IRIS
MANETTI, FABRIZIO
 Distribuzione geografica
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Continente #
NA - Nord America 32.518
EU - Europa 19.745
AS - Asia 10.563
SA - Sud America 1.966
AF - Africa 427
OC - Oceania 37
Continente sconosciuto - Info sul continente non disponibili 21
AN - Antartide 2
Totale 65.279
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Nazione #
US - Stati Uniti d'America 32.184
GB - Regno Unito 4.637
CN - Cina 3.911
IT - Italia 3.390
RU - Federazione Russa 3.115
SG - Singapore 3.082
IE - Irlanda 2.281
BR - Brasile 1.626
UA - Ucraina 1.533
FR - Francia 1.390
SE - Svezia 1.257
DE - Germania 946
VN - Vietnam 883
HK - Hong Kong 824
KR - Corea 643
FI - Finlandia 507
IN - India 296
BD - Bangladesh 196
CA - Canada 171
TR - Turchia 154
ZA - Sudafrica 148
NL - Olanda 112
ES - Italia 105
AR - Argentina 104
MX - Messico 89
IQ - Iraq 82
JP - Giappone 77
PL - Polonia 73
ID - Indonesia 64
NG - Nigeria 64
EC - Ecuador 62
PK - Pakistan 62
AT - Austria 61
BE - Belgio 61
CI - Costa d'Avorio 61
CZ - Repubblica Ceca 56
RO - Romania 54
VE - Venezuela 45
CO - Colombia 39
KE - Kenya 34
CL - Cile 33
AU - Australia 32
SA - Arabia Saudita 32
EG - Egitto 31
UZ - Uzbekistan 27
GR - Grecia 25
MA - Marocco 25
TN - Tunisia 24
PH - Filippine 23
CH - Svizzera 22
MY - Malesia 22
AE - Emirati Arabi Uniti 21
JO - Giordania 21
PY - Paraguay 20
EU - Europa 19
LT - Lituania 17
AZ - Azerbaigian 15
CR - Costa Rica 14
NP - Nepal 14
UY - Uruguay 14
JM - Giamaica 13
TH - Thailandia 12
BG - Bulgaria 11
EE - Estonia 11
DK - Danimarca 10
DZ - Algeria 10
GE - Georgia 10
IL - Israele 10
KZ - Kazakistan 10
PE - Perù 10
DO - Repubblica Dominicana 9
IR - Iran 9
OM - Oman 9
TT - Trinidad e Tobago 9
AL - Albania 8
ET - Etiopia 8
HU - Ungheria 8
BA - Bosnia-Erzegovina 7
BO - Bolivia 7
PA - Panama 7
RS - Serbia 7
HR - Croazia 6
LB - Libano 6
PT - Portogallo 6
BH - Bahrain 5
BS - Bahamas 5
KG - Kirghizistan 5
NZ - Nuova Zelanda 5
PS - Palestinian Territory 5
BB - Barbados 4
BY - Bielorussia 4
GY - Guiana 4
IM - Isola di Man 4
KH - Cambogia 4
LU - Lussemburgo 4
LV - Lettonia 4
SC - Seychelles 4
SK - Slovacchia (Repubblica Slovacca) 4
SN - Senegal 4
TW - Taiwan 4
Totale 65.212
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Città #
Dallas 9.970
Southend 4.195
Menlo Park 3.988
Dublin 2.263
Fairfield 2.096
Singapore 1.726
Ashburn 1.466
Chandler 1.282
Jacksonville 1.256
Woodbridge 998
Beijing 872
Wilmington 863
Moscow 812
Milan 804
Houston 797
Seattle 787
Hong Kong 782
Cambridge 738
Hefei 721
Siena 703
Santa Clara 683
Seoul 634
San Jose 610
Ann Arbor 561
Princeton 455
Nanjing 433
The Dalles 408
Council Bluffs 400
Los Angeles 337
Rome 308
Ho Chi Minh City 281
Lauterbourg 272
Helsinki 238
Boardman 226
New York 209
Hanoi 200
Florence 171
Nanchang 167
San Diego 143
São Paulo 143
San Mateo 137
Buffalo 132
Bengaluru 116
Johannesburg 113
Shenyang 111
Dearborn 104
Shanghai 88
Izmir 84
London 84
Figino 82
Columbus 76
Hebei 76
Tianjin 76
Dong Ket 73
Fremont 73
Orem 73
Changsha 71
Kunming 62
Abidjan 61
Abuja 61
Tokyo 60
Hangzhou 55
Amsterdam 54
Málaga 53
Brussels 51
Toronto 51
Düsseldorf 50
Frankfurt am Main 49
Jiaxing 49
Montreal 48
San Francisco 48
Bologna 47
Chicago 47
Redondo Beach 47
Turin 47
Warsaw 47
Lancaster 46
Munich 46
Rio de Janeiro 45
Naples 43
Jinan 40
Vienna 38
Norwalk 37
Nuremberg 37
Zhengzhou 37
Da Nang 36
Brooklyn 35
Guangzhou 35
Chennai 34
Denver 34
Mexico City 33
Redwood City 33
Stockholm 32
Timisoara 32
Venezia 31
Baghdad 30
Guayaquil 30
Philadelphia 29
Atlanta 28
Belo Horizonte 28
Totale 47.403
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Nome #
1,5-Diaryl-2-ethyl pyrrole derivatives as antimycobacterial agents: design, synthesis, and microbiological evaluation 7.507
1,5-Diarylpyrrole-3-acetic Acids and Esters as Novel Classes of Potent and Highly Selective Cyclooxygenase-2 Inhibitors 538
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 494
1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings 425
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases 410
Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto 389
Dérivé de quinolinone 387
Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma 385
N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY 383
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 371
Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe 369
Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria 367
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 362
Gli1 inhibitors and uses thereof 356
N-Acylthourees et N-acylurees inhibiteurs de la voie de signalisation des proteines Hedgehog 351
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 351
Derives substitues en 4 de pyrazolo[3,4-d]pyrimidine et pyrrolo[2,3-d]pyrimidine et utilisations associees 351
Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog 336
Novel acylguanidine derivatives targeting smoothened induce antiproliferative and pro-apoptotic effects in chronic myeloid leukemia cells 325
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo 316
158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents 308
Stereoselective Synthesis of Sofosbuvir through Nucleoside Phosphorylation Controlled by Kinetic Resolution 307
Valutazione della specificità di substrato delle lipasi da Candida rugosa e Rhizomucor miehei 305
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 305
Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria 303
Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators 297
Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria 289
3D QSAR studies of the interaction between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA). A combined pharmacophore generation and pseudoreceptor modeling approach applied to taxanes and epothilones 279
3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors 276
Differentially activated Src kinase in chemo-naive human primary osteosarcoma cells and effects of a Src kinase inhibitor 270
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 268
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design 268
New 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 266
4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof 266
Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria 264
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth 263
Effects of in vitro simulated digestion on the antioxidant activity of different Camellia sinensis (L.) Kuntze leaves extracts 263
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3s case 256
Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials 256
N-Acylthiourees et N-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog 255
3D QSAR models of interaction between b-tubulin and MSAAs: taxanes and epothilones 251
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. 251
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation 251
A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors 251
Dihydro-alkylthio-benzyl-oxopyrimidines as Inhibitors of Reverse Transcriptase: Synthesis and Rationalization of the Biological Data on Both Wild-Type Enzyme and Relevant Clinical Mutants 250
A genetic-function-approximation-based QSAR model for the affinity of arylpiperazines toward a1 adrenoceptors 249
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria 249
Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design 248
Alpha1-Adrenoceptor Antagonists. 4. Pharmacophore-based Design, Synthesis, and Biological Evaluation of New Imidazo-, Benzimidazo-, and Indoloarylpiperazine Derivatives 247
Antifungal agents. 10. New derivatives of 1-[(Aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity and Quantitative Structure-Analysis Relationship studies 245
3D QSAR studies for the β-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): A pseudoreceptor model for taxanes based on the experimental structure of tubulin 245
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication 243
A combination of molecular dynamics and docking calculations to explore the binding mode of ADS-J1, a polyanionic compound endowed with anti-HIV-1 activity 243
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212 242
Pharmacophoric models and 3D QSAR studies of the adenosine receptor ligands 238
3D QSAR models of interactions between beta-tubulin and microtubule stabilizing antimitotic agents (MSAA): a survey on taxanes and epothilones 238
Synthesis and Evaluation of New Hsp90 Inhibitors Based on a 1,4,5-Trisubstituted 1,2,3-Triazole Scaffold 238
Simplified Analogues of Immucillin-G Retain Potent Human Purine Nucleoside Phosphorylase Inhibitory Activity 237
6-Substituted-4(3H)-pyrimidinones. A family of antiviral agents possessing a broad spectrum of activities 237
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism 237
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis 235
A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent 234
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation 234
3D QSAR model on a set of selective A1 adenosine receptor (A1AR) antagonists 233
A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor 227
Pyrazolo[3,4-d]pyrimidines Endowed with Antiproliferative Activity on Ductal Infiltrating Carcinoma Cells 227
Pirazolo[3,4-d]pirimidine come nuovi agenti antiproliferativi. Sviluppo di un modello 3D QSAR a bassa dipendenza conformazionale 226
Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress 226
Effect of in vitro simulated digestion on the anti-Helicobacter Pylori activity of different Propolis extracts 225
3-Arilpiperazinilalchilpirrolo[3,2-d]pirimidin-2,4-dione: una nuova classe di ligandi potenti ed altamente selettivi per i recettori alfa1 adrenergici 225
The anti-HIV activity of ADS-J1 targets the HIV-1 gp120 224
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model 224
TREATMENT OF ALKAPTONURIA AND TYROSINEMIA TYPE 1 224
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway 223
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds 222
A drop of enantioselectivity in the Pseudomonas cepacia lipase-catalyzed ester hydrolysis is influenced by the chain length of the fatty acid 222
Molecular Dynamics and DFT Study on HIV-1 Nucleocapsid Protein-7 in Complex with Viral Genome 222
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line 221
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors 221
Pyrrole compounds as inibitors of mycobacteria, synthesis thereof and intermediates thereto 218
Synthesis and Interaction with Copper(II) Cations of Cyano- and Aminoresorcin[4]arenes 218
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones 217
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as Smoothened antagonists 214
COR758, a negative allosteric modulator of GABAB receptors 214
Enlarging the NSAIDs Family: Ether, Ester and Acid Derivatives of the 1,5-Diarrylpyrrole Scaffold as novel anti-inflammatory and analgesic agents 212
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 211
Design and synthesis of 1-((1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N'-((E)-3,7-dimethyl-octa-2,6-dienyl)-ethane-1,2-diamine (SQ109) pyrrole hybrid derivatives: discovery of potent anti-tubercular agents effective against multi-drug resistant mycobacteria 211
Hypothesis on Serenoa repens (Bartram) small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure 210
Application of pharmacophore models in medicinal chemistry 209
A dynamic target-based pharmacophoric model mapping the CD4 binding site on HIV-1 gp120 to identify new inhibitors of gp120-CD4 protein-protein interactions 207
Acyl guanidine derivatives modulating the hedgehog protein signaling pathway 206
Antimycobacterial compounds. Optimization of the BM212 structure, the lead compound for a new pyrrole derivative class 205
Structure-Based Optimization of Pyrazolo[3,4-d]pyrimidines as Abl Inhibitors and Antiproliferative Agents toward Human Leukemia Cell Lines. 205
Synthesis, molecular modeling studies, and pharmacological activity of selective A1 receptor antagonists 205
Identification and Mechanism of Action of the Acylguanidine MRT-83, a Novel Potent Smoothened Antagonist 204
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. 204
Targets Looking for Drugs: A Multistep Computational Protocol for the Development of Structure-Based Pharmacophores and Their Applications for Hit Discovery 204
A model for the interaction of the sulfonic distamycin A derivatives, angiogenesis-modulating agents, with recombinant human basic fibroblast growth factor (bFGF) 202
α1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-Alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus 202
Developing Pyrrole-Derived Antimycobacterial Agents: a Rational Lead Optimization Approach 201
Totale 33.901
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Categoria #
all - tutte 175.895
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 175.895
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20223.799 301 552 229 225 129 158 184 128 225 459 411 798
2022/20235.194 362 363 704 773 476 1.042 92 433 538 121 195 95
2023/20243.463 149 87 251 127 118 844 1.145 171 20 91 141 319
2024/20256.844 218 423 631 377 565 250 155 467 650 339 679 2.090
2025/202624.312 1.415 4.680 7.249 2.058 2.717 611 1.661 526 606 953 384 1.452
2026/2027381 381 0 0 0 0 0 0 0 0 0 0 0
Totale 65.730