-1H-pirazolo[3,4-d]pirimidina e loro usi. 197
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 197
Targets Looking for Drugs: A Multistep Computational Protocol for the Development of Structure-Based Pharmacophores and Their Applications for Hit Discovery 197
Antimycobacterial compounds. Optimization of the BM212 structure, the lead compound for a new pyrrole derivative class 195
Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines. 195
α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus 195
Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40 195
Totale 33.181
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Categoria #
all - tutte 169.475
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 169.475
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021821 0 0 0 0 0 0 0 0 0 0 445 376
2021/20223.799 301 552 229 225 129 158 184 128 225 459 411 798
2022/20235.194 362 363 704 773 476 1.042 92 433 538 121 195 95
2023/20243.463 149 87 251 127 118 844 1.145 171 20 91 141 319
2024/20256.844 218 423 631 377 565 250 155 467 650 339 679 2.090
2025/202622.743 1.415 4.680 7.249 2.058 2.717 611 1.661 526 606 953 267 0
Totale 63.780