New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.
Schenone, S., Bruno, O., Ranise, A., Bondavalli, F., Brullo, C., Fossa, P., et al. (2004). New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14(10), 2511-2517 [10.1016/j.bmcl.2004.03.013].
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation
CARRARO, F.;NALDINI, A.;BERNINI, C.;MANETTI, F.;BOTTA, M.
2004-01-01
Abstract
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.
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https://hdl.handle.net/11365/3677
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