IRIS
MANETTI, FABRIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 30.543
EU - Europa 17.877
AS - Asia 8.611
SA - Sud America 1.766
AF - Africa 219
OC - Oceania 32
Continente sconosciuto - Info sul continente non disponibili 21
AN - Antartide 2
Totale 59.071
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Nazione #
US - Stati Uniti d'America 30.321
GB - Regno Unito 4.585
CN - Cina 3.524
RU - Federazione Russa 3.117
SG - Singapore 2.490
IE - Irlanda 2.284
IT - Italia 2.079
UA - Ucraina 1.534
BR - Brasile 1.514
SE - Svezia 1.250
FR - Francia 1.089
DE - Germania 910
HK - Hong Kong 714
KR - Corea 644
FI - Finlandia 439
VN - Vietnam 402
IN - India 243
TR - Turchia 143
CA - Canada 123
ES - Italia 89
NL - Olanda 85
AR - Argentina 81
BD - Bangladesh 78
BE - Belgio 61
CI - Costa d'Avorio 60
AT - Austria 59
MX - Messico 57
PL - Polonia 57
EC - Ecuador 55
CZ - Repubblica Ceca 54
JP - Giappone 54
ZA - Sudafrica 53
ID - Indonesia 52
RO - Romania 52
IQ - Iraq 40
PK - Pakistan 37
VE - Venezuela 29
AU - Australia 27
CO - Colombia 27
EG - Egitto 27
SA - Arabia Saudita 23
GR - Grecia 21
KE - Kenya 20
UZ - Uzbekistan 20
EU - Europa 19
CL - Cile 18
MA - Marocco 17
AE - Emirati Arabi Uniti 16
CH - Svizzera 16
TN - Tunisia 16
LT - Lituania 14
PY - Paraguay 13
EE - Estonia 11
JO - Giordania 11
UY - Uruguay 11
AZ - Azerbaigian 10
BG - Bulgaria 10
DK - Danimarca 10
KZ - Kazakistan 10
PH - Filippine 10
NP - Nepal 9
DO - Repubblica Dominicana 8
IR - Iran 8
PE - Perù 8
TH - Thailandia 8
ET - Etiopia 7
GE - Georgia 7
IL - Israele 7
MY - Malesia 7
AL - Albania 6
HU - Ungheria 6
OM - Oman 6
BH - Bahrain 5
JM - Giamaica 5
NZ - Nuova Zelanda 5
PT - Portogallo 5
TT - Trinidad e Tobago 5
BA - Bosnia-Erzegovina 4
BB - Barbados 4
BO - Bolivia 4
GY - Guiana 4
HR - Croazia 4
IM - Isola di Man 4
KG - Kirghizistan 4
KH - Cambogia 4
LB - Libano 4
LU - Lussemburgo 4
PA - Panama 4
RS - Serbia 4
AM - Armenia 3
AO - Angola 3
BS - Bahamas 3
BY - Bielorussia 3
CG - Congo 3
CR - Costa Rica 3
LK - Sri Lanka 3
LV - Lettonia 3
NI - Nicaragua 3
SK - Slovacchia (Repubblica Slovacca) 3
SN - Senegal 3
Totale 59.028
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Città #
Dallas 9.952
Southend 4.200
Menlo Park 4.002
Dublin 2.266
Fairfield 2.113
Singapore 1.395
Ashburn 1.307
Chandler 1.281
Jacksonville 1.257
Woodbridge 1.004
Wilmington 868
Beijing 849
Moscow 815
Houston 792
Seattle 788
Cambridge 743
Siena 702
Hong Kong 697
Seoul 638
Santa Clara 626
Hefei 588
Ann Arbor 562
Princeton 457
Nanjing 436
Los Angeles 268
Boardman 225
The Dalles 188
New York 175
Helsinki 173
Nanchang 167
Florence 148
San Diego 143
San Mateo 138
São Paulo 132
Council Bluffs 131
Ho Chi Minh City 129
Milan 126
Buffalo 124
Bengaluru 116
Shenyang 112
Dearborn 104
Rome 86
Izmir 84
Shanghai 81
Hebei 77
London 76
Tianjin 76
Dong Ket 73
Fremont 73
Columbus 71
Changsha 70
Hanoi 69
Kunming 62
Abidjan 60
Málaga 53
Brussels 51
Hangzhou 51
Düsseldorf 50
Jiaxing 47
Redondo Beach 47
Lancaster 46
San Francisco 46
Munich 45
Tokyo 43
Rio de Janeiro 42
Toronto 41
Jinan 40
Montreal 40
Amsterdam 39
Chicago 39
Norwalk 37
Vienna 37
Zhengzhou 37
Guangzhou 34
Redwood City 33
Warsaw 33
Bologna 32
Nuremberg 32
Timisoara 32
Venezia 31
Denver 30
Brooklyn 28
Johannesburg 28
Philadelphia 28
Belo Horizonte 27
Frankfurt am Main 27
Stockholm 27
Brno 26
Ningbo 26
Guayaquil 25
Dhaka 24
Orem 24
Curitiba 23
Guarulhos 23
Poplar 22
Brasília 21
Jakarta 20
Atlanta 19
Olomouc 19
Campinas 18
Totale 43.438
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.466
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 509
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 463
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 403
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 363
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases 357
N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY 356
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma 350
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 343
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 341
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria 341
N-Acylthourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 337
Dérivé de quinolinone 333
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 328
Gli1 inhibitors and uses thereof 327
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 327
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 308
Novel acylguanidine derivatives targeting smoothened induce antiproliferative and pro-apoptotic effects in chronic myeloid leukemia cells 306
Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog 299
Valutazione della specificità di substrato delle lipasi da Candida rugosa e Rhizomucor miehei 283
Stereoselective Synthesis of Sofosbuvir through Nucleoside Phosphorylation Controlled by Kinetic Resolution 281
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo 280
Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators 277
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 274
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 273
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 273
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 270
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 259
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design 251
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 248
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 248
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 246
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 240
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria 240
Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design 237
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 234
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 233
Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials 231
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 228
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 228
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog 227
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 226
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 225
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 225
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 224
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 223
Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts 223
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 222
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 221
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 221
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 220
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 220
A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent 220
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 219
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication 217
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth 216
3D QSAR model on a set of selective A1 adenosine receptor (A1AR) antagonists 216
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria 216
Alpha1-Adrenoceptor Antagonists. 4. Pharmacophore-based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives 214
Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold 214
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 214
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 213
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway 212
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 211
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 210
3-Arilpiperazinilalchilpirrolo[3,2-d]pirimidin-2,4-dione: una nuova classe di ligandi potenti ed altamente selettivi per i recettori alfa1 adrenergici 208
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones 208
TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 208
A drop of enantioselectivity in the Pseudomonas cepacia lipase-catalyzed ester hydrolysis is influenced by the chain length of the fatty acid 206
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 204
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis 204
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 203
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 202
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 202
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 202
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 201
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds 200
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes 199
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor 199
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 195
Application of pharmacophore models in medicinal chemistry 194
Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress 194
Treatment of alkaptonuria and tyrosinemia type I 192
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. 190
Antimycobacterial compounds. Optimization of the BM212 structure, the lead compound for a new pyrrole derivative class 189
Hypothesis on Serenoa repens (Bartram) small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure 189
Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria 188
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as Smoothened antagonists 187
Targets Looking for Drugs: A Multistep Computational Protocol for the Development of Structure-Based Pharmacophores and Their Applications for Hit Discovery 186
Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extracts 185
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 185
A model for the interaction of the sulfonic distamycin A derivatives, angiogenesis-modulating agents, with recombinant human basic fibroblast growth factor (bFGF) 184
Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines. 184
α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus 184
A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions 184
Quinolinone derivatives 183
Cyclooxygenase-2 Inhibitors. 1,5-Diarylpyrrol-3-acetic Esters with Enhanced Inhibitory Activity Toward Cyclooxygenase-2 and Improved Cyclooxygenase-2/Cyclooxygenase-1 Selectivity 183
Chemical hybridization approaches applied to natural and synthetic compounds for the discovery of drugs active against neglected tropical diseases 183
Quercetin‐3‐Oleate Contributes to Skin Wound Healing Targeting FFA1/GPR40 182
COR758, a negative allosteric modulator of GABAB receptors 182
Totale 31.429
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Categoria #
all - tutte 158.651
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 158.651
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20213.367 0 0 0 0 0 600 200 694 578 472 447 376
2021/20223.811 302 555 230 225 129 158 185 128 226 460 412 801
2022/20235.201 363 363 705 775 476 1.045 92 433 538 121 195 95
2023/20243.468 149 87 252 127 118 847 1.146 171 20 91 141 319
2024/20256.866 218 425 632 378 566 250 155 467 652 342 683 2.098
2025/202618.351 1.421 4.687 7.254 2.067 2.723 199 0 0 0 0 0 0
Totale 59.514