IRIS
MANETTI, FABRIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 30.547
EU - Europa 17.863
AS - Asia 8.656
SA - Sud America 1.783
AF - Africa 226
OC - Oceania 32
Continente sconosciuto - Info sul continente non disponibili 21
AN - Antartide 2
Totale 59.130
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Nazione #
US - Stati Uniti d'America 30.316
GB - Regno Unito 4.582
CN - Cina 3.527
RU - Federazione Russa 3.108
SG - Singapore 2.488
IE - Irlanda 2.279
IT - Italia 2.089
BR - Brasile 1.529
UA - Ucraina 1.528
SE - Svezia 1.253
FR - Francia 1.087
DE - Germania 906
HK - Hong Kong 722
KR - Corea 640
FI - Finlandia 437
VN - Vietnam 419
IN - India 246
TR - Turchia 143
CA - Canada 126
ES - Italia 89
NL - Olanda 87
AR - Argentina 78
BD - Bangladesh 78
MX - Messico 62
BE - Belgio 61
AT - Austria 60
CI - Costa d'Avorio 60
PL - Polonia 56
EC - Ecuador 55
JP - Giappone 55
ZA - Sudafrica 55
CZ - Repubblica Ceca 54
RO - Romania 52
ID - Indonesia 51
IQ - Iraq 45
PK - Pakistan 40
VE - Venezuela 32
CO - Colombia 29
AU - Australia 27
EG - Egitto 27
SA - Arabia Saudita 23
KE - Kenya 22
UZ - Uzbekistan 22
GR - Grecia 21
EU - Europa 19
CL - Cile 18
MA - Marocco 17
AE - Emirati Arabi Uniti 16
CH - Svizzera 16
TN - Tunisia 16
JO - Giordania 15
LT - Lituania 15
PY - Paraguay 13
EE - Estonia 11
PH - Filippine 11
UY - Uruguay 11
AZ - Azerbaigian 10
BG - Bulgaria 10
DK - Danimarca 10
KZ - Kazakistan 10
NP - Nepal 10
IR - Iran 9
DO - Repubblica Dominicana 8
GE - Georgia 8
MY - Malesia 8
PE - Perù 8
TH - Thailandia 8
ET - Etiopia 7
IL - Israele 7
AL - Albania 6
HU - Ungheria 6
OM - Oman 6
BH - Bahrain 5
JM - Giamaica 5
NZ - Nuova Zelanda 5
PT - Portogallo 5
RS - Serbia 5
TT - Trinidad e Tobago 5
BA - Bosnia-Erzegovina 4
BB - Barbados 4
BO - Bolivia 4
DZ - Algeria 4
GY - Guiana 4
HR - Croazia 4
IM - Isola di Man 4
KG - Kirghizistan 4
KH - Cambogia 4
LB - Libano 4
LU - Lussemburgo 4
PA - Panama 4
AM - Armenia 3
AO - Angola 3
BS - Bahamas 3
BY - Bielorussia 3
CG - Congo 3
CR - Costa Rica 3
LK - Sri Lanka 3
LV - Lettonia 3
NG - Nigeria 3
NI - Nicaragua 3
Totale 59.083
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Città #
Dallas 9.949
Southend 4.195
Menlo Park 3.988
Dublin 2.261
Fairfield 2.096
Singapore 1.391
Ashburn 1.312
Chandler 1.281
Jacksonville 1.252
Woodbridge 998
Wilmington 862
Beijing 849
Moscow 812
Houston 791
Seattle 784
Cambridge 738
Hong Kong 704
Siena 702
Seoul 634
Santa Clara 627
Hefei 586
Ann Arbor 561
Princeton 455
Nanjing 433
Los Angeles 270
Boardman 225
The Dalles 218
New York 178
Helsinki 172
Nanchang 167
Florence 148
San Diego 141
San Mateo 137
São Paulo 135
Ho Chi Minh City 134
Council Bluffs 131
Milan 127
Buffalo 123
Bengaluru 116
Shenyang 111
Dearborn 104
Rome 91
Izmir 84
Shanghai 81
London 77
Hebei 76
Tianjin 76
Dong Ket 73
Fremont 73
Hanoi 73
Columbus 71
Changsha 69
Kunming 62
Abidjan 60
Málaga 53
Brussels 51
Hangzhou 51
Düsseldorf 50
Jiaxing 47
Redondo Beach 47
Lancaster 46
San Francisco 46
Munich 45
Tokyo 44
Rio de Janeiro 43
Toronto 42
Montreal 41
Amsterdam 40
Jinan 40
Chicago 39
Vienna 38
Norwalk 37
Zhengzhou 37
Guangzhou 34
Redwood City 33
Bologna 32
Nuremberg 32
Timisoara 32
Warsaw 32
Venezia 31
Denver 30
Stockholm 30
Brooklyn 29
Johannesburg 29
Philadelphia 28
Belo Horizonte 27
Brno 26
Frankfurt am Main 26
Ningbo 26
Orem 26
Guayaquil 25
Dhaka 24
Curitiba 23
Guarulhos 23
Poplar 23
Brasília 21
San Jose 21
Atlanta 20
Jakarta 20
Naples 20
Totale 43.424
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.469
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 512
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 465
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 403
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 365
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases 360
N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY 356
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma 352
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 345
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria 344
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 341
N-Acylthourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 338
Dérivé de quinolinone 333
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 331
Gli1 inhibitors and uses thereof 327
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 327
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 308
Novel acylguanidine derivatives targeting smoothened induce antiproliferative and pro-apoptotic effects in chronic myeloid leukemia cells 306
Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog 299
Valutazione della specificità di substrato delle lipasi da Candida rugosa e Rhizomucor miehei 283
Stereoselective Synthesis of Sofosbuvir through Nucleoside Phosphorylation Controlled by Kinetic Resolution 283
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo 281
Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators 277
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 275
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 275
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 274
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 271
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 260
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 251
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design 251
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 250
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 248
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 240
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria 240
Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design 237
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 235
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 234
Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials 232
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 231
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 229
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog 227
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 227
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 226
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 226
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 226
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 224
Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts 224
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 223
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 223
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 222
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 221
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 221
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 221
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria 221
A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent 220
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth 218
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication 218
3D QSAR model on a set of selective A1 adenosine receptor (A1AR) antagonists 217
Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold 215
Alpha1-Adrenoceptor Antagonists. 4. Pharmacophore-based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives 214
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 214
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 214
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway 213
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 211
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 210
3-Arilpiperazinilalchilpirrolo[3,2-d]pirimidin-2,4-dione: una nuova classe di ligandi potenti ed altamente selettivi per i recettori alfa1 adrenergici 209
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones 209
TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 208
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis 207
A drop of enantioselectivity in the Pseudomonas cepacia lipase-catalyzed ester hydrolysis is influenced by the chain length of the fatty acid 206
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 204
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 203
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 203
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 203
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 202
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 201
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds 200
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes 199
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor 199
Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress 196
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 195
Application of pharmacophore models in medicinal chemistry 195
Treatment of alkaptonuria and tyrosinemia type I 192
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. 190
Hypothesis on Serenoa repens (Bartram) small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure 190
Antimycobacterial compounds. Optimization of the BM212 structure, the lead compound for a new pyrrole derivative class 189
Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria 188
Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extracts 187
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as Smoothened antagonists 187
Targets Looking for Drugs: A Multistep Computational Protocol for the Development of Structure-Based Pharmacophores and Their Applications for Hit Discovery 186
A model for the interaction of the sulfonic distamycin A derivatives, angiogenesis-modulating agents, with recombinant human basic fibroblast growth factor (bFGF) 185
Quinolinone derivatives 185
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 185
Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines. 184
α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus 184
A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions 184
Chemical hybridization approaches applied to natural and synthetic compounds for the discovery of drugs active against neglected tropical diseases 184
COR758, a negative allosteric modulator of GABAB receptors 184
Cyclooxygenase-2 Inhibitors. 1,5-Diarylpyrrol-3-acetic Esters with Enhanced Inhibitory Activity Toward Cyclooxygenase-2 and Improved Cyclooxygenase-2/Cyclooxygenase-1 Selectivity 183
Structure Prediction and Validation of the ERK8 Kinase Domain 183
Totale 31.523
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Categoria #
all - tutte 159.293
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 159.293
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20213.355 0 0 0 0 0 599 196 692 575 472 445 376
2021/20223.799 301 552 229 225 129 158 184 128 225 459 411 798
2022/20235.194 362 363 704 773 476 1.042 92 433 538 121 195 95
2023/20243.463 149 87 251 127 118 844 1.145 171 20 91 141 319
2024/20256.844 218 423 631 377 565 250 155 467 650 339 679 2.090
2025/202618.536 1.415 4.680 7.249 2.058 2.717 417 0 0 0 0 0 0
Totale 59.573